Nov. 20, 2018
Dr. Peter Attia, MD is the founder of Attia Medical, PC, a medical practice that focuses on increasing healthspan by minimizing the risk of chronic disease and preserving quality of life. Peter trained for five years at Johns Hopkins in general surgery and then spent two years at NIH as a surgical oncology fellow. He has since been mentored by some of the most experienced and innovative physicians and scientists in the US and Canada.
On this podcast Dr. Tommy Wood, MD talks with Peter about the critical components of lifespan and healthspan, including the factors he has identified as most important. They also discuss the controversial role of statin medication and take a close look at the necessity and sufficiency of risk factors for atherosclerosis. If you want to learn more about Peter’s work, he has a blog, a podcast and an active social media presence.
[00:00:35] Mellow Johnny’s Bike Shop.
[00:04:01] Eddy Merckx.
[00:04:16] Healthspan. Video: Peter Attia - Reverse engineered approach to human longevity.
[00:05:23] Components of healthspan: cognitive, physical, emotional.
[00:08:35] Reverse engineering healthspan.
[00:11:34] Strength, power, aerobic and anaerobic fitness, flexibility.
[00:14:57] Injuries affecting healthspan.
[00:16:27] Exercise dosing studies: Marshall, Simon J., et al. "Translating physical activity recommendations into a pedometer-based step goal: 3000 steps in 30 minutes." American journal of preventive medicine 36.5 (2009): 410-415; Merghani, Ahmed, Aneil Malhotra, and Sanjay Sharma. "The U-shaped relationship between exercise and cardiac morbidity." Trends in cardiovascular medicine 26.3 (2016): 232-240.
[00:17:26] Atrial fibrillation; mitochondrial injury.
[00:19:28] Functional threshold power (FTP).
[00:23:58] Podcast: The High-Performance Athlete with Drs Tommy Wood and Andy Galpin.
[00:23:59] Twin study: Bathgate, Katherine E., et al. "Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits." European journal of applied physiology 118.10 (2018): 2097-2110.
[00:24:50] The emotional component of healthspan.
[00:24:56] The Drive Podcast: Paul Conti, M.D.: trauma, suicide, community, and self-compassion.
[00:26:40] Sam Harris: Meditation.
[00:30:45] Vulnerability as a practitioner.
[00:33:46] Time-restricted feeding.
[00:34:23] Continuous glucose monitoring (CGM); Oura ring.
[00:35:38] Factors contributing to longevity: deprivation of calories and rapamycin.
[00:37:54] Benefits of fasting.
[00:41:04] Free T3:Reverse T3 ratios during fasting.
[00:43:30] Robert Lustig.
[00:45:07] Multi-Ethnic Study of Atherosclerosis (MESA).
[00:46:09] Statins; side effects.
[00:48:36] Lipoprotein(a) - Lp(a).
[00:49:19] Coronary Artery Calcium (CAC) scan.
[00:54:32] Risk factors for atherosclerosis: necessity and sufficiency.
[00:59:03] LDL cholesterol; ApoB.
[01:01:15] Familial Hypercholesterolemia (FH).
[01:06:25] Saturated fat/cholesterol study: Jones, P. J., A. H. Lichtenstein, and E. J. Schaefer. "Interaction of dietary fat saturation and cholesterol level on cholesterol synthesis measured using deuterium incorporation." Journal of lipid research 35.6 (1994): 1093-1101.
[01:09:43] Feldman Protocol.
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