Nourish Balance Thrive http://www.nourishbalancethrive.com/ The Nourish Balance Thrive podcast is designed to help you perform better. Christopher Kelly, your host, is co-founder of Nourish Balance Thrive, an online clinic using advanced biochemical testing to optimize performance in athletes. On the podcast, Chris interviews leading minds in medicine, nutrition and health, as well as world-class athletes and members of the NBT team, to give you up-to-date information on the lifestyle changes and personalized techniques being used to make people go faster – from weekend warriors to Olympians and world champions.

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en-us ℗ & © 2017 Nourish Balance Thrive. All rights reserved. chris@nourishbalancethrive.com Django Web Framework http://blogs.law.harvard.edu/tech/rss https://nourishbalancethrive.s3.amazonaws.com/media/podcasts/shows/img/logo_white_600x600.jpg Nourish Balance Thrive http://www.nourishbalancethrive.com/ Nourish Balance Thrive Christopher Kelly chris@nourishbalancethrive.com The Nourish Balance Thrive podcast is designed to help you perform better. Christopher Kelly, your host, is co-founder of Nourish Balance Thrive, an online clinic using advanced biochemical testing to optimize performance in athletes. On the podcast, Chris interviews leading minds in medicine, nutrition and health, as well as world-class athletes and members of the NBT team, to give you up-to-date information on the lifestyle changes and personalized techniques being used to make people go faster – from weekend warriors to Olympians and world champions. no How to Overcome Amenorrhoea https://nourishbalancethrive.s3.amazonaws.com/podcast/Tawnee.Prazak.on.2017-03-15.at.10.01.mp3 Tawnee Prazak, MS, CSCS, is a triathlete and triathlon coach living in Laguna Beach, California. She’s been involved in the endurance world for nearly a decade and is considered one of today’s leading experts in the field of endurance training, racing, strength training, nutrition and wellness.

When I first started listening to Tawnee’s Endurance Planet podcast, I was utterly addicted to carbohydrate, unable to go more than 40 minutes on the bike without sucking down 30g of sugar in the form of a maltodextrin gel. Week by week her fat-adaptation message sank in, and with some help of UCAN Superstarch training wheels, I was able to dig myself out of that hole.

You should listen to this interview to learn how Tawnee overcame an eating disorder and restored her hormone health; all while continue to enjoy endurance sports.

Check out Life Post Collective, Tawnee's inner-circle community and holistic wellness hub that focuses on taking your health, fitness and nutrition to the next level. People can get access to Tawnee, all her coaching resources, recipes, webinars, like-minded members, and more. Use code "lpc4me" to get your first month free, after that it's just $10/mo.

Contact Tawnee for coaching or consults at coachtawnee.com

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Tawnee Prazak:

[00:00:22] Endurance Planet podcast.

[00:02:47] The Paleo Mom.

[00:03:55] Tawnee's approach to triathlon in 2007.

[00:06:11] The peak before the crash.

[00:07:37] Anorexia.

[00:08:58] Using training as an excuse for disordered eating.

[00:09:49] LCHF.

[00:11:01] Specialising in not specialising; Low-carb Breckenridge.

[00:13:33] The anorexia diagnosis.

[00:16:14] Amenorrhoea.

[00:17:04] Oral birth control.

[00:18:35] Bone density.

[00:20:14] Cognitive decline and CVD risk; see Ann Hathaway podcast below.

[00:20:54] The female triad: low energy availability, amenorrhoea, decreased bone density.

[00:21:08] “Relative Energy Deficiency in Sport” (RED-S).

[00:22:06] Fertility.

[00:23:00] Podcast: Ann Hathaway, MD.

[00:23:52] Root causes of the triad.

[00:24:09] Stress (of all types).

[00:25:49] Learning to say no.

[00:26:53] Productivity .

[00:27:39] Over-exercising.

[00:27:59] Too low-carb.

[00:28:44] Book: No Period. Now What?: A Guide to Regaining Your Cycles and Improving Your Fertility by Nicola J Rinaldi, PhD.

[00:30:05] Teasing apart the effect of low-carb.

[00:31:00] Gender differences.

[00:31:33] Book: Deep Nutrition: Why Your Genes Need Traditional Food by Cate Shanahan, MD

[00:32:55] Cycling carb intake.

[00:33:34] Rapid weight loss,

[00:33:54] Trauma ,

[00:35:27] Compatability of fat-adaptation and hormonal health.

[00:37:01] Cat skiing.

[00:39:40] Tawnee's sweet spot is 90-120g CHO per day.

[00:42:27] UCAN Superstarch, and a honey solution.

[00:44:49] Energy availability formula: 30 kCal per kg of lean body mass, see Reed, Jennifer L., et al. "Energy availability discriminates clinical menstrual status in exercising women." Journal of the International Society of Sports Nutrition 12.1 (2015): 11.

[00:45:46] Gut health.

[00:48:09] Testing.

[00:48:33] Greg White.

[00:50:27] Training plans vs healing protocols.

[00:52:51] Endurance vs strength athlete differences.

[00:53:04] Outside Magazine article on health benefits of a thru-hike/backpacking.

[00:53:55] Stand-up paddle boarding.

[00:56:18] Ocean swimming in Santa Cruz.

[00:57:05] Getting a dog.

[01:00:12] Podcast: Lauren Petersen, PhD.

[01:00:28] Song, Se Jin, et al. "Cohabiting family members share microbiota with one another and with their dogs." Elife 2 (2013): e00458.

[01:01:19] Coaching with Tawnee

[01:02:04] Life Post Collective.

[01:03:41] Brie Wieselman, LAc.

]]>
chris@nourishbalancethrive.com https://nourishbalancethrive.s3.amazonaws.com/podcast/Tawnee.Prazak.on.2017-03-15.at.10.01.mp3 Thu, 20 Apr 2017 18:04:45 GMT Christopher Kelly Tawnee Prazak, MS, CSCS, is a triathlete and triathlon coach living in Laguna Beach, California. She’s been involved in the endurance world for nearly a decade and is considered one of today’s leading experts in the field of endurance training, racing, strength training, nutrition and wellness.

When I first started listening to Tawnee’s Endurance Planet podcast, I was utterly addicted to carbohydrate, unable to go more than 40 minutes on the bike without sucking down 30g of sugar in the form of a maltodextrin gel. Week by week her fat-adaptation message sank in, and with some help of UCAN Superstarch training wheels, I was able to dig myself out of that hole.

You should listen to this interview to learn how Tawnee overcame an eating disorder and restored her hormone health; all while continue to enjoy endurance sports.

Check out Life Post Collective, Tawnee's inner-circle community and holistic wellness hub that focuses on taking your health, fitness and nutrition to the next level. People can get access to Tawnee, all her coaching resources, recipes, webinars, like-minded members, and more. Use code "lpc4me" to get your first month free, after that it's just $10/mo.

Contact Tawnee for coaching or consults at coachtawnee.com

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Tawnee Prazak:

[00:00:22] Endurance Planet podcast.

[00:02:47] The Paleo Mom.

[00:03:55] Tawnee's approach to triathlon in 2007.

[00:06:11] The peak before the crash.

[00:07:37] Anorexia.

[00:08:58] Using training as an excuse for disordered eating.

[00:09:49] LCHF.

[00:11:01] Specialising in not specialising; Low-carb Breckenridge.

[00:13:33] The anorexia diagnosis.

[00:16:14] Amenorrhoea.

[00:17:04] Oral birth control.

[00:18:35] Bone density.

[00:20:14] Cognitive decline and CVD risk; see Ann Hathaway podcast below.

[00:20:54] The female triad: low energy availability, amenorrhoea, decreased bone density.

[00:21:08] “Relative Energy Deficiency in Sport” (RED-S).

[00:22:06] Fertility.

[00:23:00] Podcast: Ann Hathaway, MD.

[00:23:52] Root causes of the triad.

[00:24:09] Stress (of all types).

[00:25:49] Learning to say no.

[00:26:53] Productivity .

[00:27:39] Over-exercising.

[00:27:59] Too low-carb.

[00:28:44] Book: No Period. Now What?: A Guide to Regaining Your Cycles and Improving Your Fertility by Nicola J Rinaldi, PhD.

[00:30:05] Teasing apart the effect of low-carb.

[00:31:00] Gender differences.

[00:31:33] Book: Deep Nutrition: Why Your Genes Need Traditional Food by Cate Shanahan, MD

[00:32:55] Cycling carb intake.

[00:33:34] Rapid weight loss,

[00:33:54] Trauma ,

[00:35:27] Compatability of fat-adaptation and hormonal health.

[00:37:01] Cat skiing.

[00:39:40] Tawnee's sweet spot is 90-120g CHO per day.

[00:42:27] UCAN Superstarch, and a honey solution.

[00:44:49] Energy availability formula: 30 kCal per kg of lean body mass, see Reed, Jennifer L., et al. "Energy availability discriminates clinical menstrual status in exercising women." Journal of the International Society of Sports Nutrition 12.1 (2015): 11.

[00:45:46] Gut health.

[00:48:09] Testing.

[00:48:33] Greg White.

[00:50:27] Training plans vs healing protocols.

[00:52:51] Endurance vs strength athlete differences.

[00:53:04] Outside Magazine article on health benefits of a thru-hike/backpacking.

[00:53:55] Stand-up paddle boarding.

[00:56:18] Ocean swimming in Santa Cruz.

[00:57:05] Getting a dog.

[01:00:12] Podcast: Lauren Petersen, PhD.

[01:00:28] Song, Se Jin, et al. "Cohabiting family members share microbiota with one another and with their dogs." Elife 2 (2013): e00458.

[01:01:19] Coaching with Tawnee

[01:02:04] Life Post Collective.

[01:03:41] Brie Wieselman, LAc.

]]>
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How to Fix Autoimmunity in the over 50s https://nourishbalancethrive.s3.amazonaws.com/podcast/Deborah.Gordon.on.2017-03-14.at.11.30.mp3 Deborah Gordon, MD is a doctor practicing in Ashland, Oregon. Her focus is real food and an active lifestyle which she integrates with gentle and targeted medicine.

You should listen to this interview to learn about the common problems that Dr Gordon encounters in her practice and the treatments getting the best results. We talk about the gut microbiota and gut health in general and the potential link to autoimmunity in its various guises. I was particularly interested in learning of a potential autoimmune connection with atrial fibrillation (afib).

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One remarkable thing that we think you’ll enjoy!

Here’s the outline with this interview with Deborah Gordon, MD:

[00:00:06] Sign up for our highlights email.

[00:02:31] Physicians for Ancestral Health.

[00:04:17] Dean Ornish.

[00:04:28] Weston A. Price Foundation, Gary Taubes.

[00:05:49] Pantheism.

[00:08:58] Midwifery.

[00:11:25] Acceptance from other doctors.

[00:16:55] That Mitchell and Webb Look: Homeopathic A&E.

[00:18:03] Dr Mark Cucuzzella jokingly sent us this infographic. Do the opposite and you’ll get great results!

[00:19:09] Podcast: Prof Tim Noakes.

[00:19:31] Autoimmunity in postmenopausal women.

[00:20:00] Hashimoto's thyroiditis.

[00:20:06] Coeliac and Sjögren's.

[00:20:19] Crohn's and Ulcerative colitis.

[00:22:51] Atrial fibrillation (Afib).

[00:23:07] Anticardiolipin antibody panel.

[00:24:07] The triad: genetics, stressor, leaky gut.

[00:25:41] Gluten and zonulin signalling.

[00:26:25] Exercise-induced leaky gut.

[00:31:16] Hs-CRP.

[00:33:22] Tools to relax: Brain Wave app.

[00:33:41] Dale Bredesen, MD.

[00:34:00] HeartMath, massage.

[00:34:34] Genova Diagnostic nutrition evaluation panel (NutrEval).

[00:34:56] Vitamin A.

[00:35:13] US Wellness Meats.

[00:35:58] Chicken Liver mousse recipe on Dr Gordon’s website.

[00:36:28] Denise Minger BCMO1 gene.

[00:36:58] B1 and B2 deficiency.

[00:37:32] We like the Multi-Vitamin Elite, Dr Gordon prefers the copper-free variants.

[00:38:56] Serum copper and zinc.

[00:39:40] Podcast: Anne Hathaway, MD.

[00:40:04] Chris Masterjohn's antioxidant masterclass.

[00:40:55] 8-OHdG.

[00:41:42] ClevelandHeartLab, Inc.

[00:43:10] APOE. Podcast: Dawn Kernagis, PhD.

[00:43:31] Podcast: Bryan Walsh.

[00:44:18] Bilirubin, GGT, uric acid.

[00:45:07] Fatty liver index.

[00:47:09] Paleo f(x).

[00:48:07] Doctor's Data.

[00:48:55] Lacto and bifido.

[00:49:21] Podcast: Dr Michael Ruscio.

[00:49:53] Gut microbiome diversity.

[00:51:52] Fermented foods.

[00:52:50] Podcast: Lauren Petersen, PhD.

[00:53:56] Low-carb Breckenridge talk on fibre was not online at the time of writing.

[00:54:37] Bill Lagakos: Animal Fibre.

[00:55:03] Dr Gordon’s practice is closed except for patients interested in the Bredesen Protocol.

[00:55:34] Her Physicians for Ancestral Health talk was not online at the time of writing.

]]>
chris@nourishbalancethrive.com https://nourishbalancethrive.s3.amazonaws.com/podcast/Deborah.Gordon.on.2017-03-14.at.11.30.mp3 Fri, 14 Apr 2017 07:04:46 GMT Christopher Kelly Deborah Gordon, MD is a doctor practicing in Ashland, Oregon. Her focus is real food and an active lifestyle which she integrates with gentle and targeted medicine.

You should listen to this interview to learn about the common problems that Dr Gordon encounters in her practice and the treatments getting the best results. We talk about the gut microbiota and gut health in general and the potential link to autoimmunity in its various guises. I was particularly interested in learning of a potential autoimmune connection with atrial fibrillation (afib).

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One remarkable thing that we think you’ll enjoy!

Here’s the outline with this interview with Deborah Gordon, MD:

[00:00:06] Sign up for our highlights email.

[00:02:31] Physicians for Ancestral Health.

[00:04:17] Dean Ornish.

[00:04:28] Weston A. Price Foundation, Gary Taubes.

[00:05:49] Pantheism.

[00:08:58] Midwifery.

[00:11:25] Acceptance from other doctors.

[00:16:55] That Mitchell and Webb Look: Homeopathic A&E.

[00:18:03] Dr Mark Cucuzzella jokingly sent us this infographic. Do the opposite and you’ll get great results!

[00:19:09] Podcast: Prof Tim Noakes.

[00:19:31] Autoimmunity in postmenopausal women.

[00:20:00] Hashimoto's thyroiditis.

[00:20:06] Coeliac and Sjögren's.

[00:20:19] Crohn's and Ulcerative colitis.

[00:22:51] Atrial fibrillation (Afib).

[00:23:07] Anticardiolipin antibody panel.

[00:24:07] The triad: genetics, stressor, leaky gut.

[00:25:41] Gluten and zonulin signalling.

[00:26:25] Exercise-induced leaky gut.

[00:31:16] Hs-CRP.

[00:33:22] Tools to relax: Brain Wave app.

[00:33:41] Dale Bredesen, MD.

[00:34:00] HeartMath, massage.

[00:34:34] Genova Diagnostic nutrition evaluation panel (NutrEval).

[00:34:56] Vitamin A.

[00:35:13] US Wellness Meats.

[00:35:58] Chicken Liver mousse recipe on Dr Gordon’s website.

[00:36:28] Denise Minger BCMO1 gene.

[00:36:58] B1 and B2 deficiency.

[00:37:32] We like the Multi-Vitamin Elite, Dr Gordon prefers the copper-free variants.

[00:38:56] Serum copper and zinc.

[00:39:40] Podcast: Anne Hathaway, MD.

[00:40:04] Chris Masterjohn's antioxidant masterclass.

[00:40:55] 8-OHdG.

[00:41:42] ClevelandHeartLab, Inc.

[00:43:10] APOE. Podcast: Dawn Kernagis, PhD.

[00:43:31] Podcast: Bryan Walsh.

[00:44:18] Bilirubin, GGT, uric acid.

[00:45:07] Fatty liver index.

[00:47:09] Paleo f(x).

[00:48:07] Doctor's Data.

[00:48:55] Lacto and bifido.

[00:49:21] Podcast: Dr Michael Ruscio.

[00:49:53] Gut microbiome diversity.

[00:51:52] Fermented foods.

[00:52:50] Podcast: Lauren Petersen, PhD.

[00:53:56] Low-carb Breckenridge talk on fibre was not online at the time of writing.

[00:54:37] Bill Lagakos: Animal Fibre.

[00:55:03] Dr Gordon’s practice is closed except for patients interested in the Bredesen Protocol.

[00:55:34] Her Physicians for Ancestral Health talk was not online at the time of writing.

]]>
no
How to Make a Career in Paleo https://nourishbalancethrive.s3.amazonaws.com/podcast/Tony.Federico.on.2017-02-15.at.12.02.mp3 Tony Federico is a shining example of how to make a career out of the paleo diet and lifestyle. After a personal training client suggested the diet, Tony never looked back, going on to write for Paleo Magazine and hosting the podcast of the same name. He recently made the decision to move on to VP of marketing at Natural Force; a supplement company committed to making products using only the purest, highest quality, all-natural and organic ingredients.

You should listen to this interview for inspiration, business and career advice.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One remarkable thing that we think you’ll enjoy!

Here’s the outline of this interview with Tony Federico:

[00:00:08] Exercise in a pill? Perhaps not. Sign up for our highlights email for the references.

[00:01:57] Paleo Magazine Radio podcast.

[00:02:11] Tony is now VP of marketing at Natural Force.

[00:04:22] Exercise science in college.

[00:06:07] Psychology degree and personal training certification.

[00:07:50] Crossfit and Paleo.

[00:08:02] Dr Loren Cordain.

[00:09:09] 90-day Paleo challenge on livecaveman.com.

[00:09:50] Mark Sisson interview.

[00:11:23] Many iterations of Paleo.

[00:12:49] Mark's Daily Apple and Primal.

[00:13:15] Carbohydrate curve.

[00:13:25] Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes.

[00:14:24] Blood lipids.

[00:16:14] Metabolic flexibility.

[00:18:14] Food restrictions as symptom control.

[00:19:30] Ex-smoker syndrome.

[00:20:42] The Paleo industry has caught up.

[00:21:20] Paleo Protein and certification.

[00:22:11] Robb Wolf and Art De Vany, PhD.

[00:22:24] Paul Jaminet, PhD.

[00:22:51] Paleo f(x) and AHS.

[00:23:39] Bulletproof Coffee.

[00:26:29] Primal Kitchen – Avocado Oil Mayo.

[00:27:15] Wild Planet sardines.

[00:27:43] Costco coconut oil.

[00:28:28] General Mills Epic Bar.

[00:30:09] Hunting.

[00:31:32] Cooking.

[00:31:40] Blue Apron.

[00:35:12] Coaching and information products, e.g. summits.

[00:35:52] Physicians for Ancestral Health.

[00:36:12] Dr Dan Kalish.

[00:36:20] Paleo Magazine interview.

[00:37:16] Chris Kresser.

[00:38:08] Squatty Potty.

[00:38:31] f.lux.

[00:39:08] Nightshift on iOS.

[00:40:58] Unhelpful: “That's not Paleo!”

[00:44:12] Stay mindful.

[00:45:01] Groupthink.

[00:45:29] Natural Force pre-workout raw tea.

[00:46:41] Founders of Natural Force (Joe & Justin).

[00:49:18] Recovery Nectar.

[00:52:40] @tonyfedfitness on Instagram, FB & Twitter.

]]>
chris@nourishbalancethrive.com https://nourishbalancethrive.s3.amazonaws.com/podcast/Tony.Federico.on.2017-02-15.at.12.02.mp3 Thu, 06 Apr 2017 18:04:59 GMT Christopher Kelly Tony Federico is a shining example of how to make a career out of the paleo diet and lifestyle. After a personal training client suggested the diet, Tony never looked back, going on to write for Paleo Magazine and hosting the podcast of the same name. He recently made the decision to move on to VP of marketing at Natural Force; a supplement company committed to making products using only the purest, highest quality, all-natural and organic ingredients.

You should listen to this interview for inspiration, business and career advice.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One remarkable thing that we think you’ll enjoy!

Here’s the outline of this interview with Tony Federico:

[00:00:08] Exercise in a pill? Perhaps not. Sign up for our highlights email for the references.

[00:01:57] Paleo Magazine Radio podcast.

[00:02:11] Tony is now VP of marketing at Natural Force.

[00:04:22] Exercise science in college.

[00:06:07] Psychology degree and personal training certification.

[00:07:50] Crossfit and Paleo.

[00:08:02] Dr Loren Cordain.

[00:09:09] 90-day Paleo challenge on livecaveman.com.

[00:09:50] Mark Sisson interview.

[00:11:23] Many iterations of Paleo.

[00:12:49] Mark's Daily Apple and Primal.

[00:13:15] Carbohydrate curve.

[00:13:25] Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes.

[00:14:24] Blood lipids.

[00:16:14] Metabolic flexibility.

[00:18:14] Food restrictions as symptom control.

[00:19:30] Ex-smoker syndrome.

[00:20:42] The Paleo industry has caught up.

[00:21:20] Paleo Protein and certification.

[00:22:11] Robb Wolf and Art De Vany, PhD.

[00:22:24] Paul Jaminet, PhD.

[00:22:51] Paleo f(x) and AHS.

[00:23:39] Bulletproof Coffee.

[00:26:29] Primal Kitchen – Avocado Oil Mayo.

[00:27:15] Wild Planet sardines.

[00:27:43] Costco coconut oil.

[00:28:28] General Mills Epic Bar.

[00:30:09] Hunting.

[00:31:32] Cooking.

[00:31:40] Blue Apron.

[00:35:12] Coaching and information products, e.g. summits.

[00:35:52] Physicians for Ancestral Health.

[00:36:12] Dr Dan Kalish.

[00:36:20] Paleo Magazine interview.

[00:37:16] Chris Kresser.

[00:38:08] Squatty Potty.

[00:38:31] f.lux.

[00:39:08] Nightshift on iOS.

[00:40:58] Unhelpful: “That's not Paleo!”

[00:44:12] Stay mindful.

[00:45:01] Groupthink.

[00:45:29] Natural Force pre-workout raw tea.

[00:46:41] Founders of Natural Force (Joe & Justin).

[00:49:18] Recovery Nectar.

[00:52:40] @tonyfedfitness on Instagram, FB & Twitter.

]]>
clean
How to Run Efficiently with Drs Cucuzzella & Wood https://s3.amazonaws.com/nourishbalancethrive/podcast/Mark.Cucuzzella.4.mp3 Dr Mark Cucuzzella, MD, is Professor of medicine at West Virginia University medical school, Fellow of the American Academy of Family Physicians (AAFP), family physician for over 20 years, Lt Col in the US Air Force Reserves, and an avid runner and running coach.

In this episode, Dr Tommy Wood, MD, PhD and Dr Cucuzzella discuss optimal nutrition, running efficiency, fat-adaptation, atrial fibrillation and more.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Dr Mark Cucuzzella, MD:

[00:00:19] Eat berries! And sign up for our Highlights email series.

[00:02:39] Robb Wolf Paleo Solution Episode 329 – Dr. Mark Cucuzzella – A Doctor’s Perspective On Treating Diabetes.

[00:03:38] West Virginia University school of medicine.

[00:04:30] Food insecurity.

[00:05:11] In the Shopping Cart of a Food Stamp Household: Lots of Soda.

[00:06:25] Training people to run and be resilient to injury.

[00:08:10] Efficient Running online course.

[00:11:16] Fit to Win clinic at the Pentagon.

[00:13:03] "Born insulin resistant"–

[00:14:30] Weight Watchers 94% failure rate.

[00:15:31] $60B weight loss industry.

[00:16:20] Real Meal Revolution.

[00:18:22] Giving HOPE!

[00:19:27] Virta Health.

[00:19:42] Diabetes Prevention Program (DPP).

[00:21:20] Phinney, Volek & Hallberg.

[00:21:39] Sarah Hallberg video: Reversing Type 2 diabetes starts with ignoring the guidelines.

[00:22:36] Burn Fat for Health and Performance: Becoming A “Better Butter Burner” (Mark’s VO2 Max results).

[00:23:53] Early running days

[00:24:25] Injuries

[00:25:44] “Most of what we learned in medical school for chronic conditions is wrong”–Dr Mark Cucuzzella.

[00:25:55] Get Fast by Going Slow–Mark Allen article I couldn’t find online, see MAF Methodology instead.

[00:27:13] Brooks Running.

[00:29:54] What if It's All Been a Big Fat Lie? By Gary Taubes.

[00:30:53] Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes.

[00:31:16] Fasting blood glucose 120 mg/dL.

[00:33:12] Art DeVany. See his recent IHMC lecture.

[00:35:49] Book: The Sports Gene: Inside the Science of Extraordinary Athletic Performance by David Epstein

[00:37:01] Kettlebells and Plyometrics.

[00:39:23] Atrial fibrillation.

[00:40:17] CAC score; see The Widowmaker movie.

[00:41:39] Professor Daniel E. Lieberman.

[00:42:02] Hs-CRP.

[00:42:09] NMR LipoProfile®.

[00:43:59] Book: Nutrition and Physical Degeneration by Weston A. Price.

[00:44:45] Hydren, Jay R., and Bruce S. Cohen. "Current scientific evidence for a polarized cardiovascular endurance training model." The Journal of Strength & Conditioning Research 29.12 (2015): 3523-3530.

[00:46:02] Horses versus mules.

[00:46:58] Stephen Seiler, PhD.

[00:48:16] The basics are the same for everyone.

[00:48:31] Sleep and sunlight.

[00:49:29] 1.2 - 1.9 g per minute fat oxidation.

[00:50:57] Sami Inkinen.

[00:51:48] Burn Fat for Health and Performance: Becoming A “Better Butter Burner”

[00:55:00] Faster recovery.

[00:56:34] Rowing.

[00:58:52] The MedCHEFS program at WVU Eastern Division; Professor Robert Lustig, MD.

[01:00:18] Try This conference, West Virginia.

[01:00:56] Scientific Report of the 2015 Dietary Guidelines Advisory Committee.

[01:01:20] Nutrition Coalition.

[01:02:12] Two Rivers Treads minimalist shoe store.

[01:03:51] Natural Running Center blog.

[01:04:05] Freedom’s Run.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mark.Cucuzzella.4.mp3 Thu, 30 Mar 2017 19:03:28 GMT Christopher Kelly Dr Mark Cucuzzella, MD, is Professor of medicine at West Virginia University medical school, Fellow of the American Academy of Family Physicians (AAFP), family physician for over 20 years, Lt Col in the US Air Force Reserves, and an avid runner and running coach.

In this episode, Dr Tommy Wood, MD, PhD and Dr Cucuzzella discuss optimal nutrition, running efficiency, fat-adaptation, atrial fibrillation and more.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Dr Mark Cucuzzella, MD:

[00:00:19] Eat berries! And sign up for our Highlights email series.

[00:02:39] Robb Wolf Paleo Solution Episode 329 – Dr. Mark Cucuzzella – A Doctor’s Perspective On Treating Diabetes.

[00:03:38] West Virginia University school of medicine.

[00:04:30] Food insecurity.

[00:05:11] In the Shopping Cart of a Food Stamp Household: Lots of Soda.

[00:06:25] Training people to run and be resilient to injury.

[00:08:10] Efficient Running online course.

[00:11:16] Fit to Win clinic at the Pentagon.

[00:13:03] "Born insulin resistant"–

[00:14:30] Weight Watchers 94% failure rate.

[00:15:31] $60B weight loss industry.

[00:16:20] Real Meal Revolution.

[00:18:22] Giving HOPE!

[00:19:27] Virta Health.

[00:19:42] Diabetes Prevention Program (DPP).

[00:21:20] Phinney, Volek & Hallberg.

[00:21:39] Sarah Hallberg video: Reversing Type 2 diabetes starts with ignoring the guidelines.

[00:22:36] Burn Fat for Health and Performance: Becoming A “Better Butter Burner” (Mark’s VO2 Max results).

[00:23:53] Early running days

[00:24:25] Injuries

[00:25:44] “Most of what we learned in medical school for chronic conditions is wrong”–Dr Mark Cucuzzella.

[00:25:55] Get Fast by Going Slow–Mark Allen article I couldn’t find online, see MAF Methodology instead.

[00:27:13] Brooks Running.

[00:29:54] What if It's All Been a Big Fat Lie? By Gary Taubes.

[00:30:53] Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes.

[00:31:16] Fasting blood glucose 120 mg/dL.

[00:33:12] Art DeVany. See his recent IHMC lecture.

[00:35:49] Book: The Sports Gene: Inside the Science of Extraordinary Athletic Performance by David Epstein

[00:37:01] Kettlebells and Plyometrics.

[00:39:23] Atrial fibrillation.

[00:40:17] CAC score; see The Widowmaker movie.

[00:41:39] Professor Daniel E. Lieberman.

[00:42:02] Hs-CRP.

[00:42:09] NMR LipoProfile®.

[00:43:59] Book: Nutrition and Physical Degeneration by Weston A. Price.

[00:44:45] Hydren, Jay R., and Bruce S. Cohen. "Current scientific evidence for a polarized cardiovascular endurance training model." The Journal of Strength & Conditioning Research 29.12 (2015): 3523-3530.

[00:46:02] Horses versus mules.

[00:46:58] Stephen Seiler, PhD.

[00:48:16] The basics are the same for everyone.

[00:48:31] Sleep and sunlight.

[00:49:29] 1.2 - 1.9 g per minute fat oxidation.

[00:50:57] Sami Inkinen.

[00:51:48] Burn Fat for Health and Performance: Becoming A “Better Butter Burner”

[00:55:00] Faster recovery.

[00:56:34] Rowing.

[00:58:52] The MedCHEFS program at WVU Eastern Division; Professor Robert Lustig, MD.

[01:00:18] Try This conference, West Virginia.

[01:00:56] Scientific Report of the 2015 Dietary Guidelines Advisory Committee.

[01:01:20] Nutrition Coalition.

[01:02:12] Two Rivers Treads minimalist shoe store.

[01:03:51] Natural Running Center blog.

[01:04:05] Freedom’s Run.

]]>
no
An Update on The Athlete Microbiome Project https://nourishbalancethrive.s3.amazonaws.com/podcast/Lauren.Petersen.on.2017-02-21.at.11.30.mp3 Lauren Petersen, PhD, is a postdoctoral associate investigating the microbiome and she’s back on the podcast to update us on her research. Be sure to listen to our first interview first!

I sent Lauren some of the probiotics we use in our practice, and she said, “they look great!”

Lauren did some calculations for the number of CFUs, and she got pretty much exactly what the bottle claims for live organisms, with growth on both Lactobacillus-selective and Bifidobacterium-selective medias. The same was not true for Renew probiotics where her qPCR analysis showed that Bifidobacterium was pretty much all dead.

Here are some photos of the Lactobacillus-selective and Bifidobacterium-selective plates that Lauren used to grow the probiotics. She shot for 250 CFUs per plate (based on if all the organisms per gramme probiotic were alive) and that's pretty much what she got!

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Lauren Petersen, PhD:

[00:00:32] Previous episode: The Athlete Microbiome Project: The Search for the Golden Microbiome.

[00:03:10] Prevotella.

[00:04:42] uBiome and The American Gut Project.

[00:05:25] Scher, Jose U., et al. "Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis." Elife 2 (2013): e01202.

[00:06:33] Probiotics: S. boulardii.

[00:08:48] Bifidobacteria.

[00:09:54] Testing probiotics: Renew Life.

[00:12:06] D-Lactate Free Bifido Probiotic.

[00:12:28] Sign up for our highlights email.

[00:14:44] qPCR analysis definitely picked up lactobacillus.

[00:15:33] 16S vs qPCR.

[00:16:03] RNA-Seq.

[00:17:20] Whole-genome shotgun.

[00:18:26] 60-day Bionic Fiber Program.

[00:19:11] Brummel & Brown 35% Vegetable Oil Spread with Yogurt + bananas. I’m not linking to this rubbish because it’s not fit for human consumption.

[00:21:25] Akkamansia.

[00:21:49] Remely, Marlene, et al. "Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study." Wiener klinische Wochenschrift 127.9-10 (2015): 394-398.

[00:24:41] Tolerating inulin.

[00:25:22] Celeriac root.

[00:26:19] Where do the microbes come from?

[00:28:33] Antibiotics.

[00:29:09] Cephalexin antibiotic.

[00:29:56] Clindamycin antibiotic.

[00:32:08] Amoxicillin antibiotic.

[00:33:54] Metabolic endotoxaemia.

[00:39:28] Mother Dirt.

[00:41:42] FMT and the Taymount Clinic.

[00:42:17] 4-Cresol Vancomycin.

]]>
chris@nourishbalancethrive.com https://nourishbalancethrive.s3.amazonaws.com/podcast/Lauren.Petersen.on.2017-02-21.at.11.30.mp3 Thu, 23 Mar 2017 16:03:15 GMT Christopher Kelly Lauren Petersen, PhD, is a postdoctoral associate investigating the microbiome and she’s back on the podcast to update us on her research. Be sure to listen to our first interview first!

I sent Lauren some of the probiotics we use in our practice, and she said, “they look great!”

Lauren did some calculations for the number of CFUs, and she got pretty much exactly what the bottle claims for live organisms, with growth on both Lactobacillus-selective and Bifidobacterium-selective medias. The same was not true for Renew probiotics where her qPCR analysis showed that Bifidobacterium was pretty much all dead.

Here are some photos of the Lactobacillus-selective and Bifidobacterium-selective plates that Lauren used to grow the probiotics. She shot for 250 CFUs per plate (based on if all the organisms per gramme probiotic were alive) and that's pretty much what she got!

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Lauren Petersen, PhD:

[00:00:32] Previous episode: The Athlete Microbiome Project: The Search for the Golden Microbiome.

[00:03:10] Prevotella.

[00:04:42] uBiome and The American Gut Project.

[00:05:25] Scher, Jose U., et al. "Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis." Elife 2 (2013): e01202.

[00:06:33] Probiotics: S. boulardii.

[00:08:48] Bifidobacteria.

[00:09:54] Testing probiotics: Renew Life.

[00:12:06] D-Lactate Free Bifido Probiotic.

[00:12:28] Sign up for our highlights email.

[00:14:44] qPCR analysis definitely picked up lactobacillus.

[00:15:33] 16S vs qPCR.

[00:16:03] RNA-Seq.

[00:17:20] Whole-genome shotgun.

[00:18:26] 60-day Bionic Fiber Program.

[00:19:11] Brummel & Brown 35% Vegetable Oil Spread with Yogurt + bananas. I’m not linking to this rubbish because it’s not fit for human consumption.

[00:21:25] Akkamansia.

[00:21:49] Remely, Marlene, et al. "Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study." Wiener klinische Wochenschrift 127.9-10 (2015): 394-398.

[00:24:41] Tolerating inulin.

[00:25:22] Celeriac root.

[00:26:19] Where do the microbes come from?

[00:28:33] Antibiotics.

[00:29:09] Cephalexin antibiotic.

[00:29:56] Clindamycin antibiotic.

[00:32:08] Amoxicillin antibiotic.

[00:33:54] Metabolic endotoxaemia.

[00:39:28] Mother Dirt.

[00:41:42] FMT and the Taymount Clinic.

[00:42:17] 4-Cresol Vancomycin.

]]>
clean
Wired to Eat with Robb Wolf https://s3.amazonaws.com/nourishbalancethrive/podcast/Robb.Wolf.on.2017-02-22.at.08.59.mp3 In 2010, with his New York Times Bestselling book The Paleo Solution, Robb Wolf presented the answers that enabled me to recover my health. His podcast of the same name launched my business and connected me with the incredible partners who helped shape NBT into an online clinic that has now helped over a thousand athletes achieve optimal health and performance.

In his new book, Wired to Eat, Robb carefully examines the neuroregulation of appetite as this is necessary for eating enough to be healthy, but not so much that we see weight gain and the plethora of Western degenerative diseases such as cardiovascular disease, neurodegeneration and type 2 diabetes.

Robb's primary goal with this material is to remove the guilt and shame many people feel around making changes in their food and movement. We STILL need to do the work, but if we understand this may legitimately be a challenging process, we can avoid the sense of failure and self-loathing. Mixed into all this Robb talks about sleep, photoperiod, stress, digestion, the gut microbiome, autoimmunity. It’s a lot of material, but we think it covers most situations and will be helpful whether one is struggling with weight or is a top tier athlete.

Learn more about Wired to Eat, including the special launch bonuses!

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Robb Wolf:

[00:00:41] Robb’s first book was The Paleo Solution: The Original Human Diet (2010).

[00:01:31] The Paleo Solution podcast.

[00:01:51] Amelia Luker, RN, is my ultra hard working employee #1 who makes much of the NBT of the magic happen.

[00:02:44] Marty Kendall has a fantastic website and Facebook group both named Optimising Nutrition.

[00:04:25] Sign up for our weekly highlights email.

[00:05:35] The first book was so successful, why write a second?

[00:06:38] Customisation was lacking in the original approach.

[00:07:21] Whole30.

[00:08:09] We are wired to eat.

[00:10:52] Most health and fitness books are ghostwritten.

[00:12:55] Why not a retreat, or a training course, or self-publish?

[00:13:56] Tucker Max: Book in a Box.

[00:14:46] Reno Risk Assessment Program (explicit).

[00:15:45] Lorain Cordain and Gary Taubes.

[00:15:53] Dr Jim Greenwald.

[00:16:30] 22M savings, 33:1 return on investment.

[00:17:04] Dr Gerald Reaven.

[00:18:51] Workman's comp 1.5M cost?

[00:21:20] Train the trainer.

[00:24:06] Biomarkers to identify “the dead man walking.”

[00:24:46] William Cromwell, MD, Discipline Director, Cardiovascular Disease at LabCorp.

[00:25:26] LDL-P.

[00:27:14] Ivor Cummins (aka The Fat Emperor), and the late Dr Joseph Kraft.

[00:28:29] Book pre-order bonuses.

[00:30:12] Thrive Market.

[00:32:16] The Paleo Diet is “more misunderstood than a goth kid in Arkansas.”

[00:32:41] Continuous glucose monitoring (CGM).

[00:34:29] Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094.

[00:37:39] Glucose challenge in hunter gathers.

[00:38:58] Does one size fit all for glucose tolerance?

[00:40:56] Chris Masterjohn, PhD.

[00:46:00] The septic patient. See Robb’s talk at UCSF.

[00:46:32] Lipopolysaccharide (LPS).

[00:50:58] Straub, Rainer H., and Carsten Schradin. "Chronic inflammatory systemic diseases An evolutionary trade-off between acutely beneficial but chronically harmful programs." Evolution, medicine, and public health 2016.1 (2016): 37-51.

[00:54:52] Managing complexity.

[00:57:08] Photoperiod.

[00:58:27] Crossfit and martial arts.

[00:59:56] What should I do when I grow up?

[01:00:18] Myers-Briggs personality test.

[01:01:39] Economic risk tolerance.

[01:02:34] Physician's assistant.

[01:04:58] Cleveland Clinic Functional Medicine.

[01:05:11] Kresser Institute.

[01:06:10] Rheumatoid arthritis.

[01:07:33] f you own a gym or other business and would like to sell copies of Wired To Eat you can pre-order in bulk! Please send email to hello@robbwolf.com with “Bulk order” in the subject line for details.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Robb.Wolf.on.2017-02-22.at.08.59.mp3 Thu, 16 Mar 2017 11:03:17 GMT Christopher Kelly In 2010, with his New York Times Bestselling book The Paleo Solution, Robb Wolf presented the answers that enabled me to recover my health. His podcast of the same name launched my business and connected me with the incredible partners who helped shape NBT into an online clinic that has now helped over a thousand athletes achieve optimal health and performance.

In his new book, Wired to Eat, Robb carefully examines the neuroregulation of appetite as this is necessary for eating enough to be healthy, but not so much that we see weight gain and the plethora of Western degenerative diseases such as cardiovascular disease, neurodegeneration and type 2 diabetes.

Robb's primary goal with this material is to remove the guilt and shame many people feel around making changes in their food and movement. We STILL need to do the work, but if we understand this may legitimately be a challenging process, we can avoid the sense of failure and self-loathing. Mixed into all this Robb talks about sleep, photoperiod, stress, digestion, the gut microbiome, autoimmunity. It’s a lot of material, but we think it covers most situations and will be helpful whether one is struggling with weight or is a top tier athlete.

Learn more about Wired to Eat, including the special launch bonuses!

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Robb Wolf:

[00:00:41] Robb’s first book was The Paleo Solution: The Original Human Diet (2010).

[00:01:31] The Paleo Solution podcast.

[00:01:51] Amelia Luker, RN, is my ultra hard working employee #1 who makes much of the NBT of the magic happen.

[00:02:44] Marty Kendall has a fantastic website and Facebook group both named Optimising Nutrition.

[00:04:25] Sign up for our weekly highlights email.

[00:05:35] The first book was so successful, why write a second?

[00:06:38] Customisation was lacking in the original approach.

[00:07:21] Whole30.

[00:08:09] We are wired to eat.

[00:10:52] Most health and fitness books are ghostwritten.

[00:12:55] Why not a retreat, or a training course, or self-publish?

[00:13:56] Tucker Max: Book in a Box.

[00:14:46] Reno Risk Assessment Program (explicit).

[00:15:45] Lorain Cordain and Gary Taubes.

[00:15:53] Dr Jim Greenwald.

[00:16:30] 22M savings, 33:1 return on investment.

[00:17:04] Dr Gerald Reaven.

[00:18:51] Workman's comp 1.5M cost?

[00:21:20] Train the trainer.

[00:24:06] Biomarkers to identify “the dead man walking.”

[00:24:46] William Cromwell, MD, Discipline Director, Cardiovascular Disease at LabCorp.

[00:25:26] LDL-P.

[00:27:14] Ivor Cummins (aka The Fat Emperor), and the late Dr Joseph Kraft.

[00:28:29] Book pre-order bonuses.

[00:30:12] Thrive Market.

[00:32:16] The Paleo Diet is “more misunderstood than a goth kid in Arkansas.”

[00:32:41] Continuous glucose monitoring (CGM).

[00:34:29] Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094.

[00:37:39] Glucose challenge in hunter gathers.

[00:38:58] Does one size fit all for glucose tolerance?

[00:40:56] Chris Masterjohn, PhD.

[00:46:00] The septic patient. See Robb’s talk at UCSF.

[00:46:32] Lipopolysaccharide (LPS).

[00:50:58] Straub, Rainer H., and Carsten Schradin. "Chronic inflammatory systemic diseases An evolutionary trade-off between acutely beneficial but chronically harmful programs." Evolution, medicine, and public health 2016.1 (2016): 37-51.

[00:54:52] Managing complexity.

[00:57:08] Photoperiod.

[00:58:27] Crossfit and martial arts.

[00:59:56] What should I do when I grow up?

[01:00:18] Myers-Briggs personality test.

[01:01:39] Economic risk tolerance.

[01:02:34] Physician's assistant.

[01:04:58] Cleveland Clinic Functional Medicine.

[01:05:11] Kresser Institute.

[01:06:10] Rheumatoid arthritis.

[01:07:33] f you own a gym or other business and would like to sell copies of Wired To Eat you can pre-order in bulk! Please send email to hello@robbwolf.com with “Bulk order” in the subject line for details.

]]>
yes
Is Your Skin Missing This Essential Peacekeeping Bacteria? https://s3.amazonaws.com/nourishbalancethrive/podcast/Mother.Dirt.on.2017-02-15.at.10.32.mp3 Jasmina Aganovic is a cosmetics and consumer goods entrepreneur who received her degree in chemical and biological engineering from MIT, and she’s back on the podcast to talk about the progress AOBiome have made with their clinical trials. In this interview, we focus mostly on the potential treatment of acne and hypertension, but trials are also underway for allergies, eczema, wound healing, migraines and temperature regulation.

Mother Dirt is the company focussed on commercialising the research of AOBiome, and I’ve been using their AO+ Mist spray product for over two years for the successful prevention of nappy (diaper) rash, saddle sores, and acne caused by bike helmets. I’ve also been using the spray in the place of a deodorant, and so far my wife hasn’t divorced me. Jasmina wanted to make it clear that although my N=1 experiences are exciting, nothing has been FDA approved.

Head over to Mother Dirt and take advantage of the generous 25% discount on offer. Use the code NBT25.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Jasmina Aganovic:

[00:03:43] Environmental changes are leading to the loss of the ammonia oxidising (AO) bacteria.

[00:05:14] Nitrogen cycle.

[00:07:18] David Whitlock is the Inventor and co-founder of AOBiome.

[00:07:34] Why horses roll in the dirt in March?

[00:08:36] The link between the skin and the soil.

[00:09:36] Developing a bioreactor.

[00:10:28] Nappy rash.

[00:11:05] Bicycle helmets.

[00:13:11] The scientific process to validate the claims.

[00:13:55] Phase II trials for acne.

[00:14:26] A potential replacement for antiperspirant deodorant.

[00:14:50] Prevention of saddle sores.

[00:15:36] The war on P. acne.

[00:16:49] It's all about balance.

[00:17:23] C. diff overgrowths.

[00:18:49] Mechanism of action: acid, base balance.

[00:19:44] Nitrite and Nitric oxide.

[00:20:55] Not nitrous oxide! Which mucks up methylation by oxidising cobalamin.

[00:21:52] Hypertension.

[00:24:05] Highlights sign-up.

[00:25:09] Can nitric oxide made by the bacteria on the skin become systemic?

[00:26:47] Why FDA approval.

[00:29:37] Adverse events.

[00:30:47] Drug: B244 on clinicaltrials.gov.

[00:31:16] Romaine Bardet came 2nd in the Tour de France.

[00:32:28] Increasing O2 deliverability.

[00:33:46] Personal care product compatibility.

[00:34:11] Surfactant sodium octyl sulfate (SOS) and sodium dodecyl sulfate (SDS) surfactants.

[00:35:13] Castille and neem soap.

[00:36:11] Nurses and hand sanitisers.

[00:37:59] http://www.nourishbalancethrive.com/dirt/ use discount code NBT25.

[00:38:35] Mother Dirt is the consumer-facing site, to learn about the clinical research go to AOBiome.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mother.Dirt.on.2017-02-15.at.10.32.mp3 Thu, 09 Mar 2017 18:03:42 GMT Christopher Kelly Jasmina Aganovic is a cosmetics and consumer goods entrepreneur who received her degree in chemical and biological engineering from MIT, and she’s back on the podcast to talk about the progress AOBiome have made with their clinical trials. In this interview, we focus mostly on the potential treatment of acne and hypertension, but trials are also underway for allergies, eczema, wound healing, migraines and temperature regulation.

Mother Dirt is the company focussed on commercialising the research of AOBiome, and I’ve been using their AO+ Mist spray product for over two years for the successful prevention of nappy (diaper) rash, saddle sores, and acne caused by bike helmets. I’ve also been using the spray in the place of a deodorant, and so far my wife hasn’t divorced me. Jasmina wanted to make it clear that although my N=1 experiences are exciting, nothing has been FDA approved.

Head over to Mother Dirt and take advantage of the generous 25% discount on offer. Use the code NBT25.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  • One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  • One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  • One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Jasmina Aganovic:

[00:03:43] Environmental changes are leading to the loss of the ammonia oxidising (AO) bacteria.

[00:05:14] Nitrogen cycle.

[00:07:18] David Whitlock is the Inventor and co-founder of AOBiome.

[00:07:34] Why horses roll in the dirt in March?

[00:08:36] The link between the skin and the soil.

[00:09:36] Developing a bioreactor.

[00:10:28] Nappy rash.

[00:11:05] Bicycle helmets.

[00:13:11] The scientific process to validate the claims.

[00:13:55] Phase II trials for acne.

[00:14:26] A potential replacement for antiperspirant deodorant.

[00:14:50] Prevention of saddle sores.

[00:15:36] The war on P. acne.

[00:16:49] It's all about balance.

[00:17:23] C. diff overgrowths.

[00:18:49] Mechanism of action: acid, base balance.

[00:19:44] Nitrite and Nitric oxide.

[00:20:55] Not nitrous oxide! Which mucks up methylation by oxidising cobalamin.

[00:21:52] Hypertension.

[00:24:05] Highlights sign-up.

[00:25:09] Can nitric oxide made by the bacteria on the skin become systemic?

[00:26:47] Why FDA approval.

[00:29:37] Adverse events.

[00:30:47] Drug: B244 on clinicaltrials.gov.

[00:31:16] Romaine Bardet came 2nd in the Tour de France.

[00:32:28] Increasing O2 deliverability.

[00:33:46] Personal care product compatibility.

[00:34:11] Surfactant sodium octyl sulfate (SOS) and sodium dodecyl sulfate (SDS) surfactants.

[00:35:13] Castille and neem soap.

[00:36:11] Nurses and hand sanitisers.

[00:37:59] http://www.nourishbalancethrive.com/dirt/ use discount code NBT25.

[00:38:35] Mother Dirt is the consumer-facing site, to learn about the clinical research go to AOBiome.

]]>
clean
The Importance of Strength Training for Endurance Athletes https://s3.amazonaws.com/nourishbalancethrive/podcast/Mike.T.Nelson.on.2017-02-14.at.11.00.mp3 Since starting NBT, I’ve noticed a growing gap between what I'm doing (lots of cycling) and what I need to be doing for longevity (strength training). This year then, I plan to focus more on strength. The trouble is, I've no clue what I'm doing! Luckily, I was able to hire Dr Mike T Nelson, PhD as my strength and conditioning coach.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  1. One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  2. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  3. One awesome thing that we think you’ll enjoy!

You should listen to this interview to learn why all athletes, including endurance athletes, should be strength training. I started Dr Mike's programme about six weeks before recording which meant I had lots of questions and honest feedback.

Here’s the outline of this interview with Dr Mike T Nelson, PhD:

[00:00:56] First interview: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea…

[00:03:31] Reconciling multiple coaches.

[00:03:45] Setting goals.

[00:04:27] Strength for longevity.

[00:04:47] Dr Andy Galpin, PhD.

[00:05:32] All athletes should be strength training.

[00:08:10] Jeff Kendall-Weed.

[00:09:47] Biomechanics.

[00:11:07] Reducing risk of injury.

[00:11:32] Deadlifts.

[00:13:32] Don't squat the weight up!

[00:15:00] Don't copy powerlifters.

[00:15:52] Video: Dr Mike analysing my deadlift and his own.

[00:18:54] Psoas muscle.

[00:20:21] Warming up.

[00:21:15] RPR: reflexive performance reset.

[00:23:10] Quadratus lumborum (QL) muscle.

[00:24:32] Sets and rep ranges.

[00:26:08] Linear progression of volume.

[00:29:04] Monitoring fatigue.

[00:29:40] Heart rate variability (HRV) see my interview with Jason Moore of Elite HRV.

[00:30:25] Recording sets and reps, software.

[00:31:56] Volume, intensity, and density (volume / time).

[00:35:43] Strength vs endurance effects on HRV.

[00:37:06] Terzis, Gerasimos, et al. "Early phase interference between low-intensity running and power training in moderately trained females." European journal of applied physiology 116.5 (2016): 1063-1073. Coffey, Vernon G., and John A. Hawley. "Concurrent exercise training: do opposites distract?." The Journal of physiology (2016).

[00:39:22] Endurance volume.

[00:40:15] Session quality and progressive overload.

[00:41:20] 10% drop off for intervals.

[00:42:31] Issurin residual training effects chart.

[00:45:41] Dr Ben Peterson, PhD.

[00:46:28] MAF pace.

[00:47:12] Biofeedback range of motion test.

[00:47:54] Sumo vs conventional deadlift

[00:50:58] John Meadows - Meadows’s Row.

[00:51:56] Plate press--work with an open palm.

[00:54:21] Front squat.

[00:54:45] Zercher squat.

[00:55:03] Zombie front squat

[00:57:58] Rubix cube back squat.

[00:59:19] Chin-ups and pull-ups.

[01:00:59] Mike has two spots open.

[01:01:24] http://miketnelson.com/muscle

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mike.T.Nelson.on.2017-02-14.at.11.00.mp3 Thu, 02 Mar 2017 07:03:40 GMT Christopher Kelly Since starting NBT, I’ve noticed a growing gap between what I'm doing (lots of cycling) and what I need to be doing for longevity (strength training). This year then, I plan to focus more on strength. The trouble is, I've no clue what I'm doing! Luckily, I was able to hire Dr Mike T Nelson, PhD as my strength and conditioning coach.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  1. One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  2. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  3. One awesome thing that we think you’ll enjoy!

You should listen to this interview to learn why all athletes, including endurance athletes, should be strength training. I started Dr Mike's programme about six weeks before recording which meant I had lots of questions and honest feedback.

Here’s the outline of this interview with Dr Mike T Nelson, PhD:

[00:00:56] First interview: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea…

[00:03:31] Reconciling multiple coaches.

[00:03:45] Setting goals.

[00:04:27] Strength for longevity.

[00:04:47] Dr Andy Galpin, PhD.

[00:05:32] All athletes should be strength training.

[00:08:10] Jeff Kendall-Weed.

[00:09:47] Biomechanics.

[00:11:07] Reducing risk of injury.

[00:11:32] Deadlifts.

[00:13:32] Don't squat the weight up!

[00:15:00] Don't copy powerlifters.

[00:15:52] Video: Dr Mike analysing my deadlift and his own.

[00:18:54] Psoas muscle.

[00:20:21] Warming up.

[00:21:15] RPR: reflexive performance reset.

[00:23:10] Quadratus lumborum (QL) muscle.

[00:24:32] Sets and rep ranges.

[00:26:08] Linear progression of volume.

[00:29:04] Monitoring fatigue.

[00:29:40] Heart rate variability (HRV) see my interview with Jason Moore of Elite HRV.

[00:30:25] Recording sets and reps, software.

[00:31:56] Volume, intensity, and density (volume / time).

[00:35:43] Strength vs endurance effects on HRV.

[00:37:06] Terzis, Gerasimos, et al. "Early phase interference between low-intensity running and power training in moderately trained females." European journal of applied physiology 116.5 (2016): 1063-1073. Coffey, Vernon G., and John A. Hawley. "Concurrent exercise training: do opposites distract?." The Journal of physiology (2016).

[00:39:22] Endurance volume.

[00:40:15] Session quality and progressive overload.

[00:41:20] 10% drop off for intervals.

[00:42:31] Issurin residual training effects chart.

[00:45:41] Dr Ben Peterson, PhD.

[00:46:28] MAF pace.

[00:47:12] Biofeedback range of motion test.

[00:47:54] Sumo vs conventional deadlift

[00:50:58] John Meadows - Meadows’s Row.

[00:51:56] Plate press--work with an open palm.

[00:54:21] Front squat.

[00:54:45] Zercher squat.

[00:55:03] Zombie front squat

[00:57:58] Rubix cube back squat.

[00:59:19] Chin-ups and pull-ups.

[01:00:59] Mike has two spots open.

[01:01:24] http://miketnelson.com/muscle

]]>
clean
Specialists, Synthesizers, and Popularizers with Drs. Wood and Gerstmar https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.Tim.Gerstmar.02.15.2017.mp3 This episode is syndicated from Dr Tim Gerstmar Aspire Natural Health podcast. We love Dr Gerstmar and would highly recommend you subscribe to his show.

You should listen to this episode to get a fly-on-the-wall perspective of two brilliant doctors with different backgrounds problem-solving using similar techniques.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  1. One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  2. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  3. One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Drs Tommy Wood and Tim Gerstmar:

[00:00:48] Highlights email sign up.

[00:04:02] Protocols vs. basic science education and principles.

[00:06:05] Cooks and chefs.

[00:07:18] Tim's previous appearances on my podcast: How to Test and Predict Blood, Urine and Stool for Health, Longevity and Performance and Methylation and Environmental Pollutants with Dr. Tim Gerstmar.

[00:07:53] Tommy's background and path into medicine.

[00:09:03] Internal and emergency medicine.

[00:09:35] Tommy recently successfully defended his PhD.

[00:10:13] Emergency vs. health care

[00:10:41] Examining the root cause of multiple sclerosis using engineering techniques (paper, talk for the public, talk for physicians).

[00:11:30] Tommy's blog and podcast.

[00:11:53] Robb Wolf’s Paleo Solution podcast.

[00:12:21] Kalish Institute for Functional Medicine.

[00:13:28] Applying knowledge in the real world.

[00:13:50] PubMed warrior.

[00:14:37] The sexy abstract.

[00:16:52] Ivor Cummins, aka The Fat Emperor.

[00:18:29] The popularisers.

[00:19:04] Seattle.

[00:20:04] Neonatal neuroprotection.

[00:21:18] Dale Bredesen's protocol to reverse Alzheimer's.

[00:21:49] Buck Institute for Research on Aging.

[00:21:59] Bredesen, Dale E. "Reversal of cognitive decline: A novel therapeutic program." Aging (Albany NY) 6.9 (2014): 707-717.

[00:22:36] Bredesen, Dale E. "Metabolic profiling distinguishes three subtypes of Alzheimer's disease." Aging (Albany NY) 7.8 (2015): 595-600.

[00:23:36] Cytoplan supplements.

[00:24:40] Dementia screen.

[00:25:34] Requesting an MRI.

[00:26:07] B12, folate, vitamin D.

[00:27:08] Health insurance companies are not incentivised for the long term.

[00:30:09] Evolutionary mismatches.

[00:31:34] Article: How Iceland Got Teens to Say No to Drugs - The Atlantic.

[00:33:07] Wasting willpower on diet, the importance of family buy-in.

[00:36:04] Communal eating.

[00:36:32] Ludvigsson, Jonas F., et al. "Increased suicide risk in coeliac disease—a Swedish nationwide cohort study." Digestive and Liver Disease 43.8 (2011): 616-622.

[00:38:24] The psychological cost of achieving physical perfection.

[00:39:23] There is no biological free lunch.

[00:40:07] Book: The Power of Full Engagement: Managing Energy, Not Time, Is the Key to High Performance and Personal Renewal.

[00:41:17] Orthorexia.

[00:42:34] The goal is balance.

[00:44:00] Health Unplugged, Darryl Edwards.

[00:46:09] About NBT.

[00:48:53] Simple Guide to the Paleo Autoimmune Protocol.

[00:49:04] Jamie Kendall-Weed, MD.

[00:50:15] The basics are the same for everyone.

[00:51:18] The plant analogy of health.

[00:52:26] The Foundations of Health.

[00:53:20] Even coaches need coaches.

[00:54:25] Functional Forum.

[00:56:21] Medical doctors are trapped in a system that doesn't work.

[00:57:39] Integrative psychologist.

[00:59:17] Telemedicine.

[01:01:19] Most of what we do doesn't require a doctor, but sometimes we make a referral.

[01:02:56] The Bredesen Protocol is evidence-based medicine.

[01:05:37] The alternative world needs to publish.

[01:09:31] Chiropractor on Tim's podcast "driving out chiros out of practice"

[01:13:00] No one has all the answers

[01:15:27] Dr Ragnar on Facebook and Twitter.

 
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.Tim.Gerstmar.02.15.2017.mp3 Thu, 23 Feb 2017 13:02:58 GMT Christopher Kelly This episode is syndicated from Dr Tim Gerstmar Aspire Natural Health podcast. We love Dr Gerstmar and would highly recommend you subscribe to his show.

You should listen to this episode to get a fly-on-the-wall perspective of two brilliant doctors with different backgrounds problem-solving using similar techniques.

Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following:

  1. One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up.
  2. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why.
  3. One awesome thing that we think you’ll enjoy!

Here’s the outline of this interview with Drs Tommy Wood and Tim Gerstmar:

[00:00:48] Highlights email sign up.

[00:04:02] Protocols vs. basic science education and principles.

[00:06:05] Cooks and chefs.

[00:07:18] Tim's previous appearances on my podcast: How to Test and Predict Blood, Urine and Stool for Health, Longevity and Performance and Methylation and Environmental Pollutants with Dr. Tim Gerstmar.

[00:07:53] Tommy's background and path into medicine.

[00:09:03] Internal and emergency medicine.

[00:09:35] Tommy recently successfully defended his PhD.

[00:10:13] Emergency vs. health care

[00:10:41] Examining the root cause of multiple sclerosis using engineering techniques (paper, talk for the public, talk for physicians).

[00:11:30] Tommy's blog and podcast.

[00:11:53] Robb Wolf’s Paleo Solution podcast.

[00:12:21] Kalish Institute for Functional Medicine.

[00:13:28] Applying knowledge in the real world.

[00:13:50] PubMed warrior.

[00:14:37] The sexy abstract.

[00:16:52] Ivor Cummins, aka The Fat Emperor.

[00:18:29] The popularisers.

[00:19:04] Seattle.

[00:20:04] Neonatal neuroprotection.

[00:21:18] Dale Bredesen's protocol to reverse Alzheimer's.

[00:21:49] Buck Institute for Research on Aging.

[00:21:59] Bredesen, Dale E. "Reversal of cognitive decline: A novel therapeutic program." Aging (Albany NY) 6.9 (2014): 707-717.

[00:22:36] Bredesen, Dale E. "Metabolic profiling distinguishes three subtypes of Alzheimer's disease." Aging (Albany NY) 7.8 (2015): 595-600.

[00:23:36] Cytoplan supplements.

[00:24:40] Dementia screen.

[00:25:34] Requesting an MRI.

[00:26:07] B12, folate, vitamin D.

[00:27:08] Health insurance companies are not incentivised for the long term.

[00:30:09] Evolutionary mismatches.

[00:31:34] Article: How Iceland Got Teens to Say No to Drugs - The Atlantic.

[00:33:07] Wasting willpower on diet, the importance of family buy-in.

[00:36:04] Communal eating.

[00:36:32] Ludvigsson, Jonas F., et al. "Increased suicide risk in coeliac disease—a Swedish nationwide cohort study." Digestive and Liver Disease 43.8 (2011): 616-622.

[00:38:24] The psychological cost of achieving physical perfection.

[00:39:23] There is no biological free lunch.

[00:40:07] Book: The Power of Full Engagement: Managing Energy, Not Time, Is the Key to High Performance and Personal Renewal.

[00:41:17] Orthorexia.

[00:42:34] The goal is balance.

[00:44:00] Health Unplugged, Darryl Edwards.

[00:46:09] About NBT.

[00:48:53] Simple Guide to the Paleo Autoimmune Protocol.

[00:49:04] Jamie Kendall-Weed, MD.

[00:50:15] The basics are the same for everyone.

[00:51:18] The plant analogy of health.

[00:52:26] The Foundations of Health.

[00:53:20] Even coaches need coaches.

[00:54:25] Functional Forum.

[00:56:21] Medical doctors are trapped in a system that doesn't work.

[00:57:39] Integrative psychologist.

[00:59:17] Telemedicine.

[01:01:19] Most of what we do doesn't require a doctor, but sometimes we make a referral.

[01:02:56] The Bredesen Protocol is evidence-based medicine.

[01:05:37] The alternative world needs to publish.

[01:09:31] Chiropractor on Tim's podcast "driving out chiros out of practice"

[01:13:00] No one has all the answers

[01:15:27] Dr Ragnar on Facebook and Twitter.

 
]]>
clean
Five Things Every Athlete Needs to Do to Succeed https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2017-02-06.at.18.01.mp3 Sign up for our highlights email and each week we’ll send you:

  1. An interesting scientific paper we've read with actionable advice.
  2. Nonsense we read/heard this week and why it's nonsense.
  3. Something awesome we read/listened to this week and why it's awesome.

I was inspired to record this podcast by a discussion that took place on the Lower Insulin Facebook group. I love the conversation that goes on over there, but like many of debates we see around the Internet, the conversation is somewhat one-dimensional. Low-carb, high-fat, moderate protein, intermittent fasting and you'll be okay. After working with close to 1,000 athletes to improve their health, performance and longevity, we know that's not always true, and we’re confident that a complete solution must give consideration to everything we outline in this episode.

The five things (in no particular order):

1. Eat a minimally processed diet food free of added sugar and vegetable oils (processed fats).

Because processed foods:

  • Are less nutrient-dense.
  • Are designed to make you overeat.
  • Increase insulin responses due to processing.
  • Alter the gut microbiota unfavourably.
  • Translocate endotoxins such as LPS across the gut wall. This induces inflammation and hyperinsulinaemia.
  • Induce leptin and insulin resistance centrally which leads to overeating.

2. Get sufficient sleep and Sunlight!

3. Appropriately manage stress, social connectedness and purpose. Consider stress of dieting.

4. Move like a human, i.e. walk, stand, and occasionally lift heavy things.

5. Consider magnesium and zinc deficiency (especially in athletes).

If you’re an athlete and you’re doing all of the above (and I mean doing not knowing) and you’re still not meeting your goals then we should talk! Book a free consultation online.

Here’s the outline of this interview with Dr Tommy Wood, MD, PhD:

[00:00:34] Tommy's PhD defence.

[00:04:32] Low Carb Breckenridge 2017.

[00:04:43] Dr Jeffry N. Gerber, MD, FAAFP.

[00:06:07] LPS (endotoxin) translocation across the gut wall.

[00:07:28] Coronary artery calcium score, see The Widowmaker movie.

[00:09:12] Functional Blood Chemistry Presented by: Dr Bryan Walsh.

[00:10:32] Lower Insulin Facebook group.

[00:11:49] Minimally processed diet free of added sugar and processed fats.

[00:15:46] The gut microbiome, insulin and leptin resistance.

[00:16:11] Emulsifiers.

[00:16:47] Gluten, dairy, soy and eggs.

[00:18:06] Food sensitivity testing.

[00:19:14] Podcast with Dr Ellen Langer, PhD: How to Think Yourself Younger, Healthier, and Faster.

[00:19:58] ALCAT and MRT food sensitivity tests.

[00:22:21] Nutrition, Paleolithic. "A consideration of its nature and current implications." New England Journal of Medicine 312.5 (1985): 283-9.

[00:22:35] Sleep.

[00:25:33] Podcast: How to Get Perfect Sleep with Dr Kirk Parsley, MD.

[00:26:51] Breaking the vicious sleep cycle.

[00:27:08] Podcast with Dr Chris Masterjohn, PhD: Why We Get Fat and What You Should Really Do About It.

[00:27:20] Photoperiod: go the fuck outside already.

[00:28:43] F.lux et al.

[00:29:01] Yoon, In-Young, et al. "Luteinizing hormone following light exposure in healthy young men." Neuroscience letters 341.1 (2003): 25-28.

[00:30:57] Stress.

[00:31:09] Podcast with Dr Bryan Walsh: Social Isolation: The Most Important Topic Nobody is Talking About.

[00:32:05] Purpose.

[00:35:54] Sir Ken Robinson, PhD: books and TED Talk.

[00:36:34] Book: Why Zebras Don't Get Ulcers by Dr Robert M. Sapolsky, PhD.

[00:38:20] Headspace, Calm.

[00:39:30] Movement, especially walking.

[00:40:34] Podcasts with Katy Bowman and Dr Kelly Starrett.

[00:41:02] Getting a dog.

[00:43:07] Ivor Cummins: magnesium and zinc deficiency.

[00:44:31] Highlights email sign-up.

[00:47:38] Testing. See podcast with Dr Bill Shaw: Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health.

[00:48:17] Podcast with Todd Becker: Getting Stronger.

[00:48:36] Smoke from wood stove.

[00:49:12] Advanced glycation end products (AGEs).

[00:49:49] Allostatic load.

[00:50:11] Vlassara, Helen, et al. "Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial." Diabetologia 59.10 (2016): 2181-2192. And Uribarri, Jaime, et al. "Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes." Diabetes care 34.7 (2011): 1610-1616.

[00:52:34] Helko Vario 2000 Heavy Log Splitter (maul).

[00:53:30] Podcast with Joshua Fields Millburn: Love People and Use Things (Because the Opposite Never Works).

[00:53:36] The Fireplace Delusion by Sam Harris. Naeher, Luke P., et al. "Woodsmoke health effects: a review." Inhalation toxicology 19.1 (2007): 67-106.

[00:53:59] Carmella, Steven G., et al. "Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers." Chemical research in toxicology 22.4 (2009): 734-741.

[00:55:33] Tommy's personal blog. Trumble, Benjamin C., et al. "Age-independent increases in male salivary testosterone during horticultural activity among Tsimane forager-farmers." Evolution and Human Behavior 34.5 (2013): 350-357.

[01:00:43] Personal care products, see the EWG’s Skin Deep database.

[01:01:36] Stool testing.

[01:01:47] GI-MAP.

[01:02:43] Blastocystis parasite blog.

[01:03:20] Rajič, Borko, et al. "Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report." The Journal of Infection in Developing Countries 9.07 (2015): 788-791.

[01:05:31] Doctor's Data test.

[01:05:40] Cyclospora parasite.

[01:06:52] Jones, Kathleen R., Jeannette M. Whitmire, and D. Scott Merrell. "A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease." Frontiers in microbiology 1 (2010): 115.

[01:08:22] Biocidin liquid.

[01:09:18] Book a free consultation.

[01:10:47] If I don’t have the answer, then Tommy will, and if he doesn’t then someone I’ve interviewed will, so if you work with me you know you’re going to get fixed no matter what.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2017-02-06.at.18.01.mp3 Fri, 17 Feb 2017 08:02:41 GMT Christopher Kelly Sign up for our highlights email and each week we’ll send you:

  1. An interesting scientific paper we've read with actionable advice.
  2. Nonsense we read/heard this week and why it's nonsense.
  3. Something awesome we read/listened to this week and why it's awesome.

I was inspired to record this podcast by a discussion that took place on the Lower Insulin Facebook group. I love the conversation that goes on over there, but like many of debates we see around the Internet, the conversation is somewhat one-dimensional. Low-carb, high-fat, moderate protein, intermittent fasting and you'll be okay. After working with close to 1,000 athletes to improve their health, performance and longevity, we know that's not always true, and we’re confident that a complete solution must give consideration to everything we outline in this episode.

The five things (in no particular order):

1. Eat a minimally processed diet food free of added sugar and vegetable oils (processed fats).

Because processed foods:

  • Are less nutrient-dense.
  • Are designed to make you overeat.
  • Increase insulin responses due to processing.
  • Alter the gut microbiota unfavourably.
  • Translocate endotoxins such as LPS across the gut wall. This induces inflammation and hyperinsulinaemia.
  • Induce leptin and insulin resistance centrally which leads to overeating.

2. Get sufficient sleep and Sunlight!

3. Appropriately manage stress, social connectedness and purpose. Consider stress of dieting.

4. Move like a human, i.e. walk, stand, and occasionally lift heavy things.

5. Consider magnesium and zinc deficiency (especially in athletes).

If you’re an athlete and you’re doing all of the above (and I mean doing not knowing) and you’re still not meeting your goals then we should talk! Book a free consultation online.

Here’s the outline of this interview with Dr Tommy Wood, MD, PhD:

[00:00:34] Tommy's PhD defence.

[00:04:32] Low Carb Breckenridge 2017.

[00:04:43] Dr Jeffry N. Gerber, MD, FAAFP.

[00:06:07] LPS (endotoxin) translocation across the gut wall.

[00:07:28] Coronary artery calcium score, see The Widowmaker movie.

[00:09:12] Functional Blood Chemistry Presented by: Dr Bryan Walsh.

[00:10:32] Lower Insulin Facebook group.

[00:11:49] Minimally processed diet free of added sugar and processed fats.

[00:15:46] The gut microbiome, insulin and leptin resistance.

[00:16:11] Emulsifiers.

[00:16:47] Gluten, dairy, soy and eggs.

[00:18:06] Food sensitivity testing.

[00:19:14] Podcast with Dr Ellen Langer, PhD: How to Think Yourself Younger, Healthier, and Faster.

[00:19:58] ALCAT and MRT food sensitivity tests.

[00:22:21] Nutrition, Paleolithic. "A consideration of its nature and current implications." New England Journal of Medicine 312.5 (1985): 283-9.

[00:22:35] Sleep.

[00:25:33] Podcast: How to Get Perfect Sleep with Dr Kirk Parsley, MD.

[00:26:51] Breaking the vicious sleep cycle.

[00:27:08] Podcast with Dr Chris Masterjohn, PhD: Why We Get Fat and What You Should Really Do About It.

[00:27:20] Photoperiod: go the fuck outside already.

[00:28:43] F.lux et al.

[00:29:01] Yoon, In-Young, et al. "Luteinizing hormone following light exposure in healthy young men." Neuroscience letters 341.1 (2003): 25-28.

[00:30:57] Stress.

[00:31:09] Podcast with Dr Bryan Walsh: Social Isolation: The Most Important Topic Nobody is Talking About.

[00:32:05] Purpose.

[00:35:54] Sir Ken Robinson, PhD: books and TED Talk.

[00:36:34] Book: Why Zebras Don't Get Ulcers by Dr Robert M. Sapolsky, PhD.

[00:38:20] Headspace, Calm.

[00:39:30] Movement, especially walking.

[00:40:34] Podcasts with Katy Bowman and Dr Kelly Starrett.

[00:41:02] Getting a dog.

[00:43:07] Ivor Cummins: magnesium and zinc deficiency.

[00:44:31] Highlights email sign-up.

[00:47:38] Testing. See podcast with Dr Bill Shaw: Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health.

[00:48:17] Podcast with Todd Becker: Getting Stronger.

[00:48:36] Smoke from wood stove.

[00:49:12] Advanced glycation end products (AGEs).

[00:49:49] Allostatic load.

[00:50:11] Vlassara, Helen, et al. "Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial." Diabetologia 59.10 (2016): 2181-2192. And Uribarri, Jaime, et al. "Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes." Diabetes care 34.7 (2011): 1610-1616.

[00:52:34] Helko Vario 2000 Heavy Log Splitter (maul).

[00:53:30] Podcast with Joshua Fields Millburn: Love People and Use Things (Because the Opposite Never Works).

[00:53:36] The Fireplace Delusion by Sam Harris. Naeher, Luke P., et al. "Woodsmoke health effects: a review." Inhalation toxicology 19.1 (2007): 67-106.

[00:53:59] Carmella, Steven G., et al. "Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers." Chemical research in toxicology 22.4 (2009): 734-741.

[00:55:33] Tommy's personal blog. Trumble, Benjamin C., et al. "Age-independent increases in male salivary testosterone during horticultural activity among Tsimane forager-farmers." Evolution and Human Behavior 34.5 (2013): 350-357.

[01:00:43] Personal care products, see the EWG’s Skin Deep database.

[01:01:36] Stool testing.

[01:01:47] GI-MAP.

[01:02:43] Blastocystis parasite blog.

[01:03:20] Rajič, Borko, et al. "Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report." The Journal of Infection in Developing Countries 9.07 (2015): 788-791.

[01:05:31] Doctor's Data test.

[01:05:40] Cyclospora parasite.

[01:06:52] Jones, Kathleen R., Jeannette M. Whitmire, and D. Scott Merrell. "A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease." Frontiers in microbiology 1 (2010): 115.

[01:08:22] Biocidin liquid.

[01:09:18] Book a free consultation.

[01:10:47] If I don’t have the answer, then Tommy will, and if he doesn’t then someone I’ve interviewed will, so if you work with me you know you’re going to get fixed no matter what.

]]>
yes
World Champion Rower and Ketone Monoester Researcher Brianna Stubbs https://s3.amazonaws.com/nourishbalancethrive/podcast/Brianna.Stubbs.on.2017-01-11.at.11.53.mp3 Brianna Stubbs, PhD is an extraordinary woman on multiple levels. She was the youngest person ever to row across the English Channel, has represented GB at every age level and won gold at the World U23 Championships in 2013, and again at the senior level at the 2016 World Championships. Brianna will be looking to build on that success during the Tokyo 2020 Olympiad.

If that wasn’t enough, Brianna recently gained her PhD in Biochemical Physiology at Oxford University where she worked alongside Dr Kieran Clarke to develop a novel ketone monoester that has recently been shown to improve exercise performance in endurance athletes.

You should listen to this podcast to discover the special benefits of ketones and their supplementation.

Here’s the outline of this interview with Brianna Stubbs, PhD:

[00:01:10] Early rowing days.

[00:02:10] Different types of athlete: rowing versus sculling.

[00:03:14] Rowing training is mostly endurance, but the races are short.

[00:05:00] 24 mMol/L blood lactate!

[00:05:25] When Propel Coaching tested my lactate threshold I topped out at a measly 7.8.

[00:06:18] Lactate clearance.

[00:07:20] The road to medical school.

[00:08:52] Kieran Clarke, PhD.

[00:10:03] Juggling training and academic work.

[00:12:19] Working on the ketone monoester.

[00:12:39] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes.

[00:12:49] Ketone salts.

[00:13:22] How ketone supplements improve athletic performance.

[00:14:39] Ketones spare protein.

[00:15:09] What type of events stand to benefit.

[00:16:37] Sweet spot 2-4 mM?

[00:17:16] Stellingwerff, Trent[Author] ? Ref

[00:18:14] Palatability and tolerability.

[00:20:11] What level of athlete stands to benefit?

[00:21:29] 2% cycling performance over a 1h TT. See Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:23:16] Diet vs supplements.

[00:24:22] Interview with Mike T. Nelson: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea…

[00:24:36] Monocarboxylate transporter.

[00:25:36] Randle cycle.

[00:27:32] Ketosis implies a bias towards fat!

[00:28:19] High glucose and ketones.

[00:28:38] Exogenous ketones lower glucose.

[00:29:42] Each person may be different.

[00:29:59] Applications outside of sports performance.

[00:31:48] Ketone supplements for weight loss.

[00:32:14] Gibson, A. A., et al. "Do ketogenic diets really suppress appetite? A systematic review and meta‐analysis." obesity reviews 16.1 (2015): 64-76. And Paoli, Antonio, et al. "Ketosis, ketogenic diet and food intake control: a complex relationship." (2015).

[00:33:07] Suppressed ghrelin.

[00:35:02] Plans for the future.

[00:36:23] Dominic D'Agostino. Lots of good interviews recently, including SNR #164: Dominic D’Agostino, PhD – Press-Pulse Model of Cancer Therapy, Ketones & Metabolic Drugs.

[00:36:38] Volek J[Author] & Phinney SD[Author].

[00:36:54] PHAT FIBRE study (in press).

[00:39:59] The Precision Xtra meter by Abbott measures only the physiological D-BHB.

[00:41:10] Mass spectrometry chiral analysis.

[00:41:49] Podcast: The Race to Make a Ketone Supplement, See Lincoln, Beth C., Christine Des Rosiers, and Henri Brunengraber. "Metabolism of S-3-hydroxybutyrate in the perfused rat liver." Archives of biochemistry and biophysics 259.1 (1987): 149-156.

[00:42:13] Hsu, Wei-Yu, et al. "Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages." Journal of Chromatography B 879.29 (2011): 3331-3336. And Tsai, Yih-Chiao, et al. "Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes." Life sciences 78.12 (2006): 1385-1391.

[00:46:39] Book: The Case Against Sugar by Gary Taubes.

[00:47:14] Chris Masterjohn exchanging nutritional bogeymen.

[00:48:32] Availability of the ketone monoester.

[00:49:22] Brianna Stubbs (@BriannaStubbs) on Twitter.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Brianna.Stubbs.on.2017-01-11.at.11.53.mp3 Fri, 10 Feb 2017 07:02:14 GMT Christopher Kelly Brianna Stubbs, PhD is an extraordinary woman on multiple levels. She was the youngest person ever to row across the English Channel, has represented GB at every age level and won gold at the World U23 Championships in 2013, and again at the senior level at the 2016 World Championships. Brianna will be looking to build on that success during the Tokyo 2020 Olympiad.

If that wasn’t enough, Brianna recently gained her PhD in Biochemical Physiology at Oxford University where she worked alongside Dr Kieran Clarke to develop a novel ketone monoester that has recently been shown to improve exercise performance in endurance athletes.

You should listen to this podcast to discover the special benefits of ketones and their supplementation.

Here’s the outline of this interview with Brianna Stubbs, PhD:

[00:01:10] Early rowing days.

[00:02:10] Different types of athlete: rowing versus sculling.

[00:03:14] Rowing training is mostly endurance, but the races are short.

[00:05:00] 24 mMol/L blood lactate!

[00:05:25] When Propel Coaching tested my lactate threshold I topped out at a measly 7.8.

[00:06:18] Lactate clearance.

[00:07:20] The road to medical school.

[00:08:52] Kieran Clarke, PhD.

[00:10:03] Juggling training and academic work.

[00:12:19] Working on the ketone monoester.

[00:12:39] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes.

[00:12:49] Ketone salts.

[00:13:22] How ketone supplements improve athletic performance.

[00:14:39] Ketones spare protein.

[00:15:09] What type of events stand to benefit.

[00:16:37] Sweet spot 2-4 mM?

[00:17:16] Stellingwerff, Trent[Author] ? Ref

[00:18:14] Palatability and tolerability.

[00:20:11] What level of athlete stands to benefit?

[00:21:29] 2% cycling performance over a 1h TT. See Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:23:16] Diet vs supplements.

[00:24:22] Interview with Mike T. Nelson: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea…

[00:24:36] Monocarboxylate transporter.

[00:25:36] Randle cycle.

[00:27:32] Ketosis implies a bias towards fat!

[00:28:19] High glucose and ketones.

[00:28:38] Exogenous ketones lower glucose.

[00:29:42] Each person may be different.

[00:29:59] Applications outside of sports performance.

[00:31:48] Ketone supplements for weight loss.

[00:32:14] Gibson, A. A., et al. "Do ketogenic diets really suppress appetite? A systematic review and meta‐analysis." obesity reviews 16.1 (2015): 64-76. And Paoli, Antonio, et al. "Ketosis, ketogenic diet and food intake control: a complex relationship." (2015).

[00:33:07] Suppressed ghrelin.

[00:35:02] Plans for the future.

[00:36:23] Dominic D'Agostino. Lots of good interviews recently, including SNR #164: Dominic D’Agostino, PhD – Press-Pulse Model of Cancer Therapy, Ketones & Metabolic Drugs.

[00:36:38] Volek J[Author] & Phinney SD[Author].

[00:36:54] PHAT FIBRE study (in press).

[00:39:59] The Precision Xtra meter by Abbott measures only the physiological D-BHB.

[00:41:10] Mass spectrometry chiral analysis.

[00:41:49] Podcast: The Race to Make a Ketone Supplement, See Lincoln, Beth C., Christine Des Rosiers, and Henri Brunengraber. "Metabolism of S-3-hydroxybutyrate in the perfused rat liver." Archives of biochemistry and biophysics 259.1 (1987): 149-156.

[00:42:13] Hsu, Wei-Yu, et al. "Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages." Journal of Chromatography B 879.29 (2011): 3331-3336. And Tsai, Yih-Chiao, et al. "Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes." Life sciences 78.12 (2006): 1385-1391.

[00:46:39] Book: The Case Against Sugar by Gary Taubes.

[00:47:14] Chris Masterjohn exchanging nutritional bogeymen.

[00:48:32] Availability of the ketone monoester.

[00:49:22] Brianna Stubbs (@BriannaStubbs) on Twitter.

]]>
clean
The Critical Role of Oestradiol for Women’s Cognition https://s3.amazonaws.com/nourishbalancethrive/podcast/Ann.Hathaway.on.2017-01-18.at.12.05.mp3 Dr Ann Hathaway, MD has been successfully treating women and men with bioidentical hormones and other natural remedies since 1995. She is a member of the prestigious Institute for Functional Medicine and is a director of the Orthomolecular Health Medicine Board.

Tommy and I met Dr Hathaway at the Buck Institute for Research on Aging where she presented this excellent and incredibly well-referenced talk on the role of oestradiol in cognition for women.

Dr Hathaway is primarily using blood testing to assess hormone levels. However, urinary metabolites can be very helpful for mapping out the oestrogens. At around the twenty-minute mark, this interview gets quite technical, and I think you'll find it useful to look at this section of a DUTCH report while listening to the audio. Notice the enzyme names are written on the arrows indicating the direction of metabolism. The word "hydroxy" is abbreviated OH, so when you hear Ann say "four hydroxy E1," look for 4-OH-E1 on the map.

Here’s the outline of this interview with Dr Ann Hathaway, MD:

[00:01:35] Health problems not addressed well by the traditional system.

[00:03:13] A 1.5h first appointment in Functional Medicine is typical.

[00:04:25] Different types of practitioner.

[00:05:20] American Academy of Environmental Medicine.

[00:05:38] Jeffrey Bland, PhD.

[00:06:57] Buck Institute for Research on Aging.

[00:08:21] Principles for addressing hormone imbalance.

[00:09:41] Underlying root causes.

[00:10:40] Menopause and cognition.

[00:11:04] Oestradiol less than 20 pg/ml.

[00:13:11] The brain has oestradiol receptors.

[00:13:55] All of the neurotransmitter systems are favorably impacted by oestradiol. Acetylcholine, which is the neurotransmitter most associated with memory, serotonin, norepinephrine, dopamine. All are enhanced by oestradiol.

[00:14:30] Rasgon, Natalie L., et al. "Prospective randomized trial to assess effects of continuing hormone therapy on cerebral function in postmenopausal women at risk for dementia." PloS one 9.3 (2014): e89095.

[00:15:22] The odds ratio for women to develop Alzheimer's disease is 1.56.

[00:16:21] Balancing oestradiol with progesterone and other hormones.

[00:17:17] Endometrial hyperplasia which can turn into uterine cancer.

[00:17:32] Progesterone improves sleep

[00:18:27] Different types of testing.

[00:19:08] Never give oestrone.

[00:19:27] Metabolites of oestrogen (see the diagram above).

[00:21:13] Some of the things that you can do to increase the 2-hydroxy pathway are eating a high cruciferous diet, taking a supplement called diindolylmethane or indole-3-carbinol.

[00:21:32] Iodine sufficiency.

[00:21:39] Lignans in flaxseed.

[00:22:04] COMT enzyme and methylation.

[00:22:47] Genetic mutations.

[00:23:55] CYP1B1.

[00:24:14] Xenoestrogens.

[00:24:34] Eat organic!

[00:24:52] Pharmaceuticals.

[00:26:14] Glutathione. See Why You Should Manage Your Glutathione Status and How to Do It.

[00:26:34] Alpha lipoic acid.

[00:27:07] NutrEval and ION panel

[00:27:42] Eating a wide variety of veg

[00:28:52] Personal care products and makeup

[00:29:07] Environmental Working Group (EWG).

[00:30:01] The Women’s Health Initiative Study (WHI).

[00:31:21] Small differences matter in pharmacology.

[00:33:37] Oestradiol should only be used topically.

[00:34:19] Wharton, Whitney, et al. "Potential role of estrogen in the pathobiology and prevention of Alzheimer’s disease." American journal of translational research 1.2 (2009): 131-147.

[00:36:22] Oral oestrogen increases C-reactive protein and fibrinogen.

[00:38:28] Harman, S. M., et al. "KEEPS: the Kronos early estrogen prevention study." (2005): 3-12.

[00:44:08] APOE gene.

[00:45:05] What to do if you're taking something other than topical oestradiol.

[00:46:06] See Rasgon study linked above.

[00:46:46] Ann’s presentation at the Buck Institute: Bioidentical Hormones and Cognition.

[00:46:52] Ann Hathaway MD--Integrative Functional Medicine & Bio-identical Hormones

[00:47:06] This interview was recorded in January 2017, at that time Ann was scheduling new patients in April.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Ann.Hathaway.on.2017-01-18.at.12.05.mp3 Fri, 03 Feb 2017 07:02:22 GMT Christopher Kelly Dr Ann Hathaway, MD has been successfully treating women and men with bioidentical hormones and other natural remedies since 1995. She is a member of the prestigious Institute for Functional Medicine and is a director of the Orthomolecular Health Medicine Board.

Tommy and I met Dr Hathaway at the Buck Institute for Research on Aging where she presented this excellent and incredibly well-referenced talk on the role of oestradiol in cognition for women.

Dr Hathaway is primarily using blood testing to assess hormone levels. However, urinary metabolites can be very helpful for mapping out the oestrogens. At around the twenty-minute mark, this interview gets quite technical, and I think you'll find it useful to look at this section of a DUTCH report while listening to the audio. Notice the enzyme names are written on the arrows indicating the direction of metabolism. The word "hydroxy" is abbreviated OH, so when you hear Ann say "four hydroxy E1," look for 4-OH-E1 on the map.

Here’s the outline of this interview with Dr Ann Hathaway, MD:

[00:01:35] Health problems not addressed well by the traditional system.

[00:03:13] A 1.5h first appointment in Functional Medicine is typical.

[00:04:25] Different types of practitioner.

[00:05:20] American Academy of Environmental Medicine.

[00:05:38] Jeffrey Bland, PhD.

[00:06:57] Buck Institute for Research on Aging.

[00:08:21] Principles for addressing hormone imbalance.

[00:09:41] Underlying root causes.

[00:10:40] Menopause and cognition.

[00:11:04] Oestradiol less than 20 pg/ml.

[00:13:11] The brain has oestradiol receptors.

[00:13:55] All of the neurotransmitter systems are favorably impacted by oestradiol. Acetylcholine, which is the neurotransmitter most associated with memory, serotonin, norepinephrine, dopamine. All are enhanced by oestradiol.

[00:14:30] Rasgon, Natalie L., et al. "Prospective randomized trial to assess effects of continuing hormone therapy on cerebral function in postmenopausal women at risk for dementia." PloS one 9.3 (2014): e89095.

[00:15:22] The odds ratio for women to develop Alzheimer's disease is 1.56.

[00:16:21] Balancing oestradiol with progesterone and other hormones.

[00:17:17] Endometrial hyperplasia which can turn into uterine cancer.

[00:17:32] Progesterone improves sleep

[00:18:27] Different types of testing.

[00:19:08] Never give oestrone.

[00:19:27] Metabolites of oestrogen (see the diagram above).

[00:21:13] Some of the things that you can do to increase the 2-hydroxy pathway are eating a high cruciferous diet, taking a supplement called diindolylmethane or indole-3-carbinol.

[00:21:32] Iodine sufficiency.

[00:21:39] Lignans in flaxseed.

[00:22:04] COMT enzyme and methylation.

[00:22:47] Genetic mutations.

[00:23:55] CYP1B1.

[00:24:14] Xenoestrogens.

[00:24:34] Eat organic!

[00:24:52] Pharmaceuticals.

[00:26:14] Glutathione. See Why You Should Manage Your Glutathione Status and How to Do It.

[00:26:34] Alpha lipoic acid.

[00:27:07] NutrEval and ION panel

[00:27:42] Eating a wide variety of veg

[00:28:52] Personal care products and makeup

[00:29:07] Environmental Working Group (EWG).

[00:30:01] The Women’s Health Initiative Study (WHI).

[00:31:21] Small differences matter in pharmacology.

[00:33:37] Oestradiol should only be used topically.

[00:34:19] Wharton, Whitney, et al. "Potential role of estrogen in the pathobiology and prevention of Alzheimer’s disease." American journal of translational research 1.2 (2009): 131-147.

[00:36:22] Oral oestrogen increases C-reactive protein and fibrinogen.

[00:38:28] Harman, S. M., et al. "KEEPS: the Kronos early estrogen prevention study." (2005): 3-12.

[00:44:08] APOE gene.

[00:45:05] What to do if you're taking something other than topical oestradiol.

[00:46:06] See Rasgon study linked above.

[00:46:46] Ann’s presentation at the Buck Institute: Bioidentical Hormones and Cognition.

[00:46:52] Ann Hathaway MD--Integrative Functional Medicine & Bio-identical Hormones

[00:47:06] This interview was recorded in January 2017, at that time Ann was scheduling new patients in April.

]]>
clean
How to Use Biomedical Testing for Obstacle Course Racing Performance https://s3.amazonaws.com/nourishbalancethrive/podcast/Ryan.Baxter.on.2017-01-10.at.10.34.mp3 The ketogenic diet has many promising applications including better management of type 1 diabetes and as an adjunct cancer therapy. Thirty-five thousand people signed up for the Keto Summit where we talked about other applications including neurological diseases, fat loss and improved athletic performance. If you adopted a high-fat paleo-type diet, you could be forgiven for thinking that if that was good, then ketosis should be better. I know I did. Unfortunately, that isn’t necessarily the case, and recently in our practice, we’ve seen several athletes eating a diet that failed to fuel their activity. Obstacle course racing appears to be one type of event where carbohydrates are mandatory.

My guest this week is client and software engineer Ryan Baxter. Ryan is a competitive obstacle course racer and an excellent example of what can go wrong when you fail to fuel for your activity. The reintroduction of carbs may have been the most important recommendation we made for Ryan. To be fair, Ryan also found overgrowths of opportunistic pathogens Candida albicans and Clostridium difficile and treating those with nutritional supplements will have also contributed to the resolution of his complaints: low libido, poor sleep, foul mood and food cravings.

You should listen to this interview to find out what it’s like to be part of our Elite Performance Program for athletes.

Here’s the outline of this interview with Ryan Baxter:

[00:00:43] Ryan is a software engineer working for Pivotal before that he worked for IBM.

[00:02:46] Spartan Obstacle Course Racing.

[00:05:05] Paleo and high-fat diet and then finally ketosis.

[00:07:07] Ben Greenfield and Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast! by Mark Sisson.

[00:07:50] MAF training.

[00:08:32] MyFitnessPal.

[00:09:07] 13+ mile runs in a fasted state.

[00:09:30] Poor sleep.

[00:10:14] Low libido and foul mood.

[00:11:31] Looking for patterns, none to be found.

[00:11:53] Stress and mood.

[00:12:15] Vermont Beast race at Killington ski resort. Duration: 6-10 hours.

[00:15:12] What do people eat in an event like this?

[00:16:49] Experience with a primary care doctor.

[00:17:50] Endurance Planet podcast.

[00:18:13] DUTCH urinary hormones test.

[00:19:01] Family and work life.

[00:21:04] Saving energy for the rest of the day after training.

[00:22:33] Circadian rhythm.

[00:23:56] Cold thermogenesis.

[00:25:57] Eating more carbs.

[00:27:50] Masharani, U., et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948.

[00:28:14] Sweet potato, butternut squash, fruit, white rice.

[00:29:48] Backing off on the training.

[00:31:33] Burning fat whilst exercising.

[00:31:53] Podcast: Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More!

[00:33:22] Fasting insulin, thyroid, MCV, low T.

[00:33:57] Gut testing.

[00:34:38] Candida and C. diff.

[00:36:18] Yeast metabolism and ethanol.

[00:37:10] Establishing a baseline.

[00:38:56] Retesting.

[00:40:03] Rebound yeast overgrowth.

[00:40:45] ŌURA Ring.

[00:41:38] Improvements in deep sleep.

[00:42:26] Doc Parsley’s Sleep Remedy.

[00:43:46] Coping better with stress.

[00:44:55] Headspace.

[00:46:23] Book a free consultation.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Ryan.Baxter.on.2017-01-10.at.10.34.mp3 Fri, 27 Jan 2017 08:01:36 GMT Christopher Kelly The ketogenic diet has many promising applications including better management of type 1 diabetes and as an adjunct cancer therapy. Thirty-five thousand people signed up for the Keto Summit where we talked about other applications including neurological diseases, fat loss and improved athletic performance. If you adopted a high-fat paleo-type diet, you could be forgiven for thinking that if that was good, then ketosis should be better. I know I did. Unfortunately, that isn’t necessarily the case, and recently in our practice, we’ve seen several athletes eating a diet that failed to fuel their activity. Obstacle course racing appears to be one type of event where carbohydrates are mandatory.

My guest this week is client and software engineer Ryan Baxter. Ryan is a competitive obstacle course racer and an excellent example of what can go wrong when you fail to fuel for your activity. The reintroduction of carbs may have been the most important recommendation we made for Ryan. To be fair, Ryan also found overgrowths of opportunistic pathogens Candida albicans and Clostridium difficile and treating those with nutritional supplements will have also contributed to the resolution of his complaints: low libido, poor sleep, foul mood and food cravings.

You should listen to this interview to find out what it’s like to be part of our Elite Performance Program for athletes.

Here’s the outline of this interview with Ryan Baxter:

[00:00:43] Ryan is a software engineer working for Pivotal before that he worked for IBM.

[00:02:46] Spartan Obstacle Course Racing.

[00:05:05] Paleo and high-fat diet and then finally ketosis.

[00:07:07] Ben Greenfield and Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast! by Mark Sisson.

[00:07:50] MAF training.

[00:08:32] MyFitnessPal.

[00:09:07] 13+ mile runs in a fasted state.

[00:09:30] Poor sleep.

[00:10:14] Low libido and foul mood.

[00:11:31] Looking for patterns, none to be found.

[00:11:53] Stress and mood.

[00:12:15] Vermont Beast race at Killington ski resort. Duration: 6-10 hours.

[00:15:12] What do people eat in an event like this?

[00:16:49] Experience with a primary care doctor.

[00:17:50] Endurance Planet podcast.

[00:18:13] DUTCH urinary hormones test.

[00:19:01] Family and work life.

[00:21:04] Saving energy for the rest of the day after training.

[00:22:33] Circadian rhythm.

[00:23:56] Cold thermogenesis.

[00:25:57] Eating more carbs.

[00:27:50] Masharani, U., et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948.

[00:28:14] Sweet potato, butternut squash, fruit, white rice.

[00:29:48] Backing off on the training.

[00:31:33] Burning fat whilst exercising.

[00:31:53] Podcast: Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More!

[00:33:22] Fasting insulin, thyroid, MCV, low T.

[00:33:57] Gut testing.

[00:34:38] Candida and C. diff.

[00:36:18] Yeast metabolism and ethanol.

[00:37:10] Establishing a baseline.

[00:38:56] Retesting.

[00:40:03] Rebound yeast overgrowth.

[00:40:45] ŌURA Ring.

[00:41:38] Improvements in deep sleep.

[00:42:26] Doc Parsley’s Sleep Remedy.

[00:43:46] Coping better with stress.

[00:44:55] Headspace.

[00:46:23] Book a free consultation.

]]>
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Why We Get Fat and What You Should Really Do About It https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.Christopher.Masterjohn.on.2017-01-02.at.09.15.mp3 My guests this week are two of the brightest minds in the health and fitness industry. The first is my own Chief Medical Officer, Tommy Wood, MD PhD. Tommy is currently working as a visiting scientist researching neonatal brain injury at the University of Washington. He received his undergraduate degree in Biochemistry from the University of Cambridge, before studying medicine at the University of Oxford.

My second guest is Chris Masterjohn, PhD. Chris earned his PhD in Nutritional Science from the University of Connecticut at Storrs, where he studied the role of glutathione and dietary antioxidants in regulating the accumulation of methylglyoxal. He has authored or co-authored ten peer-reviewed publications. His writes a blog, The Daily Lipid, and produces a podcast by the same name. You can also follow his professional work on Facebook, Twitter, Instagram, YouTube, and Snapchat (whatever that is!).

Tommy’s premise for this interview was as follows:

If you fix lifestyle and environment, can you be a lot less "strict" with your diet? For instance, are low carbers needing to be so low carb because everything else is broken?

I took that idea and invited Chris Masterjohn on to the show for a roundtable discussion that starts with a general debate on the causes of obesity and then moves on to what we can all to improve or maintain our body composition.

You should listen to this interview because unlike many others I’ve heard; it includes a broad discussion of the range of issues that we see in our practice that hold people back from their body composition goals. The first time you meet someone who plateaued in their weight loss while eating a low-carb diet you realise that it’s a bit more complicated than that.

Here’s the outline of this interview with Tommy Wood and Chris Masterjohn:

[00:03:15] "The built environment," one that facilitates eating more and moving less.

[00:07:48] You, the listeners, are already winning!

[00:08:38] The composition of our food.

[00:09:32] Upsetting set points--poor sleep.

[00:09:57] Circadian rhythm.

[00:10:07] Stress and gut health.

[00:11:36] Low-carb diets and weight loss.

[00:11:52] Cronise, Raymond J., David A. Sinclair, and Andrew A. Bremer. "Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease." Metabolic Syndrome and Related Disorders (2016). Be sure to read Tommy’s response: Wood, Thomas. "If the Metabolic Winter Is Coming, When Will It Be Summer?." Metabolic Syndrome and Related Disorders (2017).

[00:12:58] Most of your stored body fat came from the fat that you ate.

[00:13:28] Calorie restriction.

[00:14:14] Insulin increases carbohydrate oxidation.

[00:19:10] Body recomposition programs.

[00:19:49] Chris Masterjohn does not see insulin as a key player.

[00:20:37] Whenever you restrict food choices, food intake goes down.

[00:22:56] MyFitnessPal.

[00:23:08] Sleep and calorie intake.

[00:24:28] Low-carb doesn't work well for the type of exercise Chris Masterjohn does.

[00:26:37] Preparing for fat-loss.

[00:29:53] Starting with other ideas that don't work can be helpful.

[00:32:47] Fueling for your activity.

[00:33:56] Start by fixing your environment.

[00:34:26] Feasting and fasting.

[00:35:14] Whole foods.

[00:38:32] Reduced activity in obesity is a symptom, not a cause.

[00:40:33] We're designed to eat when there's an abundance of food, i.e. the summer

[00:41:22] Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health.

[00:42:58] Light differential--go outside!

[00:46:05] Blue light at night.

[00:47:01] Ben Greenfield talks about the Human Charger.

[00:47:35] Desktop lights, e.g. Light Book Edge.

[00:50:01] Lindqvist, P. G., et al. "Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort." Journal of internal medicine 280.4 (2016): 375-387.

[00:55:17] Checklists before testing.

[00:58:22] Picture of metabolism and motivation for change.

[00:59:20] Daily Lipid podcast.

[00:59:45] The Ultimate Vitamin K2 Resource.

[01:02:18] Chris is now offering consultation packages.

[01:02:41] Recruiting for a human study.

[01:05:18] Gary Vaynerchuk.

[01:07:42] Developing new tests, especially for vitamin K2.

[01:09:21] VitaK.

[01:11:17] Tommy's plans for the future.

[01:12:26] Dr Pedro Domingos: How to Teach Machines That Can Learn.

[01:12:42] Book a free consultation with NBT.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.Christopher.Masterjohn.on.2017-01-02.at.09.15.mp3 Fri, 20 Jan 2017 08:01:10 GMT Christopher Kelly My guests this week are two of the brightest minds in the health and fitness industry. The first is my own Chief Medical Officer, Tommy Wood, MD PhD. Tommy is currently working as a visiting scientist researching neonatal brain injury at the University of Washington. He received his undergraduate degree in Biochemistry from the University of Cambridge, before studying medicine at the University of Oxford.

My second guest is Chris Masterjohn, PhD. Chris earned his PhD in Nutritional Science from the University of Connecticut at Storrs, where he studied the role of glutathione and dietary antioxidants in regulating the accumulation of methylglyoxal. He has authored or co-authored ten peer-reviewed publications. His writes a blog, The Daily Lipid, and produces a podcast by the same name. You can also follow his professional work on Facebook, Twitter, Instagram, YouTube, and Snapchat (whatever that is!).

Tommy’s premise for this interview was as follows:

If you fix lifestyle and environment, can you be a lot less "strict" with your diet? For instance, are low carbers needing to be so low carb because everything else is broken?

I took that idea and invited Chris Masterjohn on to the show for a roundtable discussion that starts with a general debate on the causes of obesity and then moves on to what we can all to improve or maintain our body composition.

You should listen to this interview because unlike many others I’ve heard; it includes a broad discussion of the range of issues that we see in our practice that hold people back from their body composition goals. The first time you meet someone who plateaued in their weight loss while eating a low-carb diet you realise that it’s a bit more complicated than that.

Here’s the outline of this interview with Tommy Wood and Chris Masterjohn:

[00:03:15] "The built environment," one that facilitates eating more and moving less.

[00:07:48] You, the listeners, are already winning!

[00:08:38] The composition of our food.

[00:09:32] Upsetting set points--poor sleep.

[00:09:57] Circadian rhythm.

[00:10:07] Stress and gut health.

[00:11:36] Low-carb diets and weight loss.

[00:11:52] Cronise, Raymond J., David A. Sinclair, and Andrew A. Bremer. "Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease." Metabolic Syndrome and Related Disorders (2016). Be sure to read Tommy’s response: Wood, Thomas. "If the Metabolic Winter Is Coming, When Will It Be Summer?." Metabolic Syndrome and Related Disorders (2017).

[00:12:58] Most of your stored body fat came from the fat that you ate.

[00:13:28] Calorie restriction.

[00:14:14] Insulin increases carbohydrate oxidation.

[00:19:10] Body recomposition programs.

[00:19:49] Chris Masterjohn does not see insulin as a key player.

[00:20:37] Whenever you restrict food choices, food intake goes down.

[00:22:56] MyFitnessPal.

[00:23:08] Sleep and calorie intake.

[00:24:28] Low-carb doesn't work well for the type of exercise Chris Masterjohn does.

[00:26:37] Preparing for fat-loss.

[00:29:53] Starting with other ideas that don't work can be helpful.

[00:32:47] Fueling for your activity.

[00:33:56] Start by fixing your environment.

[00:34:26] Feasting and fasting.

[00:35:14] Whole foods.

[00:38:32] Reduced activity in obesity is a symptom, not a cause.

[00:40:33] We're designed to eat when there's an abundance of food, i.e. the summer

[00:41:22] Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health.

[00:42:58] Light differential--go outside!

[00:46:05] Blue light at night.

[00:47:01] Ben Greenfield talks about the Human Charger.

[00:47:35] Desktop lights, e.g. Light Book Edge.

[00:50:01] Lindqvist, P. G., et al. "Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort." Journal of internal medicine 280.4 (2016): 375-387.

[00:55:17] Checklists before testing.

[00:58:22] Picture of metabolism and motivation for change.

[00:59:20] Daily Lipid podcast.

[00:59:45] The Ultimate Vitamin K2 Resource.

[01:02:18] Chris is now offering consultation packages.

[01:02:41] Recruiting for a human study.

[01:05:18] Gary Vaynerchuk.

[01:07:42] Developing new tests, especially for vitamin K2.

[01:09:21] VitaK.

[01:11:17] Tommy's plans for the future.

[01:12:26] Dr Pedro Domingos: How to Teach Machines That Can Learn.

[01:12:42] Book a free consultation with NBT.

]]>
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How to Think Yourself Younger, Healthier, and Faster https://s3.amazonaws.com/nourishbalancethrive/podcast/ellen.langer.on.2016-12-27.at.07.06.mp3 Several years ago, I learned about mindfulness the hard way. I was eating a cardiologist recommended diet that apparently wasn’t working for me and I failed to pay attention to any of the warning signs. The first person to draw attention to my mindlessness was the woman who is now my wife and co-founder at NBT. Only recently did I discover the decades of careful research on the simple practice of noticing, and how that can be both good for you and fun.

My guest this week is Dr Ellen Langer, PhD, a social psychologist and the first female professor to gain tenure in the Psychology Department at Harvard University. She is the author of eleven books and more than two hundred research articles written for general and academic readers on mindfulness for over 35 years. Her best-selling books include Mindfulness; The Power of Mindful Learning; On Becoming an Artist: Reinventing Yourself Through Mindful Creativity; and Counterclockwise: Mindful Health and the Power of Possibility.

See Langer EJ[Author] on PubMed.

Here’s the outline of this interview with Ellen Langer, PhD:

[00:01:22] Align Therapy podcast.

[00:02:24] Science is in based probabilities.

[00:04:29] Book: Counterclockwise: Mindful Health and the Power of Possibility.

[00:05:02] The mind-body problem.

[00:06:13] Counterclockwise study.

[00:06:46] Crum, Alia J., and Ellen J. Langer. "Mind-set matters exercise and the placebo effect." Psychological Science 18.2 (2007): 165-171.

[00:08:20] Langer, Ellen, et al. "Believing is seeing using mindlessness (mindfully) to improve visual acuity." Psychological Science (2010).

[00:10:21] Airforce pilot study.

[00:11:45] Adopting a "crutch".

[00:12:43] Mindlessness.

[00:13:16] Actively noticing new things.

[00:13:54] Doing things people hated.

[00:14:26] Meditation is a tool to lead to post-meditation.

[00:15:19] Becoming aware that you don't know anything.

[00:16:06] 1 + 1 = ?

[00:19:01] Seeing the world in black and white.

[00:20:08] Passing yourself over to a doctor.

[00:20:23] You are the keeper of the special information.

[00:20:51] Regression to the mean.

[00:22:07] Pay attention to the subtleties.

[00:22:58] Harnessing the power of the placebo.

[00:23:34] Park, Chanmo, et al. "Blood sugar level follows perceived time rather than actual time in people with type 2 diabetes." Proceedings of the National Academy of Sciences (2016): 201603444.

[00:25:36] Sports psychology.

[00:27:18] The true expert is always a learner.

[00:29:01] Golf.

[00:29:32] Quantified Body podcast: Is Your Glucose Metabolism Unique to You?

[00:32:26] Mindfulness is fun!

[00:34:23] Book: The Art of Noticing.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/ellen.langer.on.2016-12-27.at.07.06.mp3 Thu, 12 Jan 2017 17:01:38 GMT Christopher Kelly Several years ago, I learned about mindfulness the hard way. I was eating a cardiologist recommended diet that apparently wasn’t working for me and I failed to pay attention to any of the warning signs. The first person to draw attention to my mindlessness was the woman who is now my wife and co-founder at NBT. Only recently did I discover the decades of careful research on the simple practice of noticing, and how that can be both good for you and fun.

My guest this week is Dr Ellen Langer, PhD, a social psychologist and the first female professor to gain tenure in the Psychology Department at Harvard University. She is the author of eleven books and more than two hundred research articles written for general and academic readers on mindfulness for over 35 years. Her best-selling books include Mindfulness; The Power of Mindful Learning; On Becoming an Artist: Reinventing Yourself Through Mindful Creativity; and Counterclockwise: Mindful Health and the Power of Possibility.

See Langer EJ[Author] on PubMed.

Here’s the outline of this interview with Ellen Langer, PhD:

[00:01:22] Align Therapy podcast.

[00:02:24] Science is in based probabilities.

[00:04:29] Book: Counterclockwise: Mindful Health and the Power of Possibility.

[00:05:02] The mind-body problem.

[00:06:13] Counterclockwise study.

[00:06:46] Crum, Alia J., and Ellen J. Langer. "Mind-set matters exercise and the placebo effect." Psychological Science 18.2 (2007): 165-171.

[00:08:20] Langer, Ellen, et al. "Believing is seeing using mindlessness (mindfully) to improve visual acuity." Psychological Science (2010).

[00:10:21] Airforce pilot study.

[00:11:45] Adopting a "crutch".

[00:12:43] Mindlessness.

[00:13:16] Actively noticing new things.

[00:13:54] Doing things people hated.

[00:14:26] Meditation is a tool to lead to post-meditation.

[00:15:19] Becoming aware that you don't know anything.

[00:16:06] 1 + 1 = ?

[00:19:01] Seeing the world in black and white.

[00:20:08] Passing yourself over to a doctor.

[00:20:23] You are the keeper of the special information.

[00:20:51] Regression to the mean.

[00:22:07] Pay attention to the subtleties.

[00:22:58] Harnessing the power of the placebo.

[00:23:34] Park, Chanmo, et al. "Blood sugar level follows perceived time rather than actual time in people with type 2 diabetes." Proceedings of the National Academy of Sciences (2016): 201603444.

[00:25:36] Sports psychology.

[00:27:18] The true expert is always a learner.

[00:29:01] Golf.

[00:29:32] Quantified Body podcast: Is Your Glucose Metabolism Unique to You?

[00:32:26] Mindfulness is fun!

[00:34:23] Book: The Art of Noticing.

]]>
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How to Test and Predict Blood, Urine and Stool for Health, Longevity and Performance https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Gerstmar.on.2016-12-21.at.10.09.mp3 Dr Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia.

In this interview, Dr Gerstmar discusses the tests he most commonly uses, especially for gastrointestinal complaints. We also talk about strategies for dealing with health insurance and tips for keeping costs down.

These scatter plots, sometimes called calibration plots, are the ones I mentioned in the podcast. On the x-axis is what my XGBoost model predicted for previously unseen data, the y-axis represents the measured value. When the dot appears on the diagonal line, the prediction was perfect. The model was trained using results from just 260 athletes. My hope is that is these models will eventually bring down the cost of our full program by allowing us to predict the results of an expensive test using a cheaper one.

Here’s the outline of this interview with Dr Tim Gerstmar:

[00:00:15] First podcast: Methylation and Environmental Pollutants with Dr. Tim Gerstmar.

[00:00:56] Bob McRae podcast: How to Use Biomedical Testing for IRONMAN Performance.

[00:01:24] Our Elite Performance Programme.

[00:04:04] How much testing should we do?

[00:04:35] Factoring in lifetime costs.

[00:08:33] Donating blood to the Red Cross.

[00:09:44] Iron disorders: ferritin and haemochromatosis.

[00:10:53] Therapeutic phlebotomy.

[00:14:22] Treating symptoms is sometimes necessary.

[00:15:07] Steroids for eczema.

[00:17:09] Adrenal dysregulation and thyroid dysfunction.

[00:18:00] You can't feel high blood sugar in diabetes.

[00:18:46] AIMed conference.

[00:19:06] De Fauw, Jeffrey, et al. "Automated analysis of retinal imaging using machine learning techniques for computer vision." F1000Research 5 (2016).

[00:20:38] 25-OH-D testing. See Optimizing Vitamin D for Athletic Performance.

[00:22:01] Insurance interfering with testing.

[00:23:29] Liberty HealthShare.

[00:23:42] Affordable Care Act.

[00:24:10] Direct Primary Care.

[00:24:23] Health Share of Oregon.

[00:25:08] Covered California.

[00:25:32] Health Savings Account.

[00:28:52] Genova GI Effects stool test.

[00:29:27] BioHealth stool test.

[00:29:49] Doctor's Data stool test.

[00:30:13] Coeliac diagnosis.

[00:30:50] Transglutaminase.

[00:31:44] Genetic risk factors.

[00:32:43] NCGS and FODMAPs.

[00:34:22] Intestinal lymphoma.

[00:37:47] Normal test results are still useful information.

[00:38:45] Liver enzymes, e.g. ALT, AST and GGT.

[00:39:19] CBC and CMP, Hs-CRP.

[00:39:47] Testosterone and thyroid.

[00:40:09] Genova SIBO test.

[00:41:08] Organic acids by Genova and Great Plains.

[00:41:55] Beware insurance with OATs.

[00:43:23] Verifying your policy.

[00:44:07] Mitochondrial function.

[00:44:21] Nutrient deficiencies.

[00:44:52] Neurotransmitters and brain function.

[00:45:04] Oxidative stress.

[00:45:12] Detox stress, GSH status.

[00:45:38] Bacterial and yeast markers.

[00:46:49] Cortisol testing--DUTCH.

[00:48:45] Interview with Pedro Domingos: How to Teach Machines That Can Learn.

[00:49:08] XGBoost.

[00:50:33] Robb Wolf early adoption costs.

[00:51:54] HRV. See Elite HRV podcast.

[00:52:08] Supplement companies and self-assessment questionnaires.

[00:53:10] Arabinose.

[00:53:48] Hallucinating from noise in the data.

[00:54:52] Big Data.

[00:56:03] Abnormality detection.

[00:56:45] Functional versus pathological lab ranges.

[00:57:46] Mark Newman. See cortisol testing above.

[00:58:23] Adjusted reference ranges.

[00:58:45] Vanity sizing.

[01:00:52] Thyroid cancer and proximity to a mine.

[01:01:21] Aspire Natural Health podcast.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Gerstmar.on.2016-12-21.at.10.09.mp3 Fri, 06 Jan 2017 12:01:34 GMT Christopher Kelly Dr Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia.

In this interview, Dr Gerstmar discusses the tests he most commonly uses, especially for gastrointestinal complaints. We also talk about strategies for dealing with health insurance and tips for keeping costs down.

These scatter plots, sometimes called calibration plots, are the ones I mentioned in the podcast. On the x-axis is what my XGBoost model predicted for previously unseen data, the y-axis represents the measured value. When the dot appears on the diagonal line, the prediction was perfect. The model was trained using results from just 260 athletes. My hope is that is these models will eventually bring down the cost of our full program by allowing us to predict the results of an expensive test using a cheaper one.

Here’s the outline of this interview with Dr Tim Gerstmar:

[00:00:15] First podcast: Methylation and Environmental Pollutants with Dr. Tim Gerstmar.

[00:00:56] Bob McRae podcast: How to Use Biomedical Testing for IRONMAN Performance.

[00:01:24] Our Elite Performance Programme.

[00:04:04] How much testing should we do?

[00:04:35] Factoring in lifetime costs.

[00:08:33] Donating blood to the Red Cross.

[00:09:44] Iron disorders: ferritin and haemochromatosis.

[00:10:53] Therapeutic phlebotomy.

[00:14:22] Treating symptoms is sometimes necessary.

[00:15:07] Steroids for eczema.

[00:17:09] Adrenal dysregulation and thyroid dysfunction.

[00:18:00] You can't feel high blood sugar in diabetes.

[00:18:46] AIMed conference.

[00:19:06] De Fauw, Jeffrey, et al. "Automated analysis of retinal imaging using machine learning techniques for computer vision." F1000Research 5 (2016).

[00:20:38] 25-OH-D testing. See Optimizing Vitamin D for Athletic Performance.

[00:22:01] Insurance interfering with testing.

[00:23:29] Liberty HealthShare.

[00:23:42] Affordable Care Act.

[00:24:10] Direct Primary Care.

[00:24:23] Health Share of Oregon.

[00:25:08] Covered California.

[00:25:32] Health Savings Account.

[00:28:52] Genova GI Effects stool test.

[00:29:27] BioHealth stool test.

[00:29:49] Doctor's Data stool test.

[00:30:13] Coeliac diagnosis.

[00:30:50] Transglutaminase.

[00:31:44] Genetic risk factors.

[00:32:43] NCGS and FODMAPs.

[00:34:22] Intestinal lymphoma.

[00:37:47] Normal test results are still useful information.

[00:38:45] Liver enzymes, e.g. ALT, AST and GGT.

[00:39:19] CBC and CMP, Hs-CRP.

[00:39:47] Testosterone and thyroid.

[00:40:09] Genova SIBO test.

[00:41:08] Organic acids by Genova and Great Plains.

[00:41:55] Beware insurance with OATs.

[00:43:23] Verifying your policy.

[00:44:07] Mitochondrial function.

[00:44:21] Nutrient deficiencies.

[00:44:52] Neurotransmitters and brain function.

[00:45:04] Oxidative stress.

[00:45:12] Detox stress, GSH status.

[00:45:38] Bacterial and yeast markers.

[00:46:49] Cortisol testing--DUTCH.

[00:48:45] Interview with Pedro Domingos: How to Teach Machines That Can Learn.

[00:49:08] XGBoost.

[00:50:33] Robb Wolf early adoption costs.

[00:51:54] HRV. See Elite HRV podcast.

[00:52:08] Supplement companies and self-assessment questionnaires.

[00:53:10] Arabinose.

[00:53:48] Hallucinating from noise in the data.

[00:54:52] Big Data.

[00:56:03] Abnormality detection.

[00:56:45] Functional versus pathological lab ranges.

[00:57:46] Mark Newman. See cortisol testing above.

[00:58:23] Adjusted reference ranges.

[00:58:45] Vanity sizing.

[01:00:52] Thyroid cancer and proximity to a mine.

[01:01:21] Aspire Natural Health podcast.

]]>
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High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea… https://s3.amazonaws.com/nourishbalancethrive/podcast/Mike.T.Nelson.on.2016-12-06.at.07.08_edited.mp3 Coach and exercise physiologist Dr Mike T. Nelson pulled me to one side recently after seeing the results of my little experiment with a ketone ester supplement. In this interview, you’ll learn about why Dr. Mike thinks we should exercise caution before regularly simultaneously raising blood glucose and ketones.

We also talk about why metabolic flexibility, not ketosis, should be the goal for most endurance athletes.

Problems with impaired fat use:

From  Nelson, Michael T., George R. Biltz, and Donald R. Dengel. "Repeatability of Respiratory Exchange Ratio Time Series Analysis." The Journal of Strength & Conditioning Research 29.9 (2015): 2550-2558.

"Goedecke et al. (12) showed a very large interindividual variability in resting RER from 0.72 up to 0.93 that even persisted during exercise of increasing intensity. This corresponded to a relative rate of fat oxidation that ranged from 23 to 93%. This large interindividual variability in RER from 0.83 to 0.95 was also demonstrated by Helge et al. (16) during low-intensity steady-state exercise. This was quite similar to what we observed with a range of RER from 0.82 to 0.97.” (Nelson, MT, et al. 2015).

Goedecke, Julia H., et al. "Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes." American Journal of Physiology-Endocrinology And Metabolism 279.6 (2000): E1325-E1334.

Helge, Jørn W., et al. "Interrelationships between muscle fibre type, substrate oxidation and body fat." International journal of obesity 23.9 (1999): 986-991

Problems with impaired carb use:

Research has shown that those are on a very low carb diet for prolonged periods of time demonstrate a reduced ability to fully use them during exercise (Burke, LM, et al.; Stellingwerf T. et al).

Burke, Louise M., et al. "Effect of fat adaptation and carbohydrate restoration on metabolism and performance during prolonged cycling." Journal of Applied Physiology 89.6 (2000): 2413-2421.

Stellingwerff, Trent, et al. "Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration." American Journal of Physiology-Endocrinology and Metabolism 290.2 (2006): E380-E388.

Finally, we discuss the potential interference effect of endurance exercise on strength training. Context matters! Only elite athletes probably need to worry about this, and at least one study has shown untrained women can use either order and get similar responses.

Here’s the outline of this interview with Mike T. Nelson, PhD:

[00:01:02] Keto Summit interview on Metabolic Flexibility.

[00:03:25] Complete Blueprint To Faster Results...Without Pain and Plateaus.

[00:06:14] Get the "Deadlift Re-alignment for Broken Meatheads." for free.

[00:07:28] Online coaching.

[00:08:58] http://www.miketnelson.com/podcast

[00:09:15] HRV for Successful Online Coaching with Dr. Mike T. Nelson.

[00:09:38] ithlete.

[00:12:29] Zoom video conference software.

[00:13:08] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes.

[00:13:47] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet.

[00:15:34] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:16:57] Ketone esters for endurance performance.

[00:20:05] Ride time to exhaustion.

[00:21:04] Professor Kieran Clarke at Oxford University.

[00:22:27] Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More!

[00:25:19] Brooks, George A., and Jacques Mercier. "Balance of carbohydrate and lipid utilization during exercise: the" crossover" concept." Journal of applied physiology 76.6 (1994): 2253-2261.

[00:26:10] Ketone salts and C8 (caprylic) oil to "push the process".

[00:28:05] Fasting and carbohydrate adaptation.

[00:28:18] Pyruvate dehydrogenase (PDH).

[00:29:39] Ketone supplements and appetite suppression.

[00:33:36] Jeff Rothschild.

[00:34:20] FATMAX and the hard transition.

[00:35:18] Peterson, Benjamin James. Repeated Sprint Ability: The Influence of Aerobic Capacity on Energy Pathway Response and Fatigue of Hockey Players. Diss. UNIVERSITY OF MINNESOTA, 2014.

[00:37:42] Reintroducing carbs.

[00:41:43] Sprints on wet tarmac (not recommended).

[00:43:07] Terzis, Gerasimos, et al. "Early phase interference between low-intensity running and power training in moderately trained females." European journal of applied physiology 116.5 (2016): 1063-1073. Coffey, Vernon G., and John A. Hawley. "Concurrent exercise training: do opposites distract?." The Journal of physiology (2016). Also, 5-10x 2 minute intervals at 120-150% of LT (HIIT) and 15-30 minute continuous cycling at 80-100% of LT equally interfere with the adaptations to resistance training. So it’s not the intensity, more the total volume, that’s the problem.

[00:46:22] Prioritising strength in the offseason.

[00:48:40] Kiteboarding.

[00:49:55] Fortaleza.

[00:51:06] Mike's email.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mike.T.Nelson.on.2016-12-06.at.07.08_edited.mp3 Fri, 30 Dec 2016 10:12:18 GMT Christopher Kelly Coach and exercise physiologist Dr Mike T. Nelson pulled me to one side recently after seeing the results of my little experiment with a ketone ester supplement. In this interview, you’ll learn about why Dr. Mike thinks we should exercise caution before regularly simultaneously raising blood glucose and ketones.

We also talk about why metabolic flexibility, not ketosis, should be the goal for most endurance athletes.

Problems with impaired fat use:

From  Nelson, Michael T., George R. Biltz, and Donald R. Dengel. "Repeatability of Respiratory Exchange Ratio Time Series Analysis." The Journal of Strength & Conditioning Research 29.9 (2015): 2550-2558.

"Goedecke et al. (12) showed a very large interindividual variability in resting RER from 0.72 up to 0.93 that even persisted during exercise of increasing intensity. This corresponded to a relative rate of fat oxidation that ranged from 23 to 93%. This large interindividual variability in RER from 0.83 to 0.95 was also demonstrated by Helge et al. (16) during low-intensity steady-state exercise. This was quite similar to what we observed with a range of RER from 0.82 to 0.97.” (Nelson, MT, et al. 2015).

Goedecke, Julia H., et al. "Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes." American Journal of Physiology-Endocrinology And Metabolism 279.6 (2000): E1325-E1334.

Helge, Jørn W., et al. "Interrelationships between muscle fibre type, substrate oxidation and body fat." International journal of obesity 23.9 (1999): 986-991

Problems with impaired carb use:

Research has shown that those are on a very low carb diet for prolonged periods of time demonstrate a reduced ability to fully use them during exercise (Burke, LM, et al.; Stellingwerf T. et al).

Burke, Louise M., et al. "Effect of fat adaptation and carbohydrate restoration on metabolism and performance during prolonged cycling." Journal of Applied Physiology 89.6 (2000): 2413-2421.

Stellingwerff, Trent, et al. "Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration." American Journal of Physiology-Endocrinology and Metabolism 290.2 (2006): E380-E388.

Finally, we discuss the potential interference effect of endurance exercise on strength training. Context matters! Only elite athletes probably need to worry about this, and at least one study has shown untrained women can use either order and get similar responses.

Here’s the outline of this interview with Mike T. Nelson, PhD:

[00:01:02] Keto Summit interview on Metabolic Flexibility.

[00:03:25] Complete Blueprint To Faster Results...Without Pain and Plateaus.

[00:06:14] Get the "Deadlift Re-alignment for Broken Meatheads." for free.

[00:07:28] Online coaching.

[00:08:58] http://www.miketnelson.com/podcast

[00:09:15] HRV for Successful Online Coaching with Dr. Mike T. Nelson.

[00:09:38] ithlete.

[00:12:29] Zoom video conference software.

[00:13:08] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes.

[00:13:47] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet.

[00:15:34] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:16:57] Ketone esters for endurance performance.

[00:20:05] Ride time to exhaustion.

[00:21:04] Professor Kieran Clarke at Oxford University.

[00:22:27] Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More!

[00:25:19] Brooks, George A., and Jacques Mercier. "Balance of carbohydrate and lipid utilization during exercise: the" crossover" concept." Journal of applied physiology 76.6 (1994): 2253-2261.

[00:26:10] Ketone salts and C8 (caprylic) oil to "push the process".

[00:28:05] Fasting and carbohydrate adaptation.

[00:28:18] Pyruvate dehydrogenase (PDH).

[00:29:39] Ketone supplements and appetite suppression.

[00:33:36] Jeff Rothschild.

[00:34:20] FATMAX and the hard transition.

[00:35:18] Peterson, Benjamin James. Repeated Sprint Ability: The Influence of Aerobic Capacity on Energy Pathway Response and Fatigue of Hockey Players. Diss. UNIVERSITY OF MINNESOTA, 2014.

[00:37:42] Reintroducing carbs.

[00:41:43] Sprints on wet tarmac (not recommended).

[00:43:07] Terzis, Gerasimos, et al. "Early phase interference between low-intensity running and power training in moderately trained females." European journal of applied physiology 116.5 (2016): 1063-1073. Coffey, Vernon G., and John A. Hawley. "Concurrent exercise training: do opposites distract?." The Journal of physiology (2016). Also, 5-10x 2 minute intervals at 120-150% of LT (HIIT) and 15-30 minute continuous cycling at 80-100% of LT equally interfere with the adaptations to resistance training. So it’s not the intensity, more the total volume, that’s the problem.

[00:46:22] Prioritising strength in the offseason.

[00:48:40] Kiteboarding.

[00:49:55] Fortaleza.

[00:51:06] Mike's email.

]]>
clean
Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More! https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-12-4.at.13.mp3 Tommy and I recorded this interview in person at the Buck Institute for Research on Aging where we were attending Dr. Dale Bredesen’s training for reversing cognitive decline. If you’ve yet to discover Dr. Bredesen’s amazing work, I’d highly recommend his STEM-Talk interview. My attempt to capture the impressiveness of the Buck Institute leaves a lot to be desired, but since I promised a photo during the recording, here it is:

We love our supplements at Nourish Balance Thrive, and we regularly recommend them to the people we work with, usually when indicated by a test result. What we’re less keen on is expensive nonsense with no human data or even plausible mechanism of action. Oxaloacetate falls into this category, and in this interview, you'll learn enough biochemistry to understand why you should save your money. As always, we reserve the right to be proven wrong!

In the second part of this interview, you'll learn about why it's essential to eat to fuel for your activity. We're huge fans of a ketogenic diet for a handful of very specific applications, but not as a general recommendation, especially for athletes engaging in highly glycolytic activities like Crossfit and obstacle course racing.

Here’s the outline of this interview with Dr. Tommy Wood, MD PhDc:

[00:00:26] Buck Institute for Research on Aging.

[00:00:43] Bredesen, Dale E., et al. "Reversal of cognitive decline in Alzheimer's disease." Aging (Albany NY) 8.6 (2016): 1250.

[00:00:59] Journal of Neuroscience.

[00:02:00] Hippocampal volume increasing.

[00:02:26] Blood chem, genotyping, biotoxins, heavy metals.

[00:02:32] ReCode software.

[00:03:17] Send me your questions for Dr. Bredesen.

[00:03:41] Oxaloacetate supplementation.

[00:04:01] How to Achieve Near-Normal Blood Sugar with Type 1 Diabetes with Dr. Keith Runyan, MD.

[00:05:18] Caloric restriction in humans.

[00:05:23] CALERIE trial.

[00:06:08] Calorie restriction falters in the long run.

[00:07:01] The benefit comes on the refeed.

[00:07:14] Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis.

[00:07:41] Getting Stronger with Todd Becker.

[00:08:18] C. elegans.

[00:08:47] Malate-aspartate shuttle.

[00:09:20] NAD+/NADH ratio.

[00:09:32] AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1).

[00:09:45] FOXO3.

[00:10:01] Nicotinamide riboside (NR).

[00:10:19] Strong, Randy, et al. "Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68.1 (2013): 6-16.

[00:11:14] Toxic effects of glutamate.

[00:11:48] Excitotoxicity.

[00:12:30] Aspartate transaminase (AST) on a blood chem.

[00:13:37] The OAA supplements include a meaningless dose anyway.

[00:14:17] Anaplerotic reactions.

[00:15:27] Pyruvate dehydrogenase and biotin (B7) deficiency.

[00:16:54] Context for a ketogenic diet.

[00:18:06] Glycolytic activity.

[00:19:20] Fasting blood glucose.

[00:19:36] Alkaline phosphatase (Alk Phos).

[00:20:01] Zinc deficiency.

[00:21:26] Thyroid.

[00:22:02] Deiodinase enzymes.

[00:24:11] Lipids.

[00:24:39] LDL receptor.

[00:25:29] Red blood cell production

[00:25:51] Mean corpuscular volume (MCV).

[00:26:33] Macrocytosis due to folate deficiency.

[00:29:24] Masharani, U., et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948.

[00:31:07] Ketosis makes you sharp so you can go get some food.

[00:31:46] A New Hope for Brain Tumors with Dr. Adrienne Scheck.

[00:31:59] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet.

[00:32:08] A ketogenic diet shows some promise for Multiple Sclerosis and Alzheimer’s.

[00:32:33] Light dark cycles.

[00:33:18] Breast feeding and carbs.

[00:33:45] Thompson, Betty J., and Stuart Smith. "Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat." Pediatr Res 19.1 (1985): 139-143.

[00:34:05] Babies are in ketosis.

[00:34:32] Medium-chain triglyceride.

[00:35:07] Read, W. W. C., PHYLLIS G. LUTZ, and ANAHID TASHJIAN. "Human Milk Lipids II. The influence of dietary carbohydrates and fat on the fatty acids of mature milk. A study in four ethnic groups." The American journal of clinical nutrition 17.3 (1965): 180-183.

[00:35:21] Keto rat experiment.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-12-4.at.13.mp3 Thu, 22 Dec 2016 15:12:58 GMT Christopher Kelly Tommy and I recorded this interview in person at the Buck Institute for Research on Aging where we were attending Dr. Dale Bredesen’s training for reversing cognitive decline. If you’ve yet to discover Dr. Bredesen’s amazing work, I’d highly recommend his STEM-Talk interview. My attempt to capture the impressiveness of the Buck Institute leaves a lot to be desired, but since I promised a photo during the recording, here it is:

We love our supplements at Nourish Balance Thrive, and we regularly recommend them to the people we work with, usually when indicated by a test result. What we’re less keen on is expensive nonsense with no human data or even plausible mechanism of action. Oxaloacetate falls into this category, and in this interview, you'll learn enough biochemistry to understand why you should save your money. As always, we reserve the right to be proven wrong!

In the second part of this interview, you'll learn about why it's essential to eat to fuel for your activity. We're huge fans of a ketogenic diet for a handful of very specific applications, but not as a general recommendation, especially for athletes engaging in highly glycolytic activities like Crossfit and obstacle course racing.

Here’s the outline of this interview with Dr. Tommy Wood, MD PhDc:

[00:00:26] Buck Institute for Research on Aging.

[00:00:43] Bredesen, Dale E., et al. "Reversal of cognitive decline in Alzheimer's disease." Aging (Albany NY) 8.6 (2016): 1250.

[00:00:59] Journal of Neuroscience.

[00:02:00] Hippocampal volume increasing.

[00:02:26] Blood chem, genotyping, biotoxins, heavy metals.

[00:02:32] ReCode software.

[00:03:17] Send me your questions for Dr. Bredesen.

[00:03:41] Oxaloacetate supplementation.

[00:04:01] How to Achieve Near-Normal Blood Sugar with Type 1 Diabetes with Dr. Keith Runyan, MD.

[00:05:18] Caloric restriction in humans.

[00:05:23] CALERIE trial.

[00:06:08] Calorie restriction falters in the long run.

[00:07:01] The benefit comes on the refeed.

[00:07:14] Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis.

[00:07:41] Getting Stronger with Todd Becker.

[00:08:18] C. elegans.

[00:08:47] Malate-aspartate shuttle.

[00:09:20] NAD+/NADH ratio.

[00:09:32] AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1).

[00:09:45] FOXO3.

[00:10:01] Nicotinamide riboside (NR).

[00:10:19] Strong, Randy, et al. "Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68.1 (2013): 6-16.

[00:11:14] Toxic effects of glutamate.

[00:11:48] Excitotoxicity.

[00:12:30] Aspartate transaminase (AST) on a blood chem.

[00:13:37] The OAA supplements include a meaningless dose anyway.

[00:14:17] Anaplerotic reactions.

[00:15:27] Pyruvate dehydrogenase and biotin (B7) deficiency.

[00:16:54] Context for a ketogenic diet.

[00:18:06] Glycolytic activity.

[00:19:20] Fasting blood glucose.

[00:19:36] Alkaline phosphatase (Alk Phos).

[00:20:01] Zinc deficiency.

[00:21:26] Thyroid.

[00:22:02] Deiodinase enzymes.

[00:24:11] Lipids.

[00:24:39] LDL receptor.

[00:25:29] Red blood cell production

[00:25:51] Mean corpuscular volume (MCV).

[00:26:33] Macrocytosis due to folate deficiency.

[00:29:24] Masharani, U., et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948.

[00:31:07] Ketosis makes you sharp so you can go get some food.

[00:31:46] A New Hope for Brain Tumors with Dr. Adrienne Scheck.

[00:31:59] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet.

[00:32:08] A ketogenic diet shows some promise for Multiple Sclerosis and Alzheimer’s.

[00:32:33] Light dark cycles.

[00:33:18] Breast feeding and carbs.

[00:33:45] Thompson, Betty J., and Stuart Smith. "Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat." Pediatr Res 19.1 (1985): 139-143.

[00:34:05] Babies are in ketosis.

[00:34:32] Medium-chain triglyceride.

[00:35:07] Read, W. W. C., PHYLLIS G. LUTZ, and ANAHID TASHJIAN. "Human Milk Lipids II. The influence of dietary carbohydrates and fat on the fatty acids of mature milk. A study in four ethnic groups." The American journal of clinical nutrition 17.3 (1965): 180-183.

[00:35:21] Keto rat experiment.

]]>
clean
Getting Stronger https://s3.amazonaws.com/nourishbalancethrive/podcast/Todd.Becker.on.2016-11-21.at.07_edited.mp3 Hormetism is the application of progressive, intermittent stress to overcome challenges and grow stronger physically, mentally and emotionally. As athletes, we intuitively understand the hormetic effect of exercise but did you know that cold, altitude, plant toxins and even straining slightly to read can all be used to help us get stronger?

My guest is for this interview is Todd Becker, a freelance blogger based in the San Francisco Bay Area, where he lives with his wife and two children. He has degrees in Chemical Engineering and Philosophy from Stanford University and Brown University.  Todd currently works as a staff scientist for a biotechnology company in Palo Alto, where he leads project teams and holds more than 20 patents.
 
Not everyone will have access to all of the hormetic stressors we talk about in this episode. The important takeaway message is that there's more than one way to get stronger. Take advantage in whatever way you see fit.

Here’s the outline of this interview with Todd Becker:

[00:00:24] Myopia: A Modern Yet Reversible Disease.

[00:00:53] AHS16 - Todd Becker - Living High and Healthy.

[00:01:48] Hormesis.

[00:02:35] Low-carb and intermittent fasting.

[00:03:58] Going on holiday and forgetting glasses.

[00:04:40] Print pushing.

[00:05:02] Exercise.

[00:05:29] Immune system.

[00:06:07] UV.

[00:06:13] Overcompensation.

[00:07:28] Lactose tolerance.

[00:08:35] Unnecessarily avoiding the sun.

[00:10:05] Finding the perfect amount of stress.

[00:12:15] Learning to fast blog post.

[00:13:00] Heart rate variability or even just resting HR.

[00:14:02] Cold showers.

[00:14:43] Alcohol.

[00:15:53] Metabolic flexibility.

[00:16:08] Allostasis.

[00:17:07] Wood smoke.

[00:17:25] Evolutionary mismatches.

[00:17:41] Is charred meat bad for you?

[00:18:29] Catching Fire: How Cooking Made Us Human.

[00:19:02] Phases of detoxification.

[00:19:17] CYP3A4.

[00:19:42] Superoxide dismutase.

[00:20:01] Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More.

[00:21:28] Low-dose dioxins.

[00:21:53] Hormone analogues.

[00:22:14] Gluten.

[00:22:40] IgE emergency response.

[00:22:50] An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases.

[00:23:36] Peanut allergies

[00:23:56] Karelia (historical province of Finland).

[00:25:00] Reversing peanut allergies.

[00:25:22] Poison ivy and oak.

[00:26:49] Peanut oil in diaper cream.

[00:27:06] Oral vs topical exposure.

[00:27:23] Epstein–Barr virus infection at certain ages.

[00:28:09] Altitude.

[00:28:24] Boulder has the lowest obesity rate in the US.

[00:29:28] PGC1-a via hypoxia.

[00:30:16] Barry Murray on my podcast.

[00:31:36] Altitude masks.

[00:32:02] Train high race low.

[00:32:24] Jeremy Powers on this podcast.

[00:34:43] gettingstronger.org

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Todd.Becker.on.2016-11-21.at.07_edited.mp3 Thu, 15 Dec 2016 14:12:37 GMT Christopher Kelly Hormetism is the application of progressive, intermittent stress to overcome challenges and grow stronger physically, mentally and emotionally. As athletes, we intuitively understand the hormetic effect of exercise but did you know that cold, altitude, plant toxins and even straining slightly to read can all be used to help us get stronger?

My guest is for this interview is Todd Becker, a freelance blogger based in the San Francisco Bay Area, where he lives with his wife and two children. He has degrees in Chemical Engineering and Philosophy from Stanford University and Brown University.  Todd currently works as a staff scientist for a biotechnology company in Palo Alto, where he leads project teams and holds more than 20 patents.
 
Not everyone will have access to all of the hormetic stressors we talk about in this episode. The important takeaway message is that there's more than one way to get stronger. Take advantage in whatever way you see fit.

Here’s the outline of this interview with Todd Becker:

[00:00:24] Myopia: A Modern Yet Reversible Disease.

[00:00:53] AHS16 - Todd Becker - Living High and Healthy.

[00:01:48] Hormesis.

[00:02:35] Low-carb and intermittent fasting.

[00:03:58] Going on holiday and forgetting glasses.

[00:04:40] Print pushing.

[00:05:02] Exercise.

[00:05:29] Immune system.

[00:06:07] UV.

[00:06:13] Overcompensation.

[00:07:28] Lactose tolerance.

[00:08:35] Unnecessarily avoiding the sun.

[00:10:05] Finding the perfect amount of stress.

[00:12:15] Learning to fast blog post.

[00:13:00] Heart rate variability or even just resting HR.

[00:14:02] Cold showers.

[00:14:43] Alcohol.

[00:15:53] Metabolic flexibility.

[00:16:08] Allostasis.

[00:17:07] Wood smoke.

[00:17:25] Evolutionary mismatches.

[00:17:41] Is charred meat bad for you?

[00:18:29] Catching Fire: How Cooking Made Us Human.

[00:19:02] Phases of detoxification.

[00:19:17] CYP3A4.

[00:19:42] Superoxide dismutase.

[00:20:01] Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More.

[00:21:28] Low-dose dioxins.

[00:21:53] Hormone analogues.

[00:22:14] Gluten.

[00:22:40] IgE emergency response.

[00:22:50] An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases.

[00:23:36] Peanut allergies

[00:23:56] Karelia (historical province of Finland).

[00:25:00] Reversing peanut allergies.

[00:25:22] Poison ivy and oak.

[00:26:49] Peanut oil in diaper cream.

[00:27:06] Oral vs topical exposure.

[00:27:23] Epstein–Barr virus infection at certain ages.

[00:28:09] Altitude.

[00:28:24] Boulder has the lowest obesity rate in the US.

[00:29:28] PGC1-a via hypoxia.

[00:30:16] Barry Murray on my podcast.

[00:31:36] Altitude masks.

[00:32:02] Train high race low.

[00:32:24] Jeremy Powers on this podcast.

[00:34:43] gettingstronger.org

]]>
clean
How to Teach Machines That Can Learn https://s3.amazonaws.com/nourishbalancethrive/podcast/Pedro.Domingos.at.2016.11.14.mp3 Machine learning is fast becoming a part of our lives. From the order in which your search results and news feeds are ordered to the image classifiers and speech recognition features on your smartphone. Machine learning may even have had a hand in choosing your spouse or driving you to work. As with cars, only the mechanics need to understand what happens under the hood, but all drivers need to know how to operate the steering wheel. Listen to this podcast to learn how to interact with machines that can learn, and about the implications for humanity.

My guest is Dr. Pedro Domingos, Professor of Computer Science at Washington University. He is the author or co-author of over 200 technical publications in machine learning and data mining, and the author of my new favourite book The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World.

Here’s the outline of this interview with Dr. Pedro Domingos, PhD:

[00:01:55] Deep Learning.

[00:02:21] Machine learning is affecting everyone's lives.

[00:03:45] Recommender systems.

[00:03:57] Ordering newsfeeds.

[00:04:25] Text prediction and speech recognition in smart phones.

[00:04:54] Accelerometers.

[00:04:54] Selecting job applicants.

[00:05:05] Finding a spouse.

[00:05:35] OKCupid.com.

[00:06:49] Robot scientists.

[00:07:08] Artificially-intelligent Robot Scientist ‘Eve’ could boost search for new drugs.

[00:08:38] Cancer research.

[00:10:27] Central dogma of molecular biology.

[00:10:34] DNA microarrays.

[00:11:34] Robb Wolf at IHMC: Darwinian Medicine: Maybe there IS something to this evolution thing.

[00:12:29] It costs more to find the data than to do the experiment again (ref?)

[00:13:11] Making connections people could never make.

[00:14:00] Jeremy Howard’s TED talk: The wonderful and terrifying implications of computers that can learn.

[00:14:14] Pedro's TED talk: The Quest for the Master Algorithm.

[00:15:49] Craig Venter: your immune system on the Internet.

[00:16:44] Continuous blood glucose monitoring and Heart Rate Variability.

[00:17:41] Our data: DUTCH, OAT, stool, blood.

[00:19:21] Supervised and unsupervised learning.

[00:20:11] Clustering dimensionality reduction, e.g. PCA and T-SNE.

[00:21:44] Sodium to potassium ratio versus cortisol.

[00:22:24] Eosinophils.

[00:23:17] Clinical trials.

[00:24:35] Tetiana Ivanova - How to become a Data Scientist in 6 months a hacker’s approach to career planning.

[00:25:02] Deep Learning Book.

[00:25:46] Maths as a barrier to entry.

[00:27:09] Andrew Ng Coursera Machine Learning course.

[00:27:28] Pedro's Data Mining course.

[00:27:50] Theano and Keras.

[00:28:02] State Farm Distracted Driver Detection Kaggle competition.

[00:29:37] Nearest Neighbour algorithm.

[00:30:29] Driverless cars.

[00:30:41] Is a robot going to take my job?

[00:31:29] Jobs will not be lost, they will be transformed

[00:33:14] Automate your job yourself!

[00:33:27] Centaur chess player.

[00:35:32] ML is like driving, you can only learn by doing it.

[00:35:52] A Few Useful Things to Know about Machine Learning.

[00:37:00] Blood chemistry software.

[00:37:30] We are the owners of our data.

[00:38:49] Data banks and unions.

[00:40:01] The distinction with privacy.

[00:40:29] An ethical obligation to share.

[00:41:46] Data vulcanisation.

[00:42:40] Teaching the machine.

[00:43:07] Chrome incognito mode.

[00:44:13] Why can't we interact with the algorithm?

[00:45:33] New P2 Instance Type for Amazon EC2 – Up to 16 GPUs.

[00:46:01] Why now?

[00:46:47] Research breakthroughs.

[00:47:04] The amount of data.

[00:47:13] Hardware.

[00:47:31] GPUs, Moore’s law.

[00:47:57] Economics.

[00:48:32] Google TensorFlow.

[00:49:05] Facebook Torch.

[00:49:38] Recruiting.

[00:50:58] The five tribes of machine learning: evolutionaries, connectionists, Bayesians, analogizers, symbolists.

[00:51:55] Grand unified theory of ML.

[00:53:40] Decision tree ensembles (Random Forests).

[00:53:45] XGBoost.

[00:53:54] Weka.

[00:54:21] Alchemy: Open Source AI.

[00:56:16] Still do a computer science degree.

[00:56:54] Minor in probability and statistics.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Pedro.Domingos.at.2016.11.14.mp3 Thu, 08 Dec 2016 13:12:06 GMT Christopher Kelly Machine learning is fast becoming a part of our lives. From the order in which your search results and news feeds are ordered to the image classifiers and speech recognition features on your smartphone. Machine learning may even have had a hand in choosing your spouse or driving you to work. As with cars, only the mechanics need to understand what happens under the hood, but all drivers need to know how to operate the steering wheel. Listen to this podcast to learn how to interact with machines that can learn, and about the implications for humanity.

My guest is Dr. Pedro Domingos, Professor of Computer Science at Washington University. He is the author or co-author of over 200 technical publications in machine learning and data mining, and the author of my new favourite book The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World.

Here’s the outline of this interview with Dr. Pedro Domingos, PhD:

[00:01:55] Deep Learning.

[00:02:21] Machine learning is affecting everyone's lives.

[00:03:45] Recommender systems.

[00:03:57] Ordering newsfeeds.

[00:04:25] Text prediction and speech recognition in smart phones.

[00:04:54] Accelerometers.

[00:04:54] Selecting job applicants.

[00:05:05] Finding a spouse.

[00:05:35] OKCupid.com.

[00:06:49] Robot scientists.

[00:07:08] Artificially-intelligent Robot Scientist ‘Eve’ could boost search for new drugs.

[00:08:38] Cancer research.

[00:10:27] Central dogma of molecular biology.

[00:10:34] DNA microarrays.

[00:11:34] Robb Wolf at IHMC: Darwinian Medicine: Maybe there IS something to this evolution thing.

[00:12:29] It costs more to find the data than to do the experiment again (ref?)

[00:13:11] Making connections people could never make.

[00:14:00] Jeremy Howard’s TED talk: The wonderful and terrifying implications of computers that can learn.

[00:14:14] Pedro's TED talk: The Quest for the Master Algorithm.

[00:15:49] Craig Venter: your immune system on the Internet.

[00:16:44] Continuous blood glucose monitoring and Heart Rate Variability.

[00:17:41] Our data: DUTCH, OAT, stool, blood.

[00:19:21] Supervised and unsupervised learning.

[00:20:11] Clustering dimensionality reduction, e.g. PCA and T-SNE.

[00:21:44] Sodium to potassium ratio versus cortisol.

[00:22:24] Eosinophils.

[00:23:17] Clinical trials.

[00:24:35] Tetiana Ivanova - How to become a Data Scientist in 6 months a hacker’s approach to career planning.

[00:25:02] Deep Learning Book.

[00:25:46] Maths as a barrier to entry.

[00:27:09] Andrew Ng Coursera Machine Learning course.

[00:27:28] Pedro's Data Mining course.

[00:27:50] Theano and Keras.

[00:28:02] State Farm Distracted Driver Detection Kaggle competition.

[00:29:37] Nearest Neighbour algorithm.

[00:30:29] Driverless cars.

[00:30:41] Is a robot going to take my job?

[00:31:29] Jobs will not be lost, they will be transformed

[00:33:14] Automate your job yourself!

[00:33:27] Centaur chess player.

[00:35:32] ML is like driving, you can only learn by doing it.

[00:35:52] A Few Useful Things to Know about Machine Learning.

[00:37:00] Blood chemistry software.

[00:37:30] We are the owners of our data.

[00:38:49] Data banks and unions.

[00:40:01] The distinction with privacy.

[00:40:29] An ethical obligation to share.

[00:41:46] Data vulcanisation.

[00:42:40] Teaching the machine.

[00:43:07] Chrome incognito mode.

[00:44:13] Why can't we interact with the algorithm?

[00:45:33] New P2 Instance Type for Amazon EC2 – Up to 16 GPUs.

[00:46:01] Why now?

[00:46:47] Research breakthroughs.

[00:47:04] The amount of data.

[00:47:13] Hardware.

[00:47:31] GPUs, Moore’s law.

[00:47:57] Economics.

[00:48:32] Google TensorFlow.

[00:49:05] Facebook Torch.

[00:49:38] Recruiting.

[00:50:58] The five tribes of machine learning: evolutionaries, connectionists, Bayesians, analogizers, symbolists.

[00:51:55] Grand unified theory of ML.

[00:53:40] Decision tree ensembles (Random Forests).

[00:53:45] XGBoost.

[00:53:54] Weka.

[00:54:21] Alchemy: Open Source AI.

[00:56:16] Still do a computer science degree.

[00:56:54] Minor in probability and statistics.

]]>
clean
How to Use Biomedical Testing for IRONMAN Performance https://s3.amazonaws.com/nourishbalancethrive/podcast/Bob.McRae.on.2016-11-15.at.11.00_edited_full.mp3 After a rocky start to the season, NBT client Bob McRae turned everything around using our performance orientated functional medicine program for athletes. "I had the best race of my life yesterday, beyond my imagination." said 47-year old McRae, after his first age-group win (by 14-minutes) and 6th overall at IRONMAN Boulder.

Bob is now the number one USAT ranked athlete in his age group.
 
Listen to this podcast to discover how Bob used a combination of blood chemistry, urinary organic acids and hormone testing, stool culturomics together with diet and lifestyle modification and NSF certified nutritional supplements to achieve peak triathlon performance.

Here’s the outline of this interview with Bob McRae:

[00:04:22] Dr. Phil Maffetone.

[00:09:06] Quest Diagnostics.

[00:09:22] Fat Black podcast.

[00:11:26] IRONMAN Boulder and Kona.

[00:11:47] Bob was unable to elevate his heart rate.

[00:13:10] GI symptoms affected racing.

[00:13:38] Blastocystis was found on a BioHealth 401H stool test, gone on retest.

[00:13:39] Candida overgrowth found on a Great Plains urinary organic acids test.

[00:13:47] Elevated lysozyme (an enzyme secreted at the site of inflammation in the GI tract) on Doctor’s Data stool test.

[00:13:59] Elevation of white blood cells (eosinophils) on a blood chemistry.

[00:15:55] Whole30.

[00:16:16] Eliminating sugar, dairy and grains.

[00:17:23] Bob has reintroduced sprouted grains.

[00:19:03] Bob’s daughter has resolved her skin issues eating the same diet.

[00:20:35] Elevated TSH and Thyroid Peroxidase (TPO) Antibodies, both now getting better.

[00:22:59] Travelling for triathlon.

[00:26:41] Mass start in Kona.

[00:26:56] Clif Bar Triathlon Start Commercial.

[00:29:44] 1:02 swim.

[00:30:15] Working with swim coach and drafting.

[00:30:46] Muse meditation device.

[00:33:03] EmWave2.

[00:33:30] Fat Black podcast #187.

[00:33:45] Headspace.

[00:34:51] Daniela Ryf.

[00:35:57] Andrew Messick CEO of IRONMAN.

[00:39:32] First Endurance EFS drink.

[00:44:16] Dr. Keith Runyan on my podcast.

[00:45:18] 9:45 top 20 in the world.

[00:48:14] Elevation of methylmalonic on a urinary organic acids test indicates a deficiency of vitamin B12.

[00:48:42] DUTCH.

[00:49:18] Iron Rambler blog.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Bob.McRae.on.2016-11-15.at.11.00_edited_full.mp3 Thu, 01 Dec 2016 17:12:12 GMT Christopher Kelly After a rocky start to the season, NBT client Bob McRae turned everything around using our performance orientated functional medicine program for athletes. "I had the best race of my life yesterday, beyond my imagination." said 47-year old McRae, after his first age-group win (by 14-minutes) and 6th overall at IRONMAN Boulder.

Bob is now the number one USAT ranked athlete in his age group.
 
Listen to this podcast to discover how Bob used a combination of blood chemistry, urinary organic acids and hormone testing, stool culturomics together with diet and lifestyle modification and NSF certified nutritional supplements to achieve peak triathlon performance.

Here’s the outline of this interview with Bob McRae:

[00:04:22] Dr. Phil Maffetone.

[00:09:06] Quest Diagnostics.

[00:09:22] Fat Black podcast.

[00:11:26] IRONMAN Boulder and Kona.

[00:11:47] Bob was unable to elevate his heart rate.

[00:13:10] GI symptoms affected racing.

[00:13:38] Blastocystis was found on a BioHealth 401H stool test, gone on retest.

[00:13:39] Candida overgrowth found on a Great Plains urinary organic acids test.

[00:13:47] Elevated lysozyme (an enzyme secreted at the site of inflammation in the GI tract) on Doctor’s Data stool test.

[00:13:59] Elevation of white blood cells (eosinophils) on a blood chemistry.

[00:15:55] Whole30.

[00:16:16] Eliminating sugar, dairy and grains.

[00:17:23] Bob has reintroduced sprouted grains.

[00:19:03] Bob’s daughter has resolved her skin issues eating the same diet.

[00:20:35] Elevated TSH and Thyroid Peroxidase (TPO) Antibodies, both now getting better.

[00:22:59] Travelling for triathlon.

[00:26:41] Mass start in Kona.

[00:26:56] Clif Bar Triathlon Start Commercial.

[00:29:44] 1:02 swim.

[00:30:15] Working with swim coach and drafting.

[00:30:46] Muse meditation device.

[00:33:03] EmWave2.

[00:33:30] Fat Black podcast #187.

[00:33:45] Headspace.

[00:34:51] Daniela Ryf.

[00:35:57] Andrew Messick CEO of IRONMAN.

[00:39:32] First Endurance EFS drink.

[00:44:16] Dr. Keith Runyan on my podcast.

[00:45:18] 9:45 top 20 in the world.

[00:48:14] Elevation of methylmalonic on a urinary organic acids test indicates a deficiency of vitamin B12.

[00:48:42] DUTCH.

[00:49:18] Iron Rambler blog.

]]>
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A New Hope for Brain Tumors https://s3.amazonaws.com/nourishbalancethrive/podcast/Adrienne.Scheck.on.2016-10-26.at.11.12.mp3 This year in the United States, over 22,000 people will be diagnosed with a primary brain or spinal tumor. Of these, more than 13,000, many of them younger than 21 years old, will die of their disease. New treatment modalities are critical in the battle against cancer.

Adrienne Scheck, PhD, is an associate professor of neurobiology at Barrow Neurological Institute.

Dr. Scheck’s expertise includes neuro-oncology. She is a member of the American Association for Cancer Research, Society for Neuro-Oncology, American Association for Cancer Research, American Society for Biochemistry and Molecular Biology, Women in Cancer Research, and the American Association for the Advancement of Science.

Dr. Scheck’s work consists mainly of translational research to develop novel adjuvant therapies for the treatment of brain tumors. She also use various molecular and molecular genetic techniques to investigate why current therapies sometimes fail.
 

Here’s the outline of this interview with Dr. Adrienne Scheck:

[00:00:37] Dr. Jong M Rho.

[00:01:18] Glioblastoma.

[00:03:53] Hanahan, Douglas, and Robert A. Weinberg. "Hallmarks of cancer: the next generation." cell 144.5 (2011): 646-674.

[00:05:01] Cancer metabolism: see Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure.

[00:05:37] Positron emission tomography (PET).

[00:06:20] Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions.

[00:07:21] Adding ketones to a in vitro model.

[00:09:14] Poff, Angela M., et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PloS one 8.6 (2013): e65522.

[00:11:38] 4:1 KetoCal.

[00:13:14] Dr. Cate Shanahan at the Keto Summit.

[00:15:05] Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma.

[00:17:08] Charlie Foundation and Matthew's Friends.

[00:21:42] Clinical trial diet is as close to 4:1 as possible.

[00:22:09] Ketogenic Mealplanner – Electronic Ketogenic Manager (EKM).

[00:23:01] Cachexia.

[00:24:09] Ketones of 3mM, glucose of 4mM.

[00:25:59] Adrienne gave a talk in Banff but I couldn’t find it online.

[00:26:23] Trial eligibility.

[00:30:29] Confounding lifestyle factors.

[00:32:58] MRI for tumor metabolism .

[00:34:25] Is there something special about brain tumors that makes them particularly susceptible?

[00:35:25] Dominic D'Agostino on my podcast and the Keto Summit.

[00:35:48] Edema, angiogenesis, and inflammation.

[00:37:36] Lussier, Danielle M., et al. "Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet." BMC cancer16.1 (2016): 1.

[00:40:14] Gut microbiome.

[00:41:50] Ketone supplementation.

[00:47:54] Effects in cancer patients may be different from in a healthy person.

[00:48:45] Students Supporting Brain Tumor Research.

[00:50:35] MaxLove Project.

[00:50:47] Donations.

[00:52:28] Finding a physician and a dietician.

[00:55:13] Education for dietitians and practitioners.

[00:57:51] Pluripotency.

[00:58:55] Adam Sorenson and father Brad.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Adrienne.Scheck.on.2016-10-26.at.11.12.mp3 Fri, 25 Nov 2016 08:11:58 GMT Christopher Kelly This year in the United States, over 22,000 people will be diagnosed with a primary brain or spinal tumor. Of these, more than 13,000, many of them younger than 21 years old, will die of their disease. New treatment modalities are critical in the battle against cancer.

Adrienne Scheck, PhD, is an associate professor of neurobiology at Barrow Neurological Institute.

Dr. Scheck’s expertise includes neuro-oncology. She is a member of the American Association for Cancer Research, Society for Neuro-Oncology, American Association for Cancer Research, American Society for Biochemistry and Molecular Biology, Women in Cancer Research, and the American Association for the Advancement of Science.

Dr. Scheck’s work consists mainly of translational research to develop novel adjuvant therapies for the treatment of brain tumors. She also use various molecular and molecular genetic techniques to investigate why current therapies sometimes fail.
 

Here’s the outline of this interview with Dr. Adrienne Scheck:

[00:00:37] Dr. Jong M Rho.

[00:01:18] Glioblastoma.

[00:03:53] Hanahan, Douglas, and Robert A. Weinberg. "Hallmarks of cancer: the next generation." cell 144.5 (2011): 646-674.

[00:05:01] Cancer metabolism: see Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure.

[00:05:37] Positron emission tomography (PET).

[00:06:20] Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions.

[00:07:21] Adding ketones to a in vitro model.

[00:09:14] Poff, Angela M., et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PloS one 8.6 (2013): e65522.

[00:11:38] 4:1 KetoCal.

[00:13:14] Dr. Cate Shanahan at the Keto Summit.

[00:15:05] Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma.

[00:17:08] Charlie Foundation and Matthew's Friends.

[00:21:42] Clinical trial diet is as close to 4:1 as possible.

[00:22:09] Ketogenic Mealplanner – Electronic Ketogenic Manager (EKM).

[00:23:01] Cachexia.

[00:24:09] Ketones of 3mM, glucose of 4mM.

[00:25:59] Adrienne gave a talk in Banff but I couldn’t find it online.

[00:26:23] Trial eligibility.

[00:30:29] Confounding lifestyle factors.

[00:32:58] MRI for tumor metabolism .

[00:34:25] Is there something special about brain tumors that makes them particularly susceptible?

[00:35:25] Dominic D'Agostino on my podcast and the Keto Summit.

[00:35:48] Edema, angiogenesis, and inflammation.

[00:37:36] Lussier, Danielle M., et al. "Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet." BMC cancer16.1 (2016): 1.

[00:40:14] Gut microbiome.

[00:41:50] Ketone supplementation.

[00:47:54] Effects in cancer patients may be different from in a healthy person.

[00:48:45] Students Supporting Brain Tumor Research.

[00:50:35] MaxLove Project.

[00:50:47] Donations.

[00:52:28] Finding a physician and a dietician.

[00:55:13] Education for dietitians and practitioners.

[00:57:51] Pluripotency.

[00:58:55] Adam Sorenson and father Brad.

]]>
clean
Pro Tour Rider Nutrition and the Benefits of Fasted-State Training https://s3.amazonaws.com/nourishbalancethrive/podcast/Barry.Murray.on.2016-10-12.at.10.42.mp3 Barry Murray is a sports nutritionist and member of the Irish Ultramarathon Team currently working with Pro Tour cyclists. Barry has won several ultra-distance (70-200 km) running races, The Mourne Mountain Way, The Abbots Way, The Giants Causeway, The Wicklow Way, The Kerry Way, all without eating anything for breakfast. How? In a word, fat-adaptation.

In this interview, Barry describes his work with the pros and six much overlooked factors for high-performance ultra-endurance training: sunlight, cold thermogenesis, DHA from seafood, grounding, and water quality.

Here’s the outline of this interview with Barry Murray:

[00:01:56] BMC Racing Team.

[00:02:06] Ultramarathon.

[00:05:39] Low-carb, high-fat, ketogenic.

[00:06:14] Fasted state training.

[00:07:16] Sirtuins.

[00:12:38] AMP kinase.

[00:13:35] Beta-oxidation.

[00:13:44] Mitochondrial biogenesis.

[00:15:20] Acetyl-CoA.

[00:15:38] Peter Attia, MD.

[00:16:03] Stepwise adaptation.

[00:18:38] What are the pro cyclists doing?

[00:19:35] Nutrition is the new doping.

[00:23:00] Team Sky.

[00:23:55] Steve Cummins.

[00:24:29] 2-3 years to adapt.

[00:26:00] Can be done in 6-12 months.

[00:27:04] Train low, race high.

[00:28:26] Rates of brain glucose use.

[00:29:30] Pyruvate dehydrogenase.

[00:30:34] Ketone MonoEster article.

[00:31:21] Are the pros using ketone supplements?

[00:32:05] Chris Froome.

[00:32:33] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:34:00] Beta-oxidation is the goal, not ketogenesis.

[00:35:16] Jack Kruse.

[00:37:11] Six things to optimal health and living.

[00:37:30] Sunlight.

[00:37:53] Cold thermogenesis.

[00:38:05] Seafood.

[00:38:18] Grounding.

[00:38:25] Non-fluoridated water.

[00:39:55] UVB tanning booths.

[00:40:37] Schumann resonance.

[00:41:38] Electron Transport Chain (ETC)

[00:43:44] Sven Tuft of Orica Bike Exchange.

[00:44:45] Wim Hof.

[00:45:30] Kox, Matthijs, et al. "Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans." Proceedings of the National Academy of Sciences 111.20 (2014): 7379-7384.

[00:48:28] http://optimumnutrition4sport.co.uk/

[00:48:56] Fasted State Training Adaptations Jack Kruse forum post.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Barry.Murray.on.2016-10-12.at.10.42.mp3 Fri, 18 Nov 2016 07:11:30 GMT Christopher Kelly Barry Murray is a sports nutritionist and member of the Irish Ultramarathon Team currently working with Pro Tour cyclists. Barry has won several ultra-distance (70-200 km) running races, The Mourne Mountain Way, The Abbots Way, The Giants Causeway, The Wicklow Way, The Kerry Way, all without eating anything for breakfast. How? In a word, fat-adaptation.

In this interview, Barry describes his work with the pros and six much overlooked factors for high-performance ultra-endurance training: sunlight, cold thermogenesis, DHA from seafood, grounding, and water quality.

Here’s the outline of this interview with Barry Murray:

[00:01:56] BMC Racing Team.

[00:02:06] Ultramarathon.

[00:05:39] Low-carb, high-fat, ketogenic.

[00:06:14] Fasted state training.

[00:07:16] Sirtuins.

[00:12:38] AMP kinase.

[00:13:35] Beta-oxidation.

[00:13:44] Mitochondrial biogenesis.

[00:15:20] Acetyl-CoA.

[00:15:38] Peter Attia, MD.

[00:16:03] Stepwise adaptation.

[00:18:38] What are the pro cyclists doing?

[00:19:35] Nutrition is the new doping.

[00:23:00] Team Sky.

[00:23:55] Steve Cummins.

[00:24:29] 2-3 years to adapt.

[00:26:00] Can be done in 6-12 months.

[00:27:04] Train low, race high.

[00:28:26] Rates of brain glucose use.

[00:29:30] Pyruvate dehydrogenase.

[00:30:34] Ketone MonoEster article.

[00:31:21] Are the pros using ketone supplements?

[00:32:05] Chris Froome.

[00:32:33] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268.

[00:34:00] Beta-oxidation is the goal, not ketogenesis.

[00:35:16] Jack Kruse.

[00:37:11] Six things to optimal health and living.

[00:37:30] Sunlight.

[00:37:53] Cold thermogenesis.

[00:38:05] Seafood.

[00:38:18] Grounding.

[00:38:25] Non-fluoridated water.

[00:39:55] UVB tanning booths.

[00:40:37] Schumann resonance.

[00:41:38] Electron Transport Chain (ETC)

[00:43:44] Sven Tuft of Orica Bike Exchange.

[00:44:45] Wim Hof.

[00:45:30] Kox, Matthijs, et al. "Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans." Proceedings of the National Academy of Sciences 111.20 (2014): 7379-7384.

[00:48:28] http://optimumnutrition4sport.co.uk/

[00:48:56] Fasted State Training Adaptations Jack Kruse forum post.

]]>
clean
How to Achieve Near-Normal Blood Sugar with Type 1 Diabetes https://s3.amazonaws.com/nourishbalancethrive/podcast/Keith.Runyan.on.2016-10-05.at.10_edited__001.mp3 Dr. Keith Runyan, MD is a retired physician previously in private practice in St. Petersburg, Florida. Dr. Runyan specialised in internal medicine, nephrology, and obesity medicine. He practiced emergency medicine for ten years before starting his private practice in 2001.

In February 2012, he began the diet for the treatment of is diabetes and learned that this diet was also effective for the treatment of numerous other conditions, including obesity. He added obesity medicine to his practice and became board-certified in obesity medicine in December 2012. Dr. Runyan completed an Ironman-distance triathlon on October 20, 2012, in a state of nutritional ketosis and feeling great.
 
In 1998, he developed type 1 diabetes at the age of 38. Dr. Runyan controlled his diabetes was fairly well with intensive insulin therapy but was plagued with frequent hypoglycaemic episodes. In 2011, while training for an Ironman-distance triathlon, Dr. Runyan was looking for a better way to treat his diabetes and perform endurance exercise, and he decided to give the low-carb, high-fat, ketogenic diet a try.
 
I’d like to extend special thanks to RD Dikeman and Kory Seder of the TYPEONEGRIT Facebook group for providing me with many of the questions I ask Dr. Runyan during this interview.

Here’s the outline of this interview with Dr. Keith Runyan, MD:

[00:00:21] Keto Summit all access pass.

[00:02:50] Blood sugar 489 mg/dL.

[00:04:20] Latent autoimmune diabetes of adults (LADA).

[00:05:01] Beta-cell destruction.

[00:05:19] Epidemiological: viral infection, oral antibiotics, cow's milk (casein), cereals.

[00:07:28] NPH basal insulin (delayed).

[00:11:14] Glucagon.

[00:13:42] Hypoglycaemic episodes.

[00:14:19] Triathlon.

[00:16:07] IMTalk Episode 264 - Loren Cordain on the Paleo Diet.

[00:17:07] Jimmy Moore podcast.

[00:17:22] Robb Wolf.

[00:17:32] Dr. Bernstein’s Diabetes Solution.

[00:20:52] Continuous glucose monitor.

[00:22:34] Keith's blog: Ketogenic Diabetic Athlete.

[00:22:50] TYPEONEGRIT Facebook group.

[00:23:25] A day in the life of Dr. Runyan.

[00:24:37] Consistency is key.

[00:25:14] US Wellness Meats Liverwurst.

[00:26:28] Humalog insulin, finished in 2.5 hours.

[00:27:53] Exercise is key for insulin sensitivity.

[00:28:46] Swimming, weightlifting.

[00:29:05] Lantin insulin.

[00:30:16] Impact of different types of exercise on insulin sensitivity.

[00:31:31] Insulin sensitivity follows a circadian rhythm.

[00:34:54] Dr. Phil Maffetone.

[00:38:09] Powerlifting vs. Olympic lifting.

[00:38:31] Greg Everett at Catalyst Athletics.

[00:40:12] Carb cravings.

[00:41:43] Artificial pancreas.

[00:43:24] No more hypoglycaemia in ketosis.

[00:44:56] No correlation between blood BHB and symptoms.

[00:45:41] The value of lack thereof, of measuring blood BHB.

[00:47:30] Glycated proteins in the kidneys.

[00:47:50] High-sensitivity C-reactive protein.

[00:49:16] Ketosis for type 1 in children.

[00:50:09] 1.2g per kg protein.

[00:51:38] Vision for spreading the word.

[00:52:29] Medicine is an oil tanker.

[00:53:54] Dr. Runyan's books for type 1 and type 2.

[00:54:50] Ellen Davis of Ketogenic-Diet-Resource.com.

[00:55:45] "Normal" blood sugars.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Keith.Runyan.on.2016-10-05.at.10_edited__001.mp3 Fri, 11 Nov 2016 07:11:29 GMT Christopher Kelly Dr. Keith Runyan, MD is a retired physician previously in private practice in St. Petersburg, Florida. Dr. Runyan specialised in internal medicine, nephrology, and obesity medicine. He practiced emergency medicine for ten years before starting his private practice in 2001.

In February 2012, he began the diet for the treatment of is diabetes and learned that this diet was also effective for the treatment of numerous other conditions, including obesity. He added obesity medicine to his practice and became board-certified in obesity medicine in December 2012. Dr. Runyan completed an Ironman-distance triathlon on October 20, 2012, in a state of nutritional ketosis and feeling great.
 
In 1998, he developed type 1 diabetes at the age of 38. Dr. Runyan controlled his diabetes was fairly well with intensive insulin therapy but was plagued with frequent hypoglycaemic episodes. In 2011, while training for an Ironman-distance triathlon, Dr. Runyan was looking for a better way to treat his diabetes and perform endurance exercise, and he decided to give the low-carb, high-fat, ketogenic diet a try.
 
I’d like to extend special thanks to RD Dikeman and Kory Seder of the TYPEONEGRIT Facebook group for providing me with many of the questions I ask Dr. Runyan during this interview.

Here’s the outline of this interview with Dr. Keith Runyan, MD:

[00:00:21] Keto Summit all access pass.

[00:02:50] Blood sugar 489 mg/dL.

[00:04:20] Latent autoimmune diabetes of adults (LADA).

[00:05:01] Beta-cell destruction.

[00:05:19] Epidemiological: viral infection, oral antibiotics, cow's milk (casein), cereals.

[00:07:28] NPH basal insulin (delayed).

[00:11:14] Glucagon.

[00:13:42] Hypoglycaemic episodes.

[00:14:19] Triathlon.

[00:16:07] IMTalk Episode 264 - Loren Cordain on the Paleo Diet.

[00:17:07] Jimmy Moore podcast.

[00:17:22] Robb Wolf.

[00:17:32] Dr. Bernstein’s Diabetes Solution.

[00:20:52] Continuous glucose monitor.

[00:22:34] Keith's blog: Ketogenic Diabetic Athlete.

[00:22:50] TYPEONEGRIT Facebook group.

[00:23:25] A day in the life of Dr. Runyan.

[00:24:37] Consistency is key.

[00:25:14] US Wellness Meats Liverwurst.

[00:26:28] Humalog insulin, finished in 2.5 hours.

[00:27:53] Exercise is key for insulin sensitivity.

[00:28:46] Swimming, weightlifting.

[00:29:05] Lantin insulin.

[00:30:16] Impact of different types of exercise on insulin sensitivity.

[00:31:31] Insulin sensitivity follows a circadian rhythm.

[00:34:54] Dr. Phil Maffetone.

[00:38:09] Powerlifting vs. Olympic lifting.

[00:38:31] Greg Everett at Catalyst Athletics.

[00:40:12] Carb cravings.

[00:41:43] Artificial pancreas.

[00:43:24] No more hypoglycaemia in ketosis.

[00:44:56] No correlation between blood BHB and symptoms.

[00:45:41] The value of lack thereof, of measuring blood BHB.

[00:47:30] Glycated proteins in the kidneys.

[00:47:50] High-sensitivity C-reactive protein.

[00:49:16] Ketosis for type 1 in children.

[00:50:09] 1.2g per kg protein.

[00:51:38] Vision for spreading the word.

[00:52:29] Medicine is an oil tanker.

[00:53:54] Dr. Runyan's books for type 1 and type 2.

[00:54:50] Ellen Davis of Ketogenic-Diet-Resource.com.

[00:55:45] "Normal" blood sugars.

]]>
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How to Live Well with Chronic Illness https://s3.amazonaws.com/nourishbalancethrive/podcast/Mickey.Trescott.Angela.Alt.on.2016-09-07.at.10.01.mp3 Chris here, writing the show notes for this episode presented by my wife and food scientist Julia Kelly where she interviews Mickey Trescott, and Angie Alt. I’ve talked a lot about ketogenic diets on the podcast, but the truth is ketosis is a hack to improve my cognition and athletic performance. Autoimmune Paleo (AIP) is the diet that enabled me to recover my health, and since then, we’ve coached hundreds of other athletes in our practice using a very similar approach.

With the diet cornerstone in place, I became curious about what else I could do to improve my health and athletic performance. Shortly after came my discovery of functional medicine and the hundreds, if not thousands, of other lifestyle factors that needed to be in place in order for me to have what I enjoy today.
 
The Autoimmune Wellness Handbook addresses the most important of those other lifestyle factors. Authors Mickey and Angie introduce a complementary solution that focuses on seven key steps to recovery: inform, collaborate, nourish, rest, breathe, move, and connect.

Here’s the outline of this interview with Julia Kelly, Mickey Trescott, and Angie Alt:

[00:01:43] The Paleo Mom.

[00:04:26] autoimmune-paleo.com

[00:07:22] The athlete's gut.

[00:08:46] Inform - be your own expert.

[00:09:24] Collaborate - build your team.

[00:13:15] Hashimoto's.

[00:16:10] Nourish - choosing what to eat.

[00:20:17] Movement - should you back off?

[00:24:33] Rest.

[00:26:37] Breath - managing stress.

[00:27:48] Spending time in nature.

[00:29:02] Social isolation.

[00:34:13] Recipes and meal planning.

[00:41:09] The Autoimmune Wellness Handbook: A DIY Guide to Living Well with Chronic Illness.

[00:41:16] Autoimmune Paleo podcast.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mickey.Trescott.Angela.Alt.on.2016-09-07.at.10.01.mp3 Thu, 03 Nov 2016 07:11:41 GMT Christopher Kelly Chris here, writing the show notes for this episode presented by my wife and food scientist Julia Kelly where she interviews Mickey Trescott, and Angie Alt. I’ve talked a lot about ketogenic diets on the podcast, but the truth is ketosis is a hack to improve my cognition and athletic performance. Autoimmune Paleo (AIP) is the diet that enabled me to recover my health, and since then, we’ve coached hundreds of other athletes in our practice using a very similar approach.

With the diet cornerstone in place, I became curious about what else I could do to improve my health and athletic performance. Shortly after came my discovery of functional medicine and the hundreds, if not thousands, of other lifestyle factors that needed to be in place in order for me to have what I enjoy today.
 
The Autoimmune Wellness Handbook addresses the most important of those other lifestyle factors. Authors Mickey and Angie introduce a complementary solution that focuses on seven key steps to recovery: inform, collaborate, nourish, rest, breathe, move, and connect.

Here’s the outline of this interview with Julia Kelly, Mickey Trescott, and Angie Alt:

[00:01:43] The Paleo Mom.

[00:04:26] autoimmune-paleo.com

[00:07:22] The athlete's gut.

[00:08:46] Inform - be your own expert.

[00:09:24] Collaborate - build your team.

[00:13:15] Hashimoto's.

[00:16:10] Nourish - choosing what to eat.

[00:20:17] Movement - should you back off?

[00:24:33] Rest.

[00:26:37] Breath - managing stress.

[00:27:48] Spending time in nature.

[00:29:02] Social isolation.

[00:34:13] Recipes and meal planning.

[00:41:09] The Autoimmune Wellness Handbook: A DIY Guide to Living Well with Chronic Illness.

[00:41:16] Autoimmune Paleo podcast.

]]>
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Methylation and Environmental Pollutants with Dr. Tim Gerstmar https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Gerstmar.on.2016-09-28.at.10.mp3 Dr. Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia.

In this interview, Dr. Tim talks about methylation, sequencing diet and lifestyle medicine, environmental pollutants, detoxification physiology and treatments plus much more!

Here’s the outline of this interview with Dr. Tim Gerstmar, ND:

[00:04:22] Gut, autoimmune, hard-to-treat cases.

[00:05:21] Autism.

[00:06:20] Sequencing diet and lifestyle medicine.

[00:09:33] Dr. Gerstmar employs health coaches.

[00:10:33] 23andMe, penetrance.

[00:12:23] Robb Wolf.

[00:14:55] Environment toxicity.

[00:17:18] Toxicity and thyroid function.

[00:18:26] AHS 16 - Tim Gerstmar - Obesogens and Endocrine Disruptors.

[00:19:22] 100,000 chemicals into the environment since WWII.

[00:19:53] According to the EU, many haven't been adequately safety tested.

[00:23:05] Obvious exposure revealed via a detailed history.

[00:24:03] Scorecard.

[00:24:59] Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health with Dr. Bill Shaw, PhD.

[00:25:46] Xylene on the Genova organic acids test (it's also on the Great Plains TOX).

[00:30:43] Environmental Working Group Body Burden.

[00:32:38] Heavy metals: mercury, arsenic, lead.

[00:34:44] Fat soluble compounds.

[00:35:16] Nutrient dependencies for detoxification.

[00:36:12] Caloric restriction.

[00:36:38] Milk thistle.

[00:37:03] Sulforaphane Nrf2.

[00:37:47] Peeing and pooping.

[00:38:33] Sweating and sauna.

[00:38:58] Household chemicals.

[00:39:19] Flame retardants in clothing.

[00:40:18] EWG Dirty dozen and clean fifteen.

[00:40:50] Leaner cuts of meat.

[00:41:36] Mattresses.

[00:42:43] Niacin uses up methyl groups.

[00:43:51] Methylation and detoxification.

[00:44:37] Sequencing detoxification.

[00:45:20] Enterohepatic recirculation.

[00:47:31] Evolutionary mismatches.

[00:48:08] The gut microbiome, glucuronidation bonds.

[00:49:07] Olestra.

[00:49:46] Rice bran, psyllium.

[00:51:21] Apple pectin.

[00:51:45] Aspire Natural Health.

[00:53:48] Preconception care for both men and women.

[00:56:29] Changing the political climate.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Gerstmar.on.2016-09-28.at.10.mp3 Thu, 27 Oct 2016 16:10:31 GMT Christopher Kelly Dr. Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia.

In this interview, Dr. Tim talks about methylation, sequencing diet and lifestyle medicine, environmental pollutants, detoxification physiology and treatments plus much more!

Here’s the outline of this interview with Dr. Tim Gerstmar, ND:

[00:04:22] Gut, autoimmune, hard-to-treat cases.

[00:05:21] Autism.

[00:06:20] Sequencing diet and lifestyle medicine.

[00:09:33] Dr. Gerstmar employs health coaches.

[00:10:33] 23andMe, penetrance.

[00:12:23] Robb Wolf.

[00:14:55] Environment toxicity.

[00:17:18] Toxicity and thyroid function.

[00:18:26] AHS 16 - Tim Gerstmar - Obesogens and Endocrine Disruptors.

[00:19:22] 100,000 chemicals into the environment since WWII.

[00:19:53] According to the EU, many haven't been adequately safety tested.

[00:23:05] Obvious exposure revealed via a detailed history.

[00:24:03] Scorecard.

[00:24:59] Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health with Dr. Bill Shaw, PhD.

[00:25:46] Xylene on the Genova organic acids test (it's also on the Great Plains TOX).

[00:30:43] Environmental Working Group Body Burden.

[00:32:38] Heavy metals: mercury, arsenic, lead.

[00:34:44] Fat soluble compounds.

[00:35:16] Nutrient dependencies for detoxification.

[00:36:12] Caloric restriction.

[00:36:38] Milk thistle.

[00:37:03] Sulforaphane Nrf2.

[00:37:47] Peeing and pooping.

[00:38:33] Sweating and sauna.

[00:38:58] Household chemicals.

[00:39:19] Flame retardants in clothing.

[00:40:18] EWG Dirty dozen and clean fifteen.

[00:40:50] Leaner cuts of meat.

[00:41:36] Mattresses.

[00:42:43] Niacin uses up methyl groups.

[00:43:51] Methylation and detoxification.

[00:44:37] Sequencing detoxification.

[00:45:20] Enterohepatic recirculation.

[00:47:31] Evolutionary mismatches.

[00:48:08] The gut microbiome, glucuronidation bonds.

[00:49:07] Olestra.

[00:49:46] Rice bran, psyllium.

[00:51:21] Apple pectin.

[00:51:45] Aspire Natural Health.

[00:53:48] Preconception care for both men and women.

[00:56:29] Changing the political climate.

]]>
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Human Performance and Resilience in Extreme Environments https://s3.amazonaws.com/nourishbalancethrive/podcast/Dawn.Kernagis.on.2016-09-28.at.12.42.mp3 Dr. Dawn Kernagis is a Research Scientist in the area of human performance optimization and risk mitigation for operators in extreme environments, such as those working in undersea diving, high altitude aviation, and space. Dr. Kernagis came to IHMC from Duke University Medical Center, where her postdoctoral research was funded by the Office of Naval Research and the American Heart Association to identify pathophysiological mechanisms and potential therapeutic targets in multiple forms of acute brain injury.

Here’s the outline of this interview with Dr. Dawn Kernagis

[00:00:20] STEM-Talk podcast.

[00:01:35] Ken Ford.

[00:03:44] Keto Summit.

[00:04:06] Outside Magazine: Is the High-Fat, Low-Carb Ketogenic Diet Right for You?

[00:04:22] NEEMO expedition.

[00:08:30] The Twins Study was the first study of its kind to compare molecular profiles of identical twin astronauts with one in space and another on Earth.

[00:12:04] Apolipoprotein E (APOE).

[00:12:13] STEM-Talk Episode 12: Dale Bredesen Discusses The Metabolic Factors Underlying Alzheimer’s Disease.

[00:16:28] Apolipoprotein E4 protective against malaria?

[00:19:14] AHS 16 - Steven Gundry - Dietary Management of the Apo E4.

[00:20:37] STEM-Talk Episode 14: Dominic D'Agostino.

[00:21:28] Lauren Petersen: The Athlete Microbiome Project: The Search for the Golden Microbiome.

[00:22:55] A combination of 16S, metagenomic shotgun, and metatranscriptomic sequencing.

[00:29:48] Estrogen receptor (ER), progesterone receptor (PR), and HER2 expression.

[00:31:16] Python, scikit-learn, TensorFlow.

[00:31:32] The R Project for Statistical Computing.

[00:33:15] MATLAB.

[00:34:10] STEM-TALK Episode 1: Peter Attia On How To Live Longer And Better.

[00:35:23] Swiss cheese model, Gareth Lock.

[00:40:48] Duke University.

[00:41:04] Richard Moon.

[00:42:59] NEEMO blog.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Dawn.Kernagis.on.2016-09-28.at.12.42.mp3 Fri, 21 Oct 2016 08:10:52 GMT Christopher Kelly Dr. Dawn Kernagis is a Research Scientist in the area of human performance optimization and risk mitigation for operators in extreme environments, such as those working in undersea diving, high altitude aviation, and space. Dr. Kernagis came to IHMC from Duke University Medical Center, where her postdoctoral research was funded by the Office of Naval Research and the American Heart Association to identify pathophysiological mechanisms and potential therapeutic targets in multiple forms of acute brain injury.

Here’s the outline of this interview with Dr. Dawn Kernagis

[00:00:20] STEM-Talk podcast.

[00:01:35] Ken Ford.

[00:03:44] Keto Summit.

[00:04:06] Outside Magazine: Is the High-Fat, Low-Carb Ketogenic Diet Right for You?

[00:04:22] NEEMO expedition.

[00:08:30] The Twins Study was the first study of its kind to compare molecular profiles of identical twin astronauts with one in space and another on Earth.

[00:12:04] Apolipoprotein E (APOE).

[00:12:13] STEM-Talk Episode 12: Dale Bredesen Discusses The Metabolic Factors Underlying Alzheimer’s Disease.

[00:16:28] Apolipoprotein E4 protective against malaria?

[00:19:14] AHS 16 - Steven Gundry - Dietary Management of the Apo E4.

[00:20:37] STEM-Talk Episode 14: Dominic D'Agostino.

[00:21:28] Lauren Petersen: The Athlete Microbiome Project: The Search for the Golden Microbiome.

[00:22:55] A combination of 16S, metagenomic shotgun, and metatranscriptomic sequencing.

[00:29:48] Estrogen receptor (ER), progesterone receptor (PR), and HER2 expression.

[00:31:16] Python, scikit-learn, TensorFlow.

[00:31:32] The R Project for Statistical Computing.

[00:33:15] MATLAB.

[00:34:10] STEM-TALK Episode 1: Peter Attia On How To Live Longer And Better.

[00:35:23] Swiss cheese model, Gareth Lock.

[00:40:48] Duke University.

[00:41:04] Richard Moon.

[00:42:59] NEEMO blog.

]]>
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How to Start a Functional Medicine Practice https://s3.amazonaws.com/nourishbalancethrive/podcast/AMA_edited_29.09.mp3 A Whole Health Educator and Personal Trainer from Mountain View, California asked me some questions about the FDN certification and since we get so many questions like the ones below, Tommy and I did a webinar to answer those and more, live.

The questions:

  • What health services did you offer before studying with FDN?  How did you integrate your new training into your service offerings at the beginning?
  • Have you been able to use FDN to build a solid/sustaining income and business model?  If so, how long did that ramp up process take?
  • What marketing initiatives/strategies have you tried?  Which worked best/least?
  • Were there additional/unforeseen start up costs?
  • What challenges have you had along the way to setting up business with FDN?  What might you have done differently?
  • What are your thoughts on the current lab testing that FDN recommends, as well as the supplement brands they have relationships with?  
  • Do you find that most of your income from FDN stems from patient sessions or from supplement income?  Some other avenue?

Here’s the outline of this webinar with Dr. Tommy Wood:

[00:03:25] Kalish Institute.

[00:05:54] Robb Wolf.

[00:06:27] Root cause of multiple sclerosis using engineering techniques (paper, talk for the public, talk for physicians).

[00:07:16] Tommy's blog.

[00:07:53] OAT, DUTCH, blood chemistry.

[00:09:09] Chris Kresser's ADAPT course.

[00:10:10] Bryan Walsh's Metabolic Fitness Pro biochemistry course.

[00:10:28] Khan Academy chemistry.

[00:13:31] Mark Sisson's Primal Health Coaching certification.

[00:14:59] Functional Diagnostic Nutrition.

[00:17:53] Coursera Physiology Course form Duke University.

[00:20:01] Why Zebras Don't Get Ulcers.

[00:21:34] Jamie Kendall-Weed.

[00:24:06] Paleo Physicians Network.

[00:26:27] Tommy WOULD do it all again the same :)

[00:29:19] "A ticket to play the game"‒Physician's Assistant

[00:33:44] Student debt.

[00:35:35] How to Start a Startup.

[00:36:51] The Elite Performance Program (EPP).

[00:37:09] Ralston Consulting.

[00:37:49] Lisa Fraley, legal coach.

[00:38:08] Client agreements.

[00:39:53] Amelia.

[00:41:16] Jordan Reasoner podcast.

[00:42:33] Practitioner Liberation Project.

[00:43:24] Ben Greenfield podcast with Jamie.

[00:44:47] Zoom, Zendesk, Slack.

[00:45:02] ScheduleOnce.

[00:47:04] Trello.

[00:48:07] Google Drive

[00:48:48] HIPAA compliance.

[00:51:24] Data extraction and model building.

[00:51:45] Python Machine Learning.

[00:52:00] scikit-learn, TensorFlow.

[00:52:52] BioHealth Adrenal Stress Profile (saliva).

[00:53:17] BioHealth 101.

[00:53:53] Mediator Release Test (MRT).

[00:54:53] AIP, Whole30.

[00:55:13] Cyrex Labs.

[00:56:35] Aristo Vojdani.

[00:57:00] Ellen Langer.

[00:58:01] Align Podcast.

[00:58:26] Counterclockwise: Mindful Health and the Power of Possibility.

[00:59:10] Ron Rosedale.

[01:00:34] Keto Summit.

[01:01:04] PHAT FIBRE.

[01:03:21] PHAT COW!

[01:03:33] Fruition chocolate.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/AMA_edited_29.09.mp3 Fri, 14 Oct 2016 08:10:45 GMT Christopher Kelly A Whole Health Educator and Personal Trainer from Mountain View, California asked me some questions about the FDN certification and since we get so many questions like the ones below, Tommy and I did a webinar to answer those and more, live.

The questions:

  • What health services did you offer before studying with FDN?  How did you integrate your new training into your service offerings at the beginning?
  • Have you been able to use FDN to build a solid/sustaining income and business model?  If so, how long did that ramp up process take?
  • What marketing initiatives/strategies have you tried?  Which worked best/least?
  • Were there additional/unforeseen start up costs?
  • What challenges have you had along the way to setting up business with FDN?  What might you have done differently?
  • What are your thoughts on the current lab testing that FDN recommends, as well as the supplement brands they have relationships with?  
  • Do you find that most of your income from FDN stems from patient sessions or from supplement income?  Some other avenue?

Here’s the outline of this webinar with Dr. Tommy Wood:

[00:03:25] Kalish Institute.

[00:05:54] Robb Wolf.

[00:06:27] Root cause of multiple sclerosis using engineering techniques (paper, talk for the public, talk for physicians).

[00:07:16] Tommy's blog.

[00:07:53] OAT, DUTCH, blood chemistry.

[00:09:09] Chris Kresser's ADAPT course.

[00:10:10] Bryan Walsh's Metabolic Fitness Pro biochemistry course.

[00:10:28] Khan Academy chemistry.

[00:13:31] Mark Sisson's Primal Health Coaching certification.

[00:14:59] Functional Diagnostic Nutrition.

[00:17:53] Coursera Physiology Course form Duke University.

[00:20:01] Why Zebras Don't Get Ulcers.

[00:21:34] Jamie Kendall-Weed.

[00:24:06] Paleo Physicians Network.

[00:26:27] Tommy WOULD do it all again the same :)

[00:29:19] "A ticket to play the game"‒Physician's Assistant

[00:33:44] Student debt.

[00:35:35] How to Start a Startup.

[00:36:51] The Elite Performance Program (EPP).

[00:37:09] Ralston Consulting.

[00:37:49] Lisa Fraley, legal coach.

[00:38:08] Client agreements.

[00:39:53] Amelia.

[00:41:16] Jordan Reasoner podcast.

[00:42:33] Practitioner Liberation Project.

[00:43:24] Ben Greenfield podcast with Jamie.

[00:44:47] Zoom, Zendesk, Slack.

[00:45:02] ScheduleOnce.

[00:47:04] Trello.

[00:48:07] Google Drive

[00:48:48] HIPAA compliance.

[00:51:24] Data extraction and model building.

[00:51:45] Python Machine Learning.

[00:52:00] scikit-learn, TensorFlow.

[00:52:52] BioHealth Adrenal Stress Profile (saliva).

[00:53:17] BioHealth 101.

[00:53:53] Mediator Release Test (MRT).

[00:54:53] AIP, Whole30.

[00:55:13] Cyrex Labs.

[00:56:35] Aristo Vojdani.

[00:57:00] Ellen Langer.

[00:58:01] Align Podcast.

[00:58:26] Counterclockwise: Mindful Health and the Power of Possibility.

[00:59:10] Ron Rosedale.

[01:00:34] Keto Summit.

[01:01:04] PHAT FIBRE.

[01:03:21] PHAT COW!

[01:03:33] Fruition chocolate.

]]>
clean
Self-Care and Integrated Movement for the Modern World https://s3.amazonaws.com/nourishbalancethrive/podcast/aaron.alexander.on.2016-09-14.at.12.05.mp3 Aaron Alexander is an accomplished manual therapist and movement coach with over a decade of experience. He is the founder of Align Therapy™, an integrated approach to functional movement and self-care that has helped thousands including Olympic and professional level athletes. He is the creator of the 'Self-Care Kit' and the host of a highly ridiculous and informative podcast.

Here’s the outline of this interview with Aaron Alexander:

[00:00:18] Rolfing Institute.

[00:00:28] Structural alignment.

[00:01:34] Entrepreneurship.

[00:02:10] Align Podcast.

[00:02:41] Dr. Stuart McGill.

[00:02:50] Bike Fit Done Right: Nigel McHolland on my podcast.

[00:02:54] Dr. Ellen Langer.

[00:03:59] David Epstein.

[00:04:33] Prof. Tim Noakes.

[00:04:50] Keto Summit.

[00:05:58] Mindfulness.

[00:08:42] Hormesis.

[00:08:58] Aaron at AHS 16.

[00:09:16] Dr. Grace Liu.

[00:12:53] Amy Cuddy.

[00:15:31] Strongfirst instructor.

[00:16:28] Read to Run: Kelly Starrett on my podcast.

[00:21:44] Futsal.

[00:24:02] Alexander Technique.

[00:29:10] Sitting cross-legged.

[00:30:09] Pomodoro alarm.

[00:30:20] Lotus position.

[00:31:47] Esther Gokhale chair.

[00:37:26] Aaron is looking for a publisher.

[00:40:00] Glidewalking.

[00:41:12] Dr. Mark Cucuzzella barefoot running.

[00:44:28] Aaron's self-care kit.

[00:46:59] Rogue Fitness chinup bar.

[00:47:29] My interview on Aaron's podcast.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/aaron.alexander.on.2016-09-14.at.12.05.mp3 Fri, 07 Oct 2016 13:10:31 GMT Christopher Kelly Aaron Alexander is an accomplished manual therapist and movement coach with over a decade of experience. He is the founder of Align Therapy™, an integrated approach to functional movement and self-care that has helped thousands including Olympic and professional level athletes. He is the creator of the 'Self-Care Kit' and the host of a highly ridiculous and informative podcast.

Here’s the outline of this interview with Aaron Alexander:

[00:00:18] Rolfing Institute.

[00:00:28] Structural alignment.

[00:01:34] Entrepreneurship.

[00:02:10] Align Podcast.

[00:02:41] Dr. Stuart McGill.

[00:02:50] Bike Fit Done Right: Nigel McHolland on my podcast.

[00:02:54] Dr. Ellen Langer.

[00:03:59] David Epstein.

[00:04:33] Prof. Tim Noakes.

[00:04:50] Keto Summit.

[00:05:58] Mindfulness.

[00:08:42] Hormesis.

[00:08:58] Aaron at AHS 16.

[00:09:16] Dr. Grace Liu.

[00:12:53] Amy Cuddy.

[00:15:31] Strongfirst instructor.

[00:16:28] Read to Run: Kelly Starrett on my podcast.

[00:21:44] Futsal.

[00:24:02] Alexander Technique.

[00:29:10] Sitting cross-legged.

[00:30:09] Pomodoro alarm.

[00:30:20] Lotus position.

[00:31:47] Esther Gokhale chair.

[00:37:26] Aaron is looking for a publisher.

[00:40:00] Glidewalking.

[00:41:12] Dr. Mark Cucuzzella barefoot running.

[00:44:28] Aaron's self-care kit.

[00:46:59] Rogue Fitness chinup bar.

[00:47:29] My interview on Aaron's podcast.

]]>
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The Athlete Microbiome Project: The Search for the Golden Microbiome https://s3.amazonaws.com/nourishbalancethrive/podcast/Lauren.Petersen.on.2016-09-13.at.09.01.mp3 Lauren Petersen, PhD, is a postdoctoral associate working for Dr. George Weinstock and investigating the microbiome. Our knowledge of the 100 trillion microorganisms that inhabit the human body is still very limited, but the advent of next-generation sequencing technology has allowed researchers to start understanding what kind of microorganisms inhabit the human body and identifying the types of genes these organisms carry. As part of the NIH-funded Human Microbiome Project, her lab is focused on developing and applying the latest technologies to characterize the microbiome and its impact on human health. One of her main projects is metatranscriptomic analysis whereby they are attempting to characterize gene expression of an entire community from human samples such as stool and saliva. Gaining information on what signals or environmental factors can trigger changes in global gene expression of an entire microbial community may provide us with the tools to better treat certain types of diseases in humans.

Lauren is currently working on the Athlete Microbiome Project. By collecting stool and saliva samples from a cohort of highly fit professional cyclists, she will make an attempt to understand how their microbiomes may differ from those of the general population. The goal is to characterize the species present, the genes they carry, and how gene expression is modulated in athletes who push their bodies to the limit.

Here’s the outline of this interview with Lauren Petersen:

[00:00:28] George Weinstock, PhD.

[00:01:27] Jeremy Powers interview.

[00:01:43] Jeff Kendall-Weed.

[00:02:15] Why care about the gut microbiome?

[00:03:32] Metabolic functions.

[00:03:51] NIH Human Microbiome Project.

[00:04:39] Phase II longitudinal study.

[00:06:01] Microbial diversity.

[00:07:33] Lyme and antibiotics.

[00:08:15] Chronic Fatigue Syndrome.

[00:09:35] Gordon conferences - Rob Knight.

[00:10:27] American Gut Project.

[00:10:48] Firmicutes and Bacteroidetes.

[00:11:05] Enterobacteriaceae.

[00:11:59] Fecal transplant.

[00:13:16] Screening donors.

[00:13:32] DIY.

[00:13:52] C. diff.

[00:14:14] Transplants started in the 50s.

[00:14:47] IBS.

[00:16:12] Healthy donor.

[00:17:43] Within a month, Lauren was feeling a lot better.

[00:18:13] Instantaneous improvement on the bike.

[00:19:22] No more stomach issues, "more energy than I knew what to do with".

[00:19:54] Retest data showed perfect match with donor.

[00:20:56] Sequencing large vs. small intestinal microbes.

[00:21:28] FDA has no idea what to do.

[00:23:02] Strategies for maintaining a healthy gut microbiome.

[00:23:31] Whole foods, lots of fruit and vegetables.

[00:23:48] No gels.

[00:24:26] Athlete Microbiome Project.

[00:26:34] Microbiome doping?

[00:27:05] Ruminococcus - starch digester.

[00:28:26] Enterotype - the dominate species in the gut.

[00:28:56] Prevotella.

[00:30:14] Teasing apart the cause and the effect.

[00:32:28] Endotoxins released during intense exercise.

[00:32:49] 25 participants at the time of recording, I'm number 26!

[00:33:29] Matching cohort of healthy controls.

[00:34:28] Ibis World Cup racer.

[00:35:01] uBiome.

[00:35:08] My app.

[00:35:54] The problem with 16S sequencing.

[00:36:16] Missing bifidobacteria.

[00:37:05] A combination of methods is required for accurate testing.

[00:38:30] New commercially available test?

[00:39:11] Probiotic quality.

[00:40:04] Testing probiotics.

[00:41:37] Bifido doesn't like oxygen (or your stomach).

[00:42:02] Lactobacillus is more resilient.

[00:42:50] Bifido love fructooligosaccharides.

[00:43:36] Lack of association with dietary restrictions.

[00:44:53] Feed your microbiome!

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Lauren.Petersen.on.2016-09-13.at.09.01.mp3 Thu, 29 Sep 2016 10:09:16 GMT Christopher Kelly Lauren Petersen, PhD, is a postdoctoral associate working for Dr. George Weinstock and investigating the microbiome. Our knowledge of the 100 trillion microorganisms that inhabit the human body is still very limited, but the advent of next-generation sequencing technology has allowed researchers to start understanding what kind of microorganisms inhabit the human body and identifying the types of genes these organisms carry. As part of the NIH-funded Human Microbiome Project, her lab is focused on developing and applying the latest technologies to characterize the microbiome and its impact on human health. One of her main projects is metatranscriptomic analysis whereby they are attempting to characterize gene expression of an entire community from human samples such as stool and saliva. Gaining information on what signals or environmental factors can trigger changes in global gene expression of an entire microbial community may provide us with the tools to better treat certain types of diseases in humans.

Lauren is currently working on the Athlete Microbiome Project. By collecting stool and saliva samples from a cohort of highly fit professional cyclists, she will make an attempt to understand how their microbiomes may differ from those of the general population. The goal is to characterize the species present, the genes they carry, and how gene expression is modulated in athletes who push their bodies to the limit.

Here’s the outline of this interview with Lauren Petersen:

[00:00:28] George Weinstock, PhD.

[00:01:27] Jeremy Powers interview.

[00:01:43] Jeff Kendall-Weed.

[00:02:15] Why care about the gut microbiome?

[00:03:32] Metabolic functions.

[00:03:51] NIH Human Microbiome Project.

[00:04:39] Phase II longitudinal study.

[00:06:01] Microbial diversity.

[00:07:33] Lyme and antibiotics.

[00:08:15] Chronic Fatigue Syndrome.

[00:09:35] Gordon conferences - Rob Knight.

[00:10:27] American Gut Project.

[00:10:48] Firmicutes and Bacteroidetes.

[00:11:05] Enterobacteriaceae.

[00:11:59] Fecal transplant.

[00:13:16] Screening donors.

[00:13:32] DIY.

[00:13:52] C. diff.

[00:14:14] Transplants started in the 50s.

[00:14:47] IBS.

[00:16:12] Healthy donor.

[00:17:43] Within a month, Lauren was feeling a lot better.

[00:18:13] Instantaneous improvement on the bike.

[00:19:22] No more stomach issues, "more energy than I knew what to do with".

[00:19:54] Retest data showed perfect match with donor.

[00:20:56] Sequencing large vs. small intestinal microbes.

[00:21:28] FDA has no idea what to do.

[00:23:02] Strategies for maintaining a healthy gut microbiome.

[00:23:31] Whole foods, lots of fruit and vegetables.

[00:23:48] No gels.

[00:24:26] Athlete Microbiome Project.

[00:26:34] Microbiome doping?

[00:27:05] Ruminococcus - starch digester.

[00:28:26] Enterotype - the dominate species in the gut.

[00:28:56] Prevotella.

[00:30:14] Teasing apart the cause and the effect.

[00:32:28] Endotoxins released during intense exercise.

[00:32:49] 25 participants at the time of recording, I'm number 26!

[00:33:29] Matching cohort of healthy controls.

[00:34:28] Ibis World Cup racer.

[00:35:01] uBiome.

[00:35:08] My app.

[00:35:54] The problem with 16S sequencing.

[00:36:16] Missing bifidobacteria.

[00:37:05] A combination of methods is required for accurate testing.

[00:38:30] New commercially available test?

[00:39:11] Probiotic quality.

[00:40:04] Testing probiotics.

[00:41:37] Bifido doesn't like oxygen (or your stomach).

[00:42:02] Lactobacillus is more resilient.

[00:42:50] Bifido love fructooligosaccharides.

[00:43:36] Lack of association with dietary restrictions.

[00:44:53] Feed your microbiome!

]]>
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Don't Miss the Keto Summit https://s3.amazonaws.com/nourishbalancethrive/podcast/keto_summit.mp3 It's really tough to get science-based information about the ketogenic diet - there's so much new research happening all the time, it's hard to keep up!

However, we’ve put together a free online Keto Summit with some world-class doctors, researchers, and athletes who share their latest and best knowledge - how to refine your keto diet, ketone supplements, health benefits of keto, weight loss benefits of keto, and more.

I'm especially excited about the talks by Patrick Arnold, Prof. Tim Noakes, and Dr. Kenneth Ford.

So, don’t miss out as you can watch them all for free during the event! In fact, if you sign up today, you can watch Dominic D'Agostino’s presentation on Neurodegenerative Diseases, Supplements, & Keto Disease Prevention immediately.

Just go here to get your ticket (it starts on Sunday, September 25th).

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/keto_summit.mp3 Sat, 24 Sep 2016 20:09:27 GMT Christopher Kelly It's really tough to get science-based information about the ketogenic diet - there's so much new research happening all the time, it's hard to keep up!

However, we’ve put together a free online Keto Summit with some world-class doctors, researchers, and athletes who share their latest and best knowledge - how to refine your keto diet, ketone supplements, health benefits of keto, weight loss benefits of keto, and more.

I'm especially excited about the talks by Patrick Arnold, Prof. Tim Noakes, and Dr. Kenneth Ford.

So, don’t miss out as you can watch them all for free during the event! In fact, if you sign up today, you can watch Dominic D'Agostino’s presentation on Neurodegenerative Diseases, Supplements, & Keto Disease Prevention immediately.

Just go here to get your ticket (it starts on Sunday, September 25th).

]]>
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Love People and Use Things (Because the Opposite Never Works) https://s3.amazonaws.com/nourishbalancethrive/podcast/Joshua.Fields.Millburn.on.2016-09-09.at.13.05.mp3 Joshua Fields Millburn is one half of The Minimalists.

At first glance, people might think the point of minimalism is only to get rid of material possessions: Eliminating. Jettisoning. Extracting. Detaching. Decluttering. Paring down. Letting go. But that’s a mistake. 

Minimalists don’t focus on having less, less, less; rather, they focus on making room for more: more time, more passion, more experiences, more growth, more contribution, more contentment. More freedom. Clearing the clutter from life’s path helps us make that room.

Minimalism is the thing that gets us past the things so we can make room for life’s important things—which actually aren’t things at all.

Joshua wasn’t always a minimalist. In late 2009, his mother died and marriage ended (in the same month), and Joshua started questioning everything. That’s when he discovered minimalism. Now, Joshua thinks he owns fewer than 288 things (but he doesn’t actually count his stuff).

Minimalism: A Documentary About the Important Things examines the many flavors of minimalism by taking the audience inside the lives of minimalists from all walks of life—families, entrepreneurs, architects, artists, journalists, scientists, and even a former Wall Street broker—all of whom are striving to live a meaningful life with less.

Check out the books, “Let go, change your life TEDxFargo talk” and new The Minimalists Podcast, where they discuss living a meaningful life with less stuff and answer questions from their listeners.

In the show I mentioned Colin Wright’s Exile Lifestyle blog and Derek Sivers on Tim Ferriss’s podcast.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Joshua.Fields.Millburn.on.2016-09-09.at.13.05.mp3 Thu, 22 Sep 2016 19:09:25 GMT Christopher Kelly Joshua Fields Millburn is one half of The Minimalists.

At first glance, people might think the point of minimalism is only to get rid of material possessions: Eliminating. Jettisoning. Extracting. Detaching. Decluttering. Paring down. Letting go. But that’s a mistake. 

Minimalists don’t focus on having less, less, less; rather, they focus on making room for more: more time, more passion, more experiences, more growth, more contribution, more contentment. More freedom. Clearing the clutter from life’s path helps us make that room.

Minimalism is the thing that gets us past the things so we can make room for life’s important things—which actually aren’t things at all.

Joshua wasn’t always a minimalist. In late 2009, his mother died and marriage ended (in the same month), and Joshua started questioning everything. That’s when he discovered minimalism. Now, Joshua thinks he owns fewer than 288 things (but he doesn’t actually count his stuff).

Minimalism: A Documentary About the Important Things examines the many flavors of minimalism by taking the audience inside the lives of minimalists from all walks of life—families, entrepreneurs, architects, artists, journalists, scientists, and even a former Wall Street broker—all of whom are striving to live a meaningful life with less.

Check out the books, “Let go, change your life TEDxFargo talk” and new The Minimalists Podcast, where they discuss living a meaningful life with less stuff and answer questions from their listeners.

In the show I mentioned Colin Wright’s Exile Lifestyle blog and Derek Sivers on Tim Ferriss’s podcast.

]]>
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GMOs: The State of the Science https://s3.amazonaws.com/nourishbalancethrive/podcast/Leandra.Brettner.on.2016-09-06.at.11.mp3 Any discussion of genetically modified organisms (GMOs) is fraught with difficulty, not least of which is the definition. The Non GMO Project describes them as “organisms whose genetic material has been artificially manipulated in a laboratory through genetic engineering,” but there are others, see Leandra’s AHS 16 poster for more details.          

Leandra Brettner is a PhD candidate at the University of Washington department of bioengineering, and in this interview we discuss artificial selection, DNA delivery methods, integration and mutation breeding together with their safety concerns.

One might argue that GM is a technique, and that each application should be tested for safety. In this interview I argue to Nassim Nicholas Taleb’s point that GMOs fall into a special class of problem where the potential harm is systemic (rather than localised) and the consequences can involve total irreversible ruin, such as the extinction of human beings or all life on the planet.

Here’s the outline of this interview with Leandra Brettner:

0:04:34    Legislation S. 764.

0:08:30    Sequence-specific nucleases.

0:08:49    I went looking for a Khan video on CRISPR Cas9, and found this terrifying TED talk.

0:09:22    Homologous recombination.

0:14:02    Mutation breeding.

0:16:36    Monsanto Buys Seminis (2005).

0:18:41    Leandra misspoke when she said Monsanto owned the BRCA1/2 gene, it was Myriad Genetics.

0:33:32    Bacteriophage.

0:35:54    Evolutionary computation.

0:38:44    The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro.

0:40:37    An overview of the last 10 years of genetically engineered crop safety research.

0:43:53    The Precautionary Principle (with Application to the Genetic Modification of Organisms).

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Leandra.Brettner.on.2016-09-06.at.11.mp3 Thu, 15 Sep 2016 19:09:09 GMT Christopher Kelly Any discussion of genetically modified organisms (GMOs) is fraught with difficulty, not least of which is the definition. The Non GMO Project describes them as “organisms whose genetic material has been artificially manipulated in a laboratory through genetic engineering,” but there are others, see Leandra’s AHS 16 poster for more details.          

Leandra Brettner is a PhD candidate at the University of Washington department of bioengineering, and in this interview we discuss artificial selection, DNA delivery methods, integration and mutation breeding together with their safety concerns.

One might argue that GM is a technique, and that each application should be tested for safety. In this interview I argue to Nassim Nicholas Taleb’s point that GMOs fall into a special class of problem where the potential harm is systemic (rather than localised) and the consequences can involve total irreversible ruin, such as the extinction of human beings or all life on the planet.

Here’s the outline of this interview with Leandra Brettner:

0:04:34    Legislation S. 764.

0:08:30    Sequence-specific nucleases.

0:08:49    I went looking for a Khan video on CRISPR Cas9, and found this terrifying TED talk.

0:09:22    Homologous recombination.

0:14:02    Mutation breeding.

0:16:36    Monsanto Buys Seminis (2005).

0:18:41    Leandra misspoke when she said Monsanto owned the BRCA1/2 gene, it was Myriad Genetics.

0:33:32    Bacteriophage.

0:35:54    Evolutionary computation.

0:38:44    The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro.

0:40:37    An overview of the last 10 years of genetically engineered crop safety research.

0:43:53    The Precautionary Principle (with Application to the Genetic Modification of Organisms).

]]>
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Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health https://s3.amazonaws.com/nourishbalancethrive/podcast/williamsha1.on.2016-08-30.at.07.mp3 This podcast is the second part of a series. In the first part, Dr. Shaw and I talked about how to measure metabolism using organic acids. My initial test showed two major problems: yeast and clostridia overgrowth. It’s been about six months since I took probiotics and Raintree Formulas Amazon antifungals for two months and the retest shows some but not complete improvement.

The primary focus of this interview is the new Great Plains test for organic (nonmetal) environmental toxicity, something that I think may be a problem for the people that work with us. I won’t know for sure until we collect some more data, as always I like to test myself before recommending others do the same, and my result turned out to be “one of the cleanest Dr. Shaw has ever seen.” The possible exception is a mild elevation of 2-Hydroxyisobutyric and other metabolites that indicate exposure to petrochemicals I suspect from riding my bike on the road.

Download my full result

About my guest

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., he worked for the Centers for Disease Control and Prevention (CDC).

Order an organic acids test with nonmetal chemicals profile

Use the discount code TOX for $150 off.

Here’s the outline of this interview with Dr William Shaw, Ph.D.

0:00:18    Previous interview.

0:03:25    HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid).

0:03:55    D-Lactate free probiotic.

0:04:37    Vancomycin or Metronidazole.

0:05:03    Results, markers 33 and 34.

0:07:00    Arabinose.

0:07:24    Amazon A-F.

0:10:34    The Role of Oxalates in Autism and Chronic Disorders.

0:13:19    How to Protect Your Family from Environmental Toxicity with Dr. Julie Walsh on the Paleo Baby podcast.

0:13:37    AHS16 - Tim Gerstmar - Obesogens and Endocrine Disruptors.

0:16:44    Succinic dehydrogenase.

0:18:20    Tiglylglycine.

0:19:04    Kearns-Sayre syndrome.

0:20:40    2-Hydroxyisobutyric Acid, MTBE and ETBE.

0:43:12    Sauna + niacin flush.

0:50:18    discount code TOX.

0:57:54    GPL webinar archive.

0:58:08    GPL University upcoming events.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/williamsha1.on.2016-08-30.at.07.mp3 Thu, 08 Sep 2016 13:09:14 GMT Christopher Kelly This podcast is the second part of a series. In the first part, Dr. Shaw and I talked about how to measure metabolism using organic acids. My initial test showed two major problems: yeast and clostridia overgrowth. It’s been about six months since I took probiotics and Raintree Formulas Amazon antifungals for two months and the retest shows some but not complete improvement.

The primary focus of this interview is the new Great Plains test for organic (nonmetal) environmental toxicity, something that I think may be a problem for the people that work with us. I won’t know for sure until we collect some more data, as always I like to test myself before recommending others do the same, and my result turned out to be “one of the cleanest Dr. Shaw has ever seen.” The possible exception is a mild elevation of 2-Hydroxyisobutyric and other metabolites that indicate exposure to petrochemicals I suspect from riding my bike on the road.

Download my full result

About my guest

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., he worked for the Centers for Disease Control and Prevention (CDC).

Order an organic acids test with nonmetal chemicals profile

Use the discount code TOX for $150 off.

Here’s the outline of this interview with Dr William Shaw, Ph.D.

0:00:18    Previous interview.

0:03:25    HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid).

0:03:55    D-Lactate free probiotic.

0:04:37    Vancomycin or Metronidazole.

0:05:03    Results, markers 33 and 34.

0:07:00    Arabinose.

0:07:24    Amazon A-F.

0:10:34    The Role of Oxalates in Autism and Chronic Disorders.

0:13:19    How to Protect Your Family from Environmental Toxicity with Dr. Julie Walsh on the Paleo Baby podcast.

0:13:37    AHS16 - Tim Gerstmar - Obesogens and Endocrine Disruptors.

0:16:44    Succinic dehydrogenase.

0:18:20    Tiglylglycine.

0:19:04    Kearns-Sayre syndrome.

0:20:40    2-Hydroxyisobutyric Acid, MTBE and ETBE.

0:43:12    Sauna + niacin flush.

0:50:18    discount code TOX.

0:57:54    GPL webinar archive.

0:58:08    GPL University upcoming events.

]]>
no
How to Conquer Anxiety with Tim JP Collins https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Collins.on.2016-08-16.at.07.mp3 Tim JP Collins is a British entrepreneur and host of The Anxiety Podcast. In a former life as an executive, Tim reached a tipping point onstage during a big presentation and has since turned his life around to overcome his anxiety and is now helping other people do the same.

Looking back Tim realised that he’d created the perfect storm:

  • Lots of travel away from home and family.
  • Drinking alcohol in excess and too often.
  • Staying up late and then waking up with gallons of coffee.
  • Years of bodily abuse with bad food & not enough exercise.
  • Working in a job that created no meaning.

During this interview, you’ll find out how Tim conquered his anxiety.

Tim mentioned:

I mentioned:

Part two of this conversation is on Tim’s podcast, where I talk about the connection between chronic inflammation and anxiety, and how some of the changes Tim made may have been measurable in blood:

Anxiety disorders and inflammation in a large adult cohort

  • Inflammatory markers included C-reactive protein (CRP), interleukin (IL)-6 and tumor-necrosis factor (TNF)-a.
  • Elevated levels of CRP were found in men, but not in women.
    • Interleukin 6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma.
    • (TNF)-a is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.
  • Immune dysregulation is especially found in persons with a late-onset anxiety disorder.
  • Increasing evidence links anxiety to cardiovascular risk factors and diseases such as atherosclerosis, metabolic syndrome, and coronary heart disease.
  • Chronic stress may initiate changes in the hypothalamic–pituitary–adrenal (HPA) axis and the immune system, which in turn can trigger depression as well as anxiety.
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tim.Collins.on.2016-08-16.at.07.mp3 Fri, 02 Sep 2016 12:09:56 GMT Christopher Kelly Tim JP Collins is a British entrepreneur and host of The Anxiety Podcast. In a former life as an executive, Tim reached a tipping point onstage during a big presentation and has since turned his life around to overcome his anxiety and is now helping other people do the same.

Looking back Tim realised that he’d created the perfect storm:

  • Lots of travel away from home and family.
  • Drinking alcohol in excess and too often.
  • Staying up late and then waking up with gallons of coffee.
  • Years of bodily abuse with bad food & not enough exercise.
  • Working in a job that created no meaning.

During this interview, you’ll find out how Tim conquered his anxiety.

Tim mentioned:

I mentioned:

Part two of this conversation is on Tim’s podcast, where I talk about the connection between chronic inflammation and anxiety, and how some of the changes Tim made may have been measurable in blood:

Anxiety disorders and inflammation in a large adult cohort

  • Inflammatory markers included C-reactive protein (CRP), interleukin (IL)-6 and tumor-necrosis factor (TNF)-a.
  • Elevated levels of CRP were found in men, but not in women.
    • Interleukin 6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma.
    • (TNF)-a is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.
  • Immune dysregulation is especially found in persons with a late-onset anxiety disorder.
  • Increasing evidence links anxiety to cardiovascular risk factors and diseases such as atherosclerosis, metabolic syndrome, and coronary heart disease.
  • Chronic stress may initiate changes in the hypothalamic–pituitary–adrenal (HPA) axis and the immune system, which in turn can trigger depression as well as anxiety.
]]>
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How to Recognise Good Chocolate (and Why You Should Care) https://s3.amazonaws.com/nourishbalancethrive/podcast/torea_chocolate_Aug16.mp3

I will send the first 100 people that leave me a 5-star review on iTunes (video instructions) a bar of Fruition 100% dark chocolate. Please send your US shipping address to support@nourishbalancethrive.com

Chocolate is awesome! Everyone knows that. Less well known is cacao’s (we use the terms chocolate, cocoa, and cacao synonymously in this podcast) blood pressure lowering and insulin signalling effects. The interest in the effect of cacoa on blood pressure started with the discovery that an island population of Kuna Indians suffered much lower incidence of hypertension and age-related rise of blood pressure. The people that returned to the mainland enjoyed no such benefit, even after correcting for salt intake. Island-dwelling Kuna Indians consume about 3-4 cups of cacoa drinks on average per day, while the mainland-dwelling Kuna Indians consume up to 10 times less cocoa.

Christopher Columbus in 1502

Explorers like Columbus brought cacoa to Europe but people didn't like the drink without it first being sweetened. Subsequent roasting (up to 120 °C), mixing (conching), alkalising (dutching), adding sugar, milk, vanilla and lecithin emulsifiers make chocolate as we know it today. Unfortunately, much of this processing removes the flavanols that are the compound of interest.

Flavanols are also found in other plant-derived produce, including beans, apricots, blackberries, apples and tea leaves, but in a lower concentration than in cacoa.

More trouble for chocolate

As with many crops grown in third-world countries, there are ethical concerns, especially child labour. “Bean to bar” chocolate may be nothing of sort, and some manufacturers may be in the remelting and wallpaper business.

Know what you’re buying!

As with most things in life, you pay for what you get, and the very best is not available in your local supermarket. That’s why you should listen to this podcast and consider joining a buyer’s club like the Chocolate Garage.

Here’s the outline of this podcast with Toréa Rodriguez, FDN-P:

0:00:30    Toréa has been on my podcast twice before [1, 2].

0:02:56    The Functional Diagnostic Nutrition certification program.

0:03:05    Fabian Popa interview.

0:03:57    Jeremy Powers interview.

0:05:33    torearodriguez.com

0:06:30    Video instructions for leaving me a review on iTunes.

0:07:25    Buy Fruition 100% dark chocolate direct from me.

0:09:22    Cochrane Database of Systematic Reviews: Effect of cocoa on blood pressure.

0:10:08    Cocoa, Glucose Tolerance, and Insulin Signaling: Cardiometabolic Protection.

0:11:37    Khan Academy video: Enzyme Linked Receptors.

0:15:32    A randomized, controlled, double-blind, crossover showed for the first time that the intake of just 10 g of cocoa with a very low caloric (38 kcal) and flavonol (80 mg) content per day was already significantly ameliorating arterial function in healthy subjects.

0:18:15    PHAT FIBRE MCT oil powder.

0:21:59    Cyrex Array #4 Gluten-Associated Cross-Reactive Foods and Foods Sensitivity.

0:30:58    The Meadow and Cacao in Portland.

0:32:31    Sunita De Tourreil from the Chocolate Garage.

0:33:27    Mutari Chocolate.

0:33:59    Francois Pralus Chocolate.

0:34:27    Domori Chocolate.

0:34:31    Grenada Chocolate.

0:35:01    Marou Chocolate.

0:36:35    Dick Taylor Chocolate.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/torea_chocolate_Aug16.mp3 Mon, 29 Aug 2016 09:08:49 GMT Christopher Kelly

I will send the first 100 people that leave me a 5-star review on iTunes (video instructions) a bar of Fruition 100% dark chocolate. Please send your US shipping address to support@nourishbalancethrive.com

Chocolate is awesome! Everyone knows that. Less well known is cacao’s (we use the terms chocolate, cocoa, and cacao synonymously in this podcast) blood pressure lowering and insulin signalling effects. The interest in the effect of cacoa on blood pressure started with the discovery that an island population of Kuna Indians suffered much lower incidence of hypertension and age-related rise of blood pressure. The people that returned to the mainland enjoyed no such benefit, even after correcting for salt intake. Island-dwelling Kuna Indians consume about 3-4 cups of cacoa drinks on average per day, while the mainland-dwelling Kuna Indians consume up to 10 times less cocoa.

Christopher Columbus in 1502

Explorers like Columbus brought cacoa to Europe but people didn't like the drink without it first being sweetened. Subsequent roasting (up to 120 °C), mixing (conching), alkalising (dutching), adding sugar, milk, vanilla and lecithin emulsifiers make chocolate as we know it today. Unfortunately, much of this processing removes the flavanols that are the compound of interest.

Flavanols are also found in other plant-derived produce, including beans, apricots, blackberries, apples and tea leaves, but in a lower concentration than in cacoa.

More trouble for chocolate

As with many crops grown in third-world countries, there are ethical concerns, especially child labour. “Bean to bar” chocolate may be nothing of sort, and some manufacturers may be in the remelting and wallpaper business.

Know what you’re buying!

As with most things in life, you pay for what you get, and the very best is not available in your local supermarket. That’s why you should listen to this podcast and consider joining a buyer’s club like the Chocolate Garage.

Here’s the outline of this podcast with Toréa Rodriguez, FDN-P:

0:00:30    Toréa has been on my podcast twice before [1, 2].

0:02:56    The Functional Diagnostic Nutrition certification program.

0:03:05    Fabian Popa interview.

0:03:57    Jeremy Powers interview.

0:05:33    torearodriguez.com

0:06:30    Video instructions for leaving me a review on iTunes.

0:07:25    Buy Fruition 100% dark chocolate direct from me.

0:09:22    Cochrane Database of Systematic Reviews: Effect of cocoa on blood pressure.

0:10:08    Cocoa, Glucose Tolerance, and Insulin Signaling: Cardiometabolic Protection.

0:11:37    Khan Academy video: Enzyme Linked Receptors.

0:15:32    A randomized, controlled, double-blind, crossover showed for the first time that the intake of just 10 g of cocoa with a very low caloric (38 kcal) and flavonol (80 mg) content per day was already significantly ameliorating arterial function in healthy subjects.

0:18:15    PHAT FIBRE MCT oil powder.

0:21:59    Cyrex Array #4 Gluten-Associated Cross-Reactive Foods and Foods Sensitivity.

0:30:58    The Meadow and Cacao in Portland.

0:32:31    Sunita De Tourreil from the Chocolate Garage.

0:33:27    Mutari Chocolate.

0:33:59    Francois Pralus Chocolate.

0:34:27    Domori Chocolate.

0:34:31    Grenada Chocolate.

0:35:01    Marou Chocolate.

0:36:35    Dick Taylor Chocolate.

]]>
clean
Male ED: The Canary in the Coal Mine https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-08-16.at.13.mp3 The overall prevalence of erectile dysfunction in men aged ≥20 years was 18.4% suggesting that erectile dysfunction affects 18 million men in the US alone. Among men with diabetes, the prevalence of erectile dysfunction was 51.3%. ED can have a neurogenic, psychogenic, or endocrinologic basis, but the most common cause is thought to be related to vascular abnormalities of the penile blood supply and erectile tissue often associated with cardiovascular disease and its risk factors.

Listen to this podcast to find out about the prevalence of, and solutions for, erectile dysfunction.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-08-16.at.13.mp3 Tue, 23 Aug 2016 13:08:17 GMT Christopher Kelly The overall prevalence of erectile dysfunction in men aged ≥20 years was 18.4% suggesting that erectile dysfunction affects 18 million men in the US alone. Among men with diabetes, the prevalence of erectile dysfunction was 51.3%. ED can have a neurogenic, psychogenic, or endocrinologic basis, but the most common cause is thought to be related to vascular abnormalities of the penile blood supply and erectile tissue often associated with cardiovascular disease and its risk factors.

Listen to this podcast to find out about the prevalence of, and solutions for, erectile dysfunction.

]]>
yes
National Cyclocross Champion Jeremy Powers on Racing, Training and the Ketogenic Diet https://s3.amazonaws.com/nourishbalancethrive/podcast/Jeremy.Powers.on.2016-08-03.at.11.mp3 Jeremy Powers is the current U.S. Cyclocross champion and top-ranked American rider in the world, and he listens to my podcast! I couldn’t believe it when I found out. Jeremy emailed me to say hi, and of course, I immediately invited him on so that I could probe deep into the diet, lifestyle, training and racing strategy that has enabled him to be National Champion four times. Our contact was minimal before the interview, and I had no idea that Jeremy has a delicate relationship with carbohydrates, or that he has experimented with the ketogenic diet.

Here’s the outline of this interview with Jeremy Powers:

0:04:02    Infectious mononucleosis (mono).

0:04:31    Northampton Cycling Club Elite Team

0:04:37    Alec Donahue and Mukunda Feldman.

0:05:48    Danny from Jelly Belly cycling team.

0:06:26    Philadelphia International Cycling Classic.

0:07:25    Kirk Albers.

0:08:54    Cross is 30-40 race days per year.

0:08:59    Road is an additional 70-80.

0:11:27    Tubular tyres.

0:11:30    SRAM eTAP wireless shifting, hydraulic brakes and 1X system with clutch derailleurs.

0:17:46    "Just go out there and flap your wings."

0:18:45    “Blackboard technique where I think about absolutely nothing”

0:22:18    Behind the Barriers documentary series.

0:26:28    Very low blood sugar: 40 mg/dL!

0:29:40    Workup at the Mayo Clinic included the blood marker C-peptide.

0:32:12    CHO intake of around 200g on a day included four hours of training.

0:32:48    Cross season is Sep - Feb.

0:32:55    Five week rest break in Feb.

0:33:11    Training 25-30 hours a week.

0:33:36    6-8 weeks of base.

0:36:53    Core, plank, side-plank.

0:37:36    3x12 15-25lb Bulgarian split-squat.

0:38:13    CrossFit style box jumps.

0:45:43    After Chris Froome cut back on carbs for more protein, he lost 20 pounds, started winning the Tour de France, and became a millionaire.

0:45:46    2016 Tour de France second place finisher Romain Bardet.

0:45:52    Breakfast of Champions article by Marty Kendall.

0:47:31    MCT oil. We make a powdered version.

0:51:24    Review: Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?

0:51:40    Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.

0:55:04    Focus bikes.

0:57:18    Cyclocross camp in August with FasCat Coaching.

0:57:42    Ember: The World's First Non-invasive Haemoglobin Tracker.

0:59:28    Ferritin blood test.

0:59:55    Very low 25-OH-D.

1:01:05    The Daily Lipid Podcast 9: Balancing Calcium and Phosphorus in the Diet, and the Importance of Measuring Parathyroid Hormone (PTH).

1:05:18    JAM Fund Cycling.

1:07:41    Ellen Noble.

1:10:07    www.jpows.com

1:10:14    behindthebarriers.tv
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Jeremy.Powers.on.2016-08-03.at.11.mp3 Tue, 09 Aug 2016 09:08:24 GMT Christopher Kelly Jeremy Powers is the current U.S. Cyclocross champion and top-ranked American rider in the world, and he listens to my podcast! I couldn’t believe it when I found out. Jeremy emailed me to say hi, and of course, I immediately invited him on so that I could probe deep into the diet, lifestyle, training and racing strategy that has enabled him to be National Champion four times. Our contact was minimal before the interview, and I had no idea that Jeremy has a delicate relationship with carbohydrates, or that he has experimented with the ketogenic diet.

Here’s the outline of this interview with Jeremy Powers:

0:04:02    Infectious mononucleosis (mono).

0:04:31    Northampton Cycling Club Elite Team

0:04:37    Alec Donahue and Mukunda Feldman.

0:05:48    Danny from Jelly Belly cycling team.

0:06:26    Philadelphia International Cycling Classic.

0:07:25    Kirk Albers.

0:08:54    Cross is 30-40 race days per year.

0:08:59    Road is an additional 70-80.

0:11:27    Tubular tyres.

0:11:30    SRAM eTAP wireless shifting, hydraulic brakes and 1X system with clutch derailleurs.

0:17:46    "Just go out there and flap your wings."

0:18:45    “Blackboard technique where I think about absolutely nothing”

0:22:18    Behind the Barriers documentary series.

0:26:28    Very low blood sugar: 40 mg/dL!

0:29:40    Workup at the Mayo Clinic included the blood marker C-peptide.

0:32:12    CHO intake of around 200g on a day included four hours of training.

0:32:48    Cross season is Sep - Feb.

0:32:55    Five week rest break in Feb.

0:33:11    Training 25-30 hours a week.

0:33:36    6-8 weeks of base.

0:36:53    Core, plank, side-plank.

0:37:36    3x12 15-25lb Bulgarian split-squat.

0:38:13    CrossFit style box jumps.

0:45:43    After Chris Froome cut back on carbs for more protein, he lost 20 pounds, started winning the Tour de France, and became a millionaire.

0:45:46    2016 Tour de France second place finisher Romain Bardet.

0:45:52    Breakfast of Champions article by Marty Kendall.

0:47:31    MCT oil. We make a powdered version.

0:51:24    Review: Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?

0:51:40    Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.

0:55:04    Focus bikes.

0:57:18    Cyclocross camp in August with FasCat Coaching.

0:57:42    Ember: The World's First Non-invasive Haemoglobin Tracker.

0:59:28    Ferritin blood test.

0:59:55    Very low 25-OH-D.

1:01:05    The Daily Lipid Podcast 9: Balancing Calcium and Phosphorus in the Diet, and the Importance of Measuring Parathyroid Hormone (PTH).

1:05:18    JAM Fund Cycling.

1:07:41    Ellen Noble.

1:10:07    www.jpows.com

1:10:14    behindthebarriers.tv
]]>
clean
Recovering from Fluoroquinolone Antibiotics Injury https://s3.amazonaws.com/nourishbalancethrive/podcast/Fabian.Popa.on.2016-07-26.at.07.mp3 In January 2014, young and talented Romanian engineer Fabian Popa was feeling fine when pneumonia struck from nowhere. He remembers coming home from work and feeling a burning sensation in his chest. After a short time coping with the coughing, severe fatigue set in and Fabian found himself unable to work.

Having heard about the potential for unwanted effects caused by antibiotics, Fabian held out hoping the coughing would subside. After ten days he relented, and upon listening to his lungs, the doctor said: “Well, you have pneumonia. Take this antibiotic.” And that’s what he did.

Fabian took Bayer brand Avelox, a fluoroquinolone antibiotic. In the United States, similar drugs Ciprofloxacin ("Cipro") and Levofloxacin are more commonly prescribed. Everything was fine for a month, but then things started to go wrong in mysterious ways. The biggest signs that something was wrong were neurological in nature, and he experienced muscle weakness and twitching. Chronic diarrhoea set in and Fabian began to gain weight.

After exhausting his options in Romania, Fabian moved on to to Germany where he eventually got a diagnosis of an autoimmune disease called Hashimoto's thyroiditis.

In this interview, Fabian speaks candidly about his recovery from "iatrogenic" injury. Iatrogenesis (from the Greek for "brought forth by the healer"), doesn't necessarily imply an error, but rather an unintended outcome. Had he not taken the medicine, Fabian might not have been here to talk about his recovery. But still, the unwanted effects of the antibiotics were severe.

Fabian's story of recovery is incomplete but still inspiring. As an engineer, he applied his analytical and problem solving skills to blood chemistry, urinary organic acids, and stool culturomics to design a solution that consisted of diet and lifestyle modification and nutritional supplements. At the end of this interview, I asked Fabian: "Let me just check, you are feeling better than before aren’t you?" to which he replied: "Yes, of course [...] Maybe next time we talk, I can report that there’s autoimmune no more."

Here’s the outline of this interview with Fabian Popa:

0:05:07    Fluoroquinolone antibiotics.

0:07:47    Hashimoto's thyroiditis.

0:18:43    Dr. Grace Liu, PharmD.

0:18:46    Dr. Tommy Wood, MD is the CMO at Nourish Balance Thrive.

0:19:33    Haptoglobin.

0:22:32    Diamine oxidase is one of the two enzymes that break down histamine, the other being Histamine N-methyltransferase.

0:23:06    Complement component 3 blood test.

0:23:59    Tumor necrosis factor alpha blood test.

0:25:37    Fabian used the autoimmune Paleo diet, my favourite guide is called A Simple Guide to the Paleo Autoimmune Protocol.

0:29:58    The Marshall Protocol (please don’t do this!)

0:30:48    Tim Ferriss podcast.

0:33:58    Faecal microbiota transplantation (FMT) at the Taymount clinic.

0:37:03    Justin Sonnenburg presentation at the UCSF Paleo Symposium.

0:37:04    Diet-induced extinctions in the gut microbiota compound over generations.

0:38:54    Stool culturomics can be superior to metagenomics [1, 2, 3, 4, 5, 6, 7, 8]

0:39:46    uBiome and my report tool.

0:40:32    Iatrogenic injury.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Fabian.Popa.on.2016-07-26.at.07.mp3 Wed, 03 Aug 2016 19:08:27 GMT Christopher Kelly In January 2014, young and talented Romanian engineer Fabian Popa was feeling fine when pneumonia struck from nowhere. He remembers coming home from work and feeling a burning sensation in his chest. After a short time coping with the coughing, severe fatigue set in and Fabian found himself unable to work.

Having heard about the potential for unwanted effects caused by antibiotics, Fabian held out hoping the coughing would subside. After ten days he relented, and upon listening to his lungs, the doctor said: “Well, you have pneumonia. Take this antibiotic.” And that’s what he did.

Fabian took Bayer brand Avelox, a fluoroquinolone antibiotic. In the United States, similar drugs Ciprofloxacin ("Cipro") and Levofloxacin are more commonly prescribed. Everything was fine for a month, but then things started to go wrong in mysterious ways. The biggest signs that something was wrong were neurological in nature, and he experienced muscle weakness and twitching. Chronic diarrhoea set in and Fabian began to gain weight.

After exhausting his options in Romania, Fabian moved on to to Germany where he eventually got a diagnosis of an autoimmune disease called Hashimoto's thyroiditis.

In this interview, Fabian speaks candidly about his recovery from "iatrogenic" injury. Iatrogenesis (from the Greek for "brought forth by the healer"), doesn't necessarily imply an error, but rather an unintended outcome. Had he not taken the medicine, Fabian might not have been here to talk about his recovery. But still, the unwanted effects of the antibiotics were severe.

Fabian's story of recovery is incomplete but still inspiring. As an engineer, he applied his analytical and problem solving skills to blood chemistry, urinary organic acids, and stool culturomics to design a solution that consisted of diet and lifestyle modification and nutritional supplements. At the end of this interview, I asked Fabian: "Let me just check, you are feeling better than before aren’t you?" to which he replied: "Yes, of course [...] Maybe next time we talk, I can report that there’s autoimmune no more."

Here’s the outline of this interview with Fabian Popa:

0:05:07    Fluoroquinolone antibiotics.

0:07:47    Hashimoto's thyroiditis.

0:18:43    Dr. Grace Liu, PharmD.

0:18:46    Dr. Tommy Wood, MD is the CMO at Nourish Balance Thrive.

0:19:33    Haptoglobin.

0:22:32    Diamine oxidase is one of the two enzymes that break down histamine, the other being Histamine N-methyltransferase.

0:23:06    Complement component 3 blood test.

0:23:59    Tumor necrosis factor alpha blood test.

0:25:37    Fabian used the autoimmune Paleo diet, my favourite guide is called A Simple Guide to the Paleo Autoimmune Protocol.

0:29:58    The Marshall Protocol (please don’t do this!)

0:30:48    Tim Ferriss podcast.

0:33:58    Faecal microbiota transplantation (FMT) at the Taymount clinic.

0:37:03    Justin Sonnenburg presentation at the UCSF Paleo Symposium.

0:37:04    Diet-induced extinctions in the gut microbiota compound over generations.

0:38:54    Stool culturomics can be superior to metagenomics [1, 2, 3, 4, 5, 6, 7, 8]

0:39:46    uBiome and my report tool.

0:40:32    Iatrogenic injury.

]]>
clean
18 Hours of Mountain Bike Racing on Zero Calories https://s3.amazonaws.com/nourishbalancethrive/podcast/bc_bike_race_2016_recap.mp3 Fast facts:
  • The elimination diets that we’ve gotten great results with for our clients travel very well with a little planning.

  • Our diet didn’t vary from the norm on a recent three week road trip.

  • I’ve been eating a very high fat and fibre, moderate protein, zero acellular carbohydrate (e.g. sugar) ketogenic diet.

  • Just before we departed, my blood glucose was 77 mg/dL and blood beta-hydroxybutyrate was 1.4 mmol/L.

  • I placed 29/600 in the BC Bike Race, a 7-day race in a very wet British Columbia.

  • In over 18 hours of racing, I consumed zero calories and a total of 2L of plain water whilst on the bike.

Here’s the outline of this podcast:

0:05:06    Julie's videos: Food prep for the BC BIke Race, Truck Stop Gourmet, and How to Shop at an Unfamiliar Market.

0:05:33    Instant Pot pressure cooker.

0:05:41    FoodSaver Vacuum Sealing System.

0:09:41    Glass Mason Jars.

0:11:37    Cultured Caveman restaurant in Portland.

0:11:45    Mission Heirloom (podcast).

0:14:18    Wild Planet Wild Sardines in Extra Virgin Olive Oil.

0:14:49    Artisana Organic Raw Coconut Butter.

0:15:10    US Wellness Meats. I particularly enjoy their liverwurst, braunschweiger, head cheese, pemmican and pork rinds.

0:16:07    Epic All Natural Meat Bar, 100% Wild, Boar With Uncured Bacon.

0:16:22    LunchBots stainless snack box.

0:16:47    SeaSnax Roasted Seaweed.

0:19:38    James Wilson (podcast).

0:24:58    KetoCaNa (podcast).

0:25:04    UCAN Superstarch (podcast).

0:27:12    Gastrointestinal Complaints During Exercise: Prevalence, Etiology, and Nutritional Recommendations.

0:28:52    Carrying two copies of a somewhat common allele of the FMO3 gene, defined as E308G and E258K, has been reported to lead to mild trimethylaminuria.

0:40:33    PHAT FIBRE.

0:42:56    Catabolic Blocker (podcast).

0:43:27    PharmaNAC (podcast).

0:44:03    Podcast: Should You Supplement with Antioxidants?

0:45:05    Meriva and EnteroMend (podcast).

0:50:29    BIOHACKER SUMMIT UK with Pando.

0:51:12    Creatine (article).

0:52:05    NiaCel (nicotinamide riboside) (podcast).

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/bc_bike_race_2016_recap.mp3 Sun, 24 Jul 2016 16:07:32 GMT Christopher Kelly Fast facts:
  • The elimination diets that we’ve gotten great results with for our clients travel very well with a little planning.

  • Our diet didn’t vary from the norm on a recent three week road trip.

  • I’ve been eating a very high fat and fibre, moderate protein, zero acellular carbohydrate (e.g. sugar) ketogenic diet.

  • Just before we departed, my blood glucose was 77 mg/dL and blood beta-hydroxybutyrate was 1.4 mmol/L.

  • I placed 29/600 in the BC Bike Race, a 7-day race in a very wet British Columbia.

  • In over 18 hours of racing, I consumed zero calories and a total of 2L of plain water whilst on the bike.

Here’s the outline of this podcast:

0:05:06    Julie's videos: Food prep for the BC BIke Race, Truck Stop Gourmet, and How to Shop at an Unfamiliar Market.

0:05:33    Instant Pot pressure cooker.

0:05:41    FoodSaver Vacuum Sealing System.

0:09:41    Glass Mason Jars.

0:11:37    Cultured Caveman restaurant in Portland.

0:11:45    Mission Heirloom (podcast).

0:14:18    Wild Planet Wild Sardines in Extra Virgin Olive Oil.

0:14:49    Artisana Organic Raw Coconut Butter.

0:15:10    US Wellness Meats. I particularly enjoy their liverwurst, braunschweiger, head cheese, pemmican and pork rinds.

0:16:07    Epic All Natural Meat Bar, 100% Wild, Boar With Uncured Bacon.

0:16:22    LunchBots stainless snack box.

0:16:47    SeaSnax Roasted Seaweed.

0:19:38    James Wilson (podcast).

0:24:58    KetoCaNa (podcast).

0:25:04    UCAN Superstarch (podcast).

0:27:12    Gastrointestinal Complaints During Exercise: Prevalence, Etiology, and Nutritional Recommendations.

0:28:52    Carrying two copies of a somewhat common allele of the FMO3 gene, defined as E308G and E258K, has been reported to lead to mild trimethylaminuria.

0:40:33    PHAT FIBRE.

0:42:56    Catabolic Blocker (podcast).

0:43:27    PharmaNAC (podcast).

0:44:03    Podcast: Should You Supplement with Antioxidants?

0:45:05    Meriva and EnteroMend (podcast).

0:50:29    BIOHACKER SUMMIT UK with Pando.

0:51:12    Creatine (article).

0:52:05    NiaCel (nicotinamide riboside) (podcast).

]]>
no
An Interview with a 4th Year Medical Student https://s3.amazonaws.com/nourishbalancethrive/podcast/Rory.Heath.on.2016-06-22.at.07.15.mp3 Rory Heath is a columnist at Strength & Conditioning Research and a 4th-year medical student at King's College, London. Rory has a passion for sports medicine and attends many sports medicine conferences. Treatment for anterior cruciate ligament (ACL) injury, common in contact sports like rugby, are frequently the focus of these events. In this interview, Rory talks about how some simple dietary changes may reduce the basal level of inflammation and reduce the number of injuries happening in the first place. Potentially inflammatory foods like wheat and dairy may be a cost-effective way to feed a rugby team in the short term, but if the diet ultimately contributes to an injury that requires surgery then clearly both the team and the player lose out.

The idea of preventing illness before it happens is not limited to sports medicine, and in this interview, Rory and I discuss some of the other diet and lifestyle hacks that assist with performance and longevity.

In this interview I mentioned:

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Rory.Heath.on.2016-06-22.at.07.15.mp3 Tue, 19 Jul 2016 09:07:52 GMT Christopher Kelly Rory Heath is a columnist at Strength & Conditioning Research and a 4th-year medical student at King's College, London. Rory has a passion for sports medicine and attends many sports medicine conferences. Treatment for anterior cruciate ligament (ACL) injury, common in contact sports like rugby, are frequently the focus of these events. In this interview, Rory talks about how some simple dietary changes may reduce the basal level of inflammation and reduce the number of injuries happening in the first place. Potentially inflammatory foods like wheat and dairy may be a cost-effective way to feed a rugby team in the short term, but if the diet ultimately contributes to an injury that requires surgery then clearly both the team and the player lose out.

The idea of preventing illness before it happens is not limited to sports medicine, and in this interview, Rory and I discuss some of the other diet and lifestyle hacks that assist with performance and longevity.

In this interview I mentioned:

]]>
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How to Track Effectively https://s3.amazonaws.com/nourishbalancethrive/podcast/Daniel.Pardi.on.2016-06-08.at.10.35.mp3 Dan Pardi is a rare bird. Not only does Dan have a classical education in sports medicine and exercise physiology, he also spent time working with Dean Ornish at the Preventive Medicine Lifestyle Institute before spending a decade working in the pharmaceutical industry. Dan now collaborates with the Behavioral Sciences Department at Stanford University and the Departments of Neurology and Endocrinology at Leiden University and is also the CEO of a health-behavior technology company called Dan's Plan, which seeks to help people improve their health by establishing and sustaining an effective daily health practice.

In this interview, Dan talks about the practical use of tracking devices from the Quantified Self movement, and his new project, humanOS.

Dan’s new podcast, humanOS Radio (iTunes, Stitcher, YouTube, Overcast) has been at the top of my listening list for the past couple of months now, and for the first few episodes, Dan has focussed exclusively on interviewing professors within the realm of health, performance and longevity.

Dan also writes regularly on the blog at Dan’s Plan.

Here’s a brief outline of this interview with Dan Pardi:

0:00:26    Dan has been on my podcast once before.

0:02:15    Dean Ornish.

0:04:19    Dan works at Stanford under Jamie Zeitzer in the Circadian Biology Department.

0:07:56    dansplan.com.

0:10:23    My previous podcast with Dr. Tommy Wood where we discuss rodent studies.

0:11:55    Radiographic studies at University of Washington.

0:15:52    humanOS

0:21:38    humanOS Radio podcast.

0:25:45    Zeo, Inc.

0:29:59    Tim Ferriss almond butter at night

0:31:39    IFTTT.

0:52:48    Dan’s Plan on Facebook and Twitter.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Daniel.Pardi.on.2016-06-08.at.10.35.mp3 Fri, 01 Jul 2016 07:07:07 GMT Christopher Kelly Dan Pardi is a rare bird. Not only does Dan have a classical education in sports medicine and exercise physiology, he also spent time working with Dean Ornish at the Preventive Medicine Lifestyle Institute before spending a decade working in the pharmaceutical industry. Dan now collaborates with the Behavioral Sciences Department at Stanford University and the Departments of Neurology and Endocrinology at Leiden University and is also the CEO of a health-behavior technology company called Dan's Plan, which seeks to help people improve their health by establishing and sustaining an effective daily health practice.

In this interview, Dan talks about the practical use of tracking devices from the Quantified Self movement, and his new project, humanOS.

Dan’s new podcast, humanOS Radio (iTunes, Stitcher, YouTube, Overcast) has been at the top of my listening list for the past couple of months now, and for the first few episodes, Dan has focussed exclusively on interviewing professors within the realm of health, performance and longevity.

Dan also writes regularly on the blog at Dan’s Plan.

Here’s a brief outline of this interview with Dan Pardi:

0:00:26    Dan has been on my podcast once before.

0:02:15    Dean Ornish.

0:04:19    Dan works at Stanford under Jamie Zeitzer in the Circadian Biology Department.

0:07:56    dansplan.com.

0:10:23    My previous podcast with Dr. Tommy Wood where we discuss rodent studies.

0:11:55    Radiographic studies at University of Washington.

0:15:52    humanOS

0:21:38    humanOS Radio podcast.

0:25:45    Zeo, Inc.

0:29:59    Tim Ferriss almond butter at night

0:31:39    IFTTT.

0:52:48    Dan’s Plan on Facebook and Twitter.

]]>
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The Race to Make a Ketone Supplement https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-06-07.at.10.29.mp3 Two brilliant scientists are racing to be the first to commercialise exogenous ketones. The applications include athletic performance and metabolic therapies for CNS oxygen toxicity, epilepsy, and neurodegenerative diseases. In the red corner, Dr. Richard Veech, one of the greatest living minds in basic biochemistry. In the blue corner, the also brilliant renegade chemist Patrick Arnold. Stuck somewhere in the middle is superhuman researcher Dominic D’Agostino, associate professor in the department of molecular pharmacology and physiology at the University of South Florida, and a visiting research scientist at the IHMC.

Patrick clearly has the head start, and I’ve been supplementing with his KetoForce and KetoCaNa products for over two years for bike races. Imagine my horror then when Dr. Veech appeared on the Bulletproof and Ben Greenfield podcasts to claim that Patrick’s racemic ketone salts were “harmful and inhibitory” and “a dumb for convenience of manufacturing”.

Caution is warranted.

A racemic mixture is one that includes both the D and L enantiomers. The source of the D and L labels was the Latin words dexter (on the right) and laevus (on the left). You may also have seen the labels R and S. R comes from rectus (right-handed) and S from sinister (left-handed). The physiological form of beta-hydroxybutyrate (BHB) is the D form. This is the same reason why Tommy would never recommend synthetic vitamins (vitamin E is a good example), because you get a racemic mixture and the inactive form tends to inhibit the more active form.

L-BHB is also metabolised.

BHB is not like the synthetic vitamins. Through some elegant radiotracer studies, Dr. Veech’s colleague  Dr. Henri Brunengraber showed that the L-form is neither harmful nor inhibitory, and is also metabolised and converts to acetoacetate and back to D-BHB. The conversion is less efficient from the L-form, and relatively more of it is used for lipid synthesis and direct oxidation. 100% D-BHB might be better than a racemic mixture, but it’s not harmful or inhibitory. As Dominic points out, racemic compounds have anti-seizure, anti-cancer and anti-inflammatory effects.

If this all sounds a bit cloak and dagger.

It’s because it probably is. After an in depth conversation and then interview for the Keto Summit, Professor Kieran Clarke of Oxford University made a compelling case for the D-BHB ester that has yet to be commercialised. My feeling is that her and Dr. Veech have a superior product, but that Dr. Veech’s recent comments about racemic mixtures are anticompetitive opinion not backed up by evidence.

Is Dominic completely neutral in all this?

Probably not. See US patent US20140350105 and US20140073693 (Savind, Inc is Patrick Arnold’s company). Are we neutral? Nope. We sell an MCT oil powder!

Do you have questions for Dominic or Patrick? Please leave them in the comments section below then sign up for the Keto Summit and I’ll do my best to ask the experts when I interview them next month.

Also see the two new excellent podcast interviews with Dominic on STEM-Talk and The Quantified Body.

Here’s the outline of this interview with Dr. Tommy Wood:

0:00:20    Podcast: Bulletproof Radio.

0:00:26    Podcast: Ben Greenfield.

0:01:10    Dr. Richard Veech.

0:02:28    1995 paper: Insulin, ketone bodies, and mitochondrial energy transduction.

0:03:08    Prototype Nutrition.

0:07:37    Atrial natriuretic peptide.

0:08:10    KetoCaNa.

0:10:04    Dominic and Patrick’s study Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats.

0:13:19    Khan Academy: Stereochemistry.

0:15:03    D-L-alpha tocopherol.

0:22:32    NAD+/NADH ratios. See The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways.

0:22:35    Ubiquinone.

0:23:25    Khan Academy: ATP hydrolysis: Gibbs free energy.

0:25:13    28% increase in cardiac efficiency

0:33:12    Dr. Mary Newport.

0:33:25    Steve Newport case study.

0:35:07    Sirtuins.

0:35:41    Lactate and pyruvate.

0:41:52    Kraft dried blood spot oral glucose tolerance test with insulin.

0:44:35    PHAT FIBRE hypoallergenic MCT oil powder.

0:44:56    Concierge Clinical Coaching private membership group.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-06-07.at.10.29.mp3 Thu, 23 Jun 2016 18:06:33 GMT Christopher Kelly Two brilliant scientists are racing to be the first to commercialise exogenous ketones. The applications include athletic performance and metabolic therapies for CNS oxygen toxicity, epilepsy, and neurodegenerative diseases. In the red corner, Dr. Richard Veech, one of the greatest living minds in basic biochemistry. In the blue corner, the also brilliant renegade chemist Patrick Arnold. Stuck somewhere in the middle is superhuman researcher Dominic D’Agostino, associate professor in the department of molecular pharmacology and physiology at the University of South Florida, and a visiting research scientist at the IHMC.

Patrick clearly has the head start, and I’ve been supplementing with his KetoForce and KetoCaNa products for over two years for bike races. Imagine my horror then when Dr. Veech appeared on the Bulletproof and Ben Greenfield podcasts to claim that Patrick’s racemic ketone salts were “harmful and inhibitory” and “a dumb for convenience of manufacturing”.

Caution is warranted.

A racemic mixture is one that includes both the D and L enantiomers. The source of the D and L labels was the Latin words dexter (on the right) and laevus (on the left). You may also have seen the labels R and S. R comes from rectus (right-handed) and S from sinister (left-handed). The physiological form of beta-hydroxybutyrate (BHB) is the D form. This is the same reason why Tommy would never recommend synthetic vitamins (vitamin E is a good example), because you get a racemic mixture and the inactive form tends to inhibit the more active form.

L-BHB is also metabolised.

BHB is not like the synthetic vitamins. Through some elegant radiotracer studies, Dr. Veech’s colleague  Dr. Henri Brunengraber showed that the L-form is neither harmful nor inhibitory, and is also metabolised and converts to acetoacetate and back to D-BHB. The conversion is less efficient from the L-form, and relatively more of it is used for lipid synthesis and direct oxidation. 100% D-BHB might be better than a racemic mixture, but it’s not harmful or inhibitory. As Dominic points out, racemic compounds have anti-seizure, anti-cancer and anti-inflammatory effects.

If this all sounds a bit cloak and dagger.

It’s because it probably is. After an in depth conversation and then interview for the Keto Summit, Professor Kieran Clarke of Oxford University made a compelling case for the D-BHB ester that has yet to be commercialised. My feeling is that her and Dr. Veech have a superior product, but that Dr. Veech’s recent comments about racemic mixtures are anticompetitive opinion not backed up by evidence.

Is Dominic completely neutral in all this?

Probably not. See US patent US20140350105 and US20140073693 (Savind, Inc is Patrick Arnold’s company). Are we neutral? Nope. We sell an MCT oil powder!

Do you have questions for Dominic or Patrick? Please leave them in the comments section below then sign up for the Keto Summit and I’ll do my best to ask the experts when I interview them next month.

Also see the two new excellent podcast interviews with Dominic on STEM-Talk and The Quantified Body.

Here’s the outline of this interview with Dr. Tommy Wood:

0:00:20    Podcast: Bulletproof Radio.

0:00:26    Podcast: Ben Greenfield.

0:01:10    Dr. Richard Veech.

0:02:28    1995 paper: Insulin, ketone bodies, and mitochondrial energy transduction.

0:03:08    Prototype Nutrition.

0:07:37    Atrial natriuretic peptide.

0:08:10    KetoCaNa.

0:10:04    Dominic and Patrick’s study Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats.

0:13:19    Khan Academy: Stereochemistry.

0:15:03    D-L-alpha tocopherol.

0:22:32    NAD+/NADH ratios. See The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways.

0:22:35    Ubiquinone.

0:23:25    Khan Academy: ATP hydrolysis: Gibbs free energy.

0:25:13    28% increase in cardiac efficiency

0:33:12    Dr. Mary Newport.

0:33:25    Steve Newport case study.

0:35:07    Sirtuins.

0:35:41    Lactate and pyruvate.

0:41:52    Kraft dried blood spot oral glucose tolerance test with insulin.

0:44:35    PHAT FIBRE hypoallergenic MCT oil powder.

0:44:56    Concierge Clinical Coaching private membership group.

]]>
clean
Nootropics 101: How to Hack Memory, Creativity, and Motivation https://s3.amazonaws.com/nourishbalancethrive/podcast/Ryan.Munsey.on.2016-05-17.at.11.00.mp3 In the past two weeks for the Keto Summit, I interviewed Dave Asprey, Mark Sisson and Professors Tim Noakes, Kieran Clarke and Tom Seyfried. These are just five of the 33 expert interview I have lined up. Each interview is around one hour or 10,000 words long. So much wisdom, sometimes decades in the making, is there anything I can do to help retain some of it in my long term memory? Quite possibly: nootropics are are drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. I’m completely new to the idea, and if you are too you’ll find this podcast both helpful and intriguing.

My expert guest is Ryan Munsey. Ryan is a former fitness model and gym owner turned writer, speaker, and biohacker. He's a mental and physical performance specialist with a degree in Food Science & Human Nutrition from Clemson University. An avid hunter, you'll often find him in the woods.

Here’s the outline of this interview with Ryan Munsey:

0:00:12    Optimal Performance Podcast.

0:01:12    Book: Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast! By Mark Sisson and Brad Kearns.

0:01:17    Keto Summit.

0:05:50    House of Strength gym.

0:05:57    Ryan has written for EliteFts, T-Nation, Men's Fitness.

0:06:06    Natural Stacks.

0:06:07    Joe Rogan Podcast.

0:06:08    Dave Asprey of the Bulletproof Radio Podcast.

0:11:36    Mental and physical performance stacks.

0:12:25    CILTEP (use the discount code CILTEPNBT).

0:13:04    My transcriptions are done by the wonderful people at Cabbage Tree.

0:16:14    Eat to Perform podcast.

0:17:37    Modafinil.

0:18:20    Racetam family.

0:19:30    Smart caffeine.

0:19:46    Abelard Lindsay.

0:20:19    Phosphodiesterase type 4 (PDE4) inhibitor.

0:20:24    Khan Academy video: G Protein Coupled Receptors and cAMP.

0:21:44    Book: The Edge Effect: Achieve Total Health and Longevity with the Balanced Brain Advantage by Eric R. Braverman.

0:22:15    L-Alpha glycerylphosphorylcholine (alpha-GPC).

0:22:18    Choline.

0:22:22    ONNIT Alpha Brain.

0:22:28    Bulletproof Choline Force.

0:23:35    Dopamine Brain Food and Serotonin Brain Food.

0:26:19    CILTEP (use the discount code CILTEPNBT).

0:28:17    Grand master of memory Mattias Ribbing.

0:40:14    NAC podcast.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Ryan.Munsey.on.2016-05-17.at.11.00.mp3 Fri, 17 Jun 2016 12:06:10 GMT Christopher Kelly In the past two weeks for the Keto Summit, I interviewed Dave Asprey, Mark Sisson and Professors Tim Noakes, Kieran Clarke and Tom Seyfried. These are just five of the 33 expert interview I have lined up. Each interview is around one hour or 10,000 words long. So much wisdom, sometimes decades in the making, is there anything I can do to help retain some of it in my long term memory? Quite possibly: nootropics are are drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. I’m completely new to the idea, and if you are too you’ll find this podcast both helpful and intriguing.

My expert guest is Ryan Munsey. Ryan is a former fitness model and gym owner turned writer, speaker, and biohacker. He's a mental and physical performance specialist with a degree in Food Science & Human Nutrition from Clemson University. An avid hunter, you'll often find him in the woods.

Here’s the outline of this interview with Ryan Munsey:

0:00:12    Optimal Performance Podcast.

0:01:12    Book: Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast! By Mark Sisson and Brad Kearns.

0:01:17    Keto Summit.

0:05:50    House of Strength gym.

0:05:57    Ryan has written for EliteFts, T-Nation, Men's Fitness.

0:06:06    Natural Stacks.

0:06:07    Joe Rogan Podcast.

0:06:08    Dave Asprey of the Bulletproof Radio Podcast.

0:11:36    Mental and physical performance stacks.

0:12:25    CILTEP (use the discount code CILTEPNBT).

0:13:04    My transcriptions are done by the wonderful people at Cabbage Tree.

0:16:14    Eat to Perform podcast.

0:17:37    Modafinil.

0:18:20    Racetam family.

0:19:30    Smart caffeine.

0:19:46    Abelard Lindsay.

0:20:19    Phosphodiesterase type 4 (PDE4) inhibitor.

0:20:24    Khan Academy video: G Protein Coupled Receptors and cAMP.

0:21:44    Book: The Edge Effect: Achieve Total Health and Longevity with the Balanced Brain Advantage by Eric R. Braverman.

0:22:15    L-Alpha glycerylphosphorylcholine (alpha-GPC).

0:22:18    Choline.

0:22:22    ONNIT Alpha Brain.

0:22:28    Bulletproof Choline Force.

0:23:35    Dopamine Brain Food and Serotonin Brain Food.

0:26:19    CILTEP (use the discount code CILTEPNBT).

0:28:17    Grand master of memory Mattias Ribbing.

0:40:14    NAC podcast.

]]>
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Foodloose Recap https://s3.amazonaws.com/nourishbalancethrive/podcast/foodloose_wrapup.mp3 “Gary Taubes is in the building!” exclaimed Foodloose host Dr. Maryanne Demasi. Gary was scheduled to arrive at Iceland’s international airport the morning of the conference, and he’d already missed his keynote slot. British cardiologist Dr. Aseem Malhotra had assumed Gary’s position, and I’d started to wonder if the rest of the speakers would be advanced in the same way. Fortunately, that was not to be the case, and Gary delivered an impressive display of public speaking of the likes I’ve not seen before. The man barely looked down once during the entire presentation and spoke with extraordinary fluency. The Harpa concert hall that hosted the event was even more impressive than Gary's public speaking, the island even more impressive still.

The complete lineup of speakers at the IHS Foodloose conference 2016:

  • Dorrit Moussaieff, patron and First Lady of Iceland.
  • Dr. Aseem Malhotra, British Cardiologist.
  • Gary Taubes, author: Good Calories, Bad Calories.
  • Dr. Axel Sigurdsson, Icelandic Cardiologist.
  • Professor Tim Noakes, South African emeritus professor of exercise science.
  • Denise Minger, author: Death by Food Pyramid.
  • Dr. Tommy Wood, research scientist and NBT Chief Medical Officer.

The day after the conference, I had the chance to sit down with Tommy and discuss what was presented at the first ever Icelandic Health Symposium event.

We loved our time on the island and can’t wait to return next year.

Here’s the outline of this interview with Dr. Tommy Wood

0:00:42    Dr. Guðmundur Jóhannsson on this podcast.

0:02:08    Dr. Aseem Malhotra.

0:02:40    Aseem on the BBC News.

0:03:19    Action on Sugar.

0:03:23    Run on Fat movie.

0:09:40    Lilly Nichols on the Paleo Baby podcast.

0:19:20    Book: The Big Fat Surprise.

0:21:59    About Kevin Hall’s study on this podcast.

0:22:40    Dr. Axel Sigurdsson.

0:29:07    Prof. Tim Noakes.

0:33:19    Book: Super Food for Superchildren.

0:39:44    Denise Minger: Carbosis.

0:41:22    Swank Foundation for MS.

0:41:24    Lester M. Morrison, MD.

0:41:58    Rice Diet.

0:48:56    Dean Ornish.

0:48:59    Michael Gregor’s nutritionfacts.org

0:51:04    Rich Roll.

0:51:05    Ray Cronise.

1:00:19    Bryan Walsh social isolation podcast.

1:02:39    Chris Masterjohn melanopsin podcast.

1:10:19    Book: The Blue Zones.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/foodloose_wrapup.mp3 Thu, 09 Jun 2016 20:06:17 GMT Christopher Kelly “Gary Taubes is in the building!” exclaimed Foodloose host Dr. Maryanne Demasi. Gary was scheduled to arrive at Iceland’s international airport the morning of the conference, and he’d already missed his keynote slot. British cardiologist Dr. Aseem Malhotra had assumed Gary’s position, and I’d started to wonder if the rest of the speakers would be advanced in the same way. Fortunately, that was not to be the case, and Gary delivered an impressive display of public speaking of the likes I’ve not seen before. The man barely looked down once during the entire presentation and spoke with extraordinary fluency. The Harpa concert hall that hosted the event was even more impressive than Gary's public speaking, the island even more impressive still.

The complete lineup of speakers at the IHS Foodloose conference 2016:

  • Dorrit Moussaieff, patron and First Lady of Iceland.
  • Dr. Aseem Malhotra, British Cardiologist.
  • Gary Taubes, author: Good Calories, Bad Calories.
  • Dr. Axel Sigurdsson, Icelandic Cardiologist.
  • Professor Tim Noakes, South African emeritus professor of exercise science.
  • Denise Minger, author: Death by Food Pyramid.
  • Dr. Tommy Wood, research scientist and NBT Chief Medical Officer.

The day after the conference, I had the chance to sit down with Tommy and discuss what was presented at the first ever Icelandic Health Symposium event.

We loved our time on the island and can’t wait to return next year.

Here’s the outline of this interview with Dr. Tommy Wood

0:00:42    Dr. Guðmundur Jóhannsson on this podcast.

0:02:08    Dr. Aseem Malhotra.

0:02:40    Aseem on the BBC News.

0:03:19    Action on Sugar.

0:03:23    Run on Fat movie.

0:09:40    Lilly Nichols on the Paleo Baby podcast.

0:19:20    Book: The Big Fat Surprise.

0:21:59    About Kevin Hall’s study on this podcast.

0:22:40    Dr. Axel Sigurdsson.

0:29:07    Prof. Tim Noakes.

0:33:19    Book: Super Food for Superchildren.

0:39:44    Denise Minger: Carbosis.

0:41:22    Swank Foundation for MS.

0:41:24    Lester M. Morrison, MD.

0:41:58    Rice Diet.

0:48:56    Dean Ornish.

0:48:59    Michael Gregor’s nutritionfacts.org

0:51:04    Rich Roll.

0:51:05    Ray Cronise.

1:00:19    Bryan Walsh social isolation podcast.

1:02:39    Chris Masterjohn melanopsin podcast.

1:10:19    Book: The Blue Zones.

]]>
no
Hyperinsulinaemia and Cognitive Decline with Catherine Crofts, Ph.D https://s3.amazonaws.com/nourishbalancethrive/podcast/Catherine.Crofts.on.2016-05-21.at.18.01.mp3 Catherine Crofts is a New Zealand community-based clinical pharmacist who firmly believes in using the lowest dose of the least number of medications to treat disease. After 17 years of practice, she feels more like a “disease management specialist” than a health professional.

Together with Caryn Zinn, Mark Wheldon, and Grant Schofield, Catherine is the author of Hyperinsulinemia: A unifying theory of chronic disease?

Catherine blogs at Lifestyle Before Medication.

Catherine will soon be known as Dr. Crofts after successfully defending her Ph.D. thesis where she analysed the oral glucose and insulin tolerance data of Dr. Joseph Kraft. Catherine will talk more about that work and why fasting insulin is a useless biomarker in the upcoming Keto Summit, in this interview we focus on the role of insulin resistance in dementia.

Here’s the outline of this interview with Catherine Crofts:

0:00:42    Professor Grant Schofield and Dr. Caryn Zinn.

0:00:47    Dr. Joseph Kraft from Chicago. Book: Diabetes Epidemic & You.

0:02:37    Schizophrenia and bipolar disease.

0:03:41    Type 3 diabetes.

0:03:45    Alzheimer's dementia is very, very much a disease of diabetes and insulin and glucose.

0:04:00    Protein tangles within the brain.

0:04:03    Vascular dementia which is associated with the blood vessels.

0:04:25    Lewy body dementia which is another type of protein deposit.

0:04:32    Amyloid plaques.

0:04:42    Most people with dementia will have a mixed dementia.

0:04:53    CT scan of the brain.

0:06:04    Substantia nigra and movement problems.

0:06:13    Frontotemporal system system

0:07:11    Dr. Kirk Parsley talked about Professor Robert Sapolsky.

0:10:44    The Whitehall Study showed some people noticing cognitive changes starting at age 48.

0:12:15    Apolipoprotein E (APOE) gene.

0:12:21    Neurotransmitter acetylcholine.

0:12:28    Tau protein.

0:13:22    Large and small clumps of beta-amyloid might be protective.

0:13:51    Synaptic plasticity and PSA-NCAM

0:14:46    Type 2 diabetes is one of the biggest risk factors for Alzheimer's.

0:16:05    Insulin prevents a process called fibrinolysis.

0:17:30    GLUT1.

0:24:13    Glutamate can be a little bit toxic to the brain.

0:24:46    GABA is a calming neurotransmitter.

0:27:22    A ketogenic diet for dementia.

0:41:50    Keto Summit.

 
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Catherine.Crofts.on.2016-05-21.at.18.01.mp3 Thu, 02 Jun 2016 17:06:53 GMT Christopher Kelly Catherine Crofts is a New Zealand community-based clinical pharmacist who firmly believes in using the lowest dose of the least number of medications to treat disease. After 17 years of practice, she feels more like a “disease management specialist” than a health professional.

Together with Caryn Zinn, Mark Wheldon, and Grant Schofield, Catherine is the author of Hyperinsulinemia: A unifying theory of chronic disease?

Catherine blogs at Lifestyle Before Medication.

Catherine will soon be known as Dr. Crofts after successfully defending her Ph.D. thesis where she analysed the oral glucose and insulin tolerance data of Dr. Joseph Kraft. Catherine will talk more about that work and why fasting insulin is a useless biomarker in the upcoming Keto Summit, in this interview we focus on the role of insulin resistance in dementia.

Here’s the outline of this interview with Catherine Crofts:

0:00:42    Professor Grant Schofield and Dr. Caryn Zinn.

0:00:47    Dr. Joseph Kraft from Chicago. Book: Diabetes Epidemic & You.

0:02:37    Schizophrenia and bipolar disease.

0:03:41    Type 3 diabetes.

0:03:45    Alzheimer's dementia is very, very much a disease of diabetes and insulin and glucose.

0:04:00    Protein tangles within the brain.

0:04:03    Vascular dementia which is associated with the blood vessels.

0:04:25    Lewy body dementia which is another type of protein deposit.

0:04:32    Amyloid plaques.

0:04:42    Most people with dementia will have a mixed dementia.

0:04:53    CT scan of the brain.

0:06:04    Substantia nigra and movement problems.

0:06:13    Frontotemporal system system

0:07:11    Dr. Kirk Parsley talked about Professor Robert Sapolsky.

0:10:44    The Whitehall Study showed some people noticing cognitive changes starting at age 48.

0:12:15    Apolipoprotein E (APOE) gene.

0:12:21    Neurotransmitter acetylcholine.

0:12:28    Tau protein.

0:13:22    Large and small clumps of beta-amyloid might be protective.

0:13:51    Synaptic plasticity and PSA-NCAM

0:14:46    Type 2 diabetes is one of the biggest risk factors for Alzheimer's.

0:16:05    Insulin prevents a process called fibrinolysis.

0:17:30    GLUT1.

0:24:13    Glutamate can be a little bit toxic to the brain.

0:24:46    GABA is a calming neurotransmitter.

0:27:22    A ketogenic diet for dementia.

0:41:50    Keto Summit.

 
]]>
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Keto UFC Fighter Kyle Kingsbury: Biohacking and the Missing Low Gear https://s3.amazonaws.com/nourishbalancethrive/podcast/kyle.kingsbury.on.2016-05-18.at.12.01.mp3 I couldn’t help laughing when former UFC fighter Kyle Kingsbury described the trouble he was having deadlifting 525 lb when 495 came so easily. 180 is a problem for me! The ketogenic diet has removed Kyle’s “low gear”, but the sacrifice is worth it because, in the ketogenic state, Kyle enjoys an enormous cognitive benefit and less systemic inflammation. Having suffered two orbital fractures that ultimately lead to his retirement, I wonder if Kyle is an example of how ketosis can help with traumatic brain injury.

Do not supplement with raw potato starch!

Kyle and his wife are yet further examples of people that didn’t do well supplementing with raw potato starch. Kyle noticed changes in his immune system that lead to an increase in sickness, and his wife Natasha gained body fat. Both were able to resolve those issues following Grace Liu’s plan that included psyllium, acacia, and inulin-FOS together with a bifidobacteria probiotic.

Here’s the outline of this interview with Kyle Kingsbury

0:01:06    Kyle is 6'3.5", 235lb 20" neck!

0:02:20    He won his first two fights in under 30 seconds.

0:04:35    American Kickboxing Academy in San Jose: heavyweight champ Cain Velasquez, current middleweight champion Luke Rockhold, and current light heavyweight champion Dana Cormier.

0:06:27    Muay Thai.

0:07:15    Brazilian jiu-jitsu.

0:08:24    Book: Easy Strength: How to Get a Lot Stronger Than Your Competition-And Dominate in Your Sport.

0:08:40    Book: Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast!

0:09:45    Podcast: Elite Spartan racer Elijah Wood.

0:10:16    Kyle has a one year old boy called Bear.

0:10:30    Carb backloading.

0:10:53    When Kyle deadlifts 495, reaching 525 shouldn’t be a problem, but it is on a ketogenic diet.

0:12:07    Ben Greenfield.

0:14:07    Keto has helped with sleep deprivation and shift work.

0:14:39    Podcast: Dominic D'Agostino on Tim Ferriss’s show.

0:15:25    Podcast: Kirk Parsley on sleep.

0:15:32    Keto Summit.

0:19:04    Grace Liu.

0:19:30    uBiome app.

0:20:51    Potato starch debacle.

0:22:28    Bionic fibre.

0:22:38    Bifidomax probiotic.

0:26:04    Podcast: organic acids.

0:29:05    Podcast: Endurance Planet.

0:29:50    Book: The Better Baby Book: How to Have a Healthier, Smarter, Happier Baby.

0:31:08    Supplement: carnitine.

0:31:12    Podcast: N-Acetylcysteine (NAC).

0:34:12    The Origin (and future) of the Ketogenic Diet on Robb Wolf’s site.

0:39:41    Book: Becoming a Supple Leopard 2nd Edition: The Ultimate Guide to Resolving Pain, Preventing Injury, and Optimizing Athletic Performance.

0:40:20    Podcast: Brad Dieter, Ph.D.

0:42:22    Ultra Adventures 50k run.

0:45:16    Podcast: Joe Rogan Experience #756 - Kyle Kingsbury.

0:46:52    Book: Feed Zone Portables: A Cookbook of On-the-Go Food for Athletes.

0:52:05    Paul Chek: “Sooner or later your health will be your number one concern.”

0:53:01    @Kingsbu on Twitter and Instagram.

0:53:08    Podcast: Mom's Garage (not released yet).

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/kyle.kingsbury.on.2016-05-18.at.12.01.mp3 Fri, 27 May 2016 02:05:00 GMT Christopher Kelly I couldn’t help laughing when former UFC fighter Kyle Kingsbury described the trouble he was having deadlifting 525 lb when 495 came so easily. 180 is a problem for me! The ketogenic diet has removed Kyle’s “low gear”, but the sacrifice is worth it because, in the ketogenic state, Kyle enjoys an enormous cognitive benefit and less systemic inflammation. Having suffered two orbital fractures that ultimately lead to his retirement, I wonder if Kyle is an example of how ketosis can help with traumatic brain injury.

Do not supplement with raw potato starch!

Kyle and his wife are yet further examples of people that didn’t do well supplementing with raw potato starch. Kyle noticed changes in his immune system that lead to an increase in sickness, and his wife Natasha gained body fat. Both were able to resolve those issues following Grace Liu’s plan that included psyllium, acacia, and inulin-FOS together with a bifidobacteria probiotic.

Here’s the outline of this interview with Kyle Kingsbury

0:01:06    Kyle is 6'3.5", 235lb 20" neck!

0:02:20    He won his first two fights in under 30 seconds.

0:04:35    American Kickboxing Academy in San Jose: heavyweight champ Cain Velasquez, current middleweight champion Luke Rockhold, and current light heavyweight champion Dana Cormier.

0:06:27    Muay Thai.

0:07:15    Brazilian jiu-jitsu.

0:08:24    Book: Easy Strength: How to Get a Lot Stronger Than Your Competition-And Dominate in Your Sport.

0:08:40    Book: Primal Endurance: Escape chronic cardio and carbohydrate dependency and become a fat burning beast!

0:09:45    Podcast: Elite Spartan racer Elijah Wood.

0:10:16    Kyle has a one year old boy called Bear.

0:10:30    Carb backloading.

0:10:53    When Kyle deadlifts 495, reaching 525 shouldn’t be a problem, but it is on a ketogenic diet.

0:12:07    Ben Greenfield.

0:14:07    Keto has helped with sleep deprivation and shift work.

0:14:39    Podcast: Dominic D'Agostino on Tim Ferriss’s show.

0:15:25    Podcast: Kirk Parsley on sleep.

0:15:32    Keto Summit.

0:19:04    Grace Liu.

0:19:30    uBiome app.

0:20:51    Potato starch debacle.

0:22:28    Bionic fibre.

0:22:38    Bifidomax probiotic.

0:26:04    Podcast: organic acids.

0:29:05    Podcast: Endurance Planet.

0:29:50    Book: The Better Baby Book: How to Have a Healthier, Smarter, Happier Baby.

0:31:08    Supplement: carnitine.

0:31:12    Podcast: N-Acetylcysteine (NAC).

0:34:12    The Origin (and future) of the Ketogenic Diet on Robb Wolf’s site.

0:39:41    Book: Becoming a Supple Leopard 2nd Edition: The Ultimate Guide to Resolving Pain, Preventing Injury, and Optimizing Athletic Performance.

0:40:20    Podcast: Brad Dieter, Ph.D.

0:42:22    Ultra Adventures 50k run.

0:45:16    Podcast: Joe Rogan Experience #756 - Kyle Kingsbury.

0:46:52    Book: Feed Zone Portables: A Cookbook of On-the-Go Food for Athletes.

0:52:05    Paul Chek: “Sooner or later your health will be your number one concern.”

0:53:01    @Kingsbu on Twitter and Instagram.

0:53:08    Podcast: Mom's Garage (not released yet).

]]>
clean
How to Get Clients for Your Health Coaching Business https://s3.amazonaws.com/nourishbalancethrive/podcast/Jordan.Reasoner.on.2016-05-11.at.12.13.mp3 Imagine your name is Bob. You’re 47 years old, you have a beautiful wife, two wonderful kids, a lovely dog and a career you enjoy. Life is great is except for the nagging pain in your right pinky finger. It started as a minor irritation but now has gotten to the point where it’s affecting your work and your sleep. As you lay tossing and turning one night, all you can think about is the pain. Then suddenly you decide it’s time to get up and take action. You kiss your wife and sneak out the bedroom. The dog is confused and follows you downstairs and into the kitchen. You open up the lid of your laptop and open a new browser window. Google appears.

What are you going to search for?

Doctor [Your Name Here] Ultrawellness?

Optimal Health Nutrition Coach?

Of course not. You’re going to search for “right pinky finger pain” or some variation of those words.

So why is then that so many practitioners, good ones, create websites that are all about themselves?

You know the site I mean. The one with the picture of the practitioner on the front page, possibly wearing a white lab coat and a stethoscope around their neck. There’s a list of credentials and a longer list of health complaints the practitioner "specialises" in. The list includes virtually every condition known to man. Think about Bob reading that page. Is he going to be excited? Now imagine Bob’s delight as he discovers your series of articles talking about the most common root causes of right pinky finger pain and what you can do about them. Bob is so delighted with what he’s found that he wants to wake his wife to share the good news. "Finally! Someone that understands me" is what Bob is thinking.

Being specific about who we’re talking to is something we’ve done by accident at Nourish Balance Thrive. I’m a master’s athlete whose health fell apart in pursuit of the upgrade to pro mountain biker racer. Not everyone we work with is a mountain biker, but everyone is an athlete (even if they won’t admit it).

Starting a new health coaching business is about more than being a great practitioner.

Of course, you must be qualified to help people, but if you’re not specific with your marketing, you’ll end up helping nobody. You only have to walk down the street anywhere in the US to recognise how many people need help with their diet and lifestyle, but did you know that 50% of naturopaths never see a patient? 60% of acupuncturists go back to a previous career after less than three years of work? And yet at the same time, as of last year, there were three billion people online, and we know that there's another three billion people that are coming in the next five years or so depending on what study you read. There is no shortage of people that need your help.

This is but one of the many lessons I’ve learned as a result of completing the Practitioner Liberation Project. Listen to this interview with gut health guru and marketing conversion expert Jordan Reasoner to discover some of the others.

Click here to sign up for Jordan’s webinar.

Here’s the outline of this interview with Jordan Reasoner

0:02:12    Jordan's story.

0:03:44    Book: Breaking the Vicious Cycle: Intestinal Health Through Diet.

0:04:48    Jordan had a parasite called Strongyloides stercoralis and took a medicine called Ivermectin.

0:05:37    SCD Lifestyle will become healthygut.com

0:05:56    Their list now has 250,000 members.

0:08:14    We both did the Kalish Mentorship.

0:08:33    One email, Jordan and Steve were booked out for a month, 600 clients in the next year.

0:09:32    The gut wizard: Brie Wieselman, L.Ac.

0:13:44    50% of naturopaths never see a patient

0:13:49    60% of acupuncturists go back to a previous career within three years.

0:25:41    1.5M people in the US alone with Rheumatoid arthritis.

0:26:14    1.7B people on Facebook.

0:29:53    Start with the thing that you're passionate about.

0:32:38    Ask yourself who you want to work with.

0:38:10    500 practitioners in the PLP.

0:45:57    WeScribeIt.

0:46:47    The Essential Keto Cookbook.

0:49:33    Business supports systems.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Jordan.Reasoner.on.2016-05-11.at.12.13.mp3 Thu, 19 May 2016 17:05:15 GMT Christopher Kelly Imagine your name is Bob. You’re 47 years old, you have a beautiful wife, two wonderful kids, a lovely dog and a career you enjoy. Life is great is except for the nagging pain in your right pinky finger. It started as a minor irritation but now has gotten to the point where it’s affecting your work and your sleep. As you lay tossing and turning one night, all you can think about is the pain. Then suddenly you decide it’s time to get up and take action. You kiss your wife and sneak out the bedroom. The dog is confused and follows you downstairs and into the kitchen. You open up the lid of your laptop and open a new browser window. Google appears.

What are you going to search for?

Doctor [Your Name Here] Ultrawellness?

Optimal Health Nutrition Coach?

Of course not. You’re going to search for “right pinky finger pain” or some variation of those words.

So why is then that so many practitioners, good ones, create websites that are all about themselves?

You know the site I mean. The one with the picture of the practitioner on the front page, possibly wearing a white lab coat and a stethoscope around their neck. There’s a list of credentials and a longer list of health complaints the practitioner "specialises" in. The list includes virtually every condition known to man. Think about Bob reading that page. Is he going to be excited? Now imagine Bob’s delight as he discovers your series of articles talking about the most common root causes of right pinky finger pain and what you can do about them. Bob is so delighted with what he’s found that he wants to wake his wife to share the good news. "Finally! Someone that understands me" is what Bob is thinking.

Being specific about who we’re talking to is something we’ve done by accident at Nourish Balance Thrive. I’m a master’s athlete whose health fell apart in pursuit of the upgrade to pro mountain biker racer. Not everyone we work with is a mountain biker, but everyone is an athlete (even if they won’t admit it).

Starting a new health coaching business is about more than being a great practitioner.

Of course, you must be qualified to help people, but if you’re not specific with your marketing, you’ll end up helping nobody. You only have to walk down the street anywhere in the US to recognise how many people need help with their diet and lifestyle, but did you know that 50% of naturopaths never see a patient? 60% of acupuncturists go back to a previous career after less than three years of work? And yet at the same time, as of last year, there were three billion people online, and we know that there's another three billion people that are coming in the next five years or so depending on what study you read. There is no shortage of people that need your help.

This is but one of the many lessons I’ve learned as a result of completing the Practitioner Liberation Project. Listen to this interview with gut health guru and marketing conversion expert Jordan Reasoner to discover some of the others.

Click here to sign up for Jordan’s webinar.

Here’s the outline of this interview with Jordan Reasoner

0:02:12    Jordan's story.

0:03:44    Book: Breaking the Vicious Cycle: Intestinal Health Through Diet.

0:04:48    Jordan had a parasite called Strongyloides stercoralis and took a medicine called Ivermectin.

0:05:37    SCD Lifestyle will become healthygut.com

0:05:56    Their list now has 250,000 members.

0:08:14    We both did the Kalish Mentorship.

0:08:33    One email, Jordan and Steve were booked out for a month, 600 clients in the next year.

0:09:32    The gut wizard: Brie Wieselman, L.Ac.

0:13:44    50% of naturopaths never see a patient

0:13:49    60% of acupuncturists go back to a previous career within three years.

0:25:41    1.5M people in the US alone with Rheumatoid arthritis.

0:26:14    1.7B people on Facebook.

0:29:53    Start with the thing that you're passionate about.

0:32:38    Ask yourself who you want to work with.

0:38:10    500 practitioners in the PLP.

0:45:57    WeScribeIt.

0:46:47    The Essential Keto Cookbook.

0:49:33    Business supports systems.

]]>
clean
Vitamin D, Sunscreen, Skin Cancer: What You Need to Know https://s3.amazonaws.com/nourishbalancethrive/podcast/PrimalEyeSunshine.mp3 The Information Age brought with it’s ugly stepsister named Confusion. Never was this more true than for the information and misinformation surrounding vitamin D, sunscreen, and cancer.

Not getting burned makes intuitive sense, but will slathering on the sunscreen cause vitamin D deficiency?

Could vitamin D deficiency be causing the cancer that the sunscreen is supposed to be protecting against?

How much of a concern is skin cancer anyway?

Do we need to worry about toxic chemicals in sunscreen?

What type of sunscreen is best?

Join Dr. Tommy Wood and me in this podcast interview for everything you need to know about to protect your skin in the performance and longevity.

Also check out our article: Optimizing Vitamin D for Athletic Performance.

When Tommy and I recorded this podcast I was using the Badger brand suntan cream, since then I’ve switch to using Rocket Pure.

Here’s the outline of this interview with Dr. Tommy Wood

0:04:19    What is vitamin D (25-OH-D)?

0:05:37    Made using UVB radiation from the sun.

0:06:18    The standard reference ranges for blood levels of 25-OH-D are controversial.

0:07:49    Vitamin D affects calcium absorption, vitamin K2 controls where that calcium goes.

0:09:25    No sunscreen provides 100% block.

0:09:51    UVA is the type of radiation we’d like to avoid.

0:11:16    In studies, the use of sunscreen didn't reduce blood 25-OH-D levels.

0:11:59    Real-world application of sunscreen is less than in studies.

0:12:50    You need need a lot less light to make vitamin D than you do to burn.

0:13:20    Do not get burned!

0:13:34    Don't avoid sunlight either!

0:14:08    Childhood exposure to burning increases risk over a lifetime.

0:15:45    Three types of skin cancer.

0:16:50    Melanoma is the worst.

0:18:14    Risk is dependant on skin type and exposure.

0:20:15    We're now indoors all the time, then we go on holiday for 2 weeks.

0:21:06    Dark skin people living far from the equator are at risk of vitamin D deficiency.

0:22:08    Endogenous vitamin D synthesis is rate-limited, taking a supplement is not.

0:23:31    25-OH-D deficiency is associated with autoimmunity, but the supplement doesn't fix the disease.

0:24:14    There may be something special about sun exposure.

0:26:12    The SPF system is flawed.

0:28:19    Buy factor 20 and re-apply.

0:29:58    Chemicals in suntan cream.

0:31:39    Endocrine disrupters.

0:32:22    Beware rodent models with unrealistic dosing.

0:33:04    Zinc or titanium dioxide are probably best.

0:35:09    The UK love their fragrances.

0:36:37    The skin microbiome.

0:38:04    Can the zinc and titanium become systemic?

0:38:58    Titanium is not inert.

0:41:06    Very small amounts are absorbed and we probably don't need to worry about it.

0:41:44    Again, some flawed rodent models out there.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/PrimalEyeSunshine.mp3 Thu, 12 May 2016 17:05:58 GMT Christopher Kelly The Information Age brought with it’s ugly stepsister named Confusion. Never was this more true than for the information and misinformation surrounding vitamin D, sunscreen, and cancer.

Not getting burned makes intuitive sense, but will slathering on the sunscreen cause vitamin D deficiency?

Could vitamin D deficiency be causing the cancer that the sunscreen is supposed to be protecting against?

How much of a concern is skin cancer anyway?

Do we need to worry about toxic chemicals in sunscreen?

What type of sunscreen is best?

Join Dr. Tommy Wood and me in this podcast interview for everything you need to know about to protect your skin in the performance and longevity.

Also check out our article: Optimizing Vitamin D for Athletic Performance.

When Tommy and I recorded this podcast I was using the Badger brand suntan cream, since then I’ve switch to using Rocket Pure.

Here’s the outline of this interview with Dr. Tommy Wood

0:04:19    What is vitamin D (25-OH-D)?

0:05:37    Made using UVB radiation from the sun.

0:06:18    The standard reference ranges for blood levels of 25-OH-D are controversial.

0:07:49    Vitamin D affects calcium absorption, vitamin K2 controls where that calcium goes.

0:09:25    No sunscreen provides 100% block.

0:09:51    UVA is the type of radiation we’d like to avoid.

0:11:16    In studies, the use of sunscreen didn't reduce blood 25-OH-D levels.

0:11:59    Real-world application of sunscreen is less than in studies.

0:12:50    You need need a lot less light to make vitamin D than you do to burn.

0:13:20    Do not get burned!

0:13:34    Don't avoid sunlight either!

0:14:08    Childhood exposure to burning increases risk over a lifetime.

0:15:45    Three types of skin cancer.

0:16:50    Melanoma is the worst.

0:18:14    Risk is dependant on skin type and exposure.

0:20:15    We're now indoors all the time, then we go on holiday for 2 weeks.

0:21:06    Dark skin people living far from the equator are at risk of vitamin D deficiency.

0:22:08    Endogenous vitamin D synthesis is rate-limited, taking a supplement is not.

0:23:31    25-OH-D deficiency is associated with autoimmunity, but the supplement doesn't fix the disease.

0:24:14    There may be something special about sun exposure.

0:26:12    The SPF system is flawed.

0:28:19    Buy factor 20 and re-apply.

0:29:58    Chemicals in suntan cream.

0:31:39    Endocrine disrupters.

0:32:22    Beware rodent models with unrealistic dosing.

0:33:04    Zinc or titanium dioxide are probably best.

0:35:09    The UK love their fragrances.

0:36:37    The skin microbiome.

0:38:04    Can the zinc and titanium become systemic?

0:38:58    Titanium is not inert.

0:41:06    Very small amounts are absorbed and we probably don't need to worry about it.

0:41:44    Again, some flawed rodent models out there.

]]>
no
N-Acetylcysteine: Beyond Paracetamol Overdose https://s3.amazonaws.com/nourishbalancethrive/podcast/David.Aiello.Thiolex.on.2016-03-15.at.10.34.mp3 I asked David Aiello, President BioAdvantex Pharma Inc.: of all the molecules, why study and productise N-acetylcysteine?

“That makes me think of another question, why did you marry that woman? You become fascinated with something, and your mind sees forward. I saw this as a huge business and scientific project with such a broad scope to help people. We didn't even understand the scope way back then.”

Paracetamol-induced acute liver failure.

In the US and UK, paracetamol (acetaminophen) toxicity is the most common cause of acute liver failure. When taken in normal therapeutic doses, paracetamol is safe.

The cytochrome P450 enzymes convert approximately 5% of paracetamol to a highly reactive intermediary metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Under normal conditions, NAPQI is detoxified by conjugation with glutathione. In cases of overdose, the pathways become saturated, leading to more NAPQI. Liver supplies of glutathione become depleted, and NAPQI remains in its toxic form in the liver, reacting with cellular membrane molecules, resulting in widespread damage and death of liver cells.

Beyond Paracetamol Overdose.

Paracetamol is not the only thing that can cause oxidative stress and cell death. Inflammation and oxidative stress are almost synonymous, and we measure both in the testing we do. Urinary P-Hydroxyphenyllactate on an organic acids test is a marker of cell turnover, and 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a marker of oxidative damage to the guanine of DNA.

Enter N-acetylcysteine.

The availability of the sulfur-containing amino acid cysteine is known to be the rate-limiting substrate for glutathione resynthesis. L-cysteine is not safe to take as a supplement in high doses, what you want is the N-acetylcysteine (NAC) form. NAC doesn’t encapsulate well because the minimum effective dose is too big to fit into a capsule, and even if it did fit, the molecule would oxidise and fall apart. David's team at BioAdvantex have solved these problems by creating PharmaNAC, a large effervescent tablet sealed into a nitrogen filled blister pack.

It's important to understand that exercise is itself an antioxidant and athletes should proceed with caution before supplementing with antioxidants without testing. Context matters.

Here’s the outline of this interview with David Aiello

0:00:35    David was trained in immunology at the Stanford Herzenberg Lab.

0:01:03    He wanted to create a product that was relevant, made the right way and given at the right dose.

0:01:34    BioAdvantex have done 12 or 13 clinical trials in breathing, immunity, oxidative stress and mental health.

0:02:46    NAC is the standard of care of acetaminophen toxicity.

0:03:19    80,000 people every year are affected.

0:03:54    NAPQI.

0:04:13    Making glutathione requires glycine, glutamate and cysteine.

0:04:28    Almost every protein is less than 2% cysteine by weight.

0:05:56    You don't want L-cysteine.

0:07:30    NAC is easily oxidised.

0:08:55    Hydrogen sulfide is one of the degradation products of NAC.

0:09:20    Humans can detect H2S at 6 ppb.

0:09:31    There are 7 other degradation pathways.

0:11:43     NAC placebo pills.

0:13:42    Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial.

0:15:51    Taking NAC is NOT like pouring water on the fire.

0:18:56    There's about a three-hour gap between when you take cysteine, and when it shows up in your blood, then there's about another three-hour gap until an increase in glutathione.

0:20:07    The liver is main store of cysteine, and also there’s cysteinylglycine in the blood.

0:28:30    Logging food and supplement intake.

0:29:05    Grace Liu.

0:29:10    GAD1 mutation.

0:29:47    The cystine-glutamate antiporter (xCT).

0:35:18    Depression, ruminations and PTSD.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/David.Aiello.Thiolex.on.2016-03-15.at.10.34.mp3 Thu, 05 May 2016 18:05:27 GMT Christopher Kelly I asked David Aiello, President BioAdvantex Pharma Inc.: of all the molecules, why study and productise N-acetylcysteine?

“That makes me think of another question, why did you marry that woman? You become fascinated with something, and your mind sees forward. I saw this as a huge business and scientific project with such a broad scope to help people. We didn't even understand the scope way back then.”

Paracetamol-induced acute liver failure.

In the US and UK, paracetamol (acetaminophen) toxicity is the most common cause of acute liver failure. When taken in normal therapeutic doses, paracetamol is safe.

The cytochrome P450 enzymes convert approximately 5% of paracetamol to a highly reactive intermediary metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Under normal conditions, NAPQI is detoxified by conjugation with glutathione. In cases of overdose, the pathways become saturated, leading to more NAPQI. Liver supplies of glutathione become depleted, and NAPQI remains in its toxic form in the liver, reacting with cellular membrane molecules, resulting in widespread damage and death of liver cells.

Beyond Paracetamol Overdose.

Paracetamol is not the only thing that can cause oxidative stress and cell death. Inflammation and oxidative stress are almost synonymous, and we measure both in the testing we do. Urinary P-Hydroxyphenyllactate on an organic acids test is a marker of cell turnover, and 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a marker of oxidative damage to the guanine of DNA.

Enter N-acetylcysteine.

The availability of the sulfur-containing amino acid cysteine is known to be the rate-limiting substrate for glutathione resynthesis. L-cysteine is not safe to take as a supplement in high doses, what you want is the N-acetylcysteine (NAC) form. NAC doesn’t encapsulate well because the minimum effective dose is too big to fit into a capsule, and even if it did fit, the molecule would oxidise and fall apart. David's team at BioAdvantex have solved these problems by creating PharmaNAC, a large effervescent tablet sealed into a nitrogen filled blister pack.

It's important to understand that exercise is itself an antioxidant and athletes should proceed with caution before supplementing with antioxidants without testing. Context matters.

Here’s the outline of this interview with David Aiello

0:00:35    David was trained in immunology at the Stanford Herzenberg Lab.

0:01:03    He wanted to create a product that was relevant, made the right way and given at the right dose.

0:01:34    BioAdvantex have done 12 or 13 clinical trials in breathing, immunity, oxidative stress and mental health.

0:02:46    NAC is the standard of care of acetaminophen toxicity.

0:03:19    80,000 people every year are affected.

0:03:54    NAPQI.

0:04:13    Making glutathione requires glycine, glutamate and cysteine.

0:04:28    Almost every protein is less than 2% cysteine by weight.

0:05:56    You don't want L-cysteine.

0:07:30    NAC is easily oxidised.

0:08:55    Hydrogen sulfide is one of the degradation products of NAC.

0:09:20    Humans can detect H2S at 6 ppb.

0:09:31    There are 7 other degradation pathways.

0:11:43     NAC placebo pills.

0:13:42    Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial.

0:15:51    Taking NAC is NOT like pouring water on the fire.

0:18:56    There's about a three-hour gap between when you take cysteine, and when it shows up in your blood, then there's about another three-hour gap until an increase in glutathione.

0:20:07    The liver is main store of cysteine, and also there’s cysteinylglycine in the blood.

0:28:30    Logging food and supplement intake.

0:29:05    Grace Liu.

0:29:10    GAD1 mutation.

0:29:47    The cystine-glutamate antiporter (xCT).

0:35:18    Depression, ruminations and PTSD.

]]>
clean
The Cyclist's Guide to Obstacle Racing https://s3.amazonaws.com/nourishbalancethrive/podcast/Elijah.Markstrom.on.2016-04-20.at.11.05.mp3 I sit too much. When I’m not sitting at my desk, I’m sitting on my bike. As a mountain biker, I stand more than some cyclists, but still. The ways in which I move my body are predictable and very repetitive. I almost never move from side to side, and I expend vast amounts of energy spinning small circles with my feet. Have humans evolved to move like this? I doubt it. I know that if I’m not careful, I start to develop niggling lower back pain and piriformis syndrome.

Obstacle racing then, or at least the training for it, appeals to me because of the variety. The movement that elite Spartan racer Elijah Markstrom describes in this interview is a lot like what I think I need to do as a mountain biker looking to add variety to my workouts. James Wilson talked about similar exercises to improve strength and mobility previously on my podcast. When two people you respect talk about getting results using the same tactics, you’re on to something.

Elijah Markstrom is a health nut and fitness enthusiast.

Elijah spends an absurd amount of time combing over research papers, listening to field relevant podcast and generally being a geek, so you don’t have to!  With a discerning eye for separating crap from gold, he combs the interwebs looking for answers to common and obscure questions in health. This way he can provide you with results oriented precision. Read Elijah’s blog and you’ll get access to stories about practical application of science related to health. The topics covered on this site range from ketosis to race reports.

Together with Philip Levi, Elijah hosts the Obstacle Order podcast.

Here’s the outline of this interview with Elijah Markstrom

0:00:43    As a runner, Elijah competed at state level.

0:02:29    He gains fat and loses muscle when he stops working out.

0:05:29    The Endeavour Team Challenge.

0:06:47    Spartan race.

0:07:48    Three classes: elite, competitor and open.

0:08:34    Three distances: sprint, super and beast.

0:09:08    BattleFrog.

0:16:57    Since recording this podcast, I’ve realised that there’s a Pomodoro alarm built into my favourite app focus@will.

0:17:43    Endurance Planet podcast.

0:19:39    Cyclocross.

0:25:10    James Wilson.

0:26:37    Kettlebell windmill, swing and Turkish getup.

0:28:21    Plyometrics.

0:30:56    Rogue Fitness pull-up bar.

0:33:24    ReWild Yourself podcast by Daniel Vitalis.

0:34:03    MovNat.

0:36:58    John Mandrola.

0:41:19    The Obstacle Order on Facebook.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Elijah.Markstrom.on.2016-04-20.at.11.05.mp3 Thu, 28 Apr 2016 17:04:33 GMT Christopher Kelly I sit too much. When I’m not sitting at my desk, I’m sitting on my bike. As a mountain biker, I stand more than some cyclists, but still. The ways in which I move my body are predictable and very repetitive. I almost never move from side to side, and I expend vast amounts of energy spinning small circles with my feet. Have humans evolved to move like this? I doubt it. I know that if I’m not careful, I start to develop niggling lower back pain and piriformis syndrome.

Obstacle racing then, or at least the training for it, appeals to me because of the variety. The movement that elite Spartan racer Elijah Markstrom describes in this interview is a lot like what I think I need to do as a mountain biker looking to add variety to my workouts. James Wilson talked about similar exercises to improve strength and mobility previously on my podcast. When two people you respect talk about getting results using the same tactics, you’re on to something.

Elijah Markstrom is a health nut and fitness enthusiast.

Elijah spends an absurd amount of time combing over research papers, listening to field relevant podcast and generally being a geek, so you don’t have to!  With a discerning eye for separating crap from gold, he combs the interwebs looking for answers to common and obscure questions in health. This way he can provide you with results oriented precision. Read Elijah’s blog and you’ll get access to stories about practical application of science related to health. The topics covered on this site range from ketosis to race reports.

Together with Philip Levi, Elijah hosts the Obstacle Order podcast.

Here’s the outline of this interview with Elijah Markstrom

0:00:43    As a runner, Elijah competed at state level.

0:02:29    He gains fat and loses muscle when he stops working out.

0:05:29    The Endeavour Team Challenge.

0:06:47    Spartan race.

0:07:48    Three classes: elite, competitor and open.

0:08:34    Three distances: sprint, super and beast.

0:09:08    BattleFrog.

0:16:57    Since recording this podcast, I’ve realised that there’s a Pomodoro alarm built into my favourite app focus@will.

0:17:43    Endurance Planet podcast.

0:19:39    Cyclocross.

0:25:10    James Wilson.

0:26:37    Kettlebell windmill, swing and Turkish getup.

0:28:21    Plyometrics.

0:30:56    Rogue Fitness pull-up bar.

0:33:24    ReWild Yourself podcast by Daniel Vitalis.

0:34:03    MovNat.

0:36:58    John Mandrola.

0:41:19    The Obstacle Order on Facebook.

]]>
clean
ETP Certification Course for Coaches with Brad Dieter, Ph.D https://s3.amazonaws.com/nourishbalancethrive/podcast/Brad.Dieter.on.2016-04-13.at.08.14.mp3 Could you afford to spend $250,000 on an education? No, neither could I. How lucky are we then that people like Drs. Mike T. Nelson Ph.D. and Dr. Brad Dieter Ph.D are willing to distill what they’ve learned into a $250 training course? Over the past two years, I’ve done all kinds of biology, biochemistry, physiology, functional medicine, nutrition and fitness massively open online training courses and I’ve loved them all. Educators pour their heart and soul into these resources and we should take full advantage.

The Eat to Perform certification course covers the basic mechanisms of exercise physiology and the interactions between nutrition and human performance. The material is delivered via video and PDF and the exam is done online. A Facebook support group and lifetime updates are included in the price. Sign up now, it’s a steal!

Dr. Tommy Wood, my wife and food scientist Julia, and I have got together to create a hypoallergenic MCT oil powdered with a special bionic fibre. Find out more at phatfibre.com and let me know what you think.

Here’s the outline of this interview with Dr. Brad Dieter, Ph.D

0:05:16    Brad realised his skill set wasn't clinical, headed into research.

0:05:34    He has done human and animal research, molecular biology, biostatistical analysis.

0:06:55    Optimizing Vitamin D for Athletic Performance.

0:07:54    Over supplementing is not the answer.

0:08:43    There's no way you can know what the problem is unless you do a test.

0:08:49    ETP training course with lifetime updates!

0:13:29    Brad's approach for competitive CrossFit.

0:13:44    He starts by listening and figuring out the weak link.

0:14:41    Fat loss is the secondary goal.

0:18:48    Exercise to drive adaptation, not burn calories.

0:20:35    Calorie in calorie out is wrong?

0:21:48    Minimal effective dose.

0:23:49    The more novel the stimulus, the lower the minimal effective dose.

0:24:53    Supplements: creatine, beta-alanine and caffeine.

0:25:21    Whey protein, doesn't have to be whey, e.g. Catabolic Blocker.

0:25:58    I've written a bit about beta-alanine.

0:26:31    Smart Drug Smarts podcast with labdoor.com.

0:27:28    How much protein? 1g per pound of lean body mass is a reasonable default.

0:27:59    Alan Aragon 1g per lb of goal body weight.

0:28:16    Casually Explained: Lifting.

0:28:59    Brad see the ketogenic diet as a tool.

0:32:52    Sea Otter Classic 2016 Cross Country - Professional.

0:34:27    Bonking is a system fail.

0:34:51    Metabolic flexibility.

0:38:17    Energy systems are not mutually exclusive.

0:43:28    Do whatever you're weakest at first.

0:44:04    Joe Friel on my podcast.

0:45:09    How much difference does programming make?

0:45:59    James Wilson on my podcast.

0:48:03    sciencedrivennutrition.com.

0:49:04    Science Driven Nutrition Facebook page.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Brad.Dieter.on.2016-04-13.at.08.14.mp3 Fri, 22 Apr 2016 05:04:02 GMT Christopher Kelly Could you afford to spend $250,000 on an education? No, neither could I. How lucky are we then that people like Drs. Mike T. Nelson Ph.D. and Dr. Brad Dieter Ph.D are willing to distill what they’ve learned into a $250 training course? Over the past two years, I’ve done all kinds of biology, biochemistry, physiology, functional medicine, nutrition and fitness massively open online training courses and I’ve loved them all. Educators pour their heart and soul into these resources and we should take full advantage.

The Eat to Perform certification course covers the basic mechanisms of exercise physiology and the interactions between nutrition and human performance. The material is delivered via video and PDF and the exam is done online. A Facebook support group and lifetime updates are included in the price. Sign up now, it’s a steal!

Dr. Tommy Wood, my wife and food scientist Julia, and I have got together to create a hypoallergenic MCT oil powdered with a special bionic fibre. Find out more at phatfibre.com and let me know what you think.

Here’s the outline of this interview with Dr. Brad Dieter, Ph.D

0:05:16    Brad realised his skill set wasn't clinical, headed into research.

0:05:34    He has done human and animal research, molecular biology, biostatistical analysis.

0:06:55    Optimizing Vitamin D for Athletic Performance.

0:07:54    Over supplementing is not the answer.

0:08:43    There's no way you can know what the problem is unless you do a test.

0:08:49    ETP training course with lifetime updates!

0:13:29    Brad's approach for competitive CrossFit.

0:13:44    He starts by listening and figuring out the weak link.

0:14:41    Fat loss is the secondary goal.

0:18:48    Exercise to drive adaptation, not burn calories.

0:20:35    Calorie in calorie out is wrong?

0:21:48    Minimal effective dose.

0:23:49    The more novel the stimulus, the lower the minimal effective dose.

0:24:53    Supplements: creatine, beta-alanine and caffeine.

0:25:21    Whey protein, doesn't have to be whey, e.g. Catabolic Blocker.

0:25:58    I've written a bit about beta-alanine.

0:26:31    Smart Drug Smarts podcast with labdoor.com.

0:27:28    How much protein? 1g per pound of lean body mass is a reasonable default.

0:27:59    Alan Aragon 1g per lb of goal body weight.

0:28:16    Casually Explained: Lifting.

0:28:59    Brad see the ketogenic diet as a tool.

0:32:52    Sea Otter Classic 2016 Cross Country - Professional.

0:34:27    Bonking is a system fail.

0:34:51    Metabolic flexibility.

0:38:17    Energy systems are not mutually exclusive.

0:43:28    Do whatever you're weakest at first.

0:44:04    Joe Friel on my podcast.

0:45:09    How much difference does programming make?

0:45:59    James Wilson on my podcast.

0:48:03    sciencedrivennutrition.com.

0:49:04    Science Driven Nutrition Facebook page.

]]>
clean
How to Get Perfect Sleep with Dr. Kirk Parsley, MD https://s3.amazonaws.com/nourishbalancethrive/podcast/kirk.parsley.on.2016-04-05.at.07.32.mp3 “I’ll sleep when I’m dead,” so the lyric goes. If you don’t sleep you will be dead sooner is more true to life:

Sleep improves everything. I mean, literally everything. I've not found a single thing that I can't tie to sleep being a major component of. And if you aren't sleeping well, you're just at risk for more of anything bad. Anything bad.

--Dr. Kirk Parsley, MD, sleep expert and advisor to the Navy SEALs.

Selling sleep should be like selling sex, so why is it so hard for people to do? Two reasons:

  1. Humans are the only animals with electricity, and we’ve used it to maximal effect for disrupting our normal circadian rhythms. It’s not that people won’t sleep, the problem is they can’t sleep.
  2. Time is money and shift working is a sad fact of life.

The main thing you must do to get better sleep is appreciate its importance. I want you to buy into the idea of sleep and strive for it as you would any other goal. The rest is relatively straightforward, and that’s what Kirk and I cover in this podcast interview.

Supraphysiological testosterone.

Dr. Tommy Wood and I are constantly exploring supplements that boost testosterone, it’s one of our most frequently asked questions. Hormone replacement is usually not an option because almost everything you can think of is on the WADA banned substance list. What about herbs like Tribulus? Well perhaps, but neither herbs or HRT have the power of adequate sleep, and so that’s where we always start.

During this interview, Dr. Kirk Parsley, a former Navy SEAL himself, tells the story of one officer that increased his free testosterone by 500% simply by getting off the sleep drugs like Ambien and getting proper sleep. Another 42-year old went supraphysiological (above normal levels) using sleep alone.

What supplement should you take for more testosterone?

Easy. Take a nap. Taking a nap is probably your best bet for enhanced recovery and learning too:

I recommend to everyone to take naps even if you sleep perfectly. I take a nap every single day and I have for years and years and years. But definitely if you sleep sub-optimally, which means either you don't get great quality sleep or you don't get quite enough sleep, a nap is probably the best mitigation tool. But for what I do and for what you do and for what a lot of people do, we're in a super, super informationally dense age where we're completely overwhelmed by information.

The beauty of a nap is that you can consolidate memories in a nap and you can form what's called durable track memories which means that it's going from your working memory to short term memory into your long term memory. And this is true for physical exercise, physical muscle memory like riding a bicycle or doing jiu-jitsu or boxing, playing the piano, whatever that requires some sort of physical movement to be memorized and to become sort of automated.

Here’s the outline of this interview with Dr. Kirk Parsley

0:00:36    Kirk on Robb's podcast.

0:01:18    Robb and Kirk have attended multiple events together.

0:04:04    Like firefighters and pilots, SEALs are worried about losing their job.

0:04:57    Kirk was the SEAL confidant.

0:05:22    The SEALs can't be dependant on medicines or supplements.

0:05:41    Doctors learn how to classify and treat disease, not how to create health.

0:06:17    Normal symptoms (for an 80 year old).

0:07:02    As a physician to the SEALs, Kirk was able to get help from pretty much anyone.

0:07:56    9/11 happened and the SEALs started doing more work.

0:08:10    Now we have night vision.

0:08:22    Kirk investigated the idea of “adrenal fatigue”, had some success with treatment.

0:08:58    Ambien doesn’t help you get better sleep, it knocks you unconscious.

0:10:45    The SEALs kept asking for a supplement to save them the bother of shopping for individual supplements.

0:11:00    500% more free testosterone with better sleep!

0:11:11    No supplements, just sleep!

0:11:20    DHEA.

0:11:27    Zinc.

0:12:29    One 42 year old commanding officer developed supraphysiological testosterone by sleeping well.

0:12:53    Sleep decreases chronic inflammation and increases insulin sensitivity.

0:13:26    Kirk got out the military, started consulting.

0:13:59    This isn't just a SEAL problem.

0:15:45    Sleep improves everything.

0:16:28    Finding the most important thing is hard!

0:16:56    People are catching on.

0:17:15    The four pillars of health: Sleep, nutrition, movement, stress mitigation.

0:17:54    Sleep is not sexy.

0:19:39    Health optimisation to coin a phrase.

0:20:02    You don't have to be broken to get better.

0:21:10    Book: Textbook of Bio-Identical Hormones: Guiding Health in Uncertain Times by Edward Lichten, MD.

0:21:44    A protocol based on 98 lab markers.

0:21:57    If I can't say you have a disease, nothing is going to get covered by your insurance.

0:22:47    Trace elements, inflammation, AM cortisol.

0:23:12    Hormones and their precursors.

0:23:32    DHEA not sulfate.

0:23:56    Free androgen index.

0:24:11    In the 50s oestrogen wasn't high enough.

0:24:42    Kirk divides the year into quarters.

0:24:49    Q1 is lifestyle only.

0:25:28    No supplements until Q3.

0:25:56    No pharma until Q4.

0:26:08    Until you've idealized the lifestyle it's irresponsible to make any diagnosis.

0:26:20    Viagra for erectile dysfunction.

0:28:42    Somehow it's not ok to make money helping people.

0:29:28    Supplements are exactly that.

0:31:29    Zeitgeber.

0:32:04    Ultradian rhythm.

0:32:30    Suprachiasmatic nucleus.

0:33:10    Every single cell has a circadian clock.

0:34:14    Agile Health Coaching.

0:36:34    “Sleep hygiene” is a nebulous term.

0:37:23    Teaching yourself out of a job.

0:38:18    We used to use the sun.

0:38:26    Now we have electricity and time is money.

0:39:26    First step is value sleep.

0:40:22    Ganglion in the eye that do nothing except sense blue light/

0:40:38    Pineal gland.

0:40:42    Melatonin.

0:40:52    Adrenals keep us awake.

0:41:13    Aldosterone.

0:42:14    Wake and sleep promoting neurotransmitters.

0:42:33    That's 80% of circadian rhythm.

0:43:13    The neocortex allows us to interact with the environment.

0:43:35    GABA slows down the neocortex.

0:43:55    Altering the resting and or action potential of the neuron.

0:44:20    Feeling exhausted, having a second wind.

0:45:55    Sleep hygiene is simulating the light going away.

0:46:21    Body temp is a cue.

0:47:09    The bedroom is for sleep and sex only.

0:48:02    Dead man's handle metaphor.

0:49:53    Is the modern environment is survivable?

0:50:41    Distract yourself else your mind will go racing.

0:51:33    Notification hell.

0:52:15    People get freaked out without external stimulation.

0:52:51    Men tend to ruminate on the future, women look back on everything that went wrong.

0:54:41    Make a list.

0:54:54    You will be better after sleep!

0:55:40    Don't look at the clock

0:57:46    There’s no evidence of vitamin D at night causing a problem.

0:59:16    Sleep Cocktails is changing name.

0:59:42    All the SEALs got off Ambien

1:00:08    Vitamin K2.

1:03:59    Book: Take a Nap! Change Your Life by Mark Ehrman.

1:05:13    Double your learning speed with naps.

1:09:47    Can you have too much sleep?

1:12:09    Kirk’s website.

1:13:12    sleepcocktails.com

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/kirk.parsley.on.2016-04-05.at.07.32.mp3 Fri, 15 Apr 2016 06:04:16 GMT Christopher Kelly “I’ll sleep when I’m dead,” so the lyric goes. If you don’t sleep you will be dead sooner is more true to life:

Sleep improves everything. I mean, literally everything. I've not found a single thing that I can't tie to sleep being a major component of. And if you aren't sleeping well, you're just at risk for more of anything bad. Anything bad.

--Dr. Kirk Parsley, MD, sleep expert and advisor to the Navy SEALs.

Selling sleep should be like selling sex, so why is it so hard for people to do? Two reasons:

  1. Humans are the only animals with electricity, and we’ve used it to maximal effect for disrupting our normal circadian rhythms. It’s not that people won’t sleep, the problem is they can’t sleep.
  2. Time is money and shift working is a sad fact of life.

The main thing you must do to get better sleep is appreciate its importance. I want you to buy into the idea of sleep and strive for it as you would any other goal. The rest is relatively straightforward, and that’s what Kirk and I cover in this podcast interview.

Supraphysiological testosterone.

Dr. Tommy Wood and I are constantly exploring supplements that boost testosterone, it’s one of our most frequently asked questions. Hormone replacement is usually not an option because almost everything you can think of is on the WADA banned substance list. What about herbs like Tribulus? Well perhaps, but neither herbs or HRT have the power of adequate sleep, and so that’s where we always start.

During this interview, Dr. Kirk Parsley, a former Navy SEAL himself, tells the story of one officer that increased his free testosterone by 500% simply by getting off the sleep drugs like Ambien and getting proper sleep. Another 42-year old went supraphysiological (above normal levels) using sleep alone.

What supplement should you take for more testosterone?

Easy. Take a nap. Taking a nap is probably your best bet for enhanced recovery and learning too:

I recommend to everyone to take naps even if you sleep perfectly. I take a nap every single day and I have for years and years and years. But definitely if you sleep sub-optimally, which means either you don't get great quality sleep or you don't get quite enough sleep, a nap is probably the best mitigation tool. But for what I do and for what you do and for what a lot of people do, we're in a super, super informationally dense age where we're completely overwhelmed by information.

The beauty of a nap is that you can consolidate memories in a nap and you can form what's called durable track memories which means that it's going from your working memory to short term memory into your long term memory. And this is true for physical exercise, physical muscle memory like riding a bicycle or doing jiu-jitsu or boxing, playing the piano, whatever that requires some sort of physical movement to be memorized and to become sort of automated.

Here’s the outline of this interview with Dr. Kirk Parsley

0:00:36    Kirk on Robb's podcast.

0:01:18    Robb and Kirk have attended multiple events together.

0:04:04    Like firefighters and pilots, SEALs are worried about losing their job.

0:04:57    Kirk was the SEAL confidant.

0:05:22    The SEALs can't be dependant on medicines or supplements.

0:05:41    Doctors learn how to classify and treat disease, not how to create health.

0:06:17    Normal symptoms (for an 80 year old).

0:07:02    As a physician to the SEALs, Kirk was able to get help from pretty much anyone.

0:07:56    9/11 happened and the SEALs started doing more work.

0:08:10    Now we have night vision.

0:08:22    Kirk investigated the idea of “adrenal fatigue”, had some success with treatment.

0:08:58    Ambien doesn’t help you get better sleep, it knocks you unconscious.

0:10:45    The SEALs kept asking for a supplement to save them the bother of shopping for individual supplements.

0:11:00    500% more free testosterone with better sleep!

0:11:11    No supplements, just sleep!

0:11:20    DHEA.

0:11:27    Zinc.

0:12:29    One 42 year old commanding officer developed supraphysiological testosterone by sleeping well.

0:12:53    Sleep decreases chronic inflammation and increases insulin sensitivity.

0:13:26    Kirk got out the military, started consulting.

0:13:59    This isn't just a SEAL problem.

0:15:45    Sleep improves everything.

0:16:28    Finding the most important thing is hard!

0:16:56    People are catching on.

0:17:15    The four pillars of health: Sleep, nutrition, movement, stress mitigation.

0:17:54    Sleep is not sexy.

0:19:39    Health optimisation to coin a phrase.

0:20:02    You don't have to be broken to get better.

0:21:10    Book: Textbook of Bio-Identical Hormones: Guiding Health in Uncertain Times by Edward Lichten, MD.

0:21:44    A protocol based on 98 lab markers.

0:21:57    If I can't say you have a disease, nothing is going to get covered by your insurance.

0:22:47    Trace elements, inflammation, AM cortisol.

0:23:12    Hormones and their precursors.

0:23:32    DHEA not sulfate.

0:23:56    Free androgen index.

0:24:11    In the 50s oestrogen wasn't high enough.

0:24:42    Kirk divides the year into quarters.

0:24:49    Q1 is lifestyle only.

0:25:28    No supplements until Q3.

0:25:56    No pharma until Q4.

0:26:08    Until you've idealized the lifestyle it's irresponsible to make any diagnosis.

0:26:20    Viagra for erectile dysfunction.

0:28:42    Somehow it's not ok to make money helping people.

0:29:28    Supplements are exactly that.

0:31:29    Zeitgeber.

0:32:04    Ultradian rhythm.

0:32:30    Suprachiasmatic nucleus.

0:33:10    Every single cell has a circadian clock.

0:34:14    Agile Health Coaching.

0:36:34    “Sleep hygiene” is a nebulous term.

0:37:23    Teaching yourself out of a job.

0:38:18    We used to use the sun.

0:38:26    Now we have electricity and time is money.

0:39:26    First step is value sleep.

0:40:22    Ganglion in the eye that do nothing except sense blue light/

0:40:38    Pineal gland.

0:40:42    Melatonin.

0:40:52    Adrenals keep us awake.

0:41:13    Aldosterone.

0:42:14    Wake and sleep promoting neurotransmitters.

0:42:33    That's 80% of circadian rhythm.

0:43:13    The neocortex allows us to interact with the environment.

0:43:35    GABA slows down the neocortex.

0:43:55    Altering the resting and or action potential of the neuron.

0:44:20    Feeling exhausted, having a second wind.

0:45:55    Sleep hygiene is simulating the light going away.

0:46:21    Body temp is a cue.

0:47:09    The bedroom is for sleep and sex only.

0:48:02    Dead man's handle metaphor.

0:49:53    Is the modern environment is survivable?

0:50:41    Distract yourself else your mind will go racing.

0:51:33    Notification hell.

0:52:15    People get freaked out without external stimulation.

0:52:51    Men tend to ruminate on the future, women look back on everything that went wrong.

0:54:41    Make a list.

0:54:54    You will be better after sleep!

0:55:40    Don't look at the clock

0:57:46    There’s no evidence of vitamin D at night causing a problem.

0:59:16    Sleep Cocktails is changing name.

0:59:42    All the SEALs got off Ambien

1:00:08    Vitamin K2.

1:03:59    Book: Take a Nap! Change Your Life by Mark Ehrman.

1:05:13    Double your learning speed with naps.

1:09:47    Can you have too much sleep?

1:12:09    Kirk’s website.

1:13:12    sleepcocktails.com

]]>
no
The Essential Keto Cookbook https://s3.amazonaws.com/nourishbalancethrive/podcast/Jeremy.Hendon.on.2016-03-30.at.07.03.mp3 Ketogenic junk food is coming, and it threatens to send the second low-carbohydrate revolution to the same place the first one ended up. That would be a terrible shame because high-fat, low-carb, moderate protein diets have so much to offer for weight loss, metabolic syndrome, athletic and cognitive performance, possibly even cancer.

What can we do? Learn to cook. Prioritise food preparation. Just eat real food.

Jeremy Hendon is an author, speaker, entrepreneur, digital nomad, friend, mentor and co-author of The Essential Keto Cookbook. I wrote the foreword to the book, and the day before Jeremy and I recorded this interview, my wife Julia made two of the recipes.

Pork and Cashew Stir-Fry

INGREDIENTS

  • 1/2 lb (225 g) pork tenderloin, sliced thin
  • 1 egg, whisked
  • 1 bell pepper, diced
  • 1 onion, diced
  • 1 cup (140 g) cashews
  • 1 Tablespoon (5 g) fresh ginger, grated
  • 3 cloves of garlic, minced
  • 1 teaspoon (5 ml) Chinese chili oil (see page 185 for recipe) (optional)
  • 1 Tablespoon (15 ml) sesame oil (optional)
  • 2 Tablespoons (30 ml) tamari soy sauce
  • Salt to taste
  • Avocado oil to cook with

Kale and Chives Egg Muffins

INGREDIENTS

  • 6 eggs
  • 1 cup kale, finely chopped
  • 1/4 cup (17 g) chives, finely chopped
  • 1/2 cup (120 ml) almond or coconut milk
  • Salt and pepper to taste
  • 8 slices of prosciutto or bacon (optional)

Here’s the outline of this interview with Jeremy Hendon

0:00:52    Jeremy has been travelling with his wife Louise in China, Portugal, Taiwan, Thailand, Scotland, France, US.

0:03:04    The Hendons are really good at distilling things down.

0:03:47    It's better to establish a base, cook for yourself.

0:04:35    In Thailand they cook in coconut and olive oil.

0:04:49    Tea eggs.

0:05:08    It's hard to get vegetables in northern Thailand.

0:05:33    You may run out of willpower.

0:06:09    Telling a server that you have an allergy is a good way to make sure you don't eat anything you'd rather not.

0:06:30    Vacuum sealer bags.

0:07:01    It makes more sense to take your time for other reasons.

0:07:40    Observing modern culture.

0:07:54    The Essential Keto Cookbook: 124+ Ketogenic Diet Recipes (Including Keto Meal Plan & Food List).

0:08:09    Working coffee shops and wifi in the apartment.

0:08:15    Going through phases of working hard.

0:08:32    Coworking space.

0:08:48    Internet in Thailand is 200M down 100 up.

0:09:12    Louise is a great photographer.

0:09:29    The photos were taken abroad.

0:11:13    It's hard to remember that you're always going to be ok.

0:11:48    The risk afford certain privileges.

0:12:06    The Anxiety Podcast — Less Anxiety. More Life.

0:12:56    Nobody seems to have a good answer for stress.

0:13:23    A lot more stress working as an attorney.

0:13:43    Jeremy loved working with Goldman Sachs.

0:14:43    Serotonin binding to 5-HT4 receptor causes anxiety, tachycardia and cortisol production.

0:15:52    Jeremy has been low carb since 2004.

0:16:20    Was running 60 miles a week.

0:16:52    If you're trying to lose weight, low carb is the default thing to try.

0:17:18    Lots of people have been asking for this book.

0:17:48    Debug Me. My talk at QCon SF.

0:19:41    More and more executives are discovering the keto diet.

0:20:15    Younger people seem more up for it.

0:20:34    Louise loves keto.

0:20:54    As do older women.

0:23:19    The ketogenic diet is a hormetic stress at first.

0:23:53    There are other stressors that might make it an inappropriate time to transition to a ketogenic diet.

0:24:42    Switching back and forth.

0:24:52    Breaking Through Plateaus and Sustainable Fat-Loss with Jason Seib.

0:26:07    AltShift Facebook group.

0:26:47    Lactate dehydrogenase is part of anaerobic glycolysis.

0:27:01    I said 20 minute I meant second.

0:27:44    Leptin and Hyperpalatable Foods with Stephan Guyenet.

0:28:25    Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes

0:30:24    Initially I lost a lot of weight on a ketogenic diet, but how much of that was muscle?

0:30:52    Jeremy turned up at our house looking shredded.

0:30:59    14 day cycle.

0:31:27    Not being hungry during calorie restriction

0:33:42    Overfeeding studies show subjects gain muscle as well as fat.

0:34:59    If bodybuilders are doing it, it warrants further investigation!

0:36:05    Creating huge calorie deficits on the bike.

0:37:03    DXA scan.

0:37:41    Keto junk food.

0:39:12    Ketogenic paleo?

0:39:54    All popular diet books are paleo, even they don't say so.

0:42:32    Pork and cashew stir fry.

0:43:37    Overlooking vitamins.

0:44:10    Cronometer.

0:45:00    The recommended daily allowance (RDA) mean almost nothing.

0:45:28    Getting sufficient magnesium can be hard.

0:45:30    Possibly calcium.

0:46:06    Spectracell test.

0:46:24    How to Measure Your Metabolism with Organic Acids.

0:46:36    NutrEval test.

0:46:56    Alkaline phosphatase.

0:48:08    Artificial Intelligence for blood chemistry interpretation.

0:48:36    The Secret of Good Health Coaching with Bryan Walsh.

0:50:22    Daniel Amen.

0:50:30    Watson.

0:53:37    Functional blood chemistry analysis.

0:55:18    MediChecks UK.

0:55:38    Theranos.

0:56:57    Kale and chive egg muffins.

0:57:31    The book is top 600 in kindle books.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Jeremy.Hendon.on.2016-03-30.at.07.03.mp3 Thu, 07 Apr 2016 20:04:36 GMT Christopher Kelly Ketogenic junk food is coming, and it threatens to send the second low-carbohydrate revolution to the same place the first one ended up. That would be a terrible shame because high-fat, low-carb, moderate protein diets have so much to offer for weight loss, metabolic syndrome, athletic and cognitive performance, possibly even cancer.

What can we do? Learn to cook. Prioritise food preparation. Just eat real food.

Jeremy Hendon is an author, speaker, entrepreneur, digital nomad, friend, mentor and co-author of The Essential Keto Cookbook. I wrote the foreword to the book, and the day before Jeremy and I recorded this interview, my wife Julia made two of the recipes.

Pork and Cashew Stir-Fry

INGREDIENTS

  • 1/2 lb (225 g) pork tenderloin, sliced thin
  • 1 egg, whisked
  • 1 bell pepper, diced
  • 1 onion, diced
  • 1 cup (140 g) cashews
  • 1 Tablespoon (5 g) fresh ginger, grated
  • 3 cloves of garlic, minced
  • 1 teaspoon (5 ml) Chinese chili oil (see page 185 for recipe) (optional)
  • 1 Tablespoon (15 ml) sesame oil (optional)
  • 2 Tablespoons (30 ml) tamari soy sauce
  • Salt to taste
  • Avocado oil to cook with

Kale and Chives Egg Muffins

INGREDIENTS

  • 6 eggs
  • 1 cup kale, finely chopped
  • 1/4 cup (17 g) chives, finely chopped
  • 1/2 cup (120 ml) almond or coconut milk
  • Salt and pepper to taste
  • 8 slices of prosciutto or bacon (optional)

Here’s the outline of this interview with Jeremy Hendon

0:00:52    Jeremy has been travelling with his wife Louise in China, Portugal, Taiwan, Thailand, Scotland, France, US.

0:03:04    The Hendons are really good at distilling things down.

0:03:47    It's better to establish a base, cook for yourself.

0:04:35    In Thailand they cook in coconut and olive oil.

0:04:49    Tea eggs.

0:05:08    It's hard to get vegetables in northern Thailand.

0:05:33    You may run out of willpower.

0:06:09    Telling a server that you have an allergy is a good way to make sure you don't eat anything you'd rather not.

0:06:30    Vacuum sealer bags.

0:07:01    It makes more sense to take your time for other reasons.

0:07:40    Observing modern culture.

0:07:54    The Essential Keto Cookbook: 124+ Ketogenic Diet Recipes (Including Keto Meal Plan & Food List).

0:08:09    Working coffee shops and wifi in the apartment.

0:08:15    Going through phases of working hard.

0:08:32    Coworking space.

0:08:48    Internet in Thailand is 200M down 100 up.

0:09:12    Louise is a great photographer.

0:09:29    The photos were taken abroad.

0:11:13    It's hard to remember that you're always going to be ok.

0:11:48    The risk afford certain privileges.

0:12:06    The Anxiety Podcast — Less Anxiety. More Life.

0:12:56    Nobody seems to have a good answer for stress.

0:13:23    A lot more stress working as an attorney.

0:13:43    Jeremy loved working with Goldman Sachs.

0:14:43    Serotonin binding to 5-HT4 receptor causes anxiety, tachycardia and cortisol production.

0:15:52    Jeremy has been low carb since 2004.

0:16:20    Was running 60 miles a week.

0:16:52    If you're trying to lose weight, low carb is the default thing to try.

0:17:18    Lots of people have been asking for this book.

0:17:48    Debug Me. My talk at QCon SF.

0:19:41    More and more executives are discovering the keto diet.

0:20:15    Younger people seem more up for it.

0:20:34    Louise loves keto.

0:20:54    As do older women.

0:23:19    The ketogenic diet is a hormetic stress at first.

0:23:53    There are other stressors that might make it an inappropriate time to transition to a ketogenic diet.

0:24:42    Switching back and forth.

0:24:52    Breaking Through Plateaus and Sustainable Fat-Loss with Jason Seib.

0:26:07    AltShift Facebook group.

0:26:47    Lactate dehydrogenase is part of anaerobic glycolysis.

0:27:01    I said 20 minute I meant second.

0:27:44    Leptin and Hyperpalatable Foods with Stephan Guyenet.

0:28:25    Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes

0:30:24    Initially I lost a lot of weight on a ketogenic diet, but how much of that was muscle?

0:30:52    Jeremy turned up at our house looking shredded.

0:30:59    14 day cycle.

0:31:27    Not being hungry during calorie restriction

0:33:42    Overfeeding studies show subjects gain muscle as well as fat.

0:34:59    If bodybuilders are doing it, it warrants further investigation!

0:36:05    Creating huge calorie deficits on the bike.

0:37:03    DXA scan.

0:37:41    Keto junk food.

0:39:12    Ketogenic paleo?

0:39:54    All popular diet books are paleo, even they don't say so.

0:42:32    Pork and cashew stir fry.

0:43:37    Overlooking vitamins.

0:44:10    Cronometer.

0:45:00    The recommended daily allowance (RDA) mean almost nothing.

0:45:28    Getting sufficient magnesium can be hard.

0:45:30    Possibly calcium.

0:46:06    Spectracell test.

0:46:24    How to Measure Your Metabolism with Organic Acids.

0:46:36    NutrEval test.

0:46:56    Alkaline phosphatase.

0:48:08    Artificial Intelligence for blood chemistry interpretation.

0:48:36    The Secret of Good Health Coaching with Bryan Walsh.

0:50:22    Daniel Amen.

0:50:30    Watson.

0:53:37    Functional blood chemistry analysis.

0:55:18    MediChecks UK.

0:55:38    Theranos.

0:56:57    Kale and chive egg muffins.

0:57:31    The book is top 600 in kindle books.

]]>
clean
Is Evidence Based Medicine a Movement in Crisis? https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-03-22.at.10.15.mp3 In my early twenties, I tore a carotid artery out of my neck in a motorcycle accident. The emergency procedure that followed undoubtedly saved my life and from that point forward I had no time to listen to people complaining about the limitations of the nationalised health care that exists in the UK. In my thirties, the same system of evidence-based medicine let me down badly, and in the end, it was a chiropractor who describes himself as “the least evidence-driven person he knows” that turned my life around.

Now I’m slightly confused. I am aware that the evidence-based system has a lot to offer, but I don’t feel I can use it effectively without the assistance of someone like Dr. Tommy Wood. Why?

The system is in crisis.

The system is in crisis in part because of the sheer volume of evidence being generated, much of which is unreproducible or misappropriated by vested interests. Building a meta-analysis atop of this shoddy foundation does little to clarify the situation.

Animal and cell models.

Are used as supporting evidence but frequently what happens outside of the body or in another animal has little or nothing to do with what happens in humans in a real-life setting. The models are becoming cheap enough for scientists to make multiple attempts at finding the “correct” answer, and much of the data are never published.

Lies, damned lies, and statistics.

You cannot prove something to be true using statistical methods.

Science advances one funeral at a time.

Handing out a grant to the young and inexperienced is a risky thing to do, and so inevitably the money follows experience. But imagine if your entire life’s work was based on ideas that were later shown to be wrong. Would you come clean?

In this candid interview with Dr. Tommy Wood.

Tommy talks about the limitations of the evidence-based system, but his intention is not to throw science under the bus. Rather, he wants us all to understand the limitations and proceed with caution. As a scientist that does peer review for a living, Tommy’s goal is to leave science in better shape than he found it.

Since recording this interview, we have adopted the Agile Scrum sprint system of health coaching.

And it’s going great! We’re excited about the new system, and the first health sprints are underway. I’m still very keen to know what you think about the idea, so please complete the one question (three clicks total) survey I mention in the show.

Survey: The scrum and sprint Agile methods are applicable to health coaching.

Here’s the outline of this interview with Dr. Tommy Wood

0:00:15    The main paper from Tommy’s PhD thesis: Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.

0:01:28    Newborn babies with brain injury.

0:02:20    The cooling is only 2 or 3 degrees.

0:02:33    What's the best temperature?

0:03:28    Figure 1: Hemispheric area loss after moderate hypoxia-ischaemia.

0:04:01    Richard D. Feinman: “Nobody loses an average amount of weight.”

0:04:49    Tommy may sound anti-science, but this is what he does for a living and he hopes to leave science in a better state than when he left it.

0:06:04    People are selective about the studies they choose to dismantle.

0:06:39    The Cochrane Collaboration.

0:07:04    Cochrane do systematic reviews and meta-analysis.

0:07:37    The meta-analysis is only as good as the studies on which it's based.

0:08:13    Publication bias is a problem.

0:08:58    Anyone can learn how to do a Cochrane review.

0:09:32    Questionable discussion: Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials.

0:09:55    Tommy’s letter: The cardiovascular risk reduction benefits of a low-carbohydrate diet outweigh the potential increase in LDL-cholesterol.

0:10:47    Self-appointed expert that cannot be wrong.

0:12:11    The are a number of different funding sources.

0:13:20    It's less risky to give money to the more experienced.

0:13:35    Max Planck: “Science advances one funeral at a time.”

0:14:29    We don't know what people are doing but not publishing.

0:15:04    Cell and animal models enable you to make multiple attempts without publishing.

0:15:31    Statistics never prove anything to be true.

0:15:51    The emphasis is on new things that sound sexy.

0:16:30    One editor questioned Tommy’s animal model when a human trial was underway.

0:17:30    Papers are retracted from big journals.

0:18:27    In finance this is called backfitting.

0:19:05    How can we expect the animal model to translate to humans?

0:19:34    Most animal models don't reflect what happens in humans at all.

0:20:03    1,026 experimental treatments in acute stroke.

0:20:58    Tommy's study was a model of something that we know works in humans and other animals.

0:22:17    Because he started with the basics, Tommy is confident this work will extrapolate to humans.

0:22:59    Should consumers of science be interested in cell and animal models?

0:23:06    Tommy finds it very difficult to get excited about a mouse study.

0:23:13    There are some genetic mutations that cause Alzheimer's very young.

0:23:29    These do not translate well into humans.

0:23:48    Genomic responses in mouse models poorly mimic human inflammatory diseases.

0:24:54    The immune system is particularly complex and difficult.

0:25:41    Don't take supplements based on studies done in rats!

0:26:01    Spirulina for detox.

0:26:48    This is not even remotely close to what's going on inside a living human.

0:27:30    It's easier than ever before to get access to the science.

0:29:06    As a computer scientist, I've never done science.

0:29:43    Spend time on the basics.

0:30:28    Abraham Lincoln? “Give me six hours to chop down a tree, and I will spend four hours sharpening the axe."

0:31:17    Dr. Dan Kalish describes himself as not being evidence-driven but he still gets fantastic results.

0:31:47    Do we need to be 100% evidence-based?

0:32:04    Why Most Published Research Findings Are False.

0:32:33    Evidence based medicine: a movement in crisis?

0:32:48    Evidence-based as a starting point, not a wall of protection.

0:33:54    Anecdote is the lowest form of evidence.

0:35:52    There's no protocol for debugging a computer program but there is a system.

0:37:06    Our plans are evidence-based, but some of the newer supplements lack data.

0:37:57    My swipe file is getting out of control.

0:38:59    Gary Ralston Consulting.

0:39:07    Agile project management.

0:39:28    Could the same system work for health coaching?

0:39:53    The traditional Waterfall model.

0:41:23    Please let me know if this is a good idea.

0:41:57    I've been using Zoom.

0:42:18    Our kanban board has four columns, Todo, Doing, Review, and Done.

0:47:11    Podcast on organic acids.

0:47:49    The year one cost of our programme costs around $8,000. For the performance and longevity orientated, the cost per year thereafter is about $5,000.

0:51:18    The stool tests are not perfect, sometimes the Doctor’s Data test comes up trumps, sometimes BioHealth is best.

0:51:29    The GI-MAP™ stool test.

0:51:44    Our programme is about the cost of a mountain bike.

0:52:09    But the testing will make you faster!

0:52:49    If you're not completely happy in 8 months I will refund all of the money you spent on my time.

0:55:16    Initial round of testing and then we retest.

0:55:38    This adds accountability.

0:56:24    Agile also adds accountability.

0:57:58    My last round of testing found a blasto infection, yeast and clostridial overgrowth, b6 and carnitine deficiency.

0:58:36    How long does insulin resistance takes to happen?

0:58:55    Insulin resistance can start in your 20s and 30s.

0:59:38    Total maintenance costs.

1:00:10    $1,500 a year on supplements.

1:01:02    The people spending the most money are also the most engaged.

1:01:36    Trying too many things at once can be a problem.

1:02:19    We concentrate on teaching.

1:03:27    Podcast on the FDN training course.

1:03:57    Chet Morjaria: Coach and Director of Editorial at Breaking Muscle.

1:04:03    The best coach should be trying to work herself out of a job.

1:05:20    Getting people to pay for all of my time can be challenging.

1:05:44    The tests are more expensive on directlabs.com.

1:06:21    You can't make a living selling supplements.

1:06:23    More recently I've been charging $250 an hour for my time, but I don't bill for as much time as I spend.

1:07:00    We do lots of work on the backend but I only bill for 30 minutes of my time.

1:08:04    Dripping tests onto people.

1:08:29    If you'd like to do just one test, please order it soon!

1:10:23    We haven't made any money but we are having fun.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2016-03-22.at.10.15.mp3 Fri, 01 Apr 2016 07:04:27 GMT Christopher Kelly In my early twenties, I tore a carotid artery out of my neck in a motorcycle accident. The emergency procedure that followed undoubtedly saved my life and from that point forward I had no time to listen to people complaining about the limitations of the nationalised health care that exists in the UK. In my thirties, the same system of evidence-based medicine let me down badly, and in the end, it was a chiropractor who describes himself as “the least evidence-driven person he knows” that turned my life around.

Now I’m slightly confused. I am aware that the evidence-based system has a lot to offer, but I don’t feel I can use it effectively without the assistance of someone like Dr. Tommy Wood. Why?

The system is in crisis.

The system is in crisis in part because of the sheer volume of evidence being generated, much of which is unreproducible or misappropriated by vested interests. Building a meta-analysis atop of this shoddy foundation does little to clarify the situation.

Animal and cell models.

Are used as supporting evidence but frequently what happens outside of the body or in another animal has little or nothing to do with what happens in humans in a real-life setting. The models are becoming cheap enough for scientists to make multiple attempts at finding the “correct” answer, and much of the data are never published.

Lies, damned lies, and statistics.

You cannot prove something to be true using statistical methods.

Science advances one funeral at a time.

Handing out a grant to the young and inexperienced is a risky thing to do, and so inevitably the money follows experience. But imagine if your entire life’s work was based on ideas that were later shown to be wrong. Would you come clean?

In this candid interview with Dr. Tommy Wood.

Tommy talks about the limitations of the evidence-based system, but his intention is not to throw science under the bus. Rather, he wants us all to understand the limitations and proceed with caution. As a scientist that does peer review for a living, Tommy’s goal is to leave science in better shape than he found it.

Since recording this interview, we have adopted the Agile Scrum sprint system of health coaching.

And it’s going great! We’re excited about the new system, and the first health sprints are underway. I’m still very keen to know what you think about the idea, so please complete the one question (three clicks total) survey I mention in the show.

Survey: The scrum and sprint Agile methods are applicable to health coaching.

Here’s the outline of this interview with Dr. Tommy Wood

0:00:15    The main paper from Tommy’s PhD thesis: Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.

0:01:28    Newborn babies with brain injury.

0:02:20    The cooling is only 2 or 3 degrees.

0:02:33    What's the best temperature?

0:03:28    Figure 1: Hemispheric area loss after moderate hypoxia-ischaemia.

0:04:01    Richard D. Feinman: “Nobody loses an average amount of weight.”

0:04:49    Tommy may sound anti-science, but this is what he does for a living and he hopes to leave science in a better state than when he left it.

0:06:04    People are selective about the studies they choose to dismantle.

0:06:39    The Cochrane Collaboration.

0:07:04    Cochrane do systematic reviews and meta-analysis.

0:07:37    The meta-analysis is only as good as the studies on which it's based.

0:08:13    Publication bias is a problem.

0:08:58    Anyone can learn how to do a Cochrane review.

0:09:32    Questionable discussion: Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials.

0:09:55    Tommy’s letter: The cardiovascular risk reduction benefits of a low-carbohydrate diet outweigh the potential increase in LDL-cholesterol.

0:10:47    Self-appointed expert that cannot be wrong.

0:12:11    The are a number of different funding sources.

0:13:20    It's less risky to give money to the more experienced.

0:13:35    Max Planck: “Science advances one funeral at a time.”

0:14:29    We don't know what people are doing but not publishing.

0:15:04    Cell and animal models enable you to make multiple attempts without publishing.

0:15:31    Statistics never prove anything to be true.

0:15:51    The emphasis is on new things that sound sexy.

0:16:30    One editor questioned Tommy’s animal model when a human trial was underway.

0:17:30    Papers are retracted from big journals.

0:18:27    In finance this is called backfitting.

0:19:05    How can we expect the animal model to translate to humans?

0:19:34    Most animal models don't reflect what happens in humans at all.

0:20:03    1,026 experimental treatments in acute stroke.

0:20:58    Tommy's study was a model of something that we know works in humans and other animals.

0:22:17    Because he started with the basics, Tommy is confident this work will extrapolate to humans.

0:22:59    Should consumers of science be interested in cell and animal models?

0:23:06    Tommy finds it very difficult to get excited about a mouse study.

0:23:13    There are some genetic mutations that cause Alzheimer's very young.

0:23:29    These do not translate well into humans.

0:23:48    Genomic responses in mouse models poorly mimic human inflammatory diseases.

0:24:54    The immune system is particularly complex and difficult.

0:25:41    Don't take supplements based on studies done in rats!

0:26:01    Spirulina for detox.

0:26:48    This is not even remotely close to what's going on inside a living human.

0:27:30    It's easier than ever before to get access to the science.

0:29:06    As a computer scientist, I've never done science.

0:29:43    Spend time on the basics.

0:30:28    Abraham Lincoln? “Give me six hours to chop down a tree, and I will spend four hours sharpening the axe."

0:31:17    Dr. Dan Kalish describes himself as not being evidence-driven but he still gets fantastic results.

0:31:47    Do we need to be 100% evidence-based?

0:32:04    Why Most Published Research Findings Are False.

0:32:33    Evidence based medicine: a movement in crisis?

0:32:48    Evidence-based as a starting point, not a wall of protection.

0:33:54    Anecdote is the lowest form of evidence.

0:35:52    There's no protocol for debugging a computer program but there is a system.

0:37:06    Our plans are evidence-based, but some of the newer supplements lack data.

0:37:57    My swipe file is getting out of control.

0:38:59    Gary Ralston Consulting.

0:39:07    Agile project management.

0:39:28    Could the same system work for health coaching?

0:39:53    The traditional Waterfall model.

0:41:23    Please let me know if this is a good idea.

0:41:57    I've been using Zoom.

0:42:18    Our kanban board has four columns, Todo, Doing, Review, and Done.

0:47:11    Podcast on organic acids.

0:47:49    The year one cost of our programme costs around $8,000. For the performance and longevity orientated, the cost per year thereafter is about $5,000.

0:51:18    The stool tests are not perfect, sometimes the Doctor’s Data test comes up trumps, sometimes BioHealth is best.

0:51:29    The GI-MAP™ stool test.

0:51:44    Our programme is about the cost of a mountain bike.

0:52:09    But the testing will make you faster!

0:52:49    If you're not completely happy in 8 months I will refund all of the money you spent on my time.

0:55:16    Initial round of testing and then we retest.

0:55:38    This adds accountability.

0:56:24    Agile also adds accountability.

0:57:58    My last round of testing found a blasto infection, yeast and clostridial overgrowth, b6 and carnitine deficiency.

0:58:36    How long does insulin resistance takes to happen?

0:58:55    Insulin resistance can start in your 20s and 30s.

0:59:38    Total maintenance costs.

1:00:10    $1,500 a year on supplements.

1:01:02    The people spending the most money are also the most engaged.

1:01:36    Trying too many things at once can be a problem.

1:02:19    We concentrate on teaching.

1:03:27    Podcast on the FDN training course.

1:03:57    Chet Morjaria: Coach and Director of Editorial at Breaking Muscle.

1:04:03    The best coach should be trying to work herself out of a job.

1:05:20    Getting people to pay for all of my time can be challenging.

1:05:44    The tests are more expensive on directlabs.com.

1:06:21    You can't make a living selling supplements.

1:06:23    More recently I've been charging $250 an hour for my time, but I don't bill for as much time as I spend.

1:07:00    We do lots of work on the backend but I only bill for 30 minutes of my time.

1:08:04    Dripping tests onto people.

1:08:29    If you'd like to do just one test, please order it soon!

1:10:23    We haven't made any money but we are having fun.

]]>
clean
What's in Your Supplement? https://s3.amazonaws.com/nourishbalancethrive/podcast/Mario.Roxas.ND.02242016.mp3 Imagine you’re in the pub and you’ve just bumped into your friend Mario Roxas. Mario happens to be a naturopathic doctor and the director of research and development at Thorne, the Rolls Royce of supplement companies. Wouldn’t you want to know what supplements Mario takes? Me too, and so I couldn’t resist making that my first question.

But what is it that makes Thorne Research different? Why not buy your supplements from Costco? Two reasons: research and quality. Thorne employ a team of medical and naturopathic doctor scientists that spend their time studying the scientific literature on the lookout for evidence supporting the decision to manufacturer a specific supplement. Secondly, there’s quality. Thorne cater to the sensitive customer likely to experience allergic reactions. The raw materials used to make a supplement originate from trusted sources, but Thorne validate the content of all their supplements no less than three times during the manufacturing process. Surprisingly, the FDA laws only require a supplement manufacturer to list the ingredients they added to the supplement, and there’s no guarantee that one or more of the raw ingredients used are free of potential allergens like lactose even though they’re not listed on the label.

Are big supplement companies any different from big pharma?

Allopathic medicine is often accused of being bought, but what makes alternative any different? Are the naturopathic doctors simply prescribing Meriva in place of Humira? I would argue no, absolutely not, and the proof is in the name supplement. As Mario points out, supplement is the perfect word. You can’t supplement your way out of a bad diet or lifestyle, and so the supplement is but one tool in the extensive chest of a good functional medicine practitioner.

Three years ago I had never taken a nutritional supplement.

Now I have a cupboard full of them. The reason is simple: they work. I used to take regularly chlorpheniramine for allergies. Killing off overgrowths of opportunistic pathogens and parasites with herbs like oregano and noni got me most of the way there, now I stay symptom-free by regularly supplementing with methyl-folate. The supplement didn’t just mask my symptoms; it corrected a deficiency and as a result, my red blood cells have become normal sized.

Adverse events?

Do you know of someone who had a serious adverse event as the result of taking a nutritional supplement free of contaminants? I don’t think this happens very often, if at all. Please let me know in the comments section below.

Here’s the outline of this interview with Dr Mario Roxas, ND

0:00:42    Mario became interested in supplements whilst a resident at the National College of Natural Medicine.

0:02:12    Thorne Research are the Rolls Royce of supplements.

0:02:58    Mario takes the Basic Nutrients 2/day multivitamin.

0:03:15    Together with LipoCardia®, CoQ10, fish oil and NiaCel®.

0:03:58    Whey protein in a smoothie.

0:04:35    Interview with Bob Rountree on mitochondrial health.

0:05:15    Supplement design starts with research.

0:06:09    Thorne has a team of scientists and doctors, NDs, MDs and PhDs.

0:07:48    The product development cycle for nicotinamide riboside lasted two years.

0:08:43    Two years is a long time for a supplement.

0:09:30    When asked about supplements, what does Mario tell his friends?

0:09:37    Focus on the basics first, e.g. food.

0:10:12    Supplement is a perfect word.

0:10:41    Omega-3 fatty acids are important.

0:10:54    Also probiotics.

0:11:01    Things to help with digestion, e.g. enzymes.

0:11:25    Added fibre.

0:11:46    Chronic inflammation, curcum is helpful, e.g. Meriva-SR®.

0:13:08    What's the difference between a $60 per month Thorne multi vs. a $10 Costco multi?

0:13:45    Thorne use a capsule and there's multiple capsules.

0:14:03    The capsules easier to absorb.

0:14:23    Thorne uses no unnecessary additives, fillers or flow agents.

0:15:03    No tablets because binders.

0:15:54    There's nothing toxic about magnesium stearate, but it can interfere with absorption.

0:18:15    Flow agents and fillers may be a proxy for quality, but the type of ingredients used is probably more important.

0:18:43    The supplement manufacturer are only required to list on the label the things that they put in.

0:22:16    Thorne products are hypoallergenic.

0:23:23    The most expensive supplement is the one you don't absorb.

0:23:41    Methylcobalamin is an absorbable form of B12.

0:24:16    Originally I was iron deficient, I found out the hard way that cheap iron supplements don't work.

0:25:14    Are supplements hard on the liver?

0:25:54    By using the most bioavailable forms, the liver is unburdened of the job of conversion.

0:26:14    Some, like Meriva-SR®, are hepatoprotective (protective of the liver).

0:29:01    In the case of Meriva, the main ingredient is manufactured by a third party.

0:29:04    But even so, the raw material goes into quarantine.

0:29:27    Thorne evaluates through it's own lab to verify identity.

0:30:06    Every lot goes through at least 3 and sometimes 4 rounds of verification.

0:31:51    In house manufacturing provides a level of control.

0:32:33    If the manufacturer knows you don't have a QA department, what incentive do they have to deliver the goods?

0:32:47    Thorne calls this “trust but verify”.

0:33:19    The certificate of analysis (COA).

0:34:58    The COA shows what's in the product, and details of potential contaminants. Here’s an example for the AM part of the EXOS multivitamin.

0:36:51    The only way to make money selling supplements on Amazon is buy large quantities and then let Amazon do the fulfillment.

0:38:10    Thorne has been clamping down on Amazon sellers.

0:39:26    Thorne do keep track of adverse events.

0:39:58    This is part of FDA compliance.

0:40:17    Majority are upset stomach.

0:41:09    New IBD digestive support supplement EnteroMend®, Meriva, Boswellia, Aloe, partially hydrolyzed guar gum and glutamine

0:45:49    MCT powdered with bionic fibre.

0:47:52    Ketos OS gave me diarrhoea, KetoForce was fine (but tastes awful).

0:48:29    Creating palatability can cause problems with allergens.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mario.Roxas.ND.02242016.mp3 Fri, 25 Mar 2016 14:03:18 GMT Christopher Kelly Imagine you’re in the pub and you’ve just bumped into your friend Mario Roxas. Mario happens to be a naturopathic doctor and the director of research and development at Thorne, the Rolls Royce of supplement companies. Wouldn’t you want to know what supplements Mario takes? Me too, and so I couldn’t resist making that my first question.

But what is it that makes Thorne Research different? Why not buy your supplements from Costco? Two reasons: research and quality. Thorne employ a team of medical and naturopathic doctor scientists that spend their time studying the scientific literature on the lookout for evidence supporting the decision to manufacturer a specific supplement. Secondly, there’s quality. Thorne cater to the sensitive customer likely to experience allergic reactions. The raw materials used to make a supplement originate from trusted sources, but Thorne validate the content of all their supplements no less than three times during the manufacturing process. Surprisingly, the FDA laws only require a supplement manufacturer to list the ingredients they added to the supplement, and there’s no guarantee that one or more of the raw ingredients used are free of potential allergens like lactose even though they’re not listed on the label.

Are big supplement companies any different from big pharma?

Allopathic medicine is often accused of being bought, but what makes alternative any different? Are the naturopathic doctors simply prescribing Meriva in place of Humira? I would argue no, absolutely not, and the proof is in the name supplement. As Mario points out, supplement is the perfect word. You can’t supplement your way out of a bad diet or lifestyle, and so the supplement is but one tool in the extensive chest of a good functional medicine practitioner.

Three years ago I had never taken a nutritional supplement.

Now I have a cupboard full of them. The reason is simple: they work. I used to take regularly chlorpheniramine for allergies. Killing off overgrowths of opportunistic pathogens and parasites with herbs like oregano and noni got me most of the way there, now I stay symptom-free by regularly supplementing with methyl-folate. The supplement didn’t just mask my symptoms; it corrected a deficiency and as a result, my red blood cells have become normal sized.

Adverse events?

Do you know of someone who had a serious adverse event as the result of taking a nutritional supplement free of contaminants? I don’t think this happens very often, if at all. Please let me know in the comments section below.

Here’s the outline of this interview with Dr Mario Roxas, ND

0:00:42    Mario became interested in supplements whilst a resident at the National College of Natural Medicine.

0:02:12    Thorne Research are the Rolls Royce of supplements.

0:02:58    Mario takes the Basic Nutrients 2/day multivitamin.

0:03:15    Together with LipoCardia®, CoQ10, fish oil and NiaCel®.

0:03:58    Whey protein in a smoothie.

0:04:35    Interview with Bob Rountree on mitochondrial health.

0:05:15    Supplement design starts with research.

0:06:09    Thorne has a team of scientists and doctors, NDs, MDs and PhDs.

0:07:48    The product development cycle for nicotinamide riboside lasted two years.

0:08:43    Two years is a long time for a supplement.

0:09:30    When asked about supplements, what does Mario tell his friends?

0:09:37    Focus on the basics first, e.g. food.

0:10:12    Supplement is a perfect word.

0:10:41    Omega-3 fatty acids are important.

0:10:54    Also probiotics.

0:11:01    Things to help with digestion, e.g. enzymes.

0:11:25    Added fibre.

0:11:46    Chronic inflammation, curcum is helpful, e.g. Meriva-SR®.

0:13:08    What's the difference between a $60 per month Thorne multi vs. a $10 Costco multi?

0:13:45    Thorne use a capsule and there's multiple capsules.

0:14:03    The capsules easier to absorb.

0:14:23    Thorne uses no unnecessary additives, fillers or flow agents.

0:15:03    No tablets because binders.

0:15:54    There's nothing toxic about magnesium stearate, but it can interfere with absorption.

0:18:15    Flow agents and fillers may be a proxy for quality, but the type of ingredients used is probably more important.

0:18:43    The supplement manufacturer are only required to list on the label the things that they put in.

0:22:16    Thorne products are hypoallergenic.

0:23:23    The most expensive supplement is the one you don't absorb.

0:23:41    Methylcobalamin is an absorbable form of B12.

0:24:16    Originally I was iron deficient, I found out the hard way that cheap iron supplements don't work.

0:25:14    Are supplements hard on the liver?

0:25:54    By using the most bioavailable forms, the liver is unburdened of the job of conversion.

0:26:14    Some, like Meriva-SR®, are hepatoprotective (protective of the liver).

0:29:01    In the case of Meriva, the main ingredient is manufactured by a third party.

0:29:04    But even so, the raw material goes into quarantine.

0:29:27    Thorne evaluates through it's own lab to verify identity.

0:30:06    Every lot goes through at least 3 and sometimes 4 rounds of verification.

0:31:51    In house manufacturing provides a level of control.

0:32:33    If the manufacturer knows you don't have a QA department, what incentive do they have to deliver the goods?

0:32:47    Thorne calls this “trust but verify”.

0:33:19    The certificate of analysis (COA).

0:34:58    The COA shows what's in the product, and details of potential contaminants. Here’s an example for the AM part of the EXOS multivitamin.

0:36:51    The only way to make money selling supplements on Amazon is buy large quantities and then let Amazon do the fulfillment.

0:38:10    Thorne has been clamping down on Amazon sellers.

0:39:26    Thorne do keep track of adverse events.

0:39:58    This is part of FDA compliance.

0:40:17    Majority are upset stomach.

0:41:09    New IBD digestive support supplement EnteroMend®, Meriva, Boswellia, Aloe, partially hydrolyzed guar gum and glutamine

0:45:49    MCT powdered with bionic fibre.

0:47:52    Ketos OS gave me diarrhoea, KetoForce was fine (but tastes awful).

0:48:29    Creating palatability can cause problems with allergens.

]]>
clean
How to Measure Your Metabolism with Organic Acids https://s3.amazonaws.com/nourishbalancethrive/podcast/williamsha1.on.2016-03-02.at.12.02.mp3 Three years ago I went through round after round of blood testing until eventually I realised that the doctor was following a procedure laid out in a flow chart. Heck, he even showed me the flow chart. Two months and thousands of dollars of insurance deductibles later I was no closer to understanding the underlying cause of my fatigue, insomnia, brain fog and other symptoms.

My doctor seemed somewhat willing to run any blood test I wanted but he held the results very close to his chest. Everything was normal, and the Google searches I made in an attempt to understand better my results yielded nothing useful. It’s not that sodium and potassium on a blood chemistry don’t mean anything, they do, it’s that you won’t ever be able to figure it out without some help.

When I finally admitted defeat and looked outside the network of doctors willing to accept the insurance that was costing me a fortune and getting me nowhere fast, I found someone who wanted to run a urinary organic acids test.

What is an organic acid?

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., he worked for the Centers for Disease Control and Prevention (CDC). Dr Shaw describes organic acids as “the stuff of metabolism”. Organic acids are surrogate markers that give valuable clues about what’s going on inside your body.

Finally, I had a window on what was really going on.

I don’t think anyone expected me to look at the result as a patient, but that’s what I did, and I was excited because now my searches started yielding useful information. Take for example vanillylmandelic, a breakdown product of epinephrine and norepinephrine, also known as adrenaline. Low levels of vanillylmandelic indicate little activity of a hormone that acts increases blood pressure, respiration rate, heart rate, increases glucose, and dilates the pupils, all for the purpose of enabling you to quickly and safely get out of a potentially life-threatening situation. Sounds a lot like adrenal fatigue, huh?

But there probably wasn’t anything wrong with adrenal glands.

In addition to low vanillylmandelic, I had (and have) high levels of HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid), a metabolite created by certain Clostridia species of bacteria (C. sporogenes, C. caloritolerans, C. botulinum & others). HPHPA looks enough like dopamine to downregulate the activity of the enzyme dopamine-beta-hydroxylase, but not enough to have the other biological effects, leading to a derangement of neurotransmitter balance.

Your gut can mess with your brain!

The fix?

A high end probiotic containing 50-100 billion CFU of Lactobacillus rhamnosus.

I’ve honed in just one example of problems that can be revealed and fixed easily using organic acids. Besides offering the most complete and accurate evaluation of gut yeast and bacteria, the test also provides information on important nutritional markers, glutathione status, oxalate metabolism, and much more.

Download my full result

By all means, order an organic acids test for yourself, and I will help you understand the results but know that this test is a single tool in our chest that includes other tests and diet and lifestyle modification. Book a free consultation and Amelia will walk you through the testing process.

Here’s the outline of this interview with Dr William Shaw, Ph.D.

0:00:16    Dr William Shaw, Ph.D is the founder of Great Plains lab.

0:00:23    Formerly a clinical chemist and toxicologist at the CDC.

0:00:46    Using mass spectrometry on urine would allow Dr. Shaw to measure virtually anything in metabolism.

0:01:33    Dr Shaw has been highly motivated from the beginning.

0:02:00    It's rare for someone to do an organic acids test and not find something significant.

0:02:59    Organic acids are the stuff of metabolism.

0:03:50    The metabolites from bacteria and other microorganisms have a profound impact on human health.

0:04:49    The Great Plains OAT measures the complex balance of man and microbiome.

0:05:09    The wrong microorganisms can harm mental health.

0:05:34    Once you have the results, you can manipulate them.

0:05:47    The OAT takes out the guess work.

0:06:29    Why are GPs not running the OAT?

0:06:50    The OAT is complex.

0:07:24    A one day seminar is usually enough to cover the basics.

0:07:37    The insurance has become very tightfisted.

0:08:13    Even if you have to pay out of pocket, the test is not that expensive.

0:09:08    The OAT covers all systems of the body.

0:09:49    Mass spectrometry is the truth machine.

0:10:08    Mark Newman on my podcast.

0:11:04    The Khan Academy organic chemistry.

0:11:19    Metabolic Fitness Pro.

0:11:57    Dr Shaw has taught the grandson of Krebs.

0:12:26    My OAT result.

0:12:51    The GP has a lot more markers than the Genova equivalent.

0:13:10    Whenever you buy an OAT, you're buying some of Dr Shaw's experience.

0:13:56    The reference ranges come from healthy volunteers.

0:14:25    There's a statistical analysis, the ranges are based on the vast majority.

0:14:50    Only healthy individuals are included.

0:15:21    The Genova test use the conjugate base name.

0:16:10    Nobody is writing junk about organic acids, that makes research much easier.

0:16:44    The GP OAT has the most comprehensive coverage of the gut microbiome.

0:17:08    Some of the metabolites produced can affects neurotransmitters.

0:17:43    Marker #16 HPHPA.

0:18:15    HPHPA is very similar to dopamine.

0:18:23    This interferes with the conversion of dopamine to epinephrine and norepinephrine.

0:18:26    Most people have an equal amount of dopamine and epinephrine and norepinephrine

0:18:52    The clostridia inhibit dopamine beta dehydrogenase.

0:19:49    Markers #33 and #34.

0:20:12    High levels of dopamine are a problem.

0:20:29    Dopamine causes oxidative stress and can kill neurons.

0:21:01    10x my result have been seen in autism and schizophrenia.

0:21:32    The oxidative metabolite is called dopachrome.

0:22:29    Elevated HPHPA may start with GI symptoms.

0:22:42    Later this could become depression or obsessive compulsive behaviour.

0:23:20    The peripheral nervous system uses norepinephrine.

0:24:27    Norepinephrine is what you need at the start of a race.

0:25:18    OAT is almost like cheating.

0:26:10    The clostridial species are usually easily treatable with probiotics with lactobacillus.

0:27:19    L. rhamnosus.

0:27:42    Cresol has the same effect on dopamine but is toxic in its own right and can be smelled on the breath.

0:28:44    Cresol is made by C. diff.

0:29:04    14,000 people die of C. diff infection each year.

0:29:39    Cresol is common in anorexia.

0:30:36    We've tested for the A&B toxins in stool.

0:32:00    I've always had a yeast problem.

0:32:18    D-Arabinitol is different from D-Arabinose.

0:33:06    I have an overgrowth of Candida that can easily be treated.

0:33:22    Coconut oil or caprylic acid.

0:33:31    Nystatin.

0:33:43    Chronic fatigue, fibromyalgia.

0:34:00    Sugar craving!

0:34:39    Evidence yeast can metabolize ketones.

0:35:11    Dr Shaw thinks that the ketones will not be fuelling the yeast.

0:35:27    Markers #47-49 carnitine deficiency.

0:36:13    Carnitine shuttles fatty acids into the mitochondria.

0:37:05    Fats are oxidized with less energy yield in the peroxisomes.

0:37:56    The GP test has 9 yeast markers, I'm used to seeing one.

0:38:08    Candida can metabolize isocitrate into oxalate.

0:38:44    Dr Shaw discovered that this week!

0:38:59    The research will take time, a year or longer before anything is in print.

0:39:20    Marker #21.

0:39:57    Candida metabolize isocitrate into oxalate and that's the connection between the yeast and kidney stones. Oxalates are also capable of crystallizing anywhere in the urinary tract, blood vessels, the blood brain barrier, the thyroid, liver and muscles.

0:40:44    Oxalates may turn out to be more important than cholesterol.

0:42:10    High oxalate foods, spinach and soy, nuts and berries.

0:42:29    300mg Calcium and 150mg magnesium citrate can be protective.

0:43:02    Great Plains have just started DNA testing and they look at oxalate metabolism SNPs.

0:44:33    Vitamin B6 deficiency causes oxalate production.

0:45:09    People with high oxalates should supplement with 100 mg per of B6.

0:45:53    Dr Shaw needs to write the manual.

0:46:54    Narrowing down a list of possibilities to a list of probabilities.

0:47:23    Order a Great Plains OAT.

0:47:45    There are currently 75 markers, more soon.

0:48:36    Great Plains are working on a test for jet fuel toxicity.

0:49:19    The Dreamliner has separate air system.

0:50:05    The Great Plains webinar archive.

0:50:59    The low cholesterol problem.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/williamsha1.on.2016-03-02.at.12.02.mp3 Thu, 17 Mar 2016 19:03:21 GMT Christopher Kelly Three years ago I went through round after round of blood testing until eventually I realised that the doctor was following a procedure laid out in a flow chart. Heck, he even showed me the flow chart. Two months and thousands of dollars of insurance deductibles later I was no closer to understanding the underlying cause of my fatigue, insomnia, brain fog and other symptoms.

My doctor seemed somewhat willing to run any blood test I wanted but he held the results very close to his chest. Everything was normal, and the Google searches I made in an attempt to understand better my results yielded nothing useful. It’s not that sodium and potassium on a blood chemistry don’t mean anything, they do, it’s that you won’t ever be able to figure it out without some help.

When I finally admitted defeat and looked outside the network of doctors willing to accept the insurance that was costing me a fortune and getting me nowhere fast, I found someone who wanted to run a urinary organic acids test.

What is an organic acid?

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., he worked for the Centers for Disease Control and Prevention (CDC). Dr Shaw describes organic acids as “the stuff of metabolism”. Organic acids are surrogate markers that give valuable clues about what’s going on inside your body.

Finally, I had a window on what was really going on.

I don’t think anyone expected me to look at the result as a patient, but that’s what I did, and I was excited because now my searches started yielding useful information. Take for example vanillylmandelic, a breakdown product of epinephrine and norepinephrine, also known as adrenaline. Low levels of vanillylmandelic indicate little activity of a hormone that acts increases blood pressure, respiration rate, heart rate, increases glucose, and dilates the pupils, all for the purpose of enabling you to quickly and safely get out of a potentially life-threatening situation. Sounds a lot like adrenal fatigue, huh?

But there probably wasn’t anything wrong with adrenal glands.

In addition to low vanillylmandelic, I had (and have) high levels of HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid), a metabolite created by certain Clostridia species of bacteria (C. sporogenes, C. caloritolerans, C. botulinum & others). HPHPA looks enough like dopamine to downregulate the activity of the enzyme dopamine-beta-hydroxylase, but not enough to have the other biological effects, leading to a derangement of neurotransmitter balance.

Your gut can mess with your brain!

The fix?

A high end probiotic containing 50-100 billion CFU of Lactobacillus rhamnosus.

I’ve honed in just one example of problems that can be revealed and fixed easily using organic acids. Besides offering the most complete and accurate evaluation of gut yeast and bacteria, the test also provides information on important nutritional markers, glutathione status, oxalate metabolism, and much more.

Download my full result

By all means, order an organic acids test for yourself, and I will help you understand the results but know that this test is a single tool in our chest that includes other tests and diet and lifestyle modification. Book a free consultation and Amelia will walk you through the testing process.

Here’s the outline of this interview with Dr William Shaw, Ph.D.

0:00:16    Dr William Shaw, Ph.D is the founder of Great Plains lab.

0:00:23    Formerly a clinical chemist and toxicologist at the CDC.

0:00:46    Using mass spectrometry on urine would allow Dr. Shaw to measure virtually anything in metabolism.

0:01:33    Dr Shaw has been highly motivated from the beginning.

0:02:00    It's rare for someone to do an organic acids test and not find something significant.

0:02:59    Organic acids are the stuff of metabolism.

0:03:50    The metabolites from bacteria and other microorganisms have a profound impact on human health.

0:04:49    The Great Plains OAT measures the complex balance of man and microbiome.

0:05:09    The wrong microorganisms can harm mental health.

0:05:34    Once you have the results, you can manipulate them.

0:05:47    The OAT takes out the guess work.

0:06:29    Why are GPs not running the OAT?

0:06:50    The OAT is complex.

0:07:24    A one day seminar is usually enough to cover the basics.

0:07:37    The insurance has become very tightfisted.

0:08:13    Even if you have to pay out of pocket, the test is not that expensive.

0:09:08    The OAT covers all systems of the body.

0:09:49    Mass spectrometry is the truth machine.

0:10:08    Mark Newman on my podcast.

0:11:04    The Khan Academy organic chemistry.

0:11:19    Metabolic Fitness Pro.

0:11:57    Dr Shaw has taught the grandson of Krebs.

0:12:26    My OAT result.

0:12:51    The GP has a lot more markers than the Genova equivalent.

0:13:10    Whenever you buy an OAT, you're buying some of Dr Shaw's experience.

0:13:56    The reference ranges come from healthy volunteers.

0:14:25    There's a statistical analysis, the ranges are based on the vast majority.

0:14:50    Only healthy individuals are included.

0:15:21    The Genova test use the conjugate base name.

0:16:10    Nobody is writing junk about organic acids, that makes research much easier.

0:16:44    The GP OAT has the most comprehensive coverage of the gut microbiome.

0:17:08    Some of the metabolites produced can affects neurotransmitters.

0:17:43    Marker #16 HPHPA.

0:18:15    HPHPA is very similar to dopamine.

0:18:23    This interferes with the conversion of dopamine to epinephrine and norepinephrine.

0:18:26    Most people have an equal amount of dopamine and epinephrine and norepinephrine

0:18:52    The clostridia inhibit dopamine beta dehydrogenase.

0:19:49    Markers #33 and #34.

0:20:12    High levels of dopamine are a problem.

0:20:29    Dopamine causes oxidative stress and can kill neurons.

0:21:01    10x my result have been seen in autism and schizophrenia.

0:21:32    The oxidative metabolite is called dopachrome.

0:22:29    Elevated HPHPA may start with GI symptoms.

0:22:42    Later this could become depression or obsessive compulsive behaviour.

0:23:20    The peripheral nervous system uses norepinephrine.

0:24:27    Norepinephrine is what you need at the start of a race.

0:25:18    OAT is almost like cheating.

0:26:10    The clostridial species are usually easily treatable with probiotics with lactobacillus.

0:27:19    L. rhamnosus.

0:27:42    Cresol has the same effect on dopamine but is toxic in its own right and can be smelled on the breath.

0:28:44    Cresol is made by C. diff.

0:29:04    14,000 people die of C. diff infection each year.

0:29:39    Cresol is common in anorexia.

0:30:36    We've tested for the A&B toxins in stool.

0:32:00    I've always had a yeast problem.

0:32:18    D-Arabinitol is different from D-Arabinose.

0:33:06    I have an overgrowth of Candida that can easily be treated.

0:33:22    Coconut oil or caprylic acid.

0:33:31    Nystatin.

0:33:43    Chronic fatigue, fibromyalgia.

0:34:00    Sugar craving!

0:34:39    Evidence yeast can metabolize ketones.

0:35:11    Dr Shaw thinks that the ketones will not be fuelling the yeast.

0:35:27    Markers #47-49 carnitine deficiency.

0:36:13    Carnitine shuttles fatty acids into the mitochondria.

0:37:05    Fats are oxidized with less energy yield in the peroxisomes.

0:37:56    The GP test has 9 yeast markers, I'm used to seeing one.

0:38:08    Candida can metabolize isocitrate into oxalate.

0:38:44    Dr Shaw discovered that this week!

0:38:59    The research will take time, a year or longer before anything is in print.

0:39:20    Marker #21.

0:39:57    Candida metabolize isocitrate into oxalate and that's the connection between the yeast and kidney stones. Oxalates are also capable of crystallizing anywhere in the urinary tract, blood vessels, the blood brain barrier, the thyroid, liver and muscles.

0:40:44    Oxalates may turn out to be more important than cholesterol.

0:42:10    High oxalate foods, spinach and soy, nuts and berries.

0:42:29    300mg Calcium and 150mg magnesium citrate can be protective.

0:43:02    Great Plains have just started DNA testing and they look at oxalate metabolism SNPs.

0:44:33    Vitamin B6 deficiency causes oxalate production.

0:45:09    People with high oxalates should supplement with 100 mg per of B6.

0:45:53    Dr Shaw needs to write the manual.

0:46:54    Narrowing down a list of possibilities to a list of probabilities.

0:47:23    Order a Great Plains OAT.

0:47:45    There are currently 75 markers, more soon.

0:48:36    Great Plains are working on a test for jet fuel toxicity.

0:49:19    The Dreamliner has separate air system.

0:50:05    The Great Plains webinar archive.

0:50:59    The low cholesterol problem.

]]>
clean
Two Years On: Tech Nerd Has Entrepreneurial Episode, Starts Functional Medicine Practice https://s3.amazonaws.com/nourishbalancethrive/podcast/2015.recap.podcast.mp3 Run a blood test, find low levels of a hormone. Prescribe synthetic version of said hormone. Two weeks later your patient is back with a slightly different set of symptoms. Run another blood test, prescribe another hormone. If there's too much, block it, if there isn't enough, just add more. Rinse and repeat for hypothalamic pituitary adrenal, thyroid and gonadal axes. Refer out to a gastroenterologist for chronic diarrhoea. Gastroenterologist diagnosis is “irritable bowel syndrome”, says it’s nothing to do with diet, suggests colonoscopy, anti-inflammatory drugs, possible surgery.

This sounds like a parody.

But this is what happened to me, and it’s still happening to other athletes. Finding a better solution inspired me to quit my day job as a computer programmer at a hedge fund and start a new business with my wife (a food scientist) and a medical doctor.

2015 was our first full year in practice.

At the time of recording, we’ve helped over 600 athletes with their diet and lifestyle. We’ve gotten great results and get tremendous satisfaction from each and every success story that we receive. Our success has been in large part due to the significant research and development efforts of our new Chief Medical Officer Dr. Tommy Wood, and by the tireless efforts of our single employee and registered nurse, Amelia Luker.

Our gross revenue was nearly $500,000.

Unfortunately, Julia and I only took home $90,000 of that as profit, and that’s with both of us working full-time. If I hired two members of staff to replace us at the going market rate, we’d be making a significant loss. Health coaching is hard because not only do you have to be a great practitioner, you must also be a good business person and marketing expert.

On the plus side.

Quitting my job has enabled us to move from a condo on a busy main road in Oakland, to a small house amongst the trees in a town called Bonny Doon, not far from Santa Cruz, in California. I get a quarterly email from the recruiter at Google, but if I were to go down that route I’d be leaving to commute to an office before my daughter got up in the morning, and I’d be lucky to get home before she went to bed at night.

I don’t wish to be mean but…

I could train a monkey to run a blood test and prescribe a hormone. Doctors are being made prisoner to a system that prevents them from making proper use of their education and spending an appropriate amount time with their patients. People don’t even know how much their health insurance costs and half the time it doesn’t cover what they need. I’m still slightly angry about the current standard of care, and I’m looking forward to being made redundant; I rather miss computer programming.

Are you a financially successful health coach?

Please let me know in the comments section below.

Here’s the outline of this interview with Julia Kelly:

0:01:09    Was it fun?

0:01:33    It was a shock to the system.

0:02:04    The sudden changes are stressful.

0:02:48    We were living in Oakland.

0:03:04    Quitting my job enabled us to move to Scotts Valley.

0:03:44    We've bought a house in Bonny Doon.

0:04:10    Ours is the only WiFi signal.

0:04:46    We can grow our own food.

0:04:57    Starting a business is a double edged sword.

0:05:27    Looking after a 2 year is hard!

0:05:46    Cheating at parenting.

0:06:29    Working at home I get to see my daughter all day long.

0:07:29    I'm still slightly angry.

0:07:50    I've stopped doing free consultations now, but you can still do one with Amelia.

0:08:25    Run a blood test, find low hormone, prescribe the hormone, rinse, repeat.

0:08:44    Nobody is doing the proper investigation.

0:09:38    The low hormones are symptoms.

0:10:55    We're waiting to be replaced.

0:11:14    Julie feels the same about saturated fat.

0:11:58    Tommy is planning on doing another residency.

0:12:21    Tommy is now our Chief Medical Officer.

0:12:55    We hope that the people we help go on to spread the word.

0:13:54    All diseases are complex with many underlying causes.

0:14:41    One over the treatment is not necessarily the cause.

0:15:42    Julie doesn't do diet plans, instead she teaches.

0:16:33    Everyone else wants to hold the cards close to their chest.

0:17:09    You can check your own blood glucose.

0:17:24    By now you should have done a Google search for 8-Oxo-2'-deoxyguanosine.

0:18:15    Is this working?

0:19:13    We have more follow-up calls then we have time to publish.

0:19:56    Of course it worked!

0:20:43    We don't have a magic formula yet.

0:20:59    We've tested 605 athletes as of yesterday.

0:21:42    At this point, our programs don't resemble anything we've been trained in.

0:22:21    Social isolation with Bryan Walsh.

0:22:35    Our gross revenue for 2015 was nearly $500,000.

0:23:11    Mark Newman of Precision Analytical.

0:23:44    There's almost no markup on our tests, we're passing those on at cost.

0:23:59    Most of our money comes from selling our time.

0:24:20    We do make some money from selling supplements.

0:24:54    Amelia ships all the supplements.

0:25:20    Making money selling supplements requires the economy of scale.

0:25:52    Bob Rountree talked about NiaCell® (nicotinamide riboside).

0:26:17    Between the two of us we took home $90,000 before tax.

0:26:54    In a way, we have achieved the four-hour work week.

0:27:26    I should have a master's degree by now.

0:28:05    If you really want to get better as a practitioner you must continue your education.

0:28:35    My education is problem driven.

0:28:47    I'm racing pro again this year.

0:29:06    Computer programmers are lazy.

0:29:54    I take the same approach with my training.

0:30:46    Necessity is fantastic teacher.

0:31:17    I won the series points competition at our local cyclocross races in the elite men category.

0:32:13    The Colnago days.

0:32:57    NorCal cross is bumpy.

0:33:25    Now I can sleep after a bike race.

0:33:41    The sugar monster has slayed.

0:34:08    Tommy is a big fan of carb cycling.

0:34:42    The average power in cross is meaningless.

0:35:05    I've been supplementing with exogenous ketones.

0:35:24    Volek showed no difference in glycogen.

0:35:48    Carb cycling made no difference to me.

0:36:38    My path is becoming a theme.

0:37:17    Know who you want to help!

0:37:29    The Practitioner Liberation Project.

0:38:00    I haven't done all of the course.

0:38:10    The most important lesson is be specific.

0:39:14    The people we work with are exactly like me!

0:40:41    We haven't borrowed any money.

0:41:18    Our Concierge Clinical Coaching group.

0:42:12    Now I can answer questions without going bankrupt.

0:42:59    My education is now available for $99 a month.

0:43:55    Please let me know if you found this helpful in the comments section below.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/2015.recap.podcast.mp3 Fri, 11 Mar 2016 06:03:54 GMT Christopher Kelly Run a blood test, find low levels of a hormone. Prescribe synthetic version of said hormone. Two weeks later your patient is back with a slightly different set of symptoms. Run another blood test, prescribe another hormone. If there's too much, block it, if there isn't enough, just add more. Rinse and repeat for hypothalamic pituitary adrenal, thyroid and gonadal axes. Refer out to a gastroenterologist for chronic diarrhoea. Gastroenterologist diagnosis is “irritable bowel syndrome”, says it’s nothing to do with diet, suggests colonoscopy, anti-inflammatory drugs, possible surgery.

This sounds like a parody.

But this is what happened to me, and it’s still happening to other athletes. Finding a better solution inspired me to quit my day job as a computer programmer at a hedge fund and start a new business with my wife (a food scientist) and a medical doctor.

2015 was our first full year in practice.

At the time of recording, we’ve helped over 600 athletes with their diet and lifestyle. We’ve gotten great results and get tremendous satisfaction from each and every success story that we receive. Our success has been in large part due to the significant research and development efforts of our new Chief Medical Officer Dr. Tommy Wood, and by the tireless efforts of our single employee and registered nurse, Amelia Luker.

Our gross revenue was nearly $500,000.

Unfortunately, Julia and I only took home $90,000 of that as profit, and that’s with both of us working full-time. If I hired two members of staff to replace us at the going market rate, we’d be making a significant loss. Health coaching is hard because not only do you have to be a great practitioner, you must also be a good business person and marketing expert.

On the plus side.

Quitting my job has enabled us to move from a condo on a busy main road in Oakland, to a small house amongst the trees in a town called Bonny Doon, not far from Santa Cruz, in California. I get a quarterly email from the recruiter at Google, but if I were to go down that route I’d be leaving to commute to an office before my daughter got up in the morning, and I’d be lucky to get home before she went to bed at night.

I don’t wish to be mean but…

I could train a monkey to run a blood test and prescribe a hormone. Doctors are being made prisoner to a system that prevents them from making proper use of their education and spending an appropriate amount time with their patients. People don’t even know how much their health insurance costs and half the time it doesn’t cover what they need. I’m still slightly angry about the current standard of care, and I’m looking forward to being made redundant; I rather miss computer programming.

Are you a financially successful health coach?

Please let me know in the comments section below.

Here’s the outline of this interview with Julia Kelly:

0:01:09    Was it fun?

0:01:33    It was a shock to the system.

0:02:04    The sudden changes are stressful.

0:02:48    We were living in Oakland.

0:03:04    Quitting my job enabled us to move to Scotts Valley.

0:03:44    We've bought a house in Bonny Doon.

0:04:10    Ours is the only WiFi signal.

0:04:46    We can grow our own food.

0:04:57    Starting a business is a double edged sword.

0:05:27    Looking after a 2 year is hard!

0:05:46    Cheating at parenting.

0:06:29    Working at home I get to see my daughter all day long.

0:07:29    I'm still slightly angry.

0:07:50    I've stopped doing free consultations now, but you can still do one with Amelia.

0:08:25    Run a blood test, find low hormone, prescribe the hormone, rinse, repeat.

0:08:44    Nobody is doing the proper investigation.

0:09:38    The low hormones are symptoms.

0:10:55    We're waiting to be replaced.

0:11:14    Julie feels the same about saturated fat.

0:11:58    Tommy is planning on doing another residency.

0:12:21    Tommy is now our Chief Medical Officer.

0:12:55    We hope that the people we help go on to spread the word.

0:13:54    All diseases are complex with many underlying causes.

0:14:41    One over the treatment is not necessarily the cause.

0:15:42    Julie doesn't do diet plans, instead she teaches.

0:16:33    Everyone else wants to hold the cards close to their chest.

0:17:09    You can check your own blood glucose.

0:17:24    By now you should have done a Google search for 8-Oxo-2'-deoxyguanosine.

0:18:15    Is this working?

0:19:13    We have more follow-up calls then we have time to publish.

0:19:56    Of course it worked!

0:20:43    We don't have a magic formula yet.

0:20:59    We've tested 605 athletes as of yesterday.

0:21:42    At this point, our programs don't resemble anything we've been trained in.

0:22:21    Social isolation with Bryan Walsh.

0:22:35    Our gross revenue for 2015 was nearly $500,000.

0:23:11    Mark Newman of Precision Analytical.

0:23:44    There's almost no markup on our tests, we're passing those on at cost.

0:23:59    Most of our money comes from selling our time.

0:24:20    We do make some money from selling supplements.

0:24:54    Amelia ships all the supplements.

0:25:20    Making money selling supplements requires the economy of scale.

0:25:52    Bob Rountree talked about NiaCell® (nicotinamide riboside).

0:26:17    Between the two of us we took home $90,000 before tax.

0:26:54    In a way, we have achieved the four-hour work week.

0:27:26    I should have a master's degree by now.

0:28:05    If you really want to get better as a practitioner you must continue your education.

0:28:35    My education is problem driven.

0:28:47    I'm racing pro again this year.

0:29:06    Computer programmers are lazy.

0:29:54    I take the same approach with my training.

0:30:46    Necessity is fantastic teacher.

0:31:17    I won the series points competition at our local cyclocross races in the elite men category.

0:32:13    The Colnago days.

0:32:57    NorCal cross is bumpy.

0:33:25    Now I can sleep after a bike race.

0:33:41    The sugar monster has slayed.

0:34:08    Tommy is a big fan of carb cycling.

0:34:42    The average power in cross is meaningless.

0:35:05    I've been supplementing with exogenous ketones.

0:35:24    Volek showed no difference in glycogen.

0:35:48    Carb cycling made no difference to me.

0:36:38    My path is becoming a theme.

0:37:17    Know who you want to help!

0:37:29    The Practitioner Liberation Project.

0:38:00    I haven't done all of the course.

0:38:10    The most important lesson is be specific.

0:39:14    The people we work with are exactly like me!

0:40:41    We haven't borrowed any money.

0:41:18    Our Concierge Clinical Coaching group.

0:42:12    Now I can answer questions without going bankrupt.

0:42:59    My education is now available for $99 a month.

0:43:55    Please let me know if you found this helpful in the comments section below.

]]>
clean
How the Paleo Diet Creates Cellular Health https://s3.amazonaws.com/nourishbalancethrive/podcast/William.Chatterton.on.2016-02-05.at.11.10.mp3 My sister called me looking for help with her son’s science project. “William has some questions about the paleo diet and how it affects the health of cells.” It soon emerged that he had a particular list of questions that he wanted answering, and initially I thought I should do some research and answer them to the best of my ability just as I would with any list sent to me. The longer I thought about the list of questions, the more I thought it looked like the outline to a great podcast, and who better than Dr. Tommy Wood to provide the answers?

But why care about cellular health in the first place?

We tend to think of health in terms of big things, but a living organism is just a collection of organ systems. An organ system is a set of organs, and those organs are made up of tissue. Drilling down beyond the tissue, we arrive at the smallest level of organisation able to sustain life: the cell. We’re all just a big bag of cells, trillions and trillions of them! Happy cells make for happy bodies, so it makes sense to care about the cell.

Can your diet affect cellular health?

Yes! Absolutely. Certain oils are capable of damaging the DNA that codes for the proteins manufactured inside of the cell. Don’t eat deep fried food. Other omega-3 fats are essential for healthy mitochondrial membranes. Do eat small fatty fish.

Around 10,000 years ago, fossil records show that we became shorter, and our dental health deteriorated. At the same time, we transitioned away from hunting and gathering and became agriculturists. It seems at least possible that a switch to a grain-based diet had a deleterious effect on our health.

What about ketosis?

I’ve talked a lot about high-fat ketogenic diets on the podcast, and those shows garner a lot of interest. But do we all need to be eating ketogenic diets? Tommy thinks not, but there may be some benefits to cycling intake to mimic what would have been the natural seasonal variation of carbohydrate availability.

Beyond diet.

Through his careful research and chemical engineering inspired systems analysis, Tommy has shown that although important, diet is not the only determiner of health. Well tuned circadian rhythm and adequate sleep, appropriate stress management, time spent outdoors in nature and being part of a strong social group are also important.

Did you find the fresh, unbiased perspective of an inquisitive 12-year old helpful? Please let me know in the comments section below.

Here’s the outline of this interview with William Chatterton and Dr. Tommy Wood:

0:00:22    William Chatterton's list of questions for a school project should make for an interesting interview.

0:00:27    Let me know (in the comments below) if you found this podcast interesting!

0:00:47    Levels of organisation in biology.

0:01:54    Can your diet affect the health of new cells?

0:02:09    We're constantly growing cells, throughout life.

0:02:32    There's a very rapid turnover of cells in the gut.

0:02:48    At the same time we're constantly getting rid of the junk.

0:02:59    The building blocks are important.

0:03:18    We measure DNA damage as 8-hydroxy-2-deoxyguanosine.

0:03:29    DNA is the code that controls the manufacturer of proteins.

0:03:46    It's important then that the DNA doesn't get damaged.

0:04:00    Certain oils can cause oxidative damage to the DNA.

0:04:28    DHA is very important for mitochondrial membranes.

0:05:08    The fats story is complex.

0:05:18    Saturated fats.

0:05:31    A fatty acid is a long chain of carbon atoms.

0:05:59    The double bonds are delicated and can be broken to create a free radical.

0:06:11    Fatty acids that have carbon–carbon double bonds are known as unsaturated.

0:06:29    Polyunsaturated fats are unstable.

0:07:00    When omega-6 fats are carried around in the body, they're unprotected.

0:07:39    Omega-3s are better protected.

0:07:59    Don't eat deep fried stuff!

0:08:26    How direct is the link between diet and cell health?

0:08:49    The link is incredibly direct.

0:08:56    Food is the most important determiner of cell health.

0:09:17    Circadian rhythm and stress is important.

0:09:30    Being part of a social group.

0:09:52    Don't focus just on food.

0:10:04    Food is the first thing people figure out.

0:10:35    Everybody wants one thing they can fix.

0:10:52    Being sociable can be easier than you think

0:11:05    Give your mum a hug.

0:11:50    What is the most nutrient dense meal you could eat for cell health?

0:12:02    Small fatty fish.

0:12:13    DHA, selenium, iodine.

0:12:25    Collagen.

0:12:34    Eggs with yolks and liver.

0:12:43    Dark green leafy vegetables.

0:12:54    Preferably wild grown plants.

0:13:30    The new surf and turf!

0:13:57    Not being squeamish about certain foods at certain times of day.

0:14:39    How does a ketogenic diet affect the health of a cell.

0:15:01    Adding fat doesn't necessarily make it ketogenic.

0:16:16    My diet has zero refined carbohydrates.

0:16:30    Still lots of vegetables.

0:16:40    At this point, you've gotten rid of most of the crap.

0:17:15    Ketogenic diets can cause an increase in oxidative stress inside of the mitochondria in the short term

0:17:42    Reactive oxygen species are signalling molecules.

0:17:59    ROS Goldilocks principle.

0:19:14    Some people will say that the ketogenic diet is bad because of this initial increase in ROS.

0:19:55    Should everyone be eating a ketogenic diet?

0:19:58    No, certainly not all of the time.

0:20:11    Sodium and potassium and selenium can be difficult to hold onto in ketosis.

0:20:38    The extra stress of the diet can also be problem.

0:21:13    Seasonal ketosis.

0:22:00    Wills is already eating a high-fat diet.

0:22:21    What happened to our diet in between the paleolithic and the era of the Food Pyramid?

0:23:32    Carbohydrate consumption may have changed.

0:23:53    Access to fire and cooking has made a difference.

0:24:10    Eating fish.

0:24:19    If you didn't live near the sea, you ate brain.

0:24:40    Around 10,000 years ago, we became agriculturalists.

0:25:04    Seeds and grasses like wheat.

0:25:19    Where there is a fossil record, we see health deteriorated.

0:25:43    People got shorter and had worse teeth.

0:25:57    We can't say definitely that farming was the cause.

0:26:23    There's no benefit from eating wheat.

0:26:59    When the food shows up in front of you, that's what you eat.

0:27:36    1980 saw the first dietary guidelines with grains as the foundation.

0:27:53    Part of this decision was driven by economics.

0:29:00    The perfect storm of refined carbohydrates plus vegetable oils and refined sugar.

0:29:51    This combination used to be impossible to obtain.

0:30:26    Will the Food Pyramid change soon?

0:30:44    People are working on this problem.

0:31:04    People don't eat according to the food pyramid, but it is used to create the foods that we eat.

0:32:05    Farming is heavily subsidised, this creates momentum.

0:33:16    Nothing is going to change any time soon.

0:33:26    Wording has changed around the word saturated fat and the caution on cholesterol has been removed.

0:34:00    Tommy's two presentations on MS and dairy.

0:34:22    Terry Wahls has largely reversed her MS with her protocol.

0:35:00    Tommy comes from a family of chemical engineers.

0:35:04    His stepbrother has MS.

0:35:11    Chemical engineers are problem solvers.

0:35:27    They built a root cause analysis for MS.

0:35:42    Gluten and casein allergies.

0:35:56    Mitocondria that are not working properly.

0:36:14    Terry also advocates ketosis.

0:36:27    Tommy and Terry represent two groups of people that came up with the same conclusion using different methods.

0:37:09    Do you think that Terry Wahl's work is original?

0:37:31    There's nothing new under the sun.

0:37:53    Tommy has ideas, and then doesn't want to tell anybody about it for fear they will steal it.

0:38:21    Terry is the first person to apply these principles in MS patients and in clinical trials.

0:39:24    I had tremendous results eating the AIP diet.

0:39:40    The book The Paleo Approach.

0:39:48    Personalising the Wahls Protocol.

0:40:14    This would look like a high-plant, dairy-free, low-carb diet.

0:41:07    Not everybody needs to be that strict.

0:41:32    Eat the yolks.

0:42:11    Start with the basic elimination diet.

0:42:23    Reintroduce later.

0:42:55    You can go too far, but most people don't go far enough.

0:43:12    Be really strict for two months and then reintroduce.

0:43:56    Then the signal ratio is great enough for you to know what's causing the problem.

0:44:41    Are there any other diets that can produce the same results.

0:45:03    Yes, the Swank Diet.

0:45:25    This is the most successful diet for MS patients.

0:45:33    Terry Wahls doesn't have that much data yet.

0:45:50    The problem is the diet is a very low fat vegan diet.

0:46:14    The stricter you were with the diet, the better you did.

0:46:34    Actively engaging in your treatment has a positive effect.

0:46:58    Recent research is not impressive.

0:47:53    The Swank Diet is probably better than what people were eating before.

0:48:33    It's impossible to create a blinded trial.

0:49:11    Swank is better than standard American but perhaps not the best.

0:49:22    If these diets are so successful, then should doctor be making dietary prescriptions?

0:49:47    Yes they should, but doctors are not trained in nutrition.

0:50:18    Tommy is a traditionally trained doctor.

0:50:42    We are in an era of evidence-based medicine.

0:51:12    Clinical trials are not going to happen for diet.

0:51:35    Therefore, the doctors are not going prescribe a diet.

0:51:58    There's always confounding factor.

0:52:08    Someone will always say the evidence isn't good enough.

0:52:35    Nowadays you can use clever statistics to show that your new drug is not inferior.

0:53:03    Rather than showing superiority.

0:53:49    You cannot control for diet and lifestyle.

0:54:29    Is there any one simple takeaway message?

0:54:52    Yes, just eat real food.

0:55:04    Go to your local grocery store and buy ingredients.

0:55:19    Turn that into food and you will avoid all of the trouble.

0:55:37    Even better, go to the local farmer's market.

0:55:54    Getting enough sleep.

0:55:57    Being part of a social group.

0:56:01    Don't worry about the things you can't control.

0:56:08    Occasionally lift heavy.

0:56:16    Circadian rhythm.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/William.Chatterton.on.2016-02-05.at.11.10.mp3 Fri, 04 Mar 2016 06:03:10 GMT Christopher Kelly My sister called me looking for help with her son’s science project. “William has some questions about the paleo diet and how it affects the health of cells.” It soon emerged that he had a particular list of questions that he wanted answering, and initially I thought I should do some research and answer them to the best of my ability just as I would with any list sent to me. The longer I thought about the list of questions, the more I thought it looked like the outline to a great podcast, and who better than Dr. Tommy Wood to provide the answers?

But why care about cellular health in the first place?

We tend to think of health in terms of big things, but a living organism is just a collection of organ systems. An organ system is a set of organs, and those organs are made up of tissue. Drilling down beyond the tissue, we arrive at the smallest level of organisation able to sustain life: the cell. We’re all just a big bag of cells, trillions and trillions of them! Happy cells make for happy bodies, so it makes sense to care about the cell.

Can your diet affect cellular health?

Yes! Absolutely. Certain oils are capable of damaging the DNA that codes for the proteins manufactured inside of the cell. Don’t eat deep fried food. Other omega-3 fats are essential for healthy mitochondrial membranes. Do eat small fatty fish.

Around 10,000 years ago, fossil records show that we became shorter, and our dental health deteriorated. At the same time, we transitioned away from hunting and gathering and became agriculturists. It seems at least possible that a switch to a grain-based diet had a deleterious effect on our health.

What about ketosis?

I’ve talked a lot about high-fat ketogenic diets on the podcast, and those shows garner a lot of interest. But do we all need to be eating ketogenic diets? Tommy thinks not, but there may be some benefits to cycling intake to mimic what would have been the natural seasonal variation of carbohydrate availability.

Beyond diet.

Through his careful research and chemical engineering inspired systems analysis, Tommy has shown that although important, diet is not the only determiner of health. Well tuned circadian rhythm and adequate sleep, appropriate stress management, time spent outdoors in nature and being part of a strong social group are also important.

Did you find the fresh, unbiased perspective of an inquisitive 12-year old helpful? Please let me know in the comments section below.

Here’s the outline of this interview with William Chatterton and Dr. Tommy Wood:

0:00:22    William Chatterton's list of questions for a school project should make for an interesting interview.

0:00:27    Let me know (in the comments below) if you found this podcast interesting!

0:00:47    Levels of organisation in biology.

0:01:54    Can your diet affect the health of new cells?

0:02:09    We're constantly growing cells, throughout life.

0:02:32    There's a very rapid turnover of cells in the gut.

0:02:48    At the same time we're constantly getting rid of the junk.

0:02:59    The building blocks are important.

0:03:18    We measure DNA damage as 8-hydroxy-2-deoxyguanosine.

0:03:29    DNA is the code that controls the manufacturer of proteins.

0:03:46    It's important then that the DNA doesn't get damaged.

0:04:00    Certain oils can cause oxidative damage to the DNA.

0:04:28    DHA is very important for mitochondrial membranes.

0:05:08    The fats story is complex.

0:05:18    Saturated fats.

0:05:31    A fatty acid is a long chain of carbon atoms.

0:05:59    The double bonds are delicated and can be broken to create a free radical.

0:06:11    Fatty acids that have carbon–carbon double bonds are known as unsaturated.

0:06:29    Polyunsaturated fats are unstable.

0:07:00    When omega-6 fats are carried around in the body, they're unprotected.

0:07:39    Omega-3s are better protected.

0:07:59    Don't eat deep fried stuff!

0:08:26    How direct is the link between diet and cell health?

0:08:49    The link is incredibly direct.

0:08:56    Food is the most important determiner of cell health.

0:09:17    Circadian rhythm and stress is important.

0:09:30    Being part of a social group.

0:09:52    Don't focus just on food.

0:10:04    Food is the first thing people figure out.

0:10:35    Everybody wants one thing they can fix.

0:10:52    Being sociable can be easier than you think

0:11:05    Give your mum a hug.

0:11:50    What is the most nutrient dense meal you could eat for cell health?

0:12:02    Small fatty fish.

0:12:13    DHA, selenium, iodine.

0:12:25    Collagen.

0:12:34    Eggs with yolks and liver.

0:12:43    Dark green leafy vegetables.

0:12:54    Preferably wild grown plants.

0:13:30    The new surf and turf!

0:13:57    Not being squeamish about certain foods at certain times of day.

0:14:39    How does a ketogenic diet affect the health of a cell.

0:15:01    Adding fat doesn't necessarily make it ketogenic.

0:16:16    My diet has zero refined carbohydrates.

0:16:30    Still lots of vegetables.

0:16:40    At this point, you've gotten rid of most of the crap.

0:17:15    Ketogenic diets can cause an increase in oxidative stress inside of the mitochondria in the short term

0:17:42    Reactive oxygen species are signalling molecules.

0:17:59    ROS Goldilocks principle.

0:19:14    Some people will say that the ketogenic diet is bad because of this initial increase in ROS.

0:19:55    Should everyone be eating a ketogenic diet?

0:19:58    No, certainly not all of the time.

0:20:11    Sodium and potassium and selenium can be difficult to hold onto in ketosis.

0:20:38    The extra stress of the diet can also be problem.

0:21:13    Seasonal ketosis.

0:22:00    Wills is already eating a high-fat diet.

0:22:21    What happened to our diet in between the paleolithic and the era of the Food Pyramid?

0:23:32    Carbohydrate consumption may have changed.

0:23:53    Access to fire and cooking has made a difference.

0:24:10    Eating fish.

0:24:19    If you didn't live near the sea, you ate brain.

0:24:40    Around 10,000 years ago, we became agriculturalists.

0:25:04    Seeds and grasses like wheat.

0:25:19    Where there is a fossil record, we see health deteriorated.

0:25:43    People got shorter and had worse teeth.

0:25:57    We can't say definitely that farming was the cause.

0:26:23    There's no benefit from eating wheat.

0:26:59    When the food shows up in front of you, that's what you eat.

0:27:36    1980 saw the first dietary guidelines with grains as the foundation.

0:27:53    Part of this decision was driven by economics.

0:29:00    The perfect storm of refined carbohydrates plus vegetable oils and refined sugar.

0:29:51    This combination used to be impossible to obtain.

0:30:26    Will the Food Pyramid change soon?

0:30:44    People are working on this problem.

0:31:04    People don't eat according to the food pyramid, but it is used to create the foods that we eat.

0:32:05    Farming is heavily subsidised, this creates momentum.

0:33:16    Nothing is going to change any time soon.

0:33:26    Wording has changed around the word saturated fat and the caution on cholesterol has been removed.

0:34:00    Tommy's two presentations on MS and dairy.

0:34:22    Terry Wahls has largely reversed her MS with her protocol.

0:35:00    Tommy comes from a family of chemical engineers.

0:35:04    His stepbrother has MS.

0:35:11    Chemical engineers are problem solvers.

0:35:27    They built a root cause analysis for MS.

0:35:42    Gluten and casein allergies.

0:35:56    Mitocondria that are not working properly.

0:36:14    Terry also advocates ketosis.

0:36:27    Tommy and Terry represent two groups of people that came up with the same conclusion using different methods.

0:37:09    Do you think that Terry Wahl's work is original?

0:37:31    There's nothing new under the sun.

0:37:53    Tommy has ideas, and then doesn't want to tell anybody about it for fear they will steal it.

0:38:21    Terry is the first person to apply these principles in MS patients and in clinical trials.

0:39:24    I had tremendous results eating the AIP diet.

0:39:40    The book The Paleo Approach.

0:39:48    Personalising the Wahls Protocol.

0:40:14    This would look like a high-plant, dairy-free, low-carb diet.

0:41:07    Not everybody needs to be that strict.

0:41:32    Eat the yolks.

0:42:11    Start with the basic elimination diet.

0:42:23    Reintroduce later.

0:42:55    You can go too far, but most people don't go far enough.

0:43:12    Be really strict for two months and then reintroduce.

0:43:56    Then the signal ratio is great enough for you to know what's causing the problem.

0:44:41    Are there any other diets that can produce the same results.

0:45:03    Yes, the Swank Diet.

0:45:25    This is the most successful diet for MS patients.

0:45:33    Terry Wahls doesn't have that much data yet.

0:45:50    The problem is the diet is a very low fat vegan diet.

0:46:14    The stricter you were with the diet, the better you did.

0:46:34    Actively engaging in your treatment has a positive effect.

0:46:58    Recent research is not impressive.

0:47:53    The Swank Diet is probably better than what people were eating before.

0:48:33    It's impossible to create a blinded trial.

0:49:11    Swank is better than standard American but perhaps not the best.

0:49:22    If these diets are so successful, then should doctor be making dietary prescriptions?

0:49:47    Yes they should, but doctors are not trained in nutrition.

0:50:18    Tommy is a traditionally trained doctor.

0:50:42    We are in an era of evidence-based medicine.

0:51:12    Clinical trials are not going to happen for diet.

0:51:35    Therefore, the doctors are not going prescribe a diet.

0:51:58    There's always confounding factor.

0:52:08    Someone will always say the evidence isn't good enough.

0:52:35    Nowadays you can use clever statistics to show that your new drug is not inferior.

0:53:03    Rather than showing superiority.

0:53:49    You cannot control for diet and lifestyle.

0:54:29    Is there any one simple takeaway message?

0:54:52    Yes, just eat real food.

0:55:04    Go to your local grocery store and buy ingredients.

0:55:19    Turn that into food and you will avoid all of the trouble.

0:55:37    Even better, go to the local farmer's market.

0:55:54    Getting enough sleep.

0:55:57    Being part of a social group.

0:56:01    Don't worry about the things you can't control.

0:56:08    Occasionally lift heavy.

0:56:16    Circadian rhythm.

]]>
clean
Foodloose Iceland https://s3.amazonaws.com/nourishbalancethrive/podcast/gudmundurfj1979.on.2016-02-03.at.11.31.mp3 Something wonderful is happening in Iceland, and it has nothing to do with geysers, volcanoes or even Björk. A group of medical doctors led by Dr. Guðmundur Jóhannsson are actively engaging in a discussion of the utility of high-fat, low-carb, moderate-protein diets for treating some of the chronic health complaints they see in practice.

Imagine for a moment you’re a doctor working in emergency care. How frustrating must it be only to see the end stages of the diseases caused by insulin resistance? You’d be just like a mechanic working on the damage done to an engine caused by failure to change the oil. Not only is the situation potentially preventable, it’s also expensive enough to bring down the entire national health service.

My question is why Iceland? Is it the manageable size? Dr. Jóhannsson has been able to bring around 200 doctors to the discussion on a Facebook group. Doesn’t sound like a lot, but that’s a significant proportion of all the doctors on the island. Is it because they have nationalised health care? Nationalised means there’s a finite budget, and that may be relevant here, but I don’t see this happening in the UK, and they also have a national health service.

For now, we may have to accept that the Icelandic people are smarter than the rest of us. I’m hoping we will follow their lead.

I’m still excited about geysers and volcanoes because this May I will be visiting Iceland with my wife and food scientist Julia and chief medical officer Dr. Tommy Wood. Tommy will be speaking alongside Gary Taubes, Professor Tim Noakes and many other like-minded experts in the field at the Icelandic Health Symposium’s Foodloose conference.

Please let me know if you will be there!

Here’s the outline of this interview with Dr. Guðmundur Jóhannsson and Dr. Tommy wood:

0:01:00    Dr. Guðmundur Jóhannsson is a medical doctor from Iceland, trained in Sweden.

0:01:46    Guðmundur was overweight in medical school.

0:02:05    He quickly figured out it was the carbohydrates that were causing the problem.

0:02:45    I've visited Sweden on several occasions and the Swedes are not fatphobic.

0:03:13    The Icelandic people have started consuming more carbs in recent decades.

0:04:02    Guðmundur is an emergency doctor.

0:04:22    It's frustrating to only see people at the end stages of disease.

0:04:39    Some of this could be prevented.

0:05:10    With the right information, diabetes is preventable.

0:05:35    I work with registered nurse Amelia Luker, her motivation for a career change was similar.

0:06:08    It's so much more costly to treat once the disease has developed.

0:06:27    From insulin resistance to injecting insulin is a long process.

0:06:51    Tommy's mum is from Iceland.

0:07:25    Is the health care system in Iceland similar to those in the US or UK?

0:07:33    Tommy sees it as very similar to the NHS in the UK.

0:07:39    The Icelandic people have upgrade options.

0:08:02    Would an Icelandic doctor ever talk to a patient about food?

0:08:14    Doctors are not trained in nutrition biochemistry or exercise physiology.

0:08:38    More and more doctors are choosing to further their education.

0:08:55    In Iceland, there is a Facebook group for doctors.

0:09:18    200 doctors is a significant number.

0:10:14    Why is this situation unique to Iceland?

0:10:31    Iceland is so small, news travels fast.

0:10:49    Where did the idea for the Foodloose conference come from?

0:10:53    Book: Good Calories, Bad Calories by Gary Taubes.

0:11:15    The problems extend further than diabetes and cardiovascular disease.

0:12:15    Professor Tim Noakes has been on my podcast.

0:12:28    Why do people want to come to Iceland?

0:13:26    The Icelandic doctors are not necessarily on board with low-carb, but they are taking part in the discussion.

0:13:46    Tommy will be speaking alongside Gary Taubes and Tim Noakes.

0:13:52    Axel F. Sigurdsson.

0:14:00    Aseem Malhotra.

0:14:05    Denise Minger.

0:14:13    Maryanne Demasi will be moderating.

0:14:19    ABC Australia Catalyst Program.

0:14:28    The presenters will present and then give the audience a chance to ask questions.

0:14:57    Tommy has been on a panel with Aseem Malhotra before.

0:15:07    Tommy and Guðmundur will be publishing a paper with Axel Sigurdsson soon.

0:15:43    Gary Taubes will be talking the carbohydrate insulin hypothesis.

0:15:57    Aseem Malhotra will be talking about sugar and more.

0:16:08    Sigurdsson is going to talk about diet and heart disease.

0:16:20    Denise is going to bring in the opposing viewpoint.

0:17:53    Denise has dug up some interesting data.

0:18:10    Everybody else is going to talk about food, Tommy is going to talk about all the other things that we've found to be important.

0:18:58    Diet is the first thing people figure out.

0:19:10    Everything else is important!

0:19:38    May 26 is the main day, workshops will take place on the 27th.

0:19:52    There will be culinary workshop for people that would like to meet with the speakers.

0:20:13    High-fat, low-carb, moderate protein cooking classes.

0:21:11    What else should people see and do in Iceland?

0:21:18    Iceland is all about nature.

0:21:22    You don't go for the weather.

0:21:23    It's like a sample from all parts of the world.

0:21:45    Hiking, kayaking and biking.

0:22:08    Tommy and my family will be doing touristy stuff, come join us!

0:22:33    The Golden Circle.

0:22:42    Gullfoss waterfall.

0:22:47    The first parliament in the world.

0:22:57    The Blue Lagoon.

0:23:26    Day trips to hike up glaciers.

0:23:34    Not far Reykjavik.

0:23:51    If you're going to Iceland you have to be .prepared for anything.

0:24:06    Probably around 10c

0:24:35    The difference between summer and winter in Iceland is that in the summer you can see the rain.

0:25:12    If you're going to the conference, please email me.

0:25:32    foodloose.is

0:25:56    Updates in our Concierge Clinical Coaching group.

0:27:01    Tommy recently posted his talk for doctors on insulin resistance.

0:27:17    All the members have done testing with us.

0:27:52    Physicians for Ancestral Health.

0:28:18    Modelling insulin resistance.

0:29:03    Guðmundur and Bob Hanson has been sending the studies to put into the model.

0:30:11    It's not as simple as restricting carbohydrate.

0:30:51    Wasting is saving study.

0:31:08    The ketogenic diet may be an advantage at altitude.

0:31:36    Ketones create the same amount of energy using less oxygen.

0:32:15    Too much muscle mass could be a disadvantage at altitude.

0:32:41    People have been asking about adaptogens.

 
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/gudmundurfj1979.on.2016-02-03.at.11.31.mp3 Thu, 25 Feb 2016 18:02:25 GMT Christopher Kelly Something wonderful is happening in Iceland, and it has nothing to do with geysers, volcanoes or even Björk. A group of medical doctors led by Dr. Guðmundur Jóhannsson are actively engaging in a discussion of the utility of high-fat, low-carb, moderate-protein diets for treating some of the chronic health complaints they see in practice.

Imagine for a moment you’re a doctor working in emergency care. How frustrating must it be only to see the end stages of the diseases caused by insulin resistance? You’d be just like a mechanic working on the damage done to an engine caused by failure to change the oil. Not only is the situation potentially preventable, it’s also expensive enough to bring down the entire national health service.

My question is why Iceland? Is it the manageable size? Dr. Jóhannsson has been able to bring around 200 doctors to the discussion on a Facebook group. Doesn’t sound like a lot, but that’s a significant proportion of all the doctors on the island. Is it because they have nationalised health care? Nationalised means there’s a finite budget, and that may be relevant here, but I don’t see this happening in the UK, and they also have a national health service.

For now, we may have to accept that the Icelandic people are smarter than the rest of us. I’m hoping we will follow their lead.

I’m still excited about geysers and volcanoes because this May I will be visiting Iceland with my wife and food scientist Julia and chief medical officer Dr. Tommy Wood. Tommy will be speaking alongside Gary Taubes, Professor Tim Noakes and many other like-minded experts in the field at the Icelandic Health Symposium’s Foodloose conference.

Please let me know if you will be there!

Here’s the outline of this interview with Dr. Guðmundur Jóhannsson and Dr. Tommy wood:

0:01:00    Dr. Guðmundur Jóhannsson is a medical doctor from Iceland, trained in Sweden.

0:01:46    Guðmundur was overweight in medical school.

0:02:05    He quickly figured out it was the carbohydrates that were causing the problem.

0:02:45    I've visited Sweden on several occasions and the Swedes are not fatphobic.

0:03:13    The Icelandic people have started consuming more carbs in recent decades.

0:04:02    Guðmundur is an emergency doctor.

0:04:22    It's frustrating to only see people at the end stages of disease.

0:04:39    Some of this could be prevented.

0:05:10    With the right information, diabetes is preventable.

0:05:35    I work with registered nurse Amelia Luker, her motivation for a career change was similar.

0:06:08    It's so much more costly to treat once the disease has developed.

0:06:27    From insulin resistance to injecting insulin is a long process.

0:06:51    Tommy's mum is from Iceland.

0:07:25    Is the health care system in Iceland similar to those in the US or UK?

0:07:33    Tommy sees it as very similar to the NHS in the UK.

0:07:39    The Icelandic people have upgrade options.

0:08:02    Would an Icelandic doctor ever talk to a patient about food?

0:08:14    Doctors are not trained in nutrition biochemistry or exercise physiology.

0:08:38    More and more doctors are choosing to further their education.

0:08:55    In Iceland, there is a Facebook group for doctors.

0:09:18    200 doctors is a significant number.

0:10:14    Why is this situation unique to Iceland?

0:10:31    Iceland is so small, news travels fast.

0:10:49    Where did the idea for the Foodloose conference come from?

0:10:53    Book: Good Calories, Bad Calories by Gary Taubes.

0:11:15    The problems extend further than diabetes and cardiovascular disease.

0:12:15    Professor Tim Noakes has been on my podcast.

0:12:28    Why do people want to come to Iceland?

0:13:26    The Icelandic doctors are not necessarily on board with low-carb, but they are taking part in the discussion.

0:13:46    Tommy will be speaking alongside Gary Taubes and Tim Noakes.

0:13:52    Axel F. Sigurdsson.

0:14:00    Aseem Malhotra.

0:14:05    Denise Minger.

0:14:13    Maryanne Demasi will be moderating.

0:14:19    ABC Australia Catalyst Program.

0:14:28    The presenters will present and then give the audience a chance to ask questions.

0:14:57    Tommy has been on a panel with Aseem Malhotra before.

0:15:07    Tommy and Guðmundur will be publishing a paper with Axel Sigurdsson soon.

0:15:43    Gary Taubes will be talking the carbohydrate insulin hypothesis.

0:15:57    Aseem Malhotra will be talking about sugar and more.

0:16:08    Sigurdsson is going to talk about diet and heart disease.

0:16:20    Denise is going to bring in the opposing viewpoint.

0:17:53    Denise has dug up some interesting data.

0:18:10    Everybody else is going to talk about food, Tommy is going to talk about all the other things that we've found to be important.

0:18:58    Diet is the first thing people figure out.

0:19:10    Everything else is important!

0:19:38    May 26 is the main day, workshops will take place on the 27th.

0:19:52    There will be culinary workshop for people that would like to meet with the speakers.

0:20:13    High-fat, low-carb, moderate protein cooking classes.

0:21:11    What else should people see and do in Iceland?

0:21:18    Iceland is all about nature.

0:21:22    You don't go for the weather.

0:21:23    It's like a sample from all parts of the world.

0:21:45    Hiking, kayaking and biking.

0:22:08    Tommy and my family will be doing touristy stuff, come join us!

0:22:33    The Golden Circle.

0:22:42    Gullfoss waterfall.

0:22:47    The first parliament in the world.

0:22:57    The Blue Lagoon.

0:23:26    Day trips to hike up glaciers.

0:23:34    Not far Reykjavik.

0:23:51    If you're going to Iceland you have to be .prepared for anything.

0:24:06    Probably around 10c

0:24:35    The difference between summer and winter in Iceland is that in the summer you can see the rain.

0:25:12    If you're going to the conference, please email me.

0:25:32    foodloose.is

0:25:56    Updates in our Concierge Clinical Coaching group.

0:27:01    Tommy recently posted his talk for doctors on insulin resistance.

0:27:17    All the members have done testing with us.

0:27:52    Physicians for Ancestral Health.

0:28:18    Modelling insulin resistance.

0:29:03    Guðmundur and Bob Hanson has been sending the studies to put into the model.

0:30:11    It's not as simple as restricting carbohydrate.

0:30:51    Wasting is saving study.

0:31:08    The ketogenic diet may be an advantage at altitude.

0:31:36    Ketones create the same amount of energy using less oxygen.

0:32:15    Too much muscle mass could be a disadvantage at altitude.

0:32:41    People have been asking about adaptogens.

 
]]>
no
Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure https://s3.amazonaws.com/nourishbalancethrive/podcast/Travis.Christofferson.on.2015-12-02.at.09.50.mp3 Cancer is like a computer program gone wrong, the kernel panic of the human body. Unfortunately, we have no reboot button, and so cancer is the most serious of diseases. This year, almost six hundred thousand Americans will die from cancer. Despite the fact that cancer receives more NIH funding than any other illness, the death rates remain the same as in the 1950s.

Tripping Over the Truth: The Return of the Metabolic Theory of Cancer tells the story of molecular biologist and science writer Travis Christofferson’s journey to discover why cancer has remained so elusive. The central theme of the book is that we’ve fundamentally mischaracterized the origin of cancer. Most scientists hold to the belief that cancer is a genetic disease, Travis explores the idea that cancer is, in fact, a disease of damaged metabolism.

The metabolic theory of cancer stems from Nobel laureate Otto Warburg’s observation in 1924 that cancer cells lack the ability to produce energy using anything other than an ancient and inefficient process of fermentation. Warburg’s idea failed to gain critical mass, and by the 1960s had largely faded into oblivion. In 2012, Thomas Siegfried, Ph.D., released his book Cancer as a Metabolic Disease where he expanded on Warburg’s original hypothesis. In his book, Siegfried described how all cancer cells have damaged mitochondria, the organelle responsible for creating energy with oxygen.

Inspired by The Emperor of All Maladies by Siddhartha Mukherjee, Travis has done a excellent job of telling the rich story behind the metabolic theory of cancer. In this interview, Travis and I discuss some of the potential benefits and mechanisms of a ketogenic diet, hyperbaric oxygen, gluconeogenesis inhibitors and ketone supplements as possible cancer therapy.

I would like to thank Dr. Tommy Wood for some of the questions asked in this interview, especially those about glioblastoma and women with the BRCA1 mutation and breast cancer.

Here’s the outline of this interview with Travis Christofferson:

0:00:15    Book: Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure

0:00:34    How Travis became in terested in biology.

0:00:54    Travis has a fundamental curiosity.

0:01:10    The best doctors are the ones that do experiments on themselves.

0:01:22    Book: Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer by Tom Siegfried.

0:01:38    Book: The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee.

0:02:16    Travis wanted to tell the rich story behind the science in Tom's book.

0:03:01    Podcast: Dominic D'Agostino on the Tim Ferriss show.

0:03:30    The Emperor is gene centric.

0:03:46    The difference between the genetic and metabolic theories of cancer.

0:04:08    Radiation, cell repair.

0:04:09    In the genetic theory, cancer arises through lesions on DNA.

0:04:43    The genetic theory is still the dominant theory.

0:04:55    In the metabolic theory, cancer is proliferated by damage to the mitochondria.

0:05:07    Cancer resorts to less efficient fermentation.

0:05:25    This less efficient metabolism sends a message to the DNA.

0:05:42    This new theory makes cancer look like a disease of order.

0:06:02    Everything that causes cancer damages mitochondria.

0:06:39    Paul Davies, cosmologist.

0:07:07    Worked with Stephen Hawking.

0:07:33    Video: Anna Barker at TEDMED 2010.

0:07:53    Cancer is incredibly complex compared to other diseases.

0:08:19    In 2008 atavistic model

0:08:48    Three million studies on cancer on PubMed.

0:09:20    In the beginning, there was single celled organisms.

0:09:26    With multicellular life, the rules changed.

0:09:43    The foetal genes are reexpressed in cancer.

0:10:03    This new understanding gives hope.

0:10:17    What can we do with this new knowledge.

0:10:28    Look after our mitochondria.

0:10:38    A ketogenic diet is a great way to achieve this.

0:10:48    Also intermittent fasting.

0:10:57    Metformin as an oncology drug.

0:11:20    Exploiting the express of early genes.

0:11:44    The Warburg Effect.

0:11:53    Hyperbaric oxygen.

0:12:01    Cancer cells decouple of the adaptive immune system.

0:12:07    Cancer patients with high fever then spontaneous remission.

0:12:25    Cancer cannot withstand infection.

0:12:56    How does the ketogenic diet work against cancer?

0:13:04    Lowering blood glucose.

0:13:11    Glucose is the preferred fuel of cancer.

0:13:25    Some cancers can utilise ketones.

0:13:45    But there's promise in all cancers.

0:14:05    There's some kind of signalling mechanism.

0:14:27    Less side-effects with chemo after fasting.

0:15:05    Dr. Tommy Wood pointed me at some studies showing that certain breast cancers can use ketones as fuel. One study of women with the BRCA1 mutation showed that those with upregulated ketone metabolism did worse, which suggests that a cancer can develop metabolic flexibility too, and would be able to avoid death on a ketogenic diet.

0:15:27    Everybody is different and your results therefore will vary.

0:15:51    The brain can obtain up to 80% of its energy requirenents from ketones.

0:16:09    Some neurons are too small to include a mitochondria.

0:16:21    There is a trial going on in Arizona with glioblastoma.

0:16:25    Dr. Adrienne C. Scheck.

0:16:29    Results by April.

0:16:41    Kid in Norway, prognosis is 8 months, that was 3 years ago.

0:17:12    Tumor has shrunk and remained stable now for 3 years.

0:17:31    Metabolic therapies are good at managing cancer, but may not be the cure.

0:17:55    The studies are all done from the same line of glioblastoma.

0:18:17    Glioblastoma is where the research started, but the principle is sound

0:18:41    Will glioblastoma be the first cancer that we see a cure for?

0:18:48    Glioblastoma is usually about a year from the time of diagnosis to death.

0:19:17    How do cancers show up in a PET scanner?

0:19:24    PET scanners detect radiolabeled glucose.

0:19:43    The tumour outcompetes normal cells for glucose and show they show up in the scanner.

0:20:25    If the tumours have been lighting up in scanners for a long time, why has it taken so long for anyone to think of this?

0:20:41    Dr. Scheck’s study is using a standard ketogenic diet.

0:20:43    In some people that doesn't drive down glucose very far.

0:21:06    You can drive blood glucose very low.

0:21:21    In extended fasts, blood glucose would go down in the 60s (mg/dL).

0:21:24    Now we have exogenous ketone supplementation.

0:21:27    And gluconeogenesis inhibitors.

0:22:50    What were gluconeogenesis inhibitors originally designed for?

0:23:05    We're only just starting to appreciate Metformin.

0:23:06    25-30% reduction in the chances of getting cancer on Metformin.

0:23:07    Nobody really knows how is works.

0:23:31    Phenylbutyrate.

0:23:55    Metformin also inhibits complex 1 of the ETC.

0:24:07    ROS are bad, but also signalling molecules.

0:24:23    Another line of research has shown that Metformin works through altering the gut microbiome.

0:24:44    Podcast: Exercise is an antioxidant.

0:25:02    Podcast: Tommy and me on the Robb Wolf podcast.

0:25:11    Podcast: Insulin resistance.

0:25:15    Podcast: Iron overload.

0:25:46    In biology, you focus on one thing. One protein, one pathway.

0:25:55    Dr. Coe? in Travis's book.

0:25:56    ATPase.

0:26:15    You need someone to do the detailed work, but then you need someone to step back.

0:26:30    Physics already has a mechanism in place to do that.

0:27:05    In physics, you can come up with an idea and there's more than enough data to test it out.

0:27:31    Worse, in nutrition the data conflicts each other.

0:27:33    The NCI said that 80% of the basic research in cancer biology were not reproducible.

0:27:56    Sorting through the studies is an art form.

0:28:08    Warren Buffett.

0:28:22    What do you think of the meta-analysis?

0:28:53    This is the Gold Standard of science!

0:29:11    Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes

0:30:36    Ketone supplements are not currently be used in cancer therapy.

0:31:09    Dominic D'Agostino specialises in ketone supplementation.

0:31:34    Ketones are far more than a macronutrient.

0:31:49    Ketones are anti-inflammatory.

0:32:08    Seasonal ketosis.

0:32:22    Dr. Veech at the NIH: "it's not normal to have a McDonald’s on every street corner".

0:32:30    It's normal to starve periodically.

0:32:53    Alzheimer's is now being called type 3 diabetes.

0:33:41    Is it a good idea to be constantly in ketosis?

0:33:58    Dr. Peter Attia.

0:34:32    Two studies, one at the National Institute of Aging, one at the University of Wisconson

0:34:37    Caloric restriction in monkeys.

0:34:49    Caloric restriction doesn't help as much as we thought.

0:35:02    The monkeys fed a high-sugar diet did worse.

0:35:27    When is all this going to be more widely know, or even the standard of care?

0:35:40    Things move slowly, it's easy to get depressed.

0:35:57    The trial in Arizona could be groundbreaking.

0:36:34    3-Bromopyruvate (3BP) could be the final piece for the metabolic therapy.

0:37:05    Heroin as the treatment for cocaine addiction.

0:37:47    Radical mastectomy.

0:38:25    This went on for 80 years.

0:38:37    In the end, we discovered that a local lumpectomy was as effective.

0:38:58    The trials are so slow and expensive.

0:39:16    You have to eat something, why not this?.

0:39:42    Travis talked at Paleo f(x).

0:39:57    Anecdotally, word is getting out there.

0:40:24    The ketogenic diet to treat recurrence.

0:40:37    The ketogenic diet is empowering.

0:41:11    Travis wrote an article about recurrence on his website.

0:41:20    It's not about always about a single cell that got left behind.

0:41:36    20% of cases are new, i.e. the environment for cancer is still there.

0:42:09    The same is true of bacteria, if you create the environment, it will grow.

0:42:25    Nobody wants to take high-fat diets seriously for weight loss until we're talking about cancer.

0:42:48    Cachexia is the the worst case scenario.

0:43:40    Valter Longo, PhD.

0:44:21    The state of ketosis doesn't say anything about weight loss, and may even be protective against muscle wasting.

0:44:42    Travis and Dominic's articles on Robb Wolf's website.

0:45:41    The Charlie Foundation.

0:46:04    Travis's new blog with podcast, Metabolic Optimization.

0:46:43    Dominic holds the Guinness World record for the most weight squatted in 24 hours (he broke the record in six).

0:47:15    Travis is a fulltime author.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Travis.Christofferson.on.2015-12-02.at.09.50.mp3 Thu, 18 Feb 2016 18:02:59 GMT Christopher Kelly Cancer is like a computer program gone wrong, the kernel panic of the human body. Unfortunately, we have no reboot button, and so cancer is the most serious of diseases. This year, almost six hundred thousand Americans will die from cancer. Despite the fact that cancer receives more NIH funding than any other illness, the death rates remain the same as in the 1950s.

Tripping Over the Truth: The Return of the Metabolic Theory of Cancer tells the story of molecular biologist and science writer Travis Christofferson’s journey to discover why cancer has remained so elusive. The central theme of the book is that we’ve fundamentally mischaracterized the origin of cancer. Most scientists hold to the belief that cancer is a genetic disease, Travis explores the idea that cancer is, in fact, a disease of damaged metabolism.

The metabolic theory of cancer stems from Nobel laureate Otto Warburg’s observation in 1924 that cancer cells lack the ability to produce energy using anything other than an ancient and inefficient process of fermentation. Warburg’s idea failed to gain critical mass, and by the 1960s had largely faded into oblivion. In 2012, Thomas Siegfried, Ph.D., released his book Cancer as a Metabolic Disease where he expanded on Warburg’s original hypothesis. In his book, Siegfried described how all cancer cells have damaged mitochondria, the organelle responsible for creating energy with oxygen.

Inspired by The Emperor of All Maladies by Siddhartha Mukherjee, Travis has done a excellent job of telling the rich story behind the metabolic theory of cancer. In this interview, Travis and I discuss some of the potential benefits and mechanisms of a ketogenic diet, hyperbaric oxygen, gluconeogenesis inhibitors and ketone supplements as possible cancer therapy.

I would like to thank Dr. Tommy Wood for some of the questions asked in this interview, especially those about glioblastoma and women with the BRCA1 mutation and breast cancer.

Here’s the outline of this interview with Travis Christofferson:

0:00:15    Book: Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure

0:00:34    How Travis became in terested in biology.

0:00:54    Travis has a fundamental curiosity.

0:01:10    The best doctors are the ones that do experiments on themselves.

0:01:22    Book: Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer by Tom Siegfried.

0:01:38    Book: The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee.

0:02:16    Travis wanted to tell the rich story behind the science in Tom's book.

0:03:01    Podcast: Dominic D'Agostino on the Tim Ferriss show.

0:03:30    The Emperor is gene centric.

0:03:46    The difference between the genetic and metabolic theories of cancer.

0:04:08    Radiation, cell repair.

0:04:09    In the genetic theory, cancer arises through lesions on DNA.

0:04:43    The genetic theory is still the dominant theory.

0:04:55    In the metabolic theory, cancer is proliferated by damage to the mitochondria.

0:05:07    Cancer resorts to less efficient fermentation.

0:05:25    This less efficient metabolism sends a message to the DNA.

0:05:42    This new theory makes cancer look like a disease of order.

0:06:02    Everything that causes cancer damages mitochondria.

0:06:39    Paul Davies, cosmologist.

0:07:07    Worked with Stephen Hawking.

0:07:33    Video: Anna Barker at TEDMED 2010.

0:07:53    Cancer is incredibly complex compared to other diseases.

0:08:19    In 2008 atavistic model

0:08:48    Three million studies on cancer on PubMed.

0:09:20    In the beginning, there was single celled organisms.

0:09:26    With multicellular life, the rules changed.

0:09:43    The foetal genes are reexpressed in cancer.

0:10:03    This new understanding gives hope.

0:10:17    What can we do with this new knowledge.

0:10:28    Look after our mitochondria.

0:10:38    A ketogenic diet is a great way to achieve this.

0:10:48    Also intermittent fasting.

0:10:57    Metformin as an oncology drug.

0:11:20    Exploiting the express of early genes.

0:11:44    The Warburg Effect.

0:11:53    Hyperbaric oxygen.

0:12:01    Cancer cells decouple of the adaptive immune system.

0:12:07    Cancer patients with high fever then spontaneous remission.

0:12:25    Cancer cannot withstand infection.

0:12:56    How does the ketogenic diet work against cancer?

0:13:04    Lowering blood glucose.

0:13:11    Glucose is the preferred fuel of cancer.

0:13:25    Some cancers can utilise ketones.

0:13:45    But there's promise in all cancers.

0:14:05    There's some kind of signalling mechanism.

0:14:27    Less side-effects with chemo after fasting.

0:15:05    Dr. Tommy Wood pointed me at some studies showing that certain breast cancers can use ketones as fuel. One study of women with the BRCA1 mutation showed that those with upregulated ketone metabolism did worse, which suggests that a cancer can develop metabolic flexibility too, and would be able to avoid death on a ketogenic diet.

0:15:27    Everybody is different and your results therefore will vary.

0:15:51    The brain can obtain up to 80% of its energy requirenents from ketones.

0:16:09    Some neurons are too small to include a mitochondria.

0:16:21    There is a trial going on in Arizona with glioblastoma.

0:16:25    Dr. Adrienne C. Scheck.

0:16:29    Results by April.

0:16:41    Kid in Norway, prognosis is 8 months, that was 3 years ago.

0:17:12    Tumor has shrunk and remained stable now for 3 years.

0:17:31    Metabolic therapies are good at managing cancer, but may not be the cure.

0:17:55    The studies are all done from the same line of glioblastoma.

0:18:17    Glioblastoma is where the research started, but the principle is sound

0:18:41    Will glioblastoma be the first cancer that we see a cure for?

0:18:48    Glioblastoma is usually about a year from the time of diagnosis to death.

0:19:17    How do cancers show up in a PET scanner?

0:19:24    PET scanners detect radiolabeled glucose.

0:19:43    The tumour outcompetes normal cells for glucose and show they show up in the scanner.

0:20:25    If the tumours have been lighting up in scanners for a long time, why has it taken so long for anyone to think of this?

0:20:41    Dr. Scheck’s study is using a standard ketogenic diet.

0:20:43    In some people that doesn't drive down glucose very far.

0:21:06    You can drive blood glucose very low.

0:21:21    In extended fasts, blood glucose would go down in the 60s (mg/dL).

0:21:24    Now we have exogenous ketone supplementation.

0:21:27    And gluconeogenesis inhibitors.

0:22:50    What were gluconeogenesis inhibitors originally designed for?

0:23:05    We're only just starting to appreciate Metformin.

0:23:06    25-30% reduction in the chances of getting cancer on Metformin.

0:23:07    Nobody really knows how is works.

0:23:31    Phenylbutyrate.

0:23:55    Metformin also inhibits complex 1 of the ETC.

0:24:07    ROS are bad, but also signalling molecules.

0:24:23    Another line of research has shown that Metformin works through altering the gut microbiome.

0:24:44    Podcast: Exercise is an antioxidant.

0:25:02    Podcast: Tommy and me on the Robb Wolf podcast.

0:25:11    Podcast: Insulin resistance.

0:25:15    Podcast: Iron overload.

0:25:46    In biology, you focus on one thing. One protein, one pathway.

0:25:55    Dr. Coe? in Travis's book.

0:25:56    ATPase.

0:26:15    You need someone to do the detailed work, but then you need someone to step back.

0:26:30    Physics already has a mechanism in place to do that.

0:27:05    In physics, you can come up with an idea and there's more than enough data to test it out.

0:27:31    Worse, in nutrition the data conflicts each other.

0:27:33    The NCI said that 80% of the basic research in cancer biology were not reproducible.

0:27:56    Sorting through the studies is an art form.

0:28:08    Warren Buffett.

0:28:22    What do you think of the meta-analysis?

0:28:53    This is the Gold Standard of science!

0:29:11    Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes

0:30:36    Ketone supplements are not currently be used in cancer therapy.

0:31:09    Dominic D'Agostino specialises in ketone supplementation.

0:31:34    Ketones are far more than a macronutrient.

0:31:49    Ketones are anti-inflammatory.

0:32:08    Seasonal ketosis.

0:32:22    Dr. Veech at the NIH: "it's not normal to have a McDonald’s on every street corner".

0:32:30    It's normal to starve periodically.

0:32:53    Alzheimer's is now being called type 3 diabetes.

0:33:41    Is it a good idea to be constantly in ketosis?

0:33:58    Dr. Peter Attia.

0:34:32    Two studies, one at the National Institute of Aging, one at the University of Wisconson

0:34:37    Caloric restriction in monkeys.

0:34:49    Caloric restriction doesn't help as much as we thought.

0:35:02    The monkeys fed a high-sugar diet did worse.

0:35:27    When is all this going to be more widely know, or even the standard of care?

0:35:40    Things move slowly, it's easy to get depressed.

0:35:57    The trial in Arizona could be groundbreaking.

0:36:34    3-Bromopyruvate (3BP) could be the final piece for the metabolic therapy.

0:37:05    Heroin as the treatment for cocaine addiction.

0:37:47    Radical mastectomy.

0:38:25    This went on for 80 years.

0:38:37    In the end, we discovered that a local lumpectomy was as effective.

0:38:58    The trials are so slow and expensive.

0:39:16    You have to eat something, why not this?.

0:39:42    Travis talked at Paleo f(x).

0:39:57    Anecdotally, word is getting out there.

0:40:24    The ketogenic diet to treat recurrence.

0:40:37    The ketogenic diet is empowering.

0:41:11    Travis wrote an article about recurrence on his website.

0:41:20    It's not about always about a single cell that got left behind.

0:41:36    20% of cases are new, i.e. the environment for cancer is still there.

0:42:09    The same is true of bacteria, if you create the environment, it will grow.

0:42:25    Nobody wants to take high-fat diets seriously for weight loss until we're talking about cancer.

0:42:48    Cachexia is the the worst case scenario.

0:43:40    Valter Longo, PhD.

0:44:21    The state of ketosis doesn't say anything about weight loss, and may even be protective against muscle wasting.

0:44:42    Travis and Dominic's articles on Robb Wolf's website.

0:45:41    The Charlie Foundation.

0:46:04    Travis's new blog with podcast, Metabolic Optimization.

0:46:43    Dominic holds the Guinness World record for the most weight squatted in 24 hours (he broke the record in six).

0:47:15    Travis is a fulltime author.

]]>
clean
How to Measure Hormones https://s3.amazonaws.com/nourishbalancethrive/podcast/Mark.Newman.on.2015-12-16.at.10.10.mp3 Cortisol: the emergency responder hormone that when chronically elevated, makes you fat, stupid and unsexy. Nobody wants an excess of cortisol, but like all things in physiology there’s a sweet spot; low cortisol doesn’t feel right either.

Which you have?

Symptoms of high cortisol Symptoms of low cortisol
Fatigue Extreme fatigue
Muscle weakness Muscle or joint pains
Depression, anxiety and irritability Depression, irritability
Loss of emotional control Salt craving
Cognitive difficulties Abdominal pain
New or worsened high blood pressure Low blood pressure, even fainting
Glucose intolerance that may lead to diabetes Low blood sugar (hypoglycaemia)
Headache Nausea, diarrhea or vomiting
Bone loss, leading to fractures over time Weight loss and decreased appetite
Source: Mayo Clinic

Both sets of symptoms are very similar, in fact, all of these symptoms could be attributable to half the diseases known to man. The only way to know for sure what’s going on with your cortisol is to do the test.

I tested over 500 endurance athletes

And all but a handful had low free cortisol. Free cortisol is the active fraction of the hormone, but it only accounts for 1% of the total cortisol production and so forms just part of the puzzle. I can’t give you any more information than this because free cortisol is all a saliva test measures.

Luckily the testing has gotten more sophisticated

Mark Newman is an analytical chemist and the founder of Precision Analytical, a lab using GC and LC-tandem mass spectrometry to measure not just free cortisol, but also the metabolites tetrahydrocortisol and tetrahydrocortisone. Their DUTCH test is a game changer. The extra information in this test enables me to be a better detective. Now I can differentiate between problems with cortisol production and cortisol clearance. The two have very different implications.

Not just cortisol

The DUTCH also measures no less than eight androgens, eight oestrogens and two metabolites of progesterone. The results can be overwhelming at first, but as you begin to appreciate the pathways that these hormones take, the picture becomes clear.

Testosterone

Testosterone can metabolise down one of two pathways: the more androgenic alpha pathway that leads to the hormone DHT, thinning scalp hair and prostate problems for older men or a potentially more desirable and less androgenic beta pathway. The good news is that once you understand your metabolism, there are nutritional supplements that you can take to inhibit the alpha pathway.

Oestrogen

Saliva isn’t a very accurate way to measure oestrogen. Not only is urine more precise, but it also enables us to test the metabolites that tell us all about both phase 1 and phase 2 metabolism. Oestradiol is the most abundant oestrogen, and its friend oestrone breaks down in one of two different directions. This can produce two very different, and not always desirable outcomes. The only way to know what’s happening to you is to do the test

Establishing a baseline

During this interview, Mark makes an important point. Let’s say you feel good right now. Wouldn’t it be nice to have the complete picture of your hormone metabolism for future reference? Or perhaps you suspect a problem. Either way, you can order a DUTCH though me and then together we figure out a plan to optimise your hormones. Don’t be that guy guessing using the list of symptoms you found on the Mayo Clinic website.

Here’s the outline of this interview with Mark Newman:

0:00:50    Mark Newman is an analytical chemist with a master's degree in forensic science.

0:01:07    Mark started with urine testing then moved onto saliva testing.

0:01:41    DUTCH stands for Dried Urine Test for Comprehensive Hormones.

0:02:11    The DUTCH combines the best of saliva and urine.

0:02:51    Educational videos.

0:03:32    The DUTCH is the culmination of Mark's life work.

0:05:01    My first saliva test showed high cortisol at night, and low cortisol during the day.

0:05:51    We've run over 546 saliva tests now.

0:06:12    All the results look the same.

0:06:31    The question is WHY low cortisol?

0:07:01    Mark has managed data from one million saliva results.

0:07:23    Mark started with the idea that cortisol makes you fat, yet salivary cortisol isn’t higher in fat people.

0:07:40    The free cortisol is just one piece of the puzzle.

0:08:07    With urine testing, you also get to look at the metabolites.

0:08:24    Free cortisol is only about 1% of the total.

0:08:53    40% of patient that have low free cortisol do have elevated production (metabolites).

0:09:45    What drives cortisol production also drives clearance.

0:10:00    In obesity there is high production AND clearance, overall free cortisol is often low.

0:10:33    In hypothyroidism cortisol clearance is sluggish.

0:11:06    The DUTCH is the only way to get all three dimensions.

0:11:51    I get the impression all the tests will look dated in 10 years time.

0:12:32    Mark is skeptical when I say "everybody's low".

0:13:01    Reference ranges can be very problematic.

0:13:38    You cannot easily compare results from different tests.

0:14:13    Not everybody has low cortisol.

0:14:55    Morning serum cortisol is better than nothing.

0:15:08    Saliva is better still and DUTCH better yet.

0:15:27    The term adrenal fatigue needs some work.

0:15:44    Adrenal glands are not like ovaries (they don’t tend to give out with age).

0:16:16    The problem with cortisol is probably often in the brain, not the adrenal gland.

0:17:01    The misinformation has been driven by oversimplification.

0:18:03    How are the reference ranges for the DUTCH defined.

0:18:20    You start with a bunch of healthy people.

0:18:35    The range is then two standard deviations either side of the mean.

0:18:53    This is useful for finding pathology.

0:19:17    Reference ranges require more thought than simple maths.

0:20:00    Some reference ranges are set up so that everyone is low.

0:20:23    The analytes are unique and so are the reference ranges.

0:21:07    People are critical of blood tests, both blood is very well established and standardised.

0:21:35    Saliva testing has some shoddy standards for some tests.

0:22:06    Intranasal ACTH experiment.

0:22:30    If the lab is not curious enough to do that type of experiment you have to wonder.

0:23:16    Everyone should get test to establish a baseline.

0:23:30    Hormonal symptoms overlap a lot.

0:23:51    Then when people read or hear about symptoms, they say gee that's me.

0:24:18    Lots of things can drive cortisol.

0:24:59    Hormones are worth exploring around menopause.

0:25:28    Everybody is tired.

0:26:17    Mark's sister-in-law is healthy in spite of low hormones, should anything happen in the future, having the baseline would be important.

0:27:20    DHEA comparison.

0:27:34    Mark is a skeptic when it comes to labs, he always suspects they could be wrong, even his own…that’s why having multiple markers (as in DUTCH) for hormones can be helpful.

0:28:19    Etiocholanolone and Androsterone.

0:28:43    Inflammation blocks sulfation DHEA à DHEAS.

0:29:24    The DHEA-S can misrepresent what's really going on.

0:29:55    The DUTCH represents 14 hours worth of DHEA production.

0:30:31    The DUTCH paints the big picture of hormones.

0:31:01    Iron overload in master's athletes.

0:31:24    The DUTCH helps me be a better detective.

0:31:36    Inflammation makes prostaglandins that drive aromatase.

0:32:19    Narrowing down a list possibilities to a list of probabilities.

0:32:43    DHEA and women.

0:33:03    DHT is three times as potent as testosterone.

0:33:18    Insulin can push alpha metabolism.

0:33:36    The beta pathway is less androgen.

0:33:42    Saw palmetto, nettles, pygeum, EGCG, progesterone, zinc, finasteride all block the alpha pathway.

0:33:48    DHT can cause acne, thinning scalp hair.

0:34:37    The DUTCH has 4 alpha pathways measured.

0:34:59    PCOS is a leading cause of infertility.

0:35:36    Could we take supplements without doing the tests?

0:35:59    Mark thinks that's a bad idea in some cases.

0:36:50    Pragmatism can work.

0:37:05    Thinning scalp hair can have a number of causes.

0:37:29    If you can afford the test, do it.

0:37:42    Some of the supplements are also expensive.

0:37:51    DIM for oestrogen metabolism.

0:38:03    Pushes oestrogen down the 2-OH pathway.

0:39:11    DIM as a goitrogen.

0:39:39    I3C metabolises to DIM.

0:40:52    Mark's testing matrix.

0:41:18    People take progesterone at night because it helps with sleep.

0:41:27    Oral progesterone is gone four hours later.

0:42:09    Saliva and serum are not good ways to measure oral progesterone supplementation.

0:43:13    Mark has spent 10 years putting the testing matrix together.

0:43:43    What testing oestrogen can tell you about your methylation status.

0:43:47    Oestradiol is the main oestrogen.

0:44:01    Saliva testing for oestrogen is almost useless.

0:44:20    In serum and urine there's a 10 fold difference in oestrogen between pre and postmenopausal women.

0:44:23    In saliva, it's a 2 fold difference at best.

0:44:44    This is one of the main reasons why Mark switched to urine.

0:45:11    DIM acts on phase one metabolism.

0:45:23    Phase two includes methylation.

0:45:34    Genetic defects affect phase two.

0:45:51    Methylation is an important thing to do well.

0:45:56    Mark has two very messed up COMT genes.

0:46:04    Mark's MTHFR genes are fine.

0:46:17    On the DUTCH test, Mark is a poor methylator.

0:47:40    The DUTCH is cheap to ship (filter paper is light).

0:48:07    The test is still expensive, unfortunately.

0:48:33    Precision Analytical uses GC-MS/MS and LC-MS/MS.

0:49:14    Providers should go to dutchtest.com.

0:49:26    Five tests at half price.

0:50:12    Mark will help doctors interpret the results.

0:50:28    Testing (lab testing, not sample collection) is a four day process.

0:50:55    Organic acids tests are run in batches.

0:51:10    Mark developed organic acids testing for BioTech Lab  (US BioTek).

0:51:49    You can order a DUTCH though me and then I can connect with you on the phone or Skype to explain what the results mean

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mark.Newman.on.2015-12-16.at.10.10.mp3 Thu, 11 Feb 2016 19:02:40 GMT Christopher Kelly Cortisol: the emergency responder hormone that when chronically elevated, makes you fat, stupid and unsexy. Nobody wants an excess of cortisol, but like all things in physiology there’s a sweet spot; low cortisol doesn’t feel right either.

Which you have?

Symptoms of high cortisol Symptoms of low cortisol
Fatigue Extreme fatigue
Muscle weakness Muscle or joint pains
Depression, anxiety and irritability Depression, irritability
Loss of emotional control Salt craving
Cognitive difficulties Abdominal pain
New or worsened high blood pressure Low blood pressure, even fainting
Glucose intolerance that may lead to diabetes Low blood sugar (hypoglycaemia)
Headache Nausea, diarrhea or vomiting
Bone loss, leading to fractures over time Weight loss and decreased appetite
Source: Mayo Clinic

Both sets of symptoms are very similar, in fact, all of these symptoms could be attributable to half the diseases known to man. The only way to know for sure what’s going on with your cortisol is to do the test.

I tested over 500 endurance athletes

And all but a handful had low free cortisol. Free cortisol is the active fraction of the hormone, but it only accounts for 1% of the total cortisol production and so forms just part of the puzzle. I can’t give you any more information than this because free cortisol is all a saliva test measures.

Luckily the testing has gotten more sophisticated

Mark Newman is an analytical chemist and the founder of Precision Analytical, a lab using GC and LC-tandem mass spectrometry to measure not just free cortisol, but also the metabolites tetrahydrocortisol and tetrahydrocortisone. Their DUTCH test is a game changer. The extra information in this test enables me to be a better detective. Now I can differentiate between problems with cortisol production and cortisol clearance. The two have very different implications.

Not just cortisol

The DUTCH also measures no less than eight androgens, eight oestrogens and two metabolites of progesterone. The results can be overwhelming at first, but as you begin to appreciate the pathways that these hormones take, the picture becomes clear.

Testosterone

Testosterone can metabolise down one of two pathways: the more androgenic alpha pathway that leads to the hormone DHT, thinning scalp hair and prostate problems for older men or a potentially more desirable and less androgenic beta pathway. The good news is that once you understand your metabolism, there are nutritional supplements that you can take to inhibit the alpha pathway.

Oestrogen

Saliva isn’t a very accurate way to measure oestrogen. Not only is urine more precise, but it also enables us to test the metabolites that tell us all about both phase 1 and phase 2 metabolism. Oestradiol is the most abundant oestrogen, and its friend oestrone breaks down in one of two different directions. This can produce two very different, and not always desirable outcomes. The only way to know what’s happening to you is to do the test

Establishing a baseline

During this interview, Mark makes an important point. Let’s say you feel good right now. Wouldn’t it be nice to have the complete picture of your hormone metabolism for future reference? Or perhaps you suspect a problem. Either way, you can order a DUTCH though me and then together we figure out a plan to optimise your hormones. Don’t be that guy guessing using the list of symptoms you found on the Mayo Clinic website.

Here’s the outline of this interview with Mark Newman:

0:00:50    Mark Newman is an analytical chemist with a master's degree in forensic science.

0:01:07    Mark started with urine testing then moved onto saliva testing.

0:01:41    DUTCH stands for Dried Urine Test for Comprehensive Hormones.

0:02:11    The DUTCH combines the best of saliva and urine.

0:02:51    Educational videos.

0:03:32    The DUTCH is the culmination of Mark's life work.

0:05:01    My first saliva test showed high cortisol at night, and low cortisol during the day.

0:05:51    We've run over 546 saliva tests now.

0:06:12    All the results look the same.

0:06:31    The question is WHY low cortisol?

0:07:01    Mark has managed data from one million saliva results.

0:07:23    Mark started with the idea that cortisol makes you fat, yet salivary cortisol isn’t higher in fat people.

0:07:40    The free cortisol is just one piece of the puzzle.

0:08:07    With urine testing, you also get to look at the metabolites.

0:08:24    Free cortisol is only about 1% of the total.

0:08:53    40% of patient that have low free cortisol do have elevated production (metabolites).

0:09:45    What drives cortisol production also drives clearance.

0:10:00    In obesity there is high production AND clearance, overall free cortisol is often low.

0:10:33    In hypothyroidism cortisol clearance is sluggish.

0:11:06    The DUTCH is the only way to get all three dimensions.

0:11:51    I get the impression all the tests will look dated in 10 years time.

0:12:32    Mark is skeptical when I say "everybody's low".

0:13:01    Reference ranges can be very problematic.

0:13:38    You cannot easily compare results from different tests.

0:14:13    Not everybody has low cortisol.

0:14:55    Morning serum cortisol is better than nothing.

0:15:08    Saliva is better still and DUTCH better yet.

0:15:27    The term adrenal fatigue needs some work.

0:15:44    Adrenal glands are not like ovaries (they don’t tend to give out with age).

0:16:16    The problem with cortisol is probably often in the brain, not the adrenal gland.

0:17:01    The misinformation has been driven by oversimplification.

0:18:03    How are the reference ranges for the DUTCH defined.

0:18:20    You start with a bunch of healthy people.

0:18:35    The range is then two standard deviations either side of the mean.

0:18:53    This is useful for finding pathology.

0:19:17    Reference ranges require more thought than simple maths.

0:20:00    Some reference ranges are set up so that everyone is low.

0:20:23    The analytes are unique and so are the reference ranges.

0:21:07    People are critical of blood tests, both blood is very well established and standardised.

0:21:35    Saliva testing has some shoddy standards for some tests.

0:22:06    Intranasal ACTH experiment.

0:22:30    If the lab is not curious enough to do that type of experiment you have to wonder.

0:23:16    Everyone should get test to establish a baseline.

0:23:30    Hormonal symptoms overlap a lot.

0:23:51    Then when people read or hear about symptoms, they say gee that's me.

0:24:18    Lots of things can drive cortisol.

0:24:59    Hormones are worth exploring around menopause.

0:25:28    Everybody is tired.

0:26:17    Mark's sister-in-law is healthy in spite of low hormones, should anything happen in the future, having the baseline would be important.

0:27:20    DHEA comparison.

0:27:34    Mark is a skeptic when it comes to labs, he always suspects they could be wrong, even his own…that’s why having multiple markers (as in DUTCH) for hormones can be helpful.

0:28:19    Etiocholanolone and Androsterone.

0:28:43    Inflammation blocks sulfation DHEA à DHEAS.

0:29:24    The DHEA-S can misrepresent what's really going on.

0:29:55    The DUTCH represents 14 hours worth of DHEA production.

0:30:31    The DUTCH paints the big picture of hormones.

0:31:01    Iron overload in master's athletes.

0:31:24    The DUTCH helps me be a better detective.

0:31:36    Inflammation makes prostaglandins that drive aromatase.

0:32:19    Narrowing down a list possibilities to a list of probabilities.

0:32:43    DHEA and women.

0:33:03    DHT is three times as potent as testosterone.

0:33:18    Insulin can push alpha metabolism.

0:33:36    The beta pathway is less androgen.

0:33:42    Saw palmetto, nettles, pygeum, EGCG, progesterone, zinc, finasteride all block the alpha pathway.

0:33:48    DHT can cause acne, thinning scalp hair.

0:34:37    The DUTCH has 4 alpha pathways measured.

0:34:59    PCOS is a leading cause of infertility.

0:35:36    Could we take supplements without doing the tests?

0:35:59    Mark thinks that's a bad idea in some cases.

0:36:50    Pragmatism can work.

0:37:05    Thinning scalp hair can have a number of causes.

0:37:29    If you can afford the test, do it.

0:37:42    Some of the supplements are also expensive.

0:37:51    DIM for oestrogen metabolism.

0:38:03    Pushes oestrogen down the 2-OH pathway.

0:39:11    DIM as a goitrogen.

0:39:39    I3C metabolises to DIM.

0:40:52    Mark's testing matrix.

0:41:18    People take progesterone at night because it helps with sleep.

0:41:27    Oral progesterone is gone four hours later.

0:42:09    Saliva and serum are not good ways to measure oral progesterone supplementation.

0:43:13    Mark has spent 10 years putting the testing matrix together.

0:43:43    What testing oestrogen can tell you about your methylation status.

0:43:47    Oestradiol is the main oestrogen.

0:44:01    Saliva testing for oestrogen is almost useless.

0:44:20    In serum and urine there's a 10 fold difference in oestrogen between pre and postmenopausal women.

0:44:23    In saliva, it's a 2 fold difference at best.

0:44:44    This is one of the main reasons why Mark switched to urine.

0:45:11    DIM acts on phase one metabolism.

0:45:23    Phase two includes methylation.

0:45:34    Genetic defects affect phase two.

0:45:51    Methylation is an important thing to do well.

0:45:56    Mark has two very messed up COMT genes.

0:46:04    Mark's MTHFR genes are fine.

0:46:17    On the DUTCH test, Mark is a poor methylator.

0:47:40    The DUTCH is cheap to ship (filter paper is light).

0:48:07    The test is still expensive, unfortunately.

0:48:33    Precision Analytical uses GC-MS/MS and LC-MS/MS.

0:49:14    Providers should go to dutchtest.com.

0:49:26    Five tests at half price.

0:50:12    Mark will help doctors interpret the results.

0:50:28    Testing (lab testing, not sample collection) is a four day process.

0:50:55    Organic acids tests are run in batches.

0:51:10    Mark developed organic acids testing for BioTech Lab  (US BioTek).

0:51:49    You can order a DUTCH though me and then I can connect with you on the phone or Skype to explain what the results mean

]]>
clean
How to Avoid the Antiperspirant Deodorant Trap https://s3.amazonaws.com/nourishbalancethrive/podcast/Mother.Dirt.on.2015-12-16.at.07.59.mp3 Have you ever been trapped in a small meeting room with a guy in a grey shirt with sweat marks under the arms? The meeting has a clear agenda, but all you can think about is that smell. Yikes, just thinking about this is enough to make me want to take a shower, scrub my armpits and apply some deodorant.

Is the problem an antiperspirant deodorant deficiency? Why have humans evolved to a strong revulsion complex to what is a normal human smell? Have artificial fragrances warped our sense of smell?

It’s not normal

For our teenage boys to smell of basil, lavender, and rich vanilla. It’s not normal for women to emanate Daisy Fresh, Peach Burst, Blossoming Orchid, Tropical Rush, and Berry Cool. These are all things that have been impressed upon us by the companies that make person care products, and I think it’s important that we are aware of it.

Are you telling me I should stink?

Yes, a little bit, sometimes. But also I want you to think about where the smell is coming from, and I want you to think about how the smell differs when you change your diet. I noticed a significant reduction in my body odour after adopting a minimally processed, real food diet.

Beyond diet

You’re probably familiar with the problems surrounding the overuse of antibiotics. Certain of the bacteria that live in our guts are considered keystone species, and without them, we’re in trouble. Bees are also a keystone species crucial to the survival of plants in agriculture. The same problem is happening on our skin.

Jasmina Aganovic is a chemical and biological engineer from MIT

And she’s here to talk about how the preservatives in our personal care products maybe killing a particular keystone species of ammonia oxidising bacteria that should live on our skin. These bacteria help us by eating something harmful (ammonia) and producing something beneficial (nitric oxide).

Mother Dirt

Is the name of the company that manufactures a skin probiotic product called AO+ Mist spray. I’ve been using the spray for the past couple of months and so far, so good. No stink!

Here’s the outline of this interview with Jasmina Aganovic:

0:04:25    Why would you care about the skin microbiome?

0:05:54    Why do we shower as often as we do?

0:07:34    Bad bacteria were the first to be found.

0:08:10    Now we have a new appreciation of the microbiomes.

0:08:56    We've been programmed since childhood on how we should smell.

0:09:55    What is it about teenagers?

0:10:45    Skin care products for acne.

0:11:29    How the skin microbiome affects acne.

0:12:03    Acne seems to be lasting until later in life.

0:12:54    The bacteria typically linked to acne is P. acne and is not problematic.

0:13:37    But when you introduce harsh soaps and skin care products into the environment, you remove the keystone peacekeepers.

0:15:07    Are skin care products antibiotics?

0:16:06    The preservatives in skin care products may be problematic.

0:16:29    12% of children now have eczema.

0:17:07    Now we can manipulate the skin microbiome.

0:17:29    AOBiome founder David Whitlock noticed animals rolling in dirt.

0:18:12    Soil based ammonia oxidising (AO) bacteria.

0:19:25    We've wiped out the AO bacteria in the last 50-70 years.

0:19:44    The bacteria is very sensitive to surfactants and preservatives.

0:20:44    The AO bacteria is a keystone species for the skin.

0:21:30    AOBiome have been investigating the possibility of reintroducing the AO bacteria.

0:22:45    AOBiome are in a phase 2 clinical trial for the treatment of acne.

0:24:03    C. diff treatment with S. boulardii.

0:25:41    The AO bacteria do take up residence, but you'd need a very sensitive test to find it.

0:26:23    Bumblebees are keystone species like the AO bacteria.

0:27:04    It's important that you use products that are compatible with the bacteria.

0:27:39    Even if you do still use soap you will still see benefit.

0:28:39    Stinky armpits.

0:29:17    Natural deodorants can contain aluminium.

0:29:51    Food choices affect body odour.

0:30:27    60% of AO Mist users are able to give up deodorant.

0:31:07    Is clean really the smell of freesia?

0:31:32    Part of this is coming to terms with the way humans smell.

0:32:02    Triclosan persists in the skin.

0:32:41    AO Labs helps with product development.

0:34:18    Laundry detergents stink in the US.

0:35:55    Humans were not supposed to have body odour.

0:36:18    There is a plausible mechanism for reduction in body odour.

0:37:10    Bacteria consumes ammonia in sweat, that's what smells.

0:37:58    AO bacteria consume ammonia and produce nitric oxide.

0:38:24    The nitric oxide could become systemic.

0:39:04    Diaper rash.

0:39:33    People who use the most amount products also have the most problems.

0:40:36    Spending time outdoors is beneficial.

0:41:35    The name Mother Dirt is deliberate.

0:42:25    People who are forced to use sanitisation.

0:43:14    Certain situations require a sterile environment.

0:43:49    You can still benefit from AO Mist.

0:44:17    Hand sanitizer will wreck your hands.

0:45:15    The potential effect of the product on eczema.

0:45:44    Mother Dirt cannot make any claims before FDA approval.

0:46:13    Inflammatory skin disorders are the primary focus.

0:47:03    Where to find out more about AO Mist and the skin microbiome.

0:47:27    motherdirt.com

0:47:35    aobiome.com

0:48:08    Mother Dirt special offer.

0:48:23    AO+ Mist spray.

0:48:40    Discount code NBT25.

0:48:58    Code expires at the end of February.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Mother.Dirt.on.2015-12-16.at.07.59.mp3 Fri, 05 Feb 2016 13:02:31 GMT Christopher Kelly Have you ever been trapped in a small meeting room with a guy in a grey shirt with sweat marks under the arms? The meeting has a clear agenda, but all you can think about is that smell. Yikes, just thinking about this is enough to make me want to take a shower, scrub my armpits and apply some deodorant.

Is the problem an antiperspirant deodorant deficiency? Why have humans evolved to a strong revulsion complex to what is a normal human smell? Have artificial fragrances warped our sense of smell?

It’s not normal

For our teenage boys to smell of basil, lavender, and rich vanilla. It’s not normal for women to emanate Daisy Fresh, Peach Burst, Blossoming Orchid, Tropical Rush, and Berry Cool. These are all things that have been impressed upon us by the companies that make person care products, and I think it’s important that we are aware of it.

Are you telling me I should stink?

Yes, a little bit, sometimes. But also I want you to think about where the smell is coming from, and I want you to think about how the smell differs when you change your diet. I noticed a significant reduction in my body odour after adopting a minimally processed, real food diet.

Beyond diet

You’re probably familiar with the problems surrounding the overuse of antibiotics. Certain of the bacteria that live in our guts are considered keystone species, and without them, we’re in trouble. Bees are also a keystone species crucial to the survival of plants in agriculture. The same problem is happening on our skin.

Jasmina Aganovic is a chemical and biological engineer from MIT

And she’s here to talk about how the preservatives in our personal care products maybe killing a particular keystone species of ammonia oxidising bacteria that should live on our skin. These bacteria help us by eating something harmful (ammonia) and producing something beneficial (nitric oxide).

Mother Dirt

Is the name of the company that manufactures a skin probiotic product called AO+ Mist spray. I’ve been using the spray for the past couple of months and so far, so good. No stink!

Here’s the outline of this interview with Jasmina Aganovic:

0:04:25    Why would you care about the skin microbiome?

0:05:54    Why do we shower as often as we do?

0:07:34    Bad bacteria were the first to be found.

0:08:10    Now we have a new appreciation of the microbiomes.

0:08:56    We've been programmed since childhood on how we should smell.

0:09:55    What is it about teenagers?

0:10:45    Skin care products for acne.

0:11:29    How the skin microbiome affects acne.

0:12:03    Acne seems to be lasting until later in life.

0:12:54    The bacteria typically linked to acne is P. acne and is not problematic.

0:13:37    But when you introduce harsh soaps and skin care products into the environment, you remove the keystone peacekeepers.

0:15:07    Are skin care products antibiotics?

0:16:06    The preservatives in skin care products may be problematic.

0:16:29    12% of children now have eczema.

0:17:07    Now we can manipulate the skin microbiome.

0:17:29    AOBiome founder David Whitlock noticed animals rolling in dirt.

0:18:12    Soil based ammonia oxidising (AO) bacteria.

0:19:25    We've wiped out the AO bacteria in the last 50-70 years.

0:19:44    The bacteria is very sensitive to surfactants and preservatives.

0:20:44    The AO bacteria is a keystone species for the skin.

0:21:30    AOBiome have been investigating the possibility of reintroducing the AO bacteria.

0:22:45    AOBiome are in a phase 2 clinical trial for the treatment of acne.

0:24:03    C. diff treatment with S. boulardii.

0:25:41    The AO bacteria do take up residence, but you'd need a very sensitive test to find it.

0:26:23    Bumblebees are keystone species like the AO bacteria.

0:27:04    It's important that you use products that are compatible with the bacteria.

0:27:39    Even if you do still use soap you will still see benefit.

0:28:39    Stinky armpits.

0:29:17    Natural deodorants can contain aluminium.

0:29:51    Food choices affect body odour.

0:30:27    60% of AO Mist users are able to give up deodorant.

0:31:07    Is clean really the smell of freesia?

0:31:32    Part of this is coming to terms with the way humans smell.

0:32:02    Triclosan persists in the skin.

0:32:41    AO Labs helps with product development.

0:34:18    Laundry detergents stink in the US.

0:35:55    Humans were not supposed to have body odour.

0:36:18    There is a plausible mechanism for reduction in body odour.

0:37:10    Bacteria consumes ammonia in sweat, that's what smells.

0:37:58    AO bacteria consume ammonia and produce nitric oxide.

0:38:24    The nitric oxide could become systemic.

0:39:04    Diaper rash.

0:39:33    People who use the most amount products also have the most problems.

0:40:36    Spending time outdoors is beneficial.

0:41:35    The name Mother Dirt is deliberate.

0:42:25    People who are forced to use sanitisation.

0:43:14    Certain situations require a sterile environment.

0:43:49    You can still benefit from AO Mist.

0:44:17    Hand sanitizer will wreck your hands.

0:45:15    The potential effect of the product on eczema.

0:45:44    Mother Dirt cannot make any claims before FDA approval.

0:46:13    Inflammatory skin disorders are the primary focus.

0:47:03    Where to find out more about AO Mist and the skin microbiome.

0:47:27    motherdirt.com

0:47:35    aobiome.com

0:48:08    Mother Dirt special offer.

0:48:23    AO+ Mist spray.

0:48:40    Discount code NBT25.

0:48:58    Code expires at the end of February.

]]>
no
How Busy Realtors Can Avoid Anxiety and Depression Without Prescriptions or the Help of a Doctor https://s3.amazonaws.com/nourishbalancethrive/podcast/Douglas.Hilbert.on.2015-09-22.at.08.15.mp3 The monotone of an EKG machine detecting flatline. It doesn’t get any worse than that. For realtor Douglas Hilbert, the list of low points doesn’t end there. Doug filed bankruptcy at the age of 28, had his home foreclosed on, had two vehicles repossessed, lost multiple businesses, lost 130 “investment” properties and ended up in drug rehabilitation numerous times. Each day was a rollercoaster ride of caffeine and nicotine highs followed by alcohol induced lows.

Back then, depression and anxiety were the norm. Now aged 37, Doug feels better than at any time in his life.

So what did Doug do?

Doug describes exactly what he did in his new book Letters to My Son: Choosing Yourself First, and I am honoured to get more than one mention.

It starts with food.

Doug had good results eating a low-carb paleo diet but has found a high-fat, low-carb, moderate protein ketogenic diet to be even better. If there’s one lesson to be learned, it’s just eat real food.

Prioritising sleep.

Our modern environments are seldom conducive to quality sleep, and Doug has been able to improve his sleep by hacking his environment. Avoiding light at night, especially from the screens of electronic devices, has helped tremendously. A dark and cool bedroom has also enabled Doug to get the sleep he so desperately needed.

Expressing gratitude and guided meditation.

It’s so easy to get caught up in the trivial and the negative. Doug has found that by focusing on the positive things, people, events or anything that are actually present in his real life taps into the positive energy in himself and gets his brain to attach to something with a lasting effect. How do you tap into the positivity? You write down a list of all the things you’re grateful for. Sometimes it's brutally difficult to come up with anything, and things such as air make the list. It’s not about getting the perfect list, it is about the practice.

Doug practices Vipassana, which is "insight" meditation. He has practiced with Buddhist monks, nuns and lay persons at temples and other centers, as well as on extended retreats. From day one Doug was taught to focus on the breath and just observe the thoughts, feelings, emotions and sensations that arise. Six years later he’s doing the same thing. There’s no goal; he just observes what goes on, and every once in awhile, he picks up something insightful into the nature of the mind and existence.

Eliminating the guesswork and getting himself tested.

Like me, when Doug started to feel so much better, he developed a burning desire to know what was going on inside his body. After all, biochemistry drives behaviour. Doug tested saliva, urine and stool and corrected the problems he found using nutritional supplements. He then went on to become a certified Functional Diagnostic Nutrition practitioner and now runs a health coaching business of his own.

Here’s the outline of this interview with Douglas Hilbert:

0:00:00    Letters to My Son: Choosing Yourself First by Douglas Hilbert

0:01:12    Doug's low point was an EKG flatline.

0:01:58    Overeating, smoking, drugs, working 100 hours a week.

0:02:22    Terrible physical shape.

0:02:31    Failed business, lost a ton of money.

0:02:43    Doug quit racing triathlon to try and save the business.

0:03:02    When the business still failed, Doug was left with nothing.

0:03:26    Using drugs to lose weight.

0:05:00    Doug has been in rehab three times.

0:05:26    Cycling and triathlon as a way to channel energy.

0:06:05    Spiritual based rehab didn't work, finally a science based approach worked.

0:06:34    “Biochemistry drives behaviour” - Dr Robert Lustig.

0:07:16    Even in sobriety, Doug still had a lot of anxiety and depression.

0:07:48    Doug now feels the best he ever has at 37.

0:08:46    We've recently tested Doug's cortisol, and whilst it's not perfect, it's better.

0:09:13    Doug feels fantastic without taking any prescriptions.

0:10:15    Doug was 50lb overweight at the start of the book, but never had much trouble shedding the extra.

0:11:23    Doug is using Elite HRV to guide activity.

0:11:52    Leanest ever through eating rather than exercise.

0:12:41    Doug has been prescribed a statin but refused.

0:13:54    Peter Attia's YouTube videos.

0:14:16    Despite exercise, Doug's triglycerides were once 459.

0:14:47    Doug has been doing very well on a ketogenic diet.

0:15:18    Doug wasn't performing or thinking well on 150-200g of carbs per day.

0:15:41    Doug's organic acids result showed an elevation of ketones the first time we tested.

0:16:08    A ketogenic diet has enabled Doug to write a book.

0:17:21    All the men do really well on a ketogenic diet.

0:18:22    Doug's triglycerides are now 88.

0:18:52    Ketosis is for keeps.

0:19:04    Vegetarianism lead to the worst test results.

0:19:45    Diet is not the only part, but it's the foundation.

0:20:04    Try meditating on a high-carb breakfast.

0:21:25    Doug is going to keep testing, and if anything changes, he'll make another decision.

0:22:17    The only thing that has got me into trouble is being close-minded.

0:23:23    Just eat real food!

0:24:37    NBT programs always include diet, rest walking and some kind of stress management.

0:25:21    Doug has writing in his family.

0:26:19    For Doug, writing is cathartic.

0:27:51    Publishing creates accountability.

0:28:39    Writing a gratitude list.

0:29:16    Appreciating the things you really need.

0:30:05    Doug will express gratitude and meditate as required every day.

0:31:54    Humans invent something to worry about in the absence of something really worth worrying about.

0:34:55    Doug's podcast habit.

0:36:27    Reading can be hard when you're not feeling good.

0:36:49    Podcasts are great if you have a job that requires you travel a lot.

0:39:53    Simon Hunter recommended Overcast.

0:43:18    Doug mentions me and my podcast in his book.

0:44:00    Doug is a certified Functional Diagnostic Nutrition practitioner.

0:46:23    Not getting too caught up on the physical.

0:49:08    Email Doug: douglashilbert@yahoo.com.

0:49:21    Doug on Facebook.

Are you a busy realtor struggling to cope with the pressures of your work? Book a free consultation and we’ll help you figure out the way forward.

 
]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Douglas.Hilbert.on.2015-09-22.at.08.15.mp3 Fri, 29 Jan 2016 13:01:24 GMT Christopher Kelly The monotone of an EKG machine detecting flatline. It doesn’t get any worse than that. For realtor Douglas Hilbert, the list of low points doesn’t end there. Doug filed bankruptcy at the age of 28, had his home foreclosed on, had two vehicles repossessed, lost multiple businesses, lost 130 “investment” properties and ended up in drug rehabilitation numerous times. Each day was a rollercoaster ride of caffeine and nicotine highs followed by alcohol induced lows.

Back then, depression and anxiety were the norm. Now aged 37, Doug feels better than at any time in his life.

So what did Doug do?

Doug describes exactly what he did in his new book Letters to My Son: Choosing Yourself First, and I am honoured to get more than one mention.

It starts with food.

Doug had good results eating a low-carb paleo diet but has found a high-fat, low-carb, moderate protein ketogenic diet to be even better. If there’s one lesson to be learned, it’s just eat real food.

Prioritising sleep.

Our modern environments are seldom conducive to quality sleep, and Doug has been able to improve his sleep by hacking his environment. Avoiding light at night, especially from the screens of electronic devices, has helped tremendously. A dark and cool bedroom has also enabled Doug to get the sleep he so desperately needed.

Expressing gratitude and guided meditation.

It’s so easy to get caught up in the trivial and the negative. Doug has found that by focusing on the positive things, people, events or anything that are actually present in his real life taps into the positive energy in himself and gets his brain to attach to something with a lasting effect. How do you tap into the positivity? You write down a list of all the things you’re grateful for. Sometimes it's brutally difficult to come up with anything, and things such as air make the list. It’s not about getting the perfect list, it is about the practice.

Doug practices Vipassana, which is "insight" meditation. He has practiced with Buddhist monks, nuns and lay persons at temples and other centers, as well as on extended retreats. From day one Doug was taught to focus on the breath and just observe the thoughts, feelings, emotions and sensations that arise. Six years later he’s doing the same thing. There’s no goal; he just observes what goes on, and every once in awhile, he picks up something insightful into the nature of the mind and existence.

Eliminating the guesswork and getting himself tested.

Like me, when Doug started to feel so much better, he developed a burning desire to know what was going on inside his body. After all, biochemistry drives behaviour. Doug tested saliva, urine and stool and corrected the problems he found using nutritional supplements. He then went on to become a certified Functional Diagnostic Nutrition practitioner and now runs a health coaching business of his own.

Here’s the outline of this interview with Douglas Hilbert:

0:00:00    Letters to My Son: Choosing Yourself First by Douglas Hilbert

0:01:12    Doug's low point was an EKG flatline.

0:01:58    Overeating, smoking, drugs, working 100 hours a week.

0:02:22    Terrible physical shape.

0:02:31    Failed business, lost a ton of money.

0:02:43    Doug quit racing triathlon to try and save the business.

0:03:02    When the business still failed, Doug was left with nothing.

0:03:26    Using drugs to lose weight.

0:05:00    Doug has been in rehab three times.

0:05:26    Cycling and triathlon as a way to channel energy.

0:06:05    Spiritual based rehab didn't work, finally a science based approach worked.

0:06:34    “Biochemistry drives behaviour” - Dr Robert Lustig.

0:07:16    Even in sobriety, Doug still had a lot of anxiety and depression.

0:07:48    Doug now feels the best he ever has at 37.

0:08:46    We've recently tested Doug's cortisol, and whilst it's not perfect, it's better.

0:09:13    Doug feels fantastic without taking any prescriptions.

0:10:15    Doug was 50lb overweight at the start of the book, but never had much trouble shedding the extra.

0:11:23    Doug is using Elite HRV to guide activity.

0:11:52    Leanest ever through eating rather than exercise.

0:12:41    Doug has been prescribed a statin but refused.

0:13:54    Peter Attia's YouTube videos.

0:14:16    Despite exercise, Doug's triglycerides were once 459.

0:14:47    Doug has been doing very well on a ketogenic diet.

0:15:18    Doug wasn't performing or thinking well on 150-200g of carbs per day.

0:15:41    Doug's organic acids result showed an elevation of ketones the first time we tested.

0:16:08    A ketogenic diet has enabled Doug to write a book.

0:17:21    All the men do really well on a ketogenic diet.

0:18:22    Doug's triglycerides are now 88.

0:18:52    Ketosis is for keeps.

0:19:04    Vegetarianism lead to the worst test results.

0:19:45    Diet is not the only part, but it's the foundation.

0:20:04    Try meditating on a high-carb breakfast.

0:21:25    Doug is going to keep testing, and if anything changes, he'll make another decision.

0:22:17    The only thing that has got me into trouble is being close-minded.

0:23:23    Just eat real food!

0:24:37    NBT programs always include diet, rest walking and some kind of stress management.

0:25:21    Doug has writing in his family.

0:26:19    For Doug, writing is cathartic.

0:27:51    Publishing creates accountability.

0:28:39    Writing a gratitude list.

0:29:16    Appreciating the things you really need.

0:30:05    Doug will express gratitude and meditate as required every day.

0:31:54    Humans invent something to worry about in the absence of something really worth worrying about.

0:34:55    Doug's podcast habit.

0:36:27    Reading can be hard when you're not feeling good.

0:36:49    Podcasts are great if you have a job that requires you travel a lot.

0:39:53    Simon Hunter recommended Overcast.

0:43:18    Doug mentions me and my podcast in his book.

0:44:00    Doug is a certified Functional Diagnostic Nutrition practitioner.

0:46:23    Not getting too caught up on the physical.

0:49:08    Email Doug: douglashilbert@yahoo.com.

0:49:21    Doug on Facebook.

Are you a busy realtor struggling to cope with the pressures of your work? Book a free consultation and we’ll help you figure out the way forward.

 
]]>
clean
Critical Thinking in Health and Nutrition with Danny Lennon https://s3.amazonaws.com/nourishbalancethrive/podcast/Danny.Lennon.on.2015-10-28.at.07.01.mp3 Apple Frudel.

Banana Chocolate Chip Bread.

Cinnamon French Toast Bread.

Blueberry Snack’N Waffle.

Cocoa Puffs Cereal Bar.

Cheerios Cereal Bar.

Cinnamon Pop Tart.

Strawberry Splash Pancake.

Super Donut.

All these “food” items were taken from the breakfast menu for my nephew’s school. Presumably an expert designed this menu because it bares the logo of ChooseMyPlate.gov.

If you can't trust the experts, who can you trust?

How do you protect yourself from misinformation that has the potential to hurt you and your children’s health?

There is only one way, and that’s to learn how to evaluate scientific evidence and think critically.

Danny Lennon is a nutrition educator and critical thinker, and his Sigma Nutrition podcast is a powerful platform.

As you can probably tell from his accent, Danny is from Ireland.

After completing a degree in biology and physics, Danny worked as a teacher for a while before returning to the University of Cork to complete a master’s degree in Nutrition Science.

After failing to achieve the results he deserved from training, Danny set out to discover the truth about what works in nutrition and health. His goal is to teach us how to be our own expert, to enable us to separate the brilliant from the misleading, even if the difference is more subtle than a Super Donut on your breakfast menu.

If you’re listening to this interview, my guess is that you’re already an accomplished nutrition critical thinker. My question to you is how do we get this message out there more efficiently? Please let me know in the comments section below.

Here’s the outline of this interview with Danny Lennon:

0:00:00    Danny Lennon's Sigma Nutrition Radio podcast.

0:00:51    Sigma Nutrition Radio has helped me professionally.

0:01:10    Why is Danny interested in nutrition?

0:01:33    Danny has always been an athlete.

0:01:41    Danny studied biology and physics.

0:02:06    Boyd Eaton paper on evolutionary biology.

0:02:06    Necessity is a great teacher!

0:02:34    Danny taught science for a while.

0:02:50    Danny was born just outside London, grew up in Dublin, now in Limerick.

0:03:36    I have Kelly on both sides of my family!

0:03:53    Is there an obesity problem in Ireland?

0:04:35    Danny is a type-A!

0:04:57    Danny was eating a very low-fat diet with lots of whole grains, something with hindsight he wouldn't recommend.

0:05:52    Danny wasn't as lean as he should have been given how much training he was doing.

0:06:38    I used to eat a completely fat-free diet, thank you Teflon!

0:07:07    Danny has a classical education.

0:07:55    Danny started to wonder who else he could help.

0:08:15    Vitamin D research at the University of Cork under Prof. Kevin Cashman

0:08:44    Understanding individuality.

0:09:28    Biochemistry in a master's degree is fine.

0:09:59    But the public health education is questionable.

0:10:25    The falsely claimed dangers of red meat consumption as an example.

0:10:54    Danny did his own research and sent them to his professor.

0:11:22    The 80s and 90s were the nutritional stone age.

0:11:59    Robb Wolf interview with RD who struggled (Laura Schoenfeld).

0:12:30    My wife Julia decided not to become registered or licensed.

0:12:54    What motivates Danny to teach.

0:13:25    The podcast allows Danny to educate at a level he enjoys.

0:14:18    Danny likes to inspire people to think critically for themselves.

0:15:00    Danny's podcast on calorie restriction and longevity with Dr. Eric Ravussin.

0:15:29    An upcoming interview is a powerful motivator for learning.

0:16:04    My social isolation podcast with Bryan Walsh.

0:16:50    Sarcopenic obesity.

0:17:12    Danny aims to provides the best platform for getting the information out there.

0:17:36    The dangers of "canned answers".

0:18:18    Danny does not write down a list of questions.

0:18:36    My interview with Jason Fung.

0:18:58    A list of questions didn't work for me.

0:19:24    Danny picks guests to create a narrative that spans multiple episodes.

0:20:32    The narrative clusters two or three podcasts.

0:20:32    Adrenal fatigue with Bryan Walsh.

0:21:05    How do you reconcile when a guest says something you think is wrong and unhelpful?

0:21:51    A podcast interview is not a debate!

0:22:11    Practitioners talk about what they do.

0:22:29    Danny can still raise counterpoints.

0:23:06    I've had guests that have said things I've thought was questionable.

0:23:44    How does the information you glean from the podcast fit into your practice.

0:23:53    There's a common core consensus e.g. sleep, minimally processed foods.

0:25:18    It's OK to change your mind based on the new information.

0:25:29    Danny is always thinking about key messages, and he would like you to do the same.

0:26:05    Getting caught up in the details.

0:27:26    The basics come first.

0:27:52    Snowing people with everything you've learnt is a mistake.

0:28:45    My fictitious example: overtrained half marathon runner.

0:29:27    Initial starting point is to look at the big picture.

0:30:00    No need to jump into test until you've addressed the basics.

0:30:29    The test results are not going to change what we do first until we've addressed the basics.

0:30:57    Depending on the person, changing one thing at a time can be helpful.

0:31:26    Sleep and diet first.

0:32:21    Regaining weight and regressing because people think they need to make changes all the time.

0:33:05    Modification in preference to complete overhaul.

0:33:47    Usually people come to me having already done the basic stuff.

0:34:11    Some people seem better able to make change once they've seen a test result.

0:34:52    Getting emotional commitment is important.

0:35:39    A diagnosis is a powerful motivator.

0:36:31    Getting to the underlying goals.

0:36:51    Quantification can be important

0:37:24    Danny sets up a series of consultations.

0:38:11    Avoids snowing.

0:38:11    This adds accountability.

0:38:28    12 week block of coaching.

0:38:43    Danny works with a lot of boxers and MMA fighters.

0:39:14    Maybe I've been doing this wrong: too many things at once.

0:39:58    I do get great results but we spend so much time following up.

0:40:47    The intermediates and advanced people might do better with taking it all on at once.

0:41:36    Every coach should have a coach.

0:42:00    Otherwise you end up second guessing.

0:42:40    I love ticking boxes and following plans.

0:43:04    I have at least one example of a person that did better with weekly contact.

0:43:35    Lacking the call to action.

0:44:16    Sign up at sigmanutriton.com.

0:45:01    Danny's article on key fundamentals.

0:45:33    Danny finds writing harder.

0:45:56    Danny tends towards perfectionism and long articles.

0:48:23    The Ridiculously Simple Guide to Sustainable Fat Loss.

0:48:47    The 2016 Sigma Nutrition Conference is in February.

0:49:42    For fitness professionals.

0:50:02    In Dublin.

0:50:15    Possibly one or even to in England.

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Danny.Lennon.on.2015-10-28.at.07.01.mp3 Mon, 18 Jan 2016 15:01:46 GMT Christopher Kelly Apple Frudel.

Banana Chocolate Chip Bread.

Cinnamon French Toast Bread.

Blueberry Snack’N Waffle.

Cocoa Puffs Cereal Bar.

Cheerios Cereal Bar.

Cinnamon Pop Tart.

Strawberry Splash Pancake.

Super Donut.

All these “food” items were taken from the breakfast menu for my nephew’s school. Presumably an expert designed this menu because it bares the logo of ChooseMyPlate.gov.

If you can't trust the experts, who can you trust?

How do you protect yourself from misinformation that has the potential to hurt you and your children’s health?

There is only one way, and that’s to learn how to evaluate scientific evidence and think critically.

Danny Lennon is a nutrition educator and critical thinker, and his Sigma Nutrition podcast is a powerful platform.

As you can probably tell from his accent, Danny is from Ireland.

After completing a degree in biology and physics, Danny worked as a teacher for a while before returning to the University of Cork to complete a master’s degree in Nutrition Science.

After failing to achieve the results he deserved from training, Danny set out to discover the truth about what works in nutrition and health. His goal is to teach us how to be our own expert, to enable us to separate the brilliant from the misleading, even if the difference is more subtle than a Super Donut on your breakfast menu.

If you’re listening to this interview, my guess is that you’re already an accomplished nutrition critical thinker. My question to you is how do we get this message out there more efficiently? Please let me know in the comments section below.

Here’s the outline of this interview with Danny Lennon:

0:00:00    Danny Lennon's Sigma Nutrition Radio podcast.

0:00:51    Sigma Nutrition Radio has helped me professionally.

0:01:10    Why is Danny interested in nutrition?

0:01:33    Danny has always been an athlete.

0:01:41    Danny studied biology and physics.

0:02:06    Boyd Eaton paper on evolutionary biology.

0:02:06    Necessity is a great teacher!

0:02:34    Danny taught science for a while.

0:02:50    Danny was born just outside London, grew up in Dublin, now in Limerick.

0:03:36    I have Kelly on both sides of my family!

0:03:53    Is there an obesity problem in Ireland?

0:04:35    Danny is a type-A!

0:04:57    Danny was eating a very low-fat diet with lots of whole grains, something with hindsight he wouldn't recommend.

0:05:52    Danny wasn't as lean as he should have been given how much training he was doing.

0:06:38    I used to eat a completely fat-free diet, thank you Teflon!

0:07:07    Danny has a classical education.

0:07:55    Danny started to wonder who else he could help.

0:08:15    Vitamin D research at the University of Cork under Prof. Kevin Cashman

0:08:44    Understanding individuality.

0:09:28    Biochemistry in a master's degree is fine.

0:09:59    But the public health education is questionable.

0:10:25    The falsely claimed dangers of red meat consumption as an example.

0:10:54    Danny did his own research and sent them to his professor.

0:11:22    The 80s and 90s were the nutritional stone age.

0:11:59    Robb Wolf interview with RD who struggled (Laura Schoenfeld).

0:12:30    My wife Julia decided not to become registered or licensed.

0:12:54    What motivates Danny to teach.

0:13:25    The podcast allows Danny to educate at a level he enjoys.

0:14:18    Danny likes to inspire people to think critically for themselves.

0:15:00    Danny's podcast on calorie restriction and longevity with Dr. Eric Ravussin.

0:15:29    An upcoming interview is a powerful motivator for learning.

0:16:04    My social isolation podcast with Bryan Walsh.

0:16:50    Sarcopenic obesity.

0:17:12    Danny aims to provides the best platform for getting the information out there.

0:17:36    The dangers of "canned answers".

0:18:18    Danny does not write down a list of questions.

0:18:36    My interview with Jason Fung.

0:18:58    A list of questions didn't work for me.

0:19:24    Danny picks guests to create a narrative that spans multiple episodes.

0:20:32    The narrative clusters two or three podcasts.

0:20:32    Adrenal fatigue with Bryan Walsh.

0:21:05    How do you reconcile when a guest says something you think is wrong and unhelpful?

0:21:51    A podcast interview is not a debate!

0:22:11    Practitioners talk about what they do.

0:22:29    Danny can still raise counterpoints.

0:23:06    I've had guests that have said things I've thought was questionable.

0:23:44    How does the information you glean from the podcast fit into your practice.

0:23:53    There's a common core consensus e.g. sleep, minimally processed foods.

0:25:18    It's OK to change your mind based on the new information.

0:25:29    Danny is always thinking about key messages, and he would like you to do the same.

0:26:05    Getting caught up in the details.

0:27:26    The basics come first.

0:27:52    Snowing people with everything you've learnt is a mistake.

0:28:45    My fictitious example: overtrained half marathon runner.

0:29:27    Initial starting point is to look at the big picture.

0:30:00    No need to jump into test until you've addressed the basics.

0:30:29    The test results are not going to change what we do first until we've addressed the basics.

0:30:57    Depending on the person, changing one thing at a time can be helpful.

0:31:26    Sleep and diet first.

0:32:21    Regaining weight and regressing because people think they need to make changes all the time.

0:33:05    Modification in preference to complete overhaul.

0:33:47    Usually people come to me having already done the basic stuff.

0:34:11    Some people seem better able to make change once they've seen a test result.

0:34:52    Getting emotional commitment is important.

0:35:39    A diagnosis is a powerful motivator.

0:36:31    Getting to the underlying goals.

0:36:51    Quantification can be important

0:37:24    Danny sets up a series of consultations.

0:38:11    Avoids snowing.

0:38:11    This adds accountability.

0:38:28    12 week block of coaching.

0:38:43    Danny works with a lot of boxers and MMA fighters.

0:39:14    Maybe I've been doing this wrong: too many things at once.

0:39:58    I do get great results but we spend so much time following up.

0:40:47    The intermediates and advanced people might do better with taking it all on at once.

0:41:36    Every coach should have a coach.

0:42:00    Otherwise you end up second guessing.

0:42:40    I love ticking boxes and following plans.

0:43:04    I have at least one example of a person that did better with weekly contact.

0:43:35    Lacking the call to action.

0:44:16    Sign up at sigmanutriton.com.

0:45:01    Danny's article on key fundamentals.

0:45:33    Danny finds writing harder.

0:45:56    Danny tends towards perfectionism and long articles.

0:48:23    The Ridiculously Simple Guide to Sustainable Fat Loss.

0:48:47    The 2016 Sigma Nutrition Conference is in February.

0:49:42    For fitness professionals.

0:50:02    In Dublin.

0:50:15    Possibly one or even to in England.

]]>
no
Poor Misunderstood Insulin with Dr. Tommy Wood https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2015-12-30.at.11.07.003.mp3 If you’d have asked me six months ago what insulin did, I would have answered, “it stuffs energy into cells”. I think most people would say something similar. My answer isn’t wrong, but facilitating the uptake of energy into cells is not the most first or most important thing that insulin does.

Last week I completed the first few modules of an introductory physiology course from Duke University, and I found this in one of the lectures:

The type two diabetic is a situation where we have receptor desensitization and the individual does not respond correctly to insulin. Insulin is present in the system, but the receptor is desensitized. And so, you don't get the movement of glucose from the blood into the skeletal muscle cells correctly.

These statements don’t directly answer my question “what does insulin do?”, but they imply that insulin is required to move glucose (energy) into a cell. This is wrong, and they’re not the first to make the mistake. This quote from “Insulin: understanding its action in health and disease”, explains:

The effects of this ‘black age’ are still with us because these incorrect hypotheses have, with the passage of time, been turned into dogma and become cast into ‘tablets of stone’ in undergraduate textbooks. They are also carried forward into postgraduate teaching. For example, even in well respected texts it is still common to find statements such as ‘The basic action of insulin is to facilitate glucose entry into cells, primarily skeletal muscle and hepatocytes.’

So what does insulin do?

The basic action of insulin is anti-catabolic, that is, it halts breaking down. Insulin works in this order:

  1. Hits alpha cells in the pancreas to suppress glucagon.
  2. Then goes to the liver to suppress gluconeogenesis (and stimulate lipogenesis).
  3. Then goes to the peripheral body to do other stuff.

So if you're using insulin to stimulate glucose uptake, you're already WAY above the concentrations needed to affect the pancreas and liver, which is going to make those cells insulin resistant first. You've also already shoved a lot of fat into those cells first, which is going to interfere with glucose metabolism.

So what should you do?

Don’t worry about insulin facilitating the uptake of glucose into cells, and instead focus on creating the demand for glucose through movement. Lift weights.

I want you to have the same teaching experience that I have enjoyed.

One of my most frequently asked questions is “How did you learn so much in so little time? How did you build a successful functional medicine practice in less than two years?”. The answer is I had two great teachers: necessity and Dr. Tommy Wood. If it weren’t for Tommy, I’d still be dependant on protocols rather than understanding the principles by which our programmes work.  

Concierge Clinical Coaching is my way of sharing my expertise and education with you, the health and performance enthusiast. You already have necessity, let me give you the other part. As a member of our programme, you’ll have the ability to ask both Tommy and me your diet, lifestyle, training and supplementation questions. You will have ongoing access to us for input on everything from your latest blood test results to advice on diet and training optimisation. As the science and questions evolve, we will be there to help guide you through your personalized route to long-term health and performance.

In short, we will be your functional medicine practitioner, coach and nutritionist all rolled into one.

Here’s the outline of this interview with Dr. Tommy Wood:

0:00:13    What Tommy ate over Christmas.

0:01:02    Tommy is OK with vegetable oils and gluten, so long as it's Christmas!

0:02:20    We love buying our meat from a local farmer.

0:03:01    What is insulin?

0:03:13    Optimising Insulin Facebook group.

0:03:40    Tommy's presentation on insulin resistance.

0:04:01    Most people have been taught that the primary role of insulin is to put glucose into cells.

0:04:26    Insulin isn't very good at pushing insulin into cells.

0:04:40    Insulin is a peptide hormone secreted from the beta cells of the pancreas.

0:04:54    Expecting food can increase insulin.

0:05:26    Insulin decides where nutrients go.

0:05:43    So what is insulin's primary role?

0:06:01    Insulin is anabolic.

0:06:27    The main thing insulin does is anti-catabolic.

0:06:48    Insulin prevents the breakdown of fat.

0:07:27    Insulin first acts on the alpha cells of the pancreas.

0:07:29    The alpha cells secrete glucagon.

0:07:48    Glucose is gone, glucagon.

0:08:00    Insulin turns off glucagon.

0:08:32    Only tiny amounts of insulin are needed to turn off glucagon.

0:08:47    Next insulin goes to the liver.

0:08:57    Turns off gluconeogenesis.

0:09:17    Now at greater concentrations, insulin acts in the periphery to tell cells to stop breaking down fat.

0:09:32    There are some nice experiments showing this in forearm muscles.

0:09:53    10 uIU/mL cells start taking up fatty acids.

0:10:16    Insulin only causes glucose uptake at levels of 40-50 uIU/mL.

0:11:03    How did this mistaken belief become common knowledge?

0:11:06    Partly from work done in type 1 diabetes.

0:11:41    Without the action of insulin, the catabolic hormones act unopposed.

0:12:14    Roger Unger glucagon presentation.

0:12:39    Without insulin, there is uncontrolled glucagon release.

0:13:13    Insulin given as medicine is to act against glucagon.

0:13:31    No one was really thinking about this.

0:13:42    Insulin does increase the uptake of glucose into cells so this was an easy mistake to make.

0:14:15    Your high blood sugar might be coming from the liver.

0:14:56    The problem with injecting insulin into subcutaneous fat.

0:15:57    My carbohydrate experiment.

0:16:17    I did an oral glucose tolerance test at home using a dried blood spot test.

0:16:37    My insulin never got above 7.4 uIU/mL.

0:16:56    Most people eating a standard western diet end up relying on insulin to stuff glucose into cells.

0:17:26    Carbohydrates plus fat is maximally insulinogenic.

0:17:56    This is not something we're necessarily adapted to.

0:18:12    It may have been an advantage to store the excess.

0:18:45    75% of glucose should go into muscles.

0:19:08    I did exercise during my test.

0:19:46    We know that I'm very insulin sensitive.

0:20:01    My muscles are primed to take the extra glucose.

0:20:20    So the carbs go straight into muscles without the insulin.

0:21:07    Most glucose uptake into muscle does not require insulin.

0:21:32    This pattern is common in people eating a high-fat diet.

0:21:56    High insulin smashes the pancreas and liver over the head.

0:22:25    The problems come when the muscles don't need the glucose.

0:22:52    My blood glucose peaked at 200 mg/dL.

0:23:08    The peak was in part due to a stress response.

0:23:31    Insulin is not for putting glucose into cells, exercise should create the demand.

0:23:48    If all your cells are overloaded already, then you create a problem.

0:24:09    Cortisol and adrenaline are there to drive up glucose.

0:24:55    We will repeat the experiment without the carbs.

0:25:18    I'm going to do an experiment to see how much cortisol I produce during a race.

0:25:56    Elevated fasted blood glucose, aka the dawn effect.

0:26:24    This questions comes up a lot.

0:26:38    A low-carb diet can cause physiological insulin resistance.

0:26:58    We're not sure if this is anything to do with insulin resistance at all.

0:27:17    Cortisol waking response.

0:27:58    Cortisol should come up before you wake.

0:28:15    People may have heart attacks more often at that time for this reason.

0:28:28    A lot of potential things could be going on here.

0:28:44    Anything which is interfering metabolic health could be causing this.

0:29:10    Are people looking at food quality?

0:29:40    Ketogenic diets can increase cortisol.

0:29:59    Insulin resistance leads to fast cortisol metabolism.

0:30:21    Previously we would have seen this as low cortisol on a saliva test.

0:30:44    It's not that the ketogenic diet is stressful per se, but that the cortisol is no longer being metabolised so quickly.

0:31:28    People that haven't addressed other health issues may find a ketogenic diet stressful.

0:32:03    The dawn effect is likely multifactorial and complicated but not normal.

0:32:35    My fasted blood glucose was creeping up into the 90s.

0:32:49    Now it's down in the low 80s and even high 70s.

0:33:09    Could nicotinamide riboside (NR) be lowering my fasting blood glucose?

0:33:21    NR is a precursor for NAD.

0:33:35    NAD is an electron acceptor.

0:33:46    The ratio of NAD to NADH is important.

0:34:00    In type 2 diabetes there's lots of extra NADH compared to NAD.

0:34:18    Nutritional deficiencies can cause problems.

0:34:38    You can end up with not enough NAD to accept the electrons from all the calories you're taking in.

0:35:00    If NAD goes up with respect to NADH it could signal more glucose to enter the cell.

0:35:29    As always, there are confounders.

0:35:41    Beta-alanine.

0:35:46    Eating more carbs and sleeping better.

0:35:57    Not much data on NR in humans.

0:36:20    I've been racing but not training.

0:36:39    conciergeclinicalcoaching.com

0:37:04    What goes on behind the scenes at NBT.

0:37:22    Tommy is a huge part of my education.

0:37:53    Tommy sends me 1,000 words with six papers attached.

0:38:11    Tommy is a research scientist.

0:38:18    You need someone to guide you through the literature.

0:38:37    If something is published we assume it's good science but that isn't always the case.

0:39:00    So much vested interested and cognitive dissonance.

0:39:13    We have our own biases!

0:39:31    Tommy is about as evidence driven as you can get.

0:39:47    Metabolic Fitness Pro.

0:39:58    Names are just variables.

0:40:09    How can I bring this experience to more people.

0:40:36    The main feature is a private Facebook group.

0:41:13    On the Facebook group you will be following along with the studies we're looking at.

0:41:39    We didn't have enough time to explain the results after the O2 Boost programme.

0:42:00    Information is best absorbed in chunks.

0:42:12    Run some tests, think about it, ask some questions.

0:42:29    I can't afford to answer everyone's questions via email.

0:42:49    Tell us if you think this is a bad idea!

0:43:09    Context is important during our discussions so we can't just throw stuff up on the blog.

0:43:52    We develop a relationship but then fail to follow up very well.

0:44:17    You get continuous feedback.

0:44:31    You keep on testing.

0:44:40    Once a month live Q&A webinars.

0:44:58    We will produce transcripts from the webinars.

0:45:30    You will be able to ask questions during the webinar live.

0:45:56    Tweaking biochemistry is where I see benefits now.

0:46:29    Having Tommy answer my questions is priceless.

0:47:03    My network of experts.

0:47:22    So even if I don't have the answer, I probably know someone that does.

0:47:46    The main benefit of the podcast is networking.

0:48:09    Joe Friel.

0:48:35    These contacts are my greatest asset.

0:48:52    The Internet is changing everything.

0:49:16    We're pricing it low, act now!

0:49:34    The first 7 days are free (not $10).

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/Tommy.Wood.on.2015-12-30.at.11.07.003.mp3 Tue, 12 Jan 2016 07:01:24 GMT Christopher Kelly If you’d have asked me six months ago what insulin did, I would have answered, “it stuffs energy into cells”. I think most people would say something similar. My answer isn’t wrong, but facilitating the uptake of energy into cells is not the most first or most important thing that insulin does.

Last week I completed the first few modules of an introductory physiology course from Duke University, and I found this in one of the lectures:

The type two diabetic is a situation where we have receptor desensitization and the individual does not respond correctly to insulin. Insulin is present in the system, but the receptor is desensitized. And so, you don't get the movement of glucose from the blood into the skeletal muscle cells correctly.

These statements don’t directly answer my question “what does insulin do?”, but they imply that insulin is required to move glucose (energy) into a cell. This is wrong, and they’re not the first to make the mistake. This quote from “Insulin: understanding its action in health and disease”, explains:

The effects of this ‘black age’ are still with us because these incorrect hypotheses have, with the passage of time, been turned into dogma and become cast into ‘tablets of stone’ in undergraduate textbooks. They are also carried forward into postgraduate teaching. For example, even in well respected texts it is still common to find statements such as ‘The basic action of insulin is to facilitate glucose entry into cells, primarily skeletal muscle and hepatocytes.’

So what does insulin do?

The basic action of insulin is anti-catabolic, that is, it halts breaking down. Insulin works in this order:

  1. Hits alpha cells in the pancreas to suppress glucagon.
  2. Then goes to the liver to suppress gluconeogenesis (and stimulate lipogenesis).
  3. Then goes to the peripheral body to do other stuff.

So if you're using insulin to stimulate glucose uptake, you're already WAY above the concentrations needed to affect the pancreas and liver, which is going to make those cells insulin resistant first. You've also already shoved a lot of fat into those cells first, which is going to interfere with glucose metabolism.

So what should you do?

Don’t worry about insulin facilitating the uptake of glucose into cells, and instead focus on creating the demand for glucose through movement. Lift weights.

I want you to have the same teaching experience that I have enjoyed.

One of my most frequently asked questions is “How did you learn so much in so little time? How did you build a successful functional medicine practice in less than two years?”. The answer is I had two great teachers: necessity and Dr. Tommy Wood. If it weren’t for Tommy, I’d still be dependant on protocols rather than understanding the principles by which our programmes work.  

Concierge Clinical Coaching is my way of sharing my expertise and education with you, the health and performance enthusiast. You already have necessity, let me give you the other part. As a member of our programme, you’ll have the ability to ask both Tommy and me your diet, lifestyle, training and supplementation questions. You will have ongoing access to us for input on everything from your latest blood test results to advice on diet and training optimisation. As the science and questions evolve, we will be there to help guide you through your personalized route to long-term health and performance.

In short, we will be your functional medicine practitioner, coach and nutritionist all rolled into one.

Here’s the outline of this interview with Dr. Tommy Wood:

0:00:13    What Tommy ate over Christmas.

0:01:02    Tommy is OK with vegetable oils and gluten, so long as it's Christmas!

0:02:20    We love buying our meat from a local farmer.

0:03:01    What is insulin?

0:03:13    Optimising Insulin Facebook group.

0:03:40    Tommy's presentation on insulin resistance.

0:04:01    Most people have been taught that the primary role of insulin is to put glucose into cells.

0:04:26    Insulin isn't very good at pushing insulin into cells.

0:04:40    Insulin is a peptide hormone secreted from the beta cells of the pancreas.

0:04:54    Expecting food can increase insulin.

0:05:26    Insulin decides where nutrients go.

0:05:43    So what is insulin's primary role?

0:06:01    Insulin is anabolic.

0:06:27    The main thing insulin does is anti-catabolic.

0:06:48    Insulin prevents the breakdown of fat.

0:07:27    Insulin first acts on the alpha cells of the pancreas.

0:07:29    The alpha cells secrete glucagon.

0:07:48    Glucose is gone, glucagon.

0:08:00    Insulin turns off glucagon.

0:08:32    Only tiny amounts of insulin are needed to turn off glucagon.

0:08:47    Next insulin goes to the liver.

0:08:57    Turns off gluconeogenesis.

0:09:17    Now at greater concentrations, insulin acts in the periphery to tell cells to stop breaking down fat.

0:09:32    There are some nice experiments showing this in forearm muscles.

0:09:53    10 uIU/mL cells start taking up fatty acids.

0:10:16    Insulin only causes glucose uptake at levels of 40-50 uIU/mL.

0:11:03    How did this mistaken belief become common knowledge?

0:11:06    Partly from work done in type 1 diabetes.

0:11:41    Without the action of insulin, the catabolic hormones act unopposed.

0:12:14    Roger Unger glucagon presentation.

0:12:39    Without insulin, there is uncontrolled glucagon release.

0:13:13    Insulin given as medicine is to act against glucagon.

0:13:31    No one was really thinking about this.

0:13:42    Insulin does increase the uptake of glucose into cells so this was an easy mistake to make.

0:14:15    Your high blood sugar might be coming from the liver.

0:14:56    The problem with injecting insulin into subcutaneous fat.

0:15:57    My carbohydrate experiment.

0:16:17    I did an oral glucose tolerance test at home using a dried blood spot test.

0:16:37    My insulin never got above 7.4 uIU/mL.

0:16:56    Most people eating a standard western diet end up relying on insulin to stuff glucose into cells.

0:17:26    Carbohydrates plus fat is maximally insulinogenic.

0:17:56    This is not something we're necessarily adapted to.

0:18:12    It may have been an advantage to store the excess.

0:18:45    75% of glucose should go into muscles.

0:19:08    I did exercise during my test.

0:19:46    We know that I'm very insulin sensitive.

0:20:01    My muscles are primed to take the extra glucose.

0:20:20    So the carbs go straight into muscles without the insulin.

0:21:07    Most glucose uptake into muscle does not require insulin.

0:21:32    This pattern is common in people eating a high-fat diet.

0:21:56    High insulin smashes the pancreas and liver over the head.

0:22:25    The problems come when the muscles don't need the glucose.

0:22:52    My blood glucose peaked at 200 mg/dL.

0:23:08    The peak was in part due to a stress response.

0:23:31    Insulin is not for putting glucose into cells, exercise should create the demand.

0:23:48    If all your cells are overloaded already, then you create a problem.

0:24:09    Cortisol and adrenaline are there to drive up glucose.

0:24:55    We will repeat the experiment without the carbs.

0:25:18    I'm going to do an experiment to see how much cortisol I produce during a race.

0:25:56    Elevated fasted blood glucose, aka the dawn effect.

0:26:24    This questions comes up a lot.

0:26:38    A low-carb diet can cause physiological insulin resistance.

0:26:58    We're not sure if this is anything to do with insulin resistance at all.

0:27:17    Cortisol waking response.

0:27:58    Cortisol should come up before you wake.

0:28:15    People may have heart attacks more often at that time for this reason.

0:28:28    A lot of potential things could be going on here.

0:28:44    Anything which is interfering metabolic health could be causing this.

0:29:10    Are people looking at food quality?

0:29:40    Ketogenic diets can increase cortisol.

0:29:59    Insulin resistance leads to fast cortisol metabolism.

0:30:21    Previously we would have seen this as low cortisol on a saliva test.

0:30:44    It's not that the ketogenic diet is stressful per se, but that the cortisol is no longer being metabolised so quickly.

0:31:28    People that haven't addressed other health issues may find a ketogenic diet stressful.

0:32:03    The dawn effect is likely multifactorial and complicated but not normal.

0:32:35    My fasted blood glucose was creeping up into the 90s.

0:32:49    Now it's down in the low 80s and even high 70s.

0:33:09    Could nicotinamide riboside (NR) be lowering my fasting blood glucose?

0:33:21    NR is a precursor for NAD.

0:33:35    NAD is an electron acceptor.

0:33:46    The ratio of NAD to NADH is important.

0:34:00    In type 2 diabetes there's lots of extra NADH compared to NAD.

0:34:18    Nutritional deficiencies can cause problems.

0:34:38    You can end up with not enough NAD to accept the electrons from all the calories you're taking in.

0:35:00    If NAD goes up with respect to NADH it could signal more glucose to enter the cell.

0:35:29    As always, there are confounders.

0:35:41    Beta-alanine.

0:35:46    Eating more carbs and sleeping better.

0:35:57    Not much data on NR in humans.

0:36:20    I've been racing but not training.

0:36:39    conciergeclinicalcoaching.com

0:37:04    What goes on behind the scenes at NBT.

0:37:22    Tommy is a huge part of my education.

0:37:53    Tommy sends me 1,000 words with six papers attached.

0:38:11    Tommy is a research scientist.

0:38:18    You need someone to guide you through the literature.

0:38:37    If something is published we assume it's good science but that isn't always the case.

0:39:00    So much vested interested and cognitive dissonance.

0:39:13    We have our own biases!

0:39:31    Tommy is about as evidence driven as you can get.

0:39:47    Metabolic Fitness Pro.

0:39:58    Names are just variables.

0:40:09    How can I bring this experience to more people.

0:40:36    The main feature is a private Facebook group.

0:41:13    On the Facebook group you will be following along with the studies we're looking at.

0:41:39    We didn't have enough time to explain the results after the O2 Boost programme.

0:42:00    Information is best absorbed in chunks.

0:42:12    Run some tests, think about it, ask some questions.

0:42:29    I can't afford to answer everyone's questions via email.

0:42:49    Tell us if you think this is a bad idea!

0:43:09    Context is important during our discussions so we can't just throw stuff up on the blog.

0:43:52    We develop a relationship but then fail to follow up very well.

0:44:17    You get continuous feedback.

0:44:31    You keep on testing.

0:44:40    Once a month live Q&A webinars.

0:44:58    We will produce transcripts from the webinars.

0:45:30    You will be able to ask questions during the webinar live.

0:45:56    Tweaking biochemistry is where I see benefits now.

0:46:29    Having Tommy answer my questions is priceless.

0:47:03    My network of experts.

0:47:22    So even if I don't have the answer, I probably know someone that does.

0:47:46    The main benefit of the podcast is networking.

0:48:09    Joe Friel.

0:48:35    These contacts are my greatest asset.

0:48:52    The Internet is changing everything.

0:49:16    We're pricing it low, act now!

0:49:34    The first 7 days are free (not $10).

]]>
no
The Importance of Strength and Mobility for Mountain Bikers https://s3.amazonaws.com/nourishbalancethrive/podcast/mtbsurf01.on.2015-10-20.at.09.08.mp3 Your performance on a mountain bike has four pillars of support: cardio, mobility, skills and strength. Most riders only worry about one or maybe two. Could you be a good rider with just one pillar? Maybe, but why limit yourself?

This week it’s been raining pretty solidly here in northern California, and honestly, I couldn’t care less. In years gone by, I'd have been donning rain gear and even spending time on the trainer in an attempt to maintain my aerobic engine, but now I understand that cardio is just one of the four pillars. I get plenty of time to improve my cardio on the trail, so in the rainy months, it makes sense to work on my strength and mobility.

James Wilson is a strength and skills coach whose programmes and teaching have been tremendously helpful to me over the past few years. James helped me understand that I wasn’t going to get any faster by doing more of the same and that road riding wasn’t going to make me a better mountain biker.

Light hands and heavy feet make for better mountain biking, and flat pedals have helped me learn this by providing instant feedback of my weight being somewhere other than on my feet. Flat pedals are also extremely comfortable and allow me to easily stick a foot out moto-style on tight switchbacks.

But what about pulling up on the backstroke?

As you’ll hear in this podcast, and as has been shown in the studies cited below, there is no advantage in pulling up on the backstroke, and so this is not a good reason to be using clipless pedals.

Not long after we recorded this interview, my new Catalyst pedals arrived and since then I've been enjoying wiggling my toes as I pedal comfortably in a midfoot position. The pedals are long enough to support my whole foot yet narrow enough to minimise rock strikes.

But yet I still race clipless! Am I suspending disbelief? Please let me know in the comments below.

Here’s the outline of this interview with James Wilson:

0:00:00    I've had fantastic results following James's training programmes.

0:00:52    James has been developing a pedal for about a year.

0:01:28    Do not listen to this podcast if you're easily offended by flat pedals on an MTB.

0:02:23    The controversial article I wrote.

0:03:10    I've ridden mountain bikes since I was a kid, but then I fell away from the sport.

0:03:43    When I moved to the US I got into road bikes.

0:04:05    I used to think weight was the most important thing.

0:04:45    Why is strength training important for mountain bikers?

0:05:05    James hates the word cyclist.

0:05:32    Mountain biking is not road biking.

0:06:25    Road biking doesn't necessarily transfer to MTB.

0:07:16    High-tension cardio on the trail.

0:08:02    The best MTB riders in the world pedal the least.

0:08:18    Aaron Gwin winning a World Cup race without a chain.

0:08:39    James's article on Pinkbike about what makes a great downhill racer.

0:09:12    Gray Cook: "The grip is the window to the core".

0:09:41    Functional core strength is extremely important.

0:10:07    Pedalling is not the only skill.

0:10:26    Mobility and strength are equally important.

0:10:40    Mobility first.

0:10:57    Can you do a bodyweight squat?

0:11:14    Is your squat "stress proof"?

0:11:50    You can make your gas tank bigger, or you can improve your miles per gallon.

0:12:15    Your body will cycle through muscle fibres.

0:12:41    More muscles fibre recruitment means more performance.

0:12:56    Most people take a unidirectional approach, i.e. cardio.

0:14:01    Strength training is the fast track.

0:14:21    Riding will make you stronger.

0:15:09    Training fills in gaps.

0:15:40    Riding already provides us with plenty of cardio.

0:16:22    When you look at it this way, strength training is obvious.

0:16:59    Lee McCormack on my podcast.

0:17:40    Your aerobic engine will only take you so far.

0:18:06    Lack of mobility can stop you from getting into a basic attack position.

0:18:37    Skills and mobility are connected.

0:18:53    You should be able to pick up a high-level skill in about 10 minutes, otherwise you're not ready.

0:19:15    The same is true of the kettlebell swing.

0:19:38    Running into the wall at James's skill camps.

0:20:32    Most skills problems boil down to lack of mobility and strength.

0:21:03    It should look effortless.

0:21:10    James's article on arete (Greek for excellence with style and grace).

0:21:44    Don't worry about speed, worry about style and grace.

0:22:12    You should be able to just tell when you see a good rider.

0:22:31    Strava times can be deceptive.

0:23:16    Smoother is also more consistent and free of injury.

0:23:45    The difference between a good rider and a good local rider.

0:24:34    If you have authentic skills, you will be able to apply them under any circumstances.

0:25:11    New riders don't know who to look up to.

0:25:38    Sometimes fast and good are concordant.

0:26:06    Consistency is key.

0:26:55    James has been through the learning process.

0:27:14    James's way is not the only way.

0:27:32    Some guys will be fast without skills.

0:28:13    Joe Friel talked about the importance of strength training on my podcast.

0:28:42    I hate going to the gym, can I still benefit?

0:29:10    You don't need to be able to go to the gym.

0:29:35    The term strength training has value, but is limiting.

0:30:01    You can train in a way without becoming bulky.

0:30:16    Push-pull, squat, hip hinge, loaded carry.

0:30:50    Loaded carry.

0:31:04    Gyms can produce zoo humans.

0:31:51    The transfer from stationary to moving (or functional).

0:32:21    Loaded carries: farmer's walk, rack walk, overhead, then mix it up.

0:33:10    Bearhug a sandbag.

0:33:28    Pushes and pulls with sleds.

0:33:44    The principle is being able to move under load.

0:34:10    This teaches high-tension cardio.

0:34:28    These are miracle exercies for MTB.

0:34:46    The upper back is the forgotten part of the core.

0:35:12    Rounded shoulders are not normal.

0:35:22    You can't breath properly with rounded shoulders.

0:35:49    Better breathing can equate to better performance.

0:36:21    Do loaded carries!

0:36:46    Dan John: “If it's important, do it every day”.

0:37:19    What are YOUR specific gaps.

0:37:35    The windmill and the stick windmill.

0:37:48    If you can't do these movements, good luck cornering on a MTB.

0:38:19    You can do these exercises without going to the gym.

0:38:33    Once you understand the principles, you can find a method.

0:38:55    Body weight is helpful, but can eventually be limiting.

0:39:10    James's article about the steel mace.

0:39:56    You don't need a bunch of fancy equipment.

0:40:16    Loaded carry with kids.

0:40:33    Zoo humans.

0:41:10    How about adults do you know that could hang from a tree for 30 seconds?

0:41:35    Not being able to throw.

0:41:57    Athletics is about being a zoo human, MTB is a neat trick.

0:42:20    If a rock falls on me...

0:42:52    If you can't deadlift your own body weight you're in trouble.

0:43:18    The loss of these innate abilities is sad.

0:43:55    We do loaded carries in the gym because we don't carry our kids any more.

0:44:20    Ditch your stroller!

0:44:45    Taking the escalator to the gym.

0:45:07    Find ways to challenge your innate human abilities.

0:45:31    Go play with your kids outside.

0:45:58    Go on a hike and get off the trail.

0:46:35    Squatting.

0:46:56    We're not MTBers, we're human beings that ride MTB.

0:47:18    Katy Bowman on my podcast.

0:47:39    Book: Move Your DNA.

0:47:52    Katy on the Joe Rogan podcast.

0:48:11    Having a couch in your living room

0:48:27    Book: Alignment Matters.

0:49:09    Flat pedals have taught me to be a better mountain biker.

0:49:41    Fallacy: riding a bike is different, throw out all the rules.

0:50:30    A lot of the equipment we know today originates from the safety cycle.

0:51:22    When people tell you need need clipless pedals, ask for the proof.

0:52:13    It's so hard to know where to start with people.

0:52:31    There is no science that supports pulling up on the backstroke.

0:52:50    Global Cycling Network video.

0:53:23    Even with crappy equipment, the test rider was still more efficient on flats!

0:54:09    The performance advantages attributed to clipless are not there.

0:54:50    We've been led to believe that clipless allow us to use our legs differently.

0:55:20    Pulling up on the backstroke is inefficient.

0:55:39    Effect of Pedaling Technique on Mechanical Effectiveness and Efficiency in Cyclists, Korf et al.

0:55:39    Effects of Pedal Type and Pull-Up Action during Cycling, Mornieux et al.

0:55:47    The Flat Pedal Manifesto.

0:56:09    When we say clipless pedals, we mean SPD.

0:56:54    How hard you can push with your quad vs how hard you can pull with your hamstring.

0:57:31    We're prewired, so we should pedal like we walk.

0:57:54    This sounds like reflexes in physiology!

0:58:20    You don't need to overpull, you just need to focus on pushing down hard.

0:58:46    Cycling leads the world in doping, and far behind in exercise science.

0:59:14    The running world has shown many times that interfering with the running stride makes matters worse.

1:00:12    Yet the cycling world is still trying to teach cyclists how to pedal.

1:00:36    The rules don't change because you're on a bike.

1:00:50    Pulling up doesn't work because you're trying to do something that unnatural.

1:01:37    James's flat pedals.

1:02:04    Suspending disbelief.

1:02:21    Pushing through the ball of the foot.

1:02:43    Why am I training my foot to do something different in the gym.

1:03:03    Greg Choat on midfoot pedalling.

1:03:18    Your foot acts differently depending on whether or not contact is lost.

1:03:43    In deadlifting and pedalling, the foot does not break contact.

1:04:13    Therefore, the midfoot pedalling position makes sense.

1:04:46    Study showing no difference in power or economy of midfoot position.

1:05:11    Tight calves.

1:05:25    With midfoot, the tension moves to the hips.

1:05:36    Study showing the hips are the main driver at all intensities.

1:06:08    An evidence driven approach to pedalling.

1:06:31    Midfoot requires stabilizing both ends of the arch.

1:06:55    The existing pedals do not support the foot properly.

1:07:16    Why can you deadlift without shoes but need stiff soled shoes on the bike?

1:08:00    Every pedal has been designed with the assumption of pedalling through the ball of the foot.

1:08:34    Standing on a pedal should be like standing on the ground.

1:09:13    James's pedals are for a midfoot position.

1:09:38    You can still shift your weight forward and back.

1:10:03    Numb toes is caused by shoving toes into the toe box.

1:10:59    Your feet stay on the pedals much easier with the midfoot position.

1:11:36    Freedom and comfort of flats.

1:11:59    Feet feel great with flats.

1:12:24    We now have a flat pedal without drawbacks.

1:12:42    Everything boils down to feet, hips and shoulders.

1:13:28    The Catalyst Pedal.

1:13:44    The Catalyst is 5" front to back, 1.5" longer.

1:14:20    Rock strikes with oversized flats.

1:15:00    The pedals are well tested.

1:15:42    pedallinginnovations.com

1:16:05    This is the only pedal based on science.

1:16:33    30-day money back guarantee.

1:17:18    You must be willing to adopt the midfoot position.

1:17:46    My preferred position is midfoot.

1:18:50    If you're open minded and willing to try something different.

1:20:08    bikejames.com

1:20:27    Free 30-day programmes.

1:20:47    The Ultimate MTB programme.

1:20:56    The No Gym No Problem programme.

1:21:22    Saving people from time on the trainer!

]]>
chris@nourishbalancethrive.com https://s3.amazonaws.com/nourishbalancethrive/podcast/mtbsurf01.on.2015-10-20.at.09.08.mp3 Thu, 07 Jan 2016 13:01:51 GMT Christopher Kelly Your performance on a mountain bike has four pillars of support: cardio, mobility, skills and strength. Most riders only worry about one or maybe two. Could you be a good rider with just one pillar? Maybe, but why limit yourself?

This week it’s been raining pretty solidly here in northern California, and honestly, I couldn’t care less. In years gone by, I'd have been donning rain gear and even spending time on the trainer in an attempt to maintain my aerobic engine, but now I understand that cardio is just one of the four pillars. I get plenty of time to improve my cardio on the trail, so in the rainy months, it makes sense to work on my strength and mobility.

James Wilson is a strength and skills coach whose programmes and teaching have been tremendously helpful to me over the past few years. James helped me understand that I wasn’t going to get any faster by doing more of the same and that road riding wasn’t going to make me a better mountain biker.

Light hands and heavy feet make for better mountain biking, and flat pedals have helped me learn this by providing instant feedback of my weight being somewhere other than on my feet. Flat pedals are also extremely comfortable and allow me to easily stick a foot out moto-style on tight switchbacks.

But what about pulling up on the backstroke?

As you’ll hear in this podcast, and as has been shown in the studies cited below, there is no advantage in pulling up on the backstroke, and so this is not a good reason to be using clipless pedals.

Not long after we recorded this interview, my new Catalyst pedals arrived and since then I've been enjoying wiggling my toes as I pedal comfortably in a midfoot position. The pedals are long enough to support my whole foot yet narrow enough to minimise rock strikes.

But yet I still race clipless! Am I suspending disbelief? Please let me know in the comments below.

Here’s the outline of this interview with James Wilson:

0:00:00    I've had fantastic results following James's training programmes.

0:00:52    James has been developing a pedal for about a year.

0:01:28    Do not listen to this podcast if you're easily offended by flat pedals on an MTB.

0:02:23    The controversial article I wrote.

0:03:10    I've ridden mountain bikes since I was a kid, but then I fell away from the sport.

0:03:43    When I moved to the US I got into road bikes.

0:04:05    I used to think weight was the most important thing.

0:04:45    Why is strength training important for mountain bikers?

0:05:05    James hates the word cyclist.

0:05:32    Mountain biking is not road biking.

0:06:25    Road biking doesn't necessarily transfer to MTB.

0:07:16    High-tension cardio on the trail.

0:08:02    The best MTB riders in the world pedal the least.

0:08:18    Aaron Gwin winning a World Cup race without a chain.

0:08:39    James's article on Pinkbike about what makes a great downhill racer.

0:09:12    Gray Cook: "The grip is the window to the core".

0:09:41    Functional core strength is extremely important.

0:10:07    Pedalling is not the only skill.

0:10:26    Mobility and strength are equally important.

0:10:40    Mobility first.

0:10:57    Can you do a bodyweight squat?

0:11:14    Is your squat "stress proof"?

0:11:50    You can make your gas tank bigger, or you can improve your miles per gallon.

0:12:15    Your body will cycle through muscle fibres.

0:12:41    More muscles fibre recruitment means more performance.

0:12:56    Most people take a unidirectional approach, i.e. cardio.

0:14:01    Strength training is the fast track.

0:14:21    Riding will make you stronger.

0:15:09    Training fills in gaps.

0:15:40    Riding already provides us with plenty of cardio.

0:16:22    When you look at it this way, strength training is obvious.

0:16:59    Lee McCormack on my podcast.

0:17:40    Your aerobic engine will only take you so far.

0:18:06    Lack of mobility can stop you from getting into a basic attack position.

0:18:37    Skills and mobility are connected.

0:18:53    You should be able to pick up a high-level skill in about 10 minutes, otherwise you're not ready.

0:19:15    The same is true of the kettlebell swing.

0:19:38    Running into the wall at James's skill camps.

0:20:32    Most skills problems boil down to lack of mobility and strength.

0:21:03    It should look effortless.

0:21:10    James's article on arete (Greek for excellence with style and grace).

0:21:44    Don't worry about speed, worry about style and grace.

0:22:12    You should be able to just tell when you see a good rider.

0:22:31    Strava times can be deceptive.

0:23:16    Smoother is also more consistent and free of injury.

0:23:45    The difference between a good rider and a good local rider.

0:24:34    If you have authentic skills, you will be able to apply them under any circumstances.

0:25:11    New riders don't know who to look up to.

0:25:38    Sometimes fast and good are concordant.

0:26:06    Consistency is key.

0:26:55    James has been through the learning process.

0:27:14    James's way is not the only way.

0:27:32    Some guys will be fast without skills.

0:28:13    Joe Friel talked about the importance of strength training on my podcast.

0:28:42    I hate going to the gym, can I still benefit?

0:29:10    You don't need to be able to go to the gym.

0:29:35    The term strength training has value, but is limiting.

0:30:01    You can train in a way without becoming bulky.

0:30:16    Push-pull, squat, hip hinge, loaded carry.

0:30:50    Loaded carry.

0:31:04    Gyms can produce zoo humans.

0:31:51    The transfer from stationary to moving (or functional).

0:32:21    Loaded carries: farmer's walk, rack walk, overhead, then mix it up.

0:33:10    Bearhug a sandbag.

0:33:28    Pushes and pulls with sleds.

0:33:44    The principle is being able to move under load.

0:34:10    This teaches high-tension cardio.

0:34:28    These are miracle exercies for MTB.

0:34:46    The upper back is the forgotten part of the core.

0:35:12    Rounded shoulders are not normal.

0:35:22    You can't breath properly with rounded shoulders.

0:35:49    Better breathing can equate to better performance.

0:36:21    Do loaded carries!

0:36:46    Dan John: “If it's important, do it every day”.

0:37:19    What are YOUR specific gaps.

0:37:35    The windmill and the stick windmill.

0:37:48    If you can't do these movements, good luck cornering on a MTB.

0:38:19    You can do these exercises without going to the gym.

0:38:33    Once you understand the principles, you can find a method.

0:38:55    Body weight is helpful, but can eventually be limiting.

0:39:10    James's article about the steel mace.

0:39:56    You don't need a bunch of fancy equipment.

0:40:16    Loaded carry with kids.

0:40:33    Zoo humans.

0:41:10    How about adults do you know that could hang from a tree for 30 seconds?

0:41:35    Not being able to throw.

0:41:57    Athletics is about being a zoo human, MTB is a neat trick.

0:42:20    If a rock falls on me...

0:42:52    If you can't deadlift your own body weight you're in trouble.

0:43:18    The loss of these innate abilities is sad.

0:43:55    We do loaded carries in the gym because we don't carry our kids any more.

0:44:20    Ditch your stroller!

0:44:45    Taking the escalator to the gym.

0:45:07    Find ways to challenge your innate human abilities.

0:45:31    Go play with your kids outside.

0:45:58    Go on a hike and get off the trail.

0:46:35    Squatting.

0:46:56    We're not MTBers, we're human beings that ride MTB.

0:47:18    Katy Bowman on my podcast.

0:47:39    Book: Move Your DNA.

0:47:52    Katy on the Joe Rogan podcast.

0:48:11    Having a couch in your living room

0:48:27    Book: Alignment Matters.

0:49:09    Flat pedals have taught me to be a better mountain biker.

0:49:41    Fallacy: riding a bike is different, throw out all the rules.

0:50:30    A lot of the equipment we know today originates from the safety cycle.

0:51:22    When people tell you need need clipless pedals, ask for the proof.

0:52:13    It's so hard to know where to start with people.

0:52:31    There is no science that supports pulling up on the backstroke.

0:52:50    Global Cycling Network video.

0:53:23    Even with crappy equipment, the test rider was still more efficient on flats!

0:54:09    The performance advantages attributed to clipless are not there.

0:54:50    We've been led to believe that clipless allow us to use our legs differently.

0:55:20    Pulling up on the backstroke is inefficient.

0:55:39    Effect of Pedaling Technique on Mechanical Effectiveness and Efficiency in Cyclists, Korf et al.

0:55:39    Effects of Pedal Type and Pull-Up Action during Cycling, Mornieux et al.

0:55:47    The Flat Pedal Manifesto.

0:56:09    When we say clipless pedals, we mean SPD.

0:56:54    How hard you can push with your quad vs how hard you can pull with your hamstring.

0:57:31    We're prewired, so we should pedal like we walk.

0:57:54    This sounds like reflexes in physiology!

0:58:20    You don't need to overpull, you just need to focus on pushing down hard.

0:58:46    Cycling leads the world in doping, and far behind in exercise science.

0:59:14    The running world has shown many times that interfering with the running stride makes matters worse.

1:00:12    Yet the cycling world is still trying to teach cyclists how to pedal.

1:00:36    The rules don't change because you're on a bike.

1:00:50    Pulling up doesn't work because you're trying to do something that unnatural.

1:01:37    James's flat pedals.

1:02:04    Suspending disbelief.

1:02:21    Pushing through the ball of the foot.

1:02:43    Why am I training my foot to do something different in the gym.

1:03:03    Greg Choat on midfoot pedalling.

1:03:18    Your foot acts differently depending on whether or not contact is lost.

1:03:43    In deadlifting and pedalling, the foot does not break contact.

1:04:13    Therefore, the midfoot pedalling position makes sense.

1:04:46    Study showing no difference in power or economy of midfoot position.

1:05:11    Tight calves.

1:05:25    With midfoot, the tension moves to the hips.

1:05:36    Study showing